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ROCK

ROCK

Gli inibitori della chinasi associata a Rho (ROCK) prendono di mira le chinasi ROCK, che sono coinvolte nella regolazione del citoscheletro, della forma cellulare e della motilità. ROCK svolge un ruolo significativo nel controllo della divisione cellulare, in particolare in processi come la citodieresi. L'inibizione di ROCK può portare a cambiamenti nella dinamica del ciclo cellulare, nella motilità cellulare e nell'apoptosi, rendendo questi inibitori preziosi nella ricerca sul cancro, nella neurobiologia e negli studi cardiovascolari. Presso CymitQuimica, offriamo una selezione di inibitori ROCK di alta qualità per supportare la tua ricerca in biologia cellulare, dinamica del citoscheletro e meccanismi delle malattie.

Trovati 66 prodotti per "ROCK".

prodotti per pagina.
  • GSK429286A
    Targetmol
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    GSK429286A

    CAS:
    GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
    Formula:C21H16F4N4O2
    Purezza:97.68% - 98.49%
    Colore e forma:Solid
    Peso molecolare:432.37

    Ref: TM-T2633

  • SAR407899 hydrochloride
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    SAR407899 hydrochloride

    CAS:
    SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and
    Formula:C14H17ClN2O2
    Purezza:99.15%
    Colore e forma:Solid
    Peso molecolare:280.75

    Ref: TM-T23308

  • SAR407899
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    SAR407899

    CAS:
    SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
    Formula:C14H16N2O2
    Purezza:99.42%
    Colore e forma:White Solid
    Peso molecolare:244.289

    Ref: TM-T7391

  • AT13148
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    AT13148

    CAS:
    AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
    Formula:C17H16ClN3O
    Purezza:98.04% - ≥95%
    Colore e forma:Solid
    Peso molecolare:313.781

    Ref: TM-T2482

  • ROCK-IN-2
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    ROCK-IN-2

    CAS:
    ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
    Formula:C18H13ClF2N6O
    Purezza:97.29%
    Colore e forma:Solid
    Peso molecolare:402.79

    Ref: TM-TQ0110

  • SR-3677
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    SR-3677

    CAS:
    SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
    Formula:C22H24N4O4
    Purezza:98.46%
    Colore e forma:Solid
    Peso molecolare:408.4504

    Ref: TM-TQ0187

  • ZINC00881524
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    ZINC00881524

    CAS:
    ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
    Formula:C21H20N2O3S
    Purezza:99.48%
    Colore e forma:Solid
    Peso molecolare:380.46

    Ref: TM-T4095

  • Fasudil hydrochloride
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    Fasudil hydrochloride

    CAS:
    Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
    Formula:C14H18ClN3O2S
    Purezza:99.54% - ≥95%
    Colore e forma:White Solid
    Peso molecolare:327.83

    Ref: TM-T3060

  • Afuresertib hydrochloride
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    Afuresertib hydrochloride

    CAS:
    Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
    Formula:C18H18Cl3FN4OS
    Purezza:99.96%
    Colore e forma:Solid
    Peso molecolare:463.784

    Ref: TM-T7885

  • Hydroxyfasudil Hydrochloride
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    Hydroxyfasudil Hydrochloride

    CAS:
    Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
    Formula:C14H18ClN3O3S
    Purezza:98.03%
    Colore e forma:White Solid
    Peso molecolare:343.83

    Ref: TM-T4276

  • GSK180736A
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    GSK180736A

    CAS:
    GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).
    Formula:C19H16FN5O2
    Purezza:98.98% - 99.51%
    Colore e forma:Solid
    Peso molecolare:365.361

    Ref: TM-T3513

  • Thiazovivin
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    Thiazovivin

    CAS:
    Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
    Formula:C15H13N5OS
    Purezza:98.00%
    Colore e forma:Solid
    Peso molecolare:311.36

    Ref: TM-T2155

  • CCG-222740
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    CCG-222740

    CAS:
    CCG-222740 is an inhibitor of Rho/MRTF pathway
    Formula:C23H19ClF2N2O3
    Purezza:98.76%
    Colore e forma:Solid
    Peso molecolare:444.858

    Ref: TM-T7764

  • RKI-1447
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    RKI-1447

    CAS:
    RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
    Formula:C16H14N4O2S
    Purezza:98% - 99.73%
    Colore e forma:White Solid
    Peso molecolare:326.373

    Ref: TM-T1898

  • Y-27632
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    Y-27632

    CAS:
    Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II.
    Formula:C14H21N3O
    Purezza:99.72% - 99.87%
    Colore e forma:Solid
    Peso molecolare:247.34

    Ref: TM-T1870

  • Belumosudil
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    Belumosudil

    CAS:
    Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
    Formula:C26H24N6O2
    Purezza:97.64% - 98.59%
    Colore e forma:White Solid
    Peso molecolare:452.51

    Ref: TM-T6867

  • Y-27632 dihydrochloride
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    Y-27632 dihydrochloride

    CAS:
    View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.
    Formula:C14H23Cl2N3O
    Purezza:97.96% - 99.98%
    Colore e forma:Solid
    Peso molecolare:320.26

    Ref: TM-T1725

  • BDP5290
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    BDP5290

    CAS:
    BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
    Formula:C17H18ClN7O
    Purezza:97.22%
    Colore e forma:White Solid
    Peso molecolare:371.824

    Ref: TM-T7301

  • Afuresertib
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    Afuresertib

    CAS:
    Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic
    Formula:C18H17Cl2FN4OS
    Purezza:97.51% - 99.51%
    Colore e forma:Solid
    Peso molecolare:427.323

    Ref: TM-T1911

  • GSK269962A
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    GSK269962A

    CAS:
    GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
    Formula:C29H30N8O5
    Purezza:99.14% - 99.71%
    Colore e forma:Yellow Solid
    Peso molecolare:570.6

    Ref: TM-T3518