ROCK
Gli inibitori della chinasi associata a Rho (ROCK) prendono di mira le chinasi ROCK, che sono coinvolte nella regolazione del citoscheletro, della forma cellulare e della motilità. ROCK svolge un ruolo significativo nel controllo della divisione cellulare, in particolare in processi come la citodieresi. L'inibizione di ROCK può portare a cambiamenti nella dinamica del ciclo cellulare, nella motilità cellulare e nell'apoptosi, rendendo questi inibitori preziosi nella ricerca sul cancro, nella neurobiologia e negli studi cardiovascolari. Presso CymitQuimica, offriamo una selezione di inibitori ROCK di alta qualità per supportare la tua ricerca in biologia cellulare, dinamica del citoscheletro e meccanismi delle malattie.
Trovati 67 prodotti di "ROCK"
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GSK429286A
CAS:<p>GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).</p>Formula:C21H16F4N4O2Purezza:97.68% - 98.49%Colore e forma:SolidPeso molecolare:432.37Y-27632 dihydrochloride
CAS:<p>View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.</p>Formula:C14H21N3O·2HClPurezza:97.96% - 99.98%Colore e forma:SolidPeso molecolare:320.26Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Formula:C14H17N3O3SPurezza:98.13%Colore e forma:SolidPeso molecolare:307.37Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Formula:C16H16N4OPurezza:98%Colore e forma:SolidPeso molecolare:280.32SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Formula:C15H20Cl2N8O2Purezza:98%Colore e forma:SolidPeso molecolare:415.28CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Formula:C26H23N3O5Purezza:99.71%Colore e forma:SolidPeso molecolare:457.48H-1152
CAS:<p>H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).</p>Formula:C16H21N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:319.42AS 1892802
CAS:AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Formula:C20H19N3O2Purezza:99.86%Colore e forma:SolidPeso molecolare:333.38Rhodblock 6
CAS:Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Formula:C12H13N3OPurezza:99.87%Colore e forma:SolidPeso molecolare:215.25CID-5056270
CAS:<p>CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma</p>Formula:C17H13N3O3SPurezza:99.6%Colore e forma:SolidPeso molecolare:339.37Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Formula:C20H24N4SPurezza:99.8%Colore e forma:SolidPeso molecolare:352.5CRT0066854 hydrochloride
CAS:CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Formula:C24H27Cl2N5SPurezza:99.63%Colore e forma:SolidPeso molecolare:488.48ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formula:C17H17N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:327.4Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Formula:C24H28N4O4Purezza:99.67% - 99.84%Colore e forma:SolidPeso molecolare:436.5ROCK-IN-9
CAS:<p>ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.</p>Formula:C20H20FN5O2Purezza:98%Colore e forma:SolidPeso molecolare:381.4ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Formula:C26H22ClF2N7OPurezza:98%Colore e forma:SolidPeso molecolare:521.95ROCK-IN-8
CAS:ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,Formula:C30H25FN4O4SPurezza:98%Colore e forma:SolidPeso molecolare:556.61ROCK2-IN-2
CAS:ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formula:C18H12N6OSPurezza:99.65%Colore e forma:SolidPeso molecolare:360.39LX7101
CAS:LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Formula:C23H29N7O3Purezza:99.08%Colore e forma:SolidPeso molecolare:451.52ROCK-IN-1
CAS:<p>ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological</p>Formula:C20H18FN3OPurezza:>99.99%Colore e forma:SolidPeso molecolare:335.37
