ROCK
Gli inibitori della chinasi associata a Rho (ROCK) prendono di mira le chinasi ROCK, che sono coinvolte nella regolazione del citoscheletro, della forma cellulare e della motilità. ROCK svolge un ruolo significativo nel controllo della divisione cellulare, in particolare in processi come la citodieresi. L'inibizione di ROCK può portare a cambiamenti nella dinamica del ciclo cellulare, nella motilità cellulare e nell'apoptosi, rendendo questi inibitori preziosi nella ricerca sul cancro, nella neurobiologia e negli studi cardiovascolari. Presso CymitQuimica, offriamo una selezione di inibitori ROCK di alta qualità per supportare la tua ricerca in biologia cellulare, dinamica del citoscheletro e meccanismi delle malattie.
Trovati 67 prodotti di "ROCK"
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RKI-1447
CAS:RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.Formula:C16H14N4O2SPurezza:98% - 99.73%Colore e forma:SolidPeso molecolare:326.37GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Formula:C24H16Cl2F2N6OPurezza:98.59%Colore e forma:SolidPeso molecolare:513.33RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFormula:C17H16N4O2SPurezza:99.53% - ≥95%Colore e forma:SolidPeso molecolare:340.4Afuresertib
CAS:<p>Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic</p>Formula:C18H17Cl2FN4OSPurezza:97.51% - 99.51%Colore e forma:SolidPeso molecolare:427.32SR-3677
CAS:<p>SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).</p>Formula:C22H24N4O4Purezza:98.46%Colore e forma:SolidPeso molecolare:408.45GSK269962A
CAS:<p>GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.</p>Formula:C29H30N8O5Purezza:99.14% - 99.71%Colore e forma:SolidPeso molecolare:570.6SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFormula:C14H17ClN2O2Purezza:99.15%Colore e forma:SolidPeso molecolare:280.75SAR407899
CAS:<p>SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.</p>Formula:C14H16N2O2Purezza:99.42%Colore e forma:SolidPeso molecolare:244.29CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formula:C11H14Cl3N3O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:358.67AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Formula:C17H16ClN3OPurezza:98.04% - ≥95%Colore e forma:SolidPeso molecolare:313.78ROCK-IN-2
CAS:ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.Formula:C18H13ClF2N6OPurezza:97.29%Colore e forma:SolidPeso molecolare:402.79HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Formula:C13H15N3O2SPurezza:99.44%Colore e forma:Pale Yellow Crystalline SolidPeso molecolare:277.34Narciclasine
CAS:Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Formula:C14H13NO7Purezza:98.16% - 99.58%Colore e forma:SolidPeso molecolare:307.26ZINC00881524
CAS:<p>ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.</p>Formula:C21H20N2O3SPurezza:99.48%Colore e forma:SolidPeso molecolare:380.46Netarsudil mesylate
CAS:Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.Formula:C30H35N3O9S2Purezza:99.7%Colore e forma:SolidPeso molecolare:645.74Fasudil hydrochloride
CAS:<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Formula:C14H18ClN3O2SPurezza:99.54% - ≥95%Colore e forma:White SolidPeso molecolare:327.83Afuresertib hydrochloride
CAS:<p>Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)</p>Formula:C18H18Cl3FN4OSPurezza:99.96%Colore e forma:SolidPeso molecolare:463.8Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Formula:C14H18ClN3O3SPurezza:98.05%Colore e forma:SolidPeso molecolare:343.83Y-27632
CAS:Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II.Formula:C14H21N3OPurezza:99.53% - 99.87%Colore e forma:SolidPeso molecolare:247.34Belumosudil
CAS:Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Formula:C26H24N6O2Purezza:97.64% - 98.59%Colore e forma:SolidPeso molecolare:452.51
