PKC
Gli inibitori della proteina chinasi C (PKC) prendono di mira la famiglia delle chinasi PKC, coinvolte in una vasta gamma di processi cellulari, tra cui la regolazione del ciclo cellulare, l'apoptosi e la differenziazione. La PKC svolge un ruolo chiave nelle vie di trasduzione del segnale che influenzano la proliferazione e la sopravvivenza cellulare. L'inibizione della PKC può portare a cambiamenti nella progressione del ciclo cellulare, rendendo questi inibitori strumenti preziosi nella ricerca sul cancro, la neurobiologia e le malattie cardiovascolari. Presso CymitQuimica, offriamo una selezione diversificata di inibitori della PKC di alta qualità per supportare la tua ricerca sulla trasduzione del segnale, la regolazione del ciclo cellulare e lo sviluppo terapeutico.
Trovati 130 prodotti per "PKC".
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CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Formula:C24H21F3N6OPurezza:99.01% - 99.04%Colore e forma:SolidPeso molecolare:466.46A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Formula:C12H14Cl2N2O2SPurezza:99.32%Colore e forma:SolidPeso molecolare:321.22Ref: TM-T14069
1mg34,00€5mg63,00€10mg90,00€1mL*10mM (DMSO)95,00€25mg161,00€50mg260,00€100mg416,00€500mg888,00€Delcasertib
CAS:Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).Formula:C120H199N45O34S2Purezza:99.96%Colore e forma:SolidPeso molecolare:2880.28Ref: TM-T11740
1mg192,00€5mg485,00€10mg700,00€25mg1.063,00€50mg1.459,00€1mL*10mM (DMSO)1.603,00€100mg1.963,00€N-Desmethyltamoxifen hydrochloride
CAS:N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.Formula:C25H28ClNOPurezza:99.15%Colore e forma:SolidPeso molecolare:393.95Mitoxantrone dihydrochloride
CAS:Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.Formula:C22H30Cl2N4O6Purezza:97.05% - >99.99%Colore e forma:SolidPeso molecolare:517.4PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Purezza:95.42%Colore e forma:SoildBisindolylmaleimide VIII acetate
CAS:Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.Formula:C26H26N4O4Purezza:99.27%Colore e forma:Red SolidPeso molecolare:458.51Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Formula:C12H15N5O5Purezza:99.85%Colore e forma:SolidPeso molecolare:309.28Ref: TM-T9605
1mg119,00€5mg260,00€1mL*10mM (DMSO)341,00€10mg394,00€25mg640,00€50mg893,00€100mg1.198,00€PKCε inhibitor peptide,myristoylated
Myristoylated PKCε inhibitor peptide (Myr-PKCε-) is a cell-permeable inhibitor consisting of a peptide linked to myristic acid that specifically inhibitsFormula:C51H91N9O14Purezza:98%Colore e forma:SolidPeso molecolare:1054.32Mitoxantrone-D8
CAS:Mitoxantrone-D8 is the deuterated form of Mitoxantrone. Mitoxantrone (T6588) acts as a topoisomerase II (topoisomeraseII) inhibitor and also inhibits protein kinase C (PKC) with an IC50 value of 8.5 μM.Formula:C22H28N4O6Colore e forma:SolidPeso molecolare:452.53PKC-ε translocation inhibitor peptide
PKC-ε Translocation Inhibitor Peptide is a selective modulator that controls the FcγR-mediated internalization rate of opsonized beads without affecting FcαRPurezza:98%Colore e forma:Odour SolidPKCθ pseudosubstrate peptide inhibitor,myristoylated
Myristoylated PKCθ pseudosubstrate peptide inhibitor is a synthetic peptide utilized to investigate the mechanism of action of protein kinase C theta (PKCθ) [1Formula:C105H184N36O21SPurezza:98%Colore e forma:SolidPeso molecolare:2318.88PKC 20-28,myristoylated
Myristoylated protein kinase C inhibitor 20-28 (PKC 20-28,myristoylated) is a cell-permeable inhibitor of protein kinase C, utilized in cancer research [1].Formula:C60H106N18O11Purezza:98%Colore e forma:SolidPeso molecolare:1255.6PKCβII Peptide Inhibitor I
CAS:PKCβII Peptide Inhibitor I, a specific PKCβII inhibitor, exhibits cardioprotective properties in a rat cardiac ischemia/reperfusion injury model and mitigatesFormula:C61H94N12O19Purezza:98%Colore e forma:SolidPeso molecolare:1299.47PKCε Inhibitor Peptide acetate
PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK).Formula:C39H69N9O15Purezza:99.62%Colore e forma:SolidPeso molecolare:904.02Ref: TM-T35827L
1mg62,00€2mg89,00€5mg110,00€10mg177,00€25mg298,00€50mg429,00€100mg587,00€200mg792,00€PKC β pseudosubstrate TFA
PKC β pseudosubstrate TFA is a selective cell-permeable inhibitor of PKC [1] .Formula:C179H295F3N62O40S3Colore e forma:SolidPeso molecolare:4108.84PKCα (C2-4) inhibitor peptide
PKCα (C2-4) inhibitor peptide is a specific antagonist to PKCα that impedes the α1A-adrenoreceptor agonist A-61603 [1] from inhibiting I_Kr.Formula:C47H74N14O17Purezza:98%Colore e forma:SolidPeso molecolare:1107.17Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formula:C14H17N3O2SPurezza:99.79% - 99.97%Colore e forma:White SolidPeso molecolare:291.37TAT-P4-(DATC5)2 TFA
TAT-P4-(DATC5)2 TFA, a high-affinity peptide inhibitor targeting the PDZ domain of protein interacting with C kinase-1 (PICK1), exhibits a K i of 1.7 nM andColore e forma:Odour SolidN-Myristoyl-Lys-Arg-Thr-Leu-Arg
CAS:N-Myristoyl-Lys-Arg-Thr-Leu-Arg: PKC inhibitor, IC50=75μM, blocks IL-2 in Jurkat cells.Formula:C42H82N12O8Colore e forma:SolidPeso molecolare:883.18pep2-EVKI
CAS:Peptide inhibits GluA2-PICK1 binding, sparing GluA2-GRIP/ABP interaction and LTD, without boosting AMPA current.Formula:C62H95N13O19Purezza:98%Colore e forma:SolidPeso molecolare:1326.51Protein Kinase C Peptide Substrate
CAS:PKC Peptide Substrate acts on cell spacers, driven by second messengers/adaptors due to external signals via g protein/tyrosine kinase receptors.Formula:C83H155N39O21SPurezza:98%Colore e forma:SolidPeso molecolare:2067.43TAT-SAMβA
TAT-SAMβA, an RNAENFDRF (SAMβA) peptide conjugated to the TAT 47–57 protein-derived cell-penetrating peptide, acts as a selective antagonist of the Mfn1-βIIPKCFormula:C118H195N51O31Purezza:98%Colore e forma:SolidPeso molecolare:2824.13ɛPKC(85-92),Myristoylated
CAS:PKC(85-92)，Myristoylated is a myristic acid-conjugated, cell-permeable peptide activator of PKC that has been shown to increase nitric oxide (NO) release inFormula:C53H80N10O15Purezza:98%Colore e forma:SolidPeso molecolare:1097.26LY 379196
LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.Formula:C30H34N4O5SColore e forma:SolidPeso molecolare:562.68Bisindolylmaleimide III
CAS:Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6Formula:C23H20N4O2Purezza:97.2%Colore e forma:SolidPeso molecolare:384.43pTH-Related Protein (1-40) (human, mouse, rat)
CAS:pTH-Related Protein (1-40) boosts rat calcium absorption via PTHR1 and PKCα/β. It up-regulates PTHR1, TRPV6, CaBP-D9k, NCX1, and PMCA1.Formula:C207H334N66O58Peso molecolare:4675.27[Ala9,10, Lys11,12] Glycogen Synthase (1-12)
CAS:[Ala9,10, Lys11,12] Glycogen Synthase (1-12): PKC's selective phosphorylation substrate, used to assess PKC activity. [1]Formula:C56H103N17O16Colore e forma:SolidPeso molecolare:1270.52(8R)-8-Hydroxyepoxyboetirane A
(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.Colore e forma:Odour SolidMyelin Basic Protein
CAS:Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Formula:C60H103N21O17Purezza:98%Colore e forma:SolidPeso molecolare:1390.59Protein Kinase C (19-36)
CAS:Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Formula:C93H159N35O24Purezza:98%Colore e forma:SolidPeso molecolare:2151.48Ac-MBP (1-11)
CAS:Ac-MBP 1-11, a primary encephalitogenic epitope in myelin basic protein (MBP), is a dominant short peptide sequence[1].Formula:C2H3K2OPS3Purezza:98%Colore e forma:SolidPeso molecolare:248.411-Oleoyl-2-acetyl-sn-glycerol
CAS:1-Oleoyl-2-acetyl-sn-glycerol (1-oleoyl-2-acetyl-glycerol) is a PKC activator that induces superoxide production.Formula:C23H42O5Colore e forma:SolidPeso molecolare:398.58Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Formula:C56H110N22O14Purezza:98%Colore e forma:SolidPeso molecolare:1315.61PKC β pseudosubstrate
CAS:Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Formula:C177H294N62O38S3Purezza:98%Colore e forma:SolidPeso molecolare:3994.84PKCiota-IN-2
CAS:PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).Formula:C24H21N5OPurezza:98.86%Colore e forma:SolidPeso molecolare:395.46Ref: TM-T9863
1mg109,00€2mg163,00€5mg243,00€1mL*10mM (DMSO)264,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€FKKSFKL-NH2
CAS:FKKSFKL-NH2 is a selective peptide for protein kinase C, employed in biochemical research [1].Formula:C45H73N11O8Colore e forma:SolidPeso molecolare:896.13ZIP
CAS:Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Formula:C90H154N30O17Purezza:98%Colore e forma:SolidPeso molecolare:1928.4Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formula:C63H118N18O14SPurezza:98%Colore e forma:SolidPeso molecolare:1383.8Protein kinase C α peptide TFA
CAS:Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.Formula:C68H115F3N24O26SColore e forma:SolidPeso molecolare:1773.85Protein Kinase C (19-35) Peptide
CAS:PKC (19-35) Peptide inhibits PKC by blocking its substrate-binding, rendering cytoplasmic PKC inactive.Formula:C89H153N33O22Colore e forma:SolidPeso molecolare:2037.4[Ala113]MBP(104-118)
CAS:Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).Formula:C67H104N20O19Purezza:98%Colore e forma:SolidPeso molecolare:1493.68NPC-15437 dihydrochloride
CAS:NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.Formula:C25H52Cl2N4O2Colore e forma:White SolidPeso molecolare:511.62[Ala107]MBP(104-118)
CAS:Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).Formula:C67H104N20O19Purezza:98%Colore e forma:SolidPeso molecolare:1493.68Neuropeptide DF2
CAS:Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish.Formula:C44H67N15O10Purezza:98%Colore e forma:SolidPeso molecolare:966.1Bisindolylmaleimide XI hydrochloride
CAS:Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is an orally active pan-PKC inhibitor that inhibits PKCα, PKCβI, PKCβII, and PKCγ.Formula:C28H29ClN4O2Purezza:99.45%Colore e forma:Red SolidPeso molecolare:489.01ε-V1-2, Cys-conjugated
Epsilon-V1-2, a Cys-conjugated, is a biologically active peptide known as the εPKC-specific inhibitor.Formula:C40H70N10O14SPurezza:98%Colore e forma:SolidPeso molecolare:947.11PKCδ Peptide Substrate
CAS:PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) andFormula:C109H191N35O29SColore e forma:SolidPeso molecolare:2487.97Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Formula:C122H203N45O36S2Purezza:98.92%Colore e forma:SolidPeso molecolare:2940.33Ref: TM-T11740L
1mg166,00€2mg213,00€5mg313,00€10mg442,00€25mg642,00€50mg880,00€100mg1.179,00€200mg1.594,00€Protein kinase inhibitor H-7
CAS:H-7: potent PKC inhibitor with 6 μM Ki, also blocks cyclic nucleotide-dependent kinases.Formula:C14H17N3O2SPurezza:99.91%Colore e forma:SoildPeso molecolare:291.37
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