Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2442 prodotti di "Cromatina/Epigenetica"
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JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormula:C22H24N6O3Purezza:98%Colore e forma:SolidPeso molecolare:420.46BET-IN-9
CAS:BET-IN-9 is a BET inhibitor[1].Formula:C22H24N4O3Colore e forma:SolidPeso molecolare:392.45SP-2-225
CAS:SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells,Formula:C28H34N2O3Purezza:98%Colore e forma:SolidPeso molecolare:446.58MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Formula:C18H18ClF2N5OSPurezza:98%Colore e forma:SolidPeso molecolare:425.88Lepzacitinib
CAS:Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formula:C18H21N5O3Purezza:99.85%Colore e forma:SolidPeso molecolare:355.39Ref: TM-T78207
1mg52,00€5mg110,00€10mg170,00€25mg359,00€50mg533,00€100mg750,00€200mg1.064,00€1mL*10mM (DMSO)120,00€KAT modulator-1
CAS:KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].Formula:C20H36O2Purezza:98%Colore e forma:SolidPeso molecolare:308.5TC-AC28
CAS:TC-AC28 is a novel potent and selective Brd2(2) ligand.Formula:C23H21N5O3Purezza:98%Colore e forma:SolidPeso molecolare:415.44GSK4028
CAS:GSK4028 is the enantiomeric negative control of GSK4027, a PCAF/GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.Formula:C17H21BrN4OColore e forma:SolidPeso molecolare:377.28CBP/p300-IN-5
CAS:P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).Formula:C29H27F5N6O4Purezza:98%Colore e forma:SolidPeso molecolare:618.55CLB-016
CAS:CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.Formula:C17H20N6O3Purezza:98%Colore e forma:SolidPeso molecolare:356.38A1B11
CAS:A1B11 is a selective SIRT2 inhibitor.Formula:C22H25N5OColore e forma:SolidPeso molecolare:375.47GSK2646264
CAS:<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formula:C24H26N2O2Colore e forma:SolidPeso molecolare:374.48BY27
CAS:BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.Formula:C22H21ClN6Purezza:99.4% - 99.68%Colore e forma:SolidPeso molecolare:404.89NSC756093
CAS:NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.Formula:C20H19NO4Purezza:99.92%Colore e forma:SolidPeso molecolare:337.37Ref: TM-T24557
1mg47,00€5mg92,00€10mg157,00€25mg329,00€50mg490,00€100mg700,00€500mg1.406,00€1mL*10mM (DMSO)117,00€KP-544
CAS:KP-544 is an agent of neurotrophin potentiator.Formula:C18H19ClN4OPurezza:98%Colore e forma:SolidPeso molecolare:342.82PARP-2-IN-1
CAS:PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).Formula:C21H19F4N5O3Purezza:98%Colore e forma:SolidPeso molecolare:465.4PI3K/HDAC-IN-2
CAS:PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.Formula:C23H23N7O4Colore e forma:SolidPeso molecolare:461.47BRCA1-IN-2
CAS:BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.Formula:C26H33N4O7PPurezza:98.04%Colore e forma:SolidPeso molecolare:544.54Lin281632
CAS:Lin281632 is an inhibitor of RNA binding protein Lin28 and bromodomain. Lin281632 promotes mESC differentiation.Formula:C15H15N5OPurezza:99.84%Colore e forma:SolidPeso molecolare:281.31Ref: TM-T27835
1mg35,00€5mg74,00€10mg106,00€25mg224,00€50mg359,00€100mg565,00€500mg1.206,00€1mL*10mM (DMSO)84,00€Bisegliptin
CAS:Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.Formula:C18H26FN3O3Purezza:98%Colore e forma:SolidPeso molecolare:351.42ZL0420
CAS:ZL0420: Potent, selective BRD4 inhibitor, IC50 27 nM BD1 & 32 nM BD2.Formula:C16H16N4O2Purezza:99.38%Colore e forma:SolidPeso molecolare:296.32GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formula:C22H24N8OPurezza:98%Colore e forma:SolidPeso molecolare:416.48F-Amidine TFA
CAS:F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.Formula:C14H19FN4O2CF3COOHColore e forma:SolidPeso molecolare:408.4CARM1-IN-3
CAS:CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFormula:C24H32N4O2Purezza:98%Colore e forma:SolidPeso molecolare:408.54GNE-207
CAS:GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM).Formula:C29H30N6O3Purezza:98%Colore e forma:SolidPeso molecolare:510.59FT895
CAS:FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.Formula:C16H15F3N4O2Purezza:98.95% - >99.99%Colore e forma:SolidPeso molecolare:352.31Ref: TM-T11329
1mg97,00€5mg230,00€10mg359,00€25mg602,00€50mg838,00€100mg1.169,00€1mL*10mM (DMSO)255,00€CW 008
CAS:CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.Formula:C21H14F2N6O2Purezza:97.39%Colore e forma:SolidPeso molecolare:420.37AMPK-α1β1γ1 activator 1
CAS:AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Formula:C25H24ClNO9Purezza:98%Colore e forma:SolidPeso molecolare:517.91JBI-589
CAS:JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.Formula:C29H28FN5OColore e forma:SolidPeso molecolare:481.56JAK-IN-1
CAS:JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.Formula:C20H24N6O2Purezza:98%Colore e forma:SolidPeso molecolare:380.44KT-531
CAS:KT-531 (KT531) is a highly potent and selective HDAC6 inhibitor with an IC50 value of 8.5 nM and is 39-fold more selective against other HDAC isoenzymes.Formula:C17H14F4N2O4SColore e forma:SolidPeso molecolare:418.36CAY10398
CAS:CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).Formula:C15H23N3O3Colore e forma:SolidPeso molecolare:293.367dBRD4-BD1
CAS:dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.Formula:C50H53F3N8O9Colore e forma:SolidPeso molecolare:967Tubulin/JAK2-IN-1
CAS:Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significantFormula:C22H20N6O3Colore e forma:SolidPeso molecolare:416.43JH-131e-153
CAS:JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈Formula:C22H38O5Colore e forma:SolidPeso molecolare:382.53Bavarostat
CAS:Bavarostat: brain-penetrant HDAC6 inhibitor; IC50=60nM; >80x selective for HDAC6; modulates tubulin over histone acetylation.Formula:C20H27FN2O2Colore e forma:SolidPeso molecolare:346.44KDM2A/7A-IN-1
CAS:KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.Formula:C33H38N4OPurezza:99.59%Colore e forma:SolidPeso molecolare:506.68UNC8153 TFA
CAS:UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFormula:C35H38F3N5O7Purezza:96.44%Colore e forma:SolidPeso molecolare:697.7ZINC08792355
CAS:ZINC08792355 is a novel inhibitor of SIRT1.Formula:C31H24N4O3Colore e forma:SolidPeso molecolare:500.55INCB059872 tosylate
CAS:INCB059872: potent, selective oral LSD1 inhibitor, increasing tumor-suppressor gene expression by promoting H3K4 and H3K9 methylation.Formula:C37H50N2O9S2Colore e forma:SolidPeso molecolare:730.932RTS-V5
CAS:RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).Formula:C27H35N5O6Purezza:98%Colore e forma:SolidPeso molecolare:525.6T-448 free base
CAS:T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).Formula:C17H20N4OSPurezza:98%Colore e forma:SolidPeso molecolare:328.43Luteolin 7-sulfate
CAS:Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.Formula:C15H10O9SPurezza:98%Colore e forma:SolidPeso molecolare:366.3Compound SA91-0178
CAS:SA91-0178 (3-{[(1-methyl-2-oxo-1'-phenyl-1,2-dihydrospiro[indole-3,4'-piperidine]-5-carbonyl)amino]methyl}benzoic acid) is a specific METTL1 inhibitor and effectively alleviated tissue injury during septic inflammation.Formula:C28H27N3O4Peso molecolare:469.54GSK3368715 hydrochloride
CAS:GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.Formula:C20H38N4O2·HClColore e forma:SolidPeso molecolare:403PARPYnD
CAS:PARPYnD: Photoaffinity PARP probe; inhibits PARP2, PARP1, PARP6 (IC50: 6, 38, 230 nM); tags PARP1/2 with N3 fluorescent probe.Formula:C34H31N9O3Colore e forma:SolidPeso molecolare:613.67ARTD3/PARP3-IN-1
CAS:ARTD3/PARP3-IN-1 is a non-selective inhibitor targeting diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3)/PARP3 [1].Formula:C17H16N4O2Colore e forma:SolidPeso molecolare:308.33I-BET762 carboxylic acid
CAS:I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).Formula:C20H17ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:396.83L-Moses
CAS:L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).Formula:C21H24N6Purezza:98%Colore e forma:SolidPeso molecolare:360.46ZINC08792229
CAS:ZINC08792229 is a novel inhibitor of SIRT1.Formula:C30H22N4O3Purezza:98%Colore e forma:SolidPeso molecolare:486.52HA-1004 dihydrochloride
CAS:HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel proteinFormula:C12H16ClN5O2SPurezza:98%Colore e forma:White Crystalline SolidPeso molecolare:329.81MS67
CAS:MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.Formula:C52H59F4N9O7SColore e forma:SolidPeso molecolare:1030.14CBP/p300-IN-19 hydrochloride
CAS:CBP/p300-IN-19 HCl is a p300/CBP HAT inhibitor (IC50: p300 1.4 μM, CBP 2.2 μM) with antitumor properties.Formula:C30H28ClN3O3Colore e forma:SolidPeso molecolare:514.02GRK2 Inhibitor 2
CAS:GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Formula:C19H16N4O2Colore e forma:SolidPeso molecolare:332.36TRC160334 sodium
CAS:TRC160334 is a HIF hydroxylases inhibitor.Formula:C14H15N3O5SColore e forma:SolidPeso molecolare:337.35UNC7145
CAS:UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Formula:C24H23N5O4Colore e forma:SolidPeso molecolare:445.4705MTDH-SND1 blocker 1
CAS:MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Formula:C14H13ClN4O3SColore e forma:SolidPeso molecolare:352.8Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formula:C42H70O12Purezza:98.46% - 99.13%Colore e forma:SolidPeso molecolare:767.00Ampkinone
CAS:Ampkinone is an indirect AMPK activator.Formula:C31H23NO6Purezza:98%Colore e forma:SolidPeso molecolare:505.52NMS-P953
CAS:NMS-P953: JAK2 inhibitor, reduces tumor growth in SET-2 model, confirmed in vivo action, good pharmacokinetics and safety.Formula:C16H11ClF3N5OColore e forma:SolidPeso molecolare:381.74Nezulcitinib
CAS:Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.Formula:C30H37N7O2Colore e forma:SolidPeso molecolare:527.66NHWD-870
CAS:NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.Formula:C29H29N7OPurezza:98%Colore e forma:SolidPeso molecolare:491.59GW814408X
CAS:GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formula:C19H16N6OPeso molecolare:344.37(S)-Ro 32-0432
CAS:(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].Formula:C28H29ClN4O2Colore e forma:SolidPeso molecolare:489.01HDAC6/HSP90-IN-1
CAS:HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.Formula:C28H37N3O6Colore e forma:SolidPeso molecolare:511.61QC6352
CAS:QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).Formula:C24H25N3O2Purezza:98%Colore e forma:SolidPeso molecolare:387.47GNE-049
CAS:GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.Formula:C27H32F2N6O2Purezza:98.67%Colore e forma:SolidPeso molecolare:510.581,2-Didecanoyl-sn-glycerol
CAS:GNN14490, a substrate for human pancreatic lipase, is utilized to create monomolecular films for enzyme assay studies.Formula:C23H44O5Colore e forma:SolidPeso molecolare:400.6GSK-2807 free base
CAS:GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Formula:C19H32N8O5Colore e forma:SolidPeso molecolare:452.51PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Formula:C25H30N8O2Purezza:98%Colore e forma:SolidPeso molecolare:474.56JAK-IN-4
CAS:JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.Formula:C18H21N4Na2O6PPurezza:98%Colore e forma:SolidPeso molecolare:466.341CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormula:C29H43Cl3N4O3Purezza:98%Colore e forma:SolidPeso molecolare:602.04ZLN024
CAS:ZLN024 is an activator of AMPK allosteric.Formula:C13H13BrN2OSPurezza:99.751%Colore e forma:SolidPeso molecolare:325.22Ref: TM-T13411
1mg87,00€5mg187,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)188,00€TNKS1/2-IN-1
CAS:TNKS1/2-IN-1: potent inhibitor for cancer, fibrosis research; pIC50 7.1-8.2.Formula:C26H23F4N3O4Colore e forma:SolidPeso molecolare:517.47Vafidemstat
CAS:Vafidemstat (ORY-2001) is a lysine-histone demethylase (LSD1)/MAO-B inhibitor for the study of neurological disorders.Formula:C19H20N4O2Purezza:99.53%Colore e forma:SolidPeso molecolare:336.39CD235
CAS:CD235 is a structurally similar analog of CD161. CD161 is an orally bioavailable inhibitor of BET bromodomain.Formula:C26H20FN5O2Purezza:98%Colore e forma:SolidPeso molecolare:453.47SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormula:C21H30Br3ClN6SPurezza:98%Colore e forma:SolidPeso molecolare:673.73YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formula:C19H17N3OS2Purezza:98%Colore e forma:SolidPeso molecolare:367.49MAK683-CH2CH2COOH
CAS:MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.Formula:C23H21FN6O3Purezza:98%Colore e forma:SolidPeso molecolare:448.45(1s,4s)-Menin-MLL inhibitor-23
<p>(1s,4s)-Menin-MLL Inhibitor-23, an enantiomer of Menin-MLL Inhibitor-23 (Example 99A), functions as an inhibitor of the menin-MLL interaction [1].</p>Formula:C36H53FN6O4Colore e forma:SolidPeso molecolare:652.84PHD2/HDACs-IN-1
CAS:PHD2/HDACs-IN-1: strong PHD2/HDAC inhibitor (IC50: 1.15-26.60 μM), low-toxicity, protects kidneys from cisplatin-induced AKI.Formula:C18H19N9O4Colore e forma:SolidPeso molecolare:425.4BRD-IN-3
CAS:BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ.Formula:C21H25N5O3Purezza:98%Colore e forma:SolidPeso molecolare:395.45GSK-3484862
CAS:Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formula:C19H19N5OSPurezza:99.87% - 99.963%Colore e forma:SolidPeso molecolare:365.45Ref: TM-T11469
1mg50,00€5mg119,00€10mg187,00€25mg335,00€50mg512,00€100mg730,00€500mg1.473,00€1mL*10mM (DMSO)215,00€SMYD3-IN-1
CAS:SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Formula:C28H31ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:507.02TCS HDAC6 20b
CAS:TCS HDAC6 20b (HDAC6-IN-7) is an HDAC6 inhibitor that blocks the growth of breast cancer cells and can be used in cancer research.Formula:C26H44N2O4SPurezza:>99.99%Colore e forma:SolidPeso molecolare:480.7KDM4-IN-2
CAS:KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Formula:C25H26N6OPurezza:98%Colore e forma:SolidPeso molecolare:426.51MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formula:C22H24F2N6O2Purezza:99.47% - >99.99%Colore e forma:SolidPeso molecolare:442.46Tankyrase-IN-5
CAS:Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitoryFormula:C17H18N2O2Purezza:98%Colore e forma:SolidPeso molecolare:282.34Brepocitinib
CAS:Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Formula:C18H21F2N7OPurezza:99.82%Colore e forma:SolidPeso molecolare:389.4Ref: TM-TQ0010
1mg35,00€2mg48,00€5mg70,00€10mg104,00€25mg216,00€50mg393,00€100mg628,00€200mg879,00€1mL*10mM (DMSO)78,00€PRMT5-IN-28
CAS:PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processesFormula:C18H19ClN4O5Purezza:98%Colore e forma:SolidPeso molecolare:406.82JAK-IN-5
CAS:JAK-IN-5 is a JAK inhibitor.Formula:C27H31FN6OPurezza:98.1% - 99.37%Colore e forma:SolidPeso molecolare:474.57Ref: TM-T11710
1mg187,00€5mg391,00€10mg582,00€25mg929,00€50mg1.254,00€100mg1.691,00€500mg3.382,00€1mL*10mM (DMSO)567,00€PHD-IN-2
CAS:PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFormula:C26H27N7O4Purezza:98%Colore e forma:SolidPeso molecolare:501.54PRMT5-IN-29
CAS:PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].Formula:C18H20Cl3N5O5Purezza:98%Colore e forma:SolidPeso molecolare:492.74PRMT5-IN-25
CAS:PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1Formula:C24H21F3N6OPurezza:98%Colore e forma:SolidPeso molecolare:466.46PARP7-IN-15
CAS:PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].Formula:C23H24F6N6O4Purezza:98%Colore e forma:SolidPeso molecolare:562.46KDM5-C70
CAS:KDM5-C70 is an ethyl ester derivative of KDM5-C49.Formula:C17H28N4O3Purezza:97.63% - 99.86%Colore e forma:SolidPeso molecolare:336.43Ref: TM-T15648
2mg44,00€5mg62,00€10mg88,00€25mg140,00€50mg245,00€100mg490,00€200mg700,00€500mg1.074,00€1mL*10mM (DMSO)73,00€Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Formula:C20H17N3O2Purezza:99.1%Colore e forma:SolidPeso molecolare:331.37BRD7-IN-1
CAS:BRD7-IN-1, a BI7273 derivative, forms PROTAC VZ185, targeting BRD7/9 with DC50s of 4.5/1.8 nM via VHL ligand linkage.Formula:C22H28Cl2N4O3Purezza:98.95%Colore e forma:SolidPeso molecolare:467.39Ref: TM-T17697
1mg99,00€2mg144,00€5mg235,00€10mg354,00€25mg635,00€50mg944,00€100mg1.311,00€200mgPrezzo su richiesta1mL*10mM (DMSO)240,00€Pim-1 kinase inhibitor 5
CAS:Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Formula:C22H13Cl2N3OPurezza:98%Colore e forma:SolidPeso molecolare:406.26Aurora Kinases-IN-4
CAS:Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Formula:C26H28N8OPurezza:98%Colore e forma:SolidPeso molecolare:468.55
