HSP
Gli inibitori delle proteine da shock termico (HSP) prendono di mira le HSP, una famiglia di chaperoni molecolari che assistono nel ripiegamento delle proteine, nella stabilità e nella protezione contro i danni indotti dallo stress. Le HSP sono spesso sovraregolate nelle cellule tumorali, aiutandole a sopravvivere in condizioni stressanti come l'ipossia e la chemioterapia. L'inibizione delle HSP può interrompere questi meccanismi protettivi, portando alla morte cellulare. Gli inibitori delle HSP sono quindi preziosi nella terapia del cancro e nella ricerca sulle risposte allo stress. Presso CymitQuimica, offriamo una gamma completa di inibitori delle HSP di alta qualità per supportare la tua ricerca nell'omeostasi delle proteine, nelle risposte allo stress e nell'oncologia.
Trovati 179 prodotti di "HSP"
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GRP78-IN-3
CAS:<p>GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.</p>Formula:C17H18N4O2SPurezza:99.11%Colore e forma:SoildPeso molecolare:342.42Ethoxyquin
CAS:<p>Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.</p>Formula:C14H19NOPurezza:97.15% - 98.73%Colore e forma:Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Peso molecolare:217.31Arimoclomol maleate
CAS:<p>Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.</p>Formula:C18H24ClN3O7Purezza:99.44% - 99.98%Colore e forma:SolidPeso molecolare:429.85Novobiocin Sodium
CAS:<p>Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.</p>Formula:C31H35N2NaO11Purezza:99% - 99.28%Colore e forma:SolidPeso molecolare:634.61Rifabutin
CAS:Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Formula:C46H62N4O11Purezza:98.87% - 99.7%Colore e forma:Red-Violet Crystalline PowderPeso molecolare:847Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Formula:C14H11NO4Purezza:99.03% - 99.96%Colore e forma:SolidPeso molecolare:257.24IPI-493
CAS:IPI-493 is a bioactive chemical.Formula:C28H39N3O8Purezza:>99.99%Colore e forma:SolidPeso molecolare:545.62CC-99677
CAS:<p>CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.</p>Formula:C22H20ClN5O3SPurezza:99.59%Colore e forma:SolidPeso molecolare:469.94MAL3-101
CAS:MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).Formula:C54H66N4O10Colore e forma:SolidPeso molecolare:931.12PU-H71 HCl
CAS:<p>PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.</p>Formula:C18H22ClIN6O2SPurezza:98.95%Colore e forma:SoildPeso molecolare:548.83HA15-Biotin
CAS:<p>HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.</p>Formula:C37H45N7O5S3Colore e forma:SolidPeso molecolare:763.99Grp94 Inhibitor-3
<p>Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.</p>Formula:C24H20ClNO4Colore e forma:SolidPeso molecolare:421.87TRAP1-IN-1
CAS:TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.Formula:C45H39F7N2O4P2Purezza:98%Colore e forma:SolidPeso molecolare:866.74Chetomin
CAS:<p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>Formula:C31H30N6O6S4Purezza:98%Colore e forma:Off-White To Fawn SolidPeso molecolare:710.87MPC-0767
CAS:<p>MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.</p>Formula:C26H36BrN7O9S2Colore e forma:SolidPeso molecolare:734.6417-DMAP-GA
CAS:17-DMAP-GA, a Geldanamycin analogue, acts as an HSP90 inhibitor, leading to cell cycle abnormalities.Formula:C33H50N4O8Colore e forma:SolidPeso molecolare:630.783Arimoclomol citrate
CAS:Arimoclomol citrate boosts Hsp expression, aiding protein aggregation and neuron protection.Formula:C20H28ClN3O10Colore e forma:SolidPeso molecolare:505.91Hsp70-derived octapeptide
CAS:TPR proteins including CHIP, TPR1, and hSGT affect luciferase refolding by DnaJ and hsc70.Formula:C36H58N8O16Purezza:98%Colore e forma:SolidPeso molecolare:858.89NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10AFormula:C28H32N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:476.63PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research.Formula:C43H50N6O7Purezza:98%Colore e forma:SolidPeso molecolare:762.89TRAP1-IN-2
CAS:<p>TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.</p>Formula:C46H42F6N2O5P2Purezza:98%Colore e forma:SolidPeso molecolare:878.77Gamitrinib TPP
CAS:<p>Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.</p>Formula:C52H65N3O8PPurezza:98%Colore e forma:SolidPeso molecolare:891.078NDNA4
<p>NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.</p>Formula:C31H35F3N2O5SPurezza:98%Colore e forma:SolidPeso molecolare:604.68Zelavespib hydrochloride
Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.Purezza:98%Colore e forma:Odour Solid3-Phenyltoxoflavin
CAS:<p>3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.</p>Formula:C13H11N5O2Purezza:99.88%Colore e forma:SolidPeso molecolare:269.26DN401
CAS:DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.Formula:C13H9BrClN5O2Purezza:99.37%Colore e forma:SolidPeso molecolare:382.6Myrtucommulone
CAS:Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Formula:C38H52O10Purezza:98%Colore e forma:SolidPeso molecolare:668.81dPDL1-4
dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.Colore e forma:Odour SolidA17 peptide
CAS:A17 peptide is an Hsp70-targeting peptide. It binds to the ATP-binding domain of Hsp70, specifically inhibiting its chaperone activity. This enhances cellular sensitivity to chemotherapeutic drugs, such as those inducing apoptosis via Cisplatin. A17 peptide is applicable in cancer chemotherapy research, including studies on multiple myeloma.Formula:C76H105N19O20SColore e forma:SolidPeso molecolare:1636.83p5 Ligand for Dnak and DnaJ
CAS:P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.Formula:C44H81N15O11SPurezza:98%Colore e forma:SolidPeso molecolare:1028.27HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Formula:C57H71N15O6Colore e forma:SolidPeso molecolare:1062.27PROTAC HSP90 degrader BP3
CAS:PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.Formula:C32H29ClN8O5Colore e forma:SolidPeso molecolare:641.08HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Formula:C29H48O10Purezza:98%Colore e forma:SolidPeso molecolare:556.69HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.Formula:C22H24N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:444.5Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Formula:C24H18F3N5O3Colore e forma:SolidPeso molecolare:481.43HS-27
CAS:HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.Formula:C52H60N6O12SPurezza:97.09%Colore e forma:SolidPeso molecolare:993.13Neoantimycin
CAS:Neoantimycin: S. orinoci antibiotic, mild antifungal, like antimycin, from different Streptomyces, biosynthesis known, active variants found.Formula:C36H46N2O12Colore e forma:SolidPeso molecolare:698.766Hsp90-IN-36
<p>Hsp90-IN-36 (compound 5) is an Hsp90 inhibitor with anticancer properties and exhibits an IC50 value of 14.74 μM against MCF-7 cells.</p>Formula:C20H13F4N3O4Colore e forma:SolidPeso molecolare:435.3286BrCaQ-C10-TPP
<p>6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.</p>Formula:C45H47Br2N2O3PColore e forma:SolidPeso molecolare:854.65Shepherdin (79-87)
CAS:Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Formula:C41H64N12O12SPurezza:98%Colore e forma:SolidPeso molecolare:949.09JG-258
CAS:JG-258 is an inactive negative control for Hsp70 inhibitors [1] .Formula:C20H22ClN3OS3Colore e forma:SolidPeso molecolare:452.06trans-Dehydrocurvularin
CAS:trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Formula:C16H18O5Colore e forma:SolidPeso molecolare:290.315HSP70/SIRT2-IN-1
<p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>Purezza:98%Colore e forma:Odour SolidNMS-E973
CAS:<p>NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.</p>Formula:C22H22N4O7Purezza:99.84%Colore e forma:SolidPeso molecolare:454.43HSP90-IN-35
CAS:HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Formula:C27H33N5O5Colore e forma:SolidPeso molecolare:507.58Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Formula:C34H49F3N4O10Colore e forma:SolidPeso molecolare:730.34008NPX800
CAS:NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Formula:C32H32FN5O4Purezza:99.29%Colore e forma:SolidPeso molecolare:569.63Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formula:C22H30N6O2SPurezza:98.98%Colore e forma:SolidPeso molecolare:442.58PU-H71
CAS:PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.Formula:C18H21IN6O2SPurezza:98.31% - 99.937%Colore e forma:SolidPeso molecolare:512.37Palmitic acid-1-13C
CAS:Palmitic acid-13C, a 16-C saturated fatty acid internal standard for GC/LC-MS, is prevalent in plasma lipids and influences protein acylation and COX-2 levels.Formula:C16H32O2Colore e forma:SolidPeso molecolare:257.422CCT245232
CAS:CCT245232 is a potent HSF1 inhibitor, possibly used for researching cancer.Formula:C27H23N3O4Colore e forma:SolidPeso molecolare:453.49Palmitic acid
CAS:Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.Formula:C16H32O2Purezza:99.17% - 99.67%Colore e forma:White Crystalline Scales SolidPeso molecolare:256.42Tanespimycin
CAS:Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!Formula:C31H43N3O8Purezza:98.24% - 99.83%Colore e forma:Dark Purple SolidPeso molecolare:585.69PF04929113
CAS:PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.Formula:C25H30F3N5O4Purezza:99.04%Colore e forma:SolidPeso molecolare:521.53L-Alanyl-L-glutamine
CAS:L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.Formula:C8H15N3O4Purezza:99.71% - 99.97%Colore e forma:SolidPeso molecolare:217.22Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurezza:99.33% - 99.79%Colore e forma:SolidPeso molecolare:181.21Apoptozole
CAS:Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.Formula:C33H25F6N3O3Purezza:99.75%Colore e forma:SolidPeso molecolare:625.56Geldanamycin
CAS:<p>Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.</p>Formula:C29H40N2O9Purezza:97.59% - 99.27%Colore e forma:Yellow To Orange PowderPeso molecolare:560.64TRC051384 HCl
CAS:<p>TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.</p>Formula:C25H32ClN5O4Purezza:97.55%Colore e forma:SolidPeso molecolare:502.01Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Formula:C20H19NO4Purezza:93.77%Colore e forma:SolidPeso molecolare:337.37BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Formula:C14H15ClN6OPurezza:98% - 99.82%Colore e forma:SolidPeso molecolare:318.76Feretoside
CAS:Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).Formula:C17H24O11Purezza:99.85%Colore e forma:SolidPeso molecolare:404.37HA15
CAS:HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.Formula:C23H22N4O3S2Purezza:99.77% - 99.86%Colore e forma:SolidPeso molecolare:466.58VER49009
CAS:<p>VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).</p>Formula:C19H18ClN3O4Purezza:98.95% - >99.99%Colore e forma:SolidPeso molecolare:387.82KNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Formula:C13H11NO4Purezza:98.90%Colore e forma:SolidPeso molecolare:245.23DTHIB
CAS:DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.Formula:C13H9ClFN3O3Purezza:98.86% - 99.29%Colore e forma:SolidPeso molecolare:309.68Azadiradione
CAS:Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indicaFormula:C28H34O5Purezza:99.52%Colore e forma:SolidPeso molecolare:450.57HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Formula:C21H19N3O2S2Purezza:98.89%Colore e forma:SolidPeso molecolare:409.52YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Formula:C21H19ClN2O4Purezza:97.25%Colore e forma:SolidPeso molecolare:398.84KBU2046
CAS:KBU2046: oral anti-metastasis compound, enhances survival, targets chaperone complexes, not a typical HSP90 inhibitor.Formula:C15H11FO2Purezza:99.89%Colore e forma:SolidPeso molecolare:242.24KW-2478
CAS:<p>KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.</p>Formula:C30H42N2O9Purezza:98.68% - 99.52%Colore e forma:SolidPeso molecolare:574.66MK2-IN-1 hydrochloride
CAS:MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.Formula:C27H26Cl2N4O2Purezza:97.32%Colore e forma:SolidPeso molecolare:509.43XL888
CAS:<p>XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.</p>Formula:C29H37N5O3Purezza:99.18%Colore e forma:SolidPeso molecolare:503.64HM03 trihydrochloride
CAS:HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.Formula:C26H30Cl4N4O2Colore e forma:SolidPeso molecolare:572.35MitoBloCK-10
CAS:MitoBloCK-10 inhibits Tim44-Hsp70 binding; first to reduce PAM complex activity.Formula:C12H8FN3O3SPurezza:99.51%Colore e forma:SolidPeso molecolare:293.27MK2-IN-1
CAS:MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.Formula:C27H25ClN4O2Colore e forma:SolidPeso molecolare:472.97HSP27 inhibitor J2
CAS:HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFormula:C13H12O4SPurezza:99.51%Colore e forma:SolidPeso molecolare:264.32-hexyl-4-Pentynoic Acid
CAS:2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Formula:C11H18O2Purezza:98%Colore e forma:SolidPeso molecolare:182.26Luminespib
CAS:<p>Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C26H31N3O5Purezza:98% - 99.25%Colore e forma:SolidPeso molecolare:465.54Onalespib
CAS:Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.Formula:C24H31N3O3Purezza:99.01% - 99.66%Colore e forma:SolidPeso molecolare:409.52Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formula:C29H31NO7Purezza:95.32% - 99.67%Colore e forma:SolidPeso molecolare:505.56Alvespimycin hydrochloride
CAS:Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.Formula:C32H48N4O8·HClPurezza:99.94%Colore e forma:SolidPeso molecolare:653.21PF-04929113 Mesylate
CAS:<p>PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37</p>Formula:C26H34F3N5O7SPurezza:99% - 99.46%Colore e forma:SolidPeso molecolare:617.63Teprenone
CAS:Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).Formula:C23H38OPurezza:99.1% - 99.96%Colore e forma:SolidPeso molecolare:330.55DDO-5936
CAS:DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.Formula:C25H29N5O4SPurezza:99.81%Colore e forma:SolidPeso molecolare:495.59NVP-HSP990
CAS:NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Formula:C20H18FN5O2Purezza:98.03% - 99.32%Colore e forma:SolidPeso molecolare:379.39Eupalinolide A
CAS:<p>Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.</p>Formula:C24H30O9Purezza:98.82% - 99.22%Colore e forma:SolidPeso molecolare:462.49Grp94 Inhibitor-1
CAS:Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).Formula:C22H28N2O2Purezza:97.02%Colore e forma:SolidPeso molecolare:352.47Paeoniflorin
CAS:Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.Formula:C23H28O11Purezza:96.9% - 97.43%Colore e forma:White Fine PowderPeso molecolare:480.46Iroxanadine hydrochloride
CAS:Iroxanadine hydrochloride is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21ClN4OColore e forma:SolidPeso molecolare:296.8Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Formula:C28H34O7Purezza:99.64% - 99.68%Colore e forma:SolidPeso molecolare:482.57Ganetespib
CAS:Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.Formula:C20H20N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:364.4TRC051384
CAS:<p>TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.</p>Formula:C25H31N5O4Purezza:98.79%Colore e forma:SolidPeso molecolare:465.54KRIBB11
CAS:<p>KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.</p>Formula:C13H12N6O2Purezza:97.25% - 99.91%Colore e forma:SolidPeso molecolare:284.27Pimitespib
CAS:Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).Formula:C25H26N8OPurezza:99.22% - 99.49%Colore e forma:SolidPeso molecolare:454.53VER-49009
CAS:VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Formula:C19H18ClN3O4Purezza:99.36% - 99.99%Colore e forma:SolidPeso molecolare:387.82VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Formula:C21H23Cl2N5O2SPurezza:97.31% - 99.85%Colore e forma:SolidPeso molecolare:480.41VER-155008
CAS:<p>VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.</p>Formula:C25H23Cl2N7O4Purezza:97.03% - 99.55%Colore e forma:SolidPeso molecolare:556.4PU-H54
CAS:<p>PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.</p>Formula:C18H19N5SPurezza:99.13%Colore e forma:SolidPeso molecolare:337.44HSP70-IN-1
CAS:<p>HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).</p>Formula:C24H28N6O2SPurezza:99.91%Colore e forma:SolidPeso molecolare:464.58
