Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2462 prodotti di "Cromatina/Epigenetica"
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PF-03622905
CAS:PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.Formula:C24H35N7O3Colore e forma:SolidPeso molecolare:469.59A-893
CAS:A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formula:C29H38Cl2N4O4Colore e forma:SolidPeso molecolare:577.54MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Colore e forma:SolidSRG-II-19F
SRG-II-19F is a BRDT BD1 degrader, useful for studying ClpC2's impact on ClpC1P1P2 protease.Formula:C80H109ClN16O14SColore e forma:SolidPeso molecolare:1586.34INCB059872
CAS:INCB059872: potent, oral, selective LSD1 inhibitor for myeloid leukemia research.Formula:C23H34N2O3Colore e forma:SolidPeso molecolare:386.536AB3067
<p>AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)</p>Formula:C74H91ClFN11O17S2Colore e forma:SolidPeso molecolare:1525.16HDAC1/2-IN-3
CAS:HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively.Formula:C24H25N5OSColore e forma:SolidPeso molecolare:431.56PROTAC BRD4 Degrader-9
CAS:PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.Formula:C59H71F2N9O15S4Colore e forma:SolidPeso molecolare:1312.5PROTAC BRD4 Degrader-15
CAS:PROTAC BRD4 Degrader-15 targets von Hippel-Lindau and BRD4 with IC50s 7.2/8.1 nM and degrades BRD4 in cancer cells.Formula:C57H62F2N10O10S2Colore e forma:SolidPeso molecolare:1149.3PRMT5-IN-12
CAS:PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formula:C32H40N4O4Colore e forma:SolidPeso molecolare:544.696PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Formula:C27H30F3N7O6S2Purezza:98%Colore e forma:SolidPeso molecolare:669.7HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFormula:C23H40O5Purezza:98%Colore e forma:SolidPeso molecolare:396.56RK 286D
CAS:<p>RK 286D is an indolocarbazole antibiotic.</p>Formula:C26H23N3O4Colore e forma:SolidPeso molecolare:441.48CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Colore e forma:SolidPROTAC CBP/P300 Degrader-1
CAS:PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.Formula:C46H53F2N11O6Colore e forma:SolidPeso molecolare:893.998BTR2004
BTR2004 is a selective PROTAC degrader targeting the BET family (BRD2/3/4) proteins. It facilitates the formation of a ternary complex with BRD proteins and KLHL20, leading to ubiquitination and proteasomal degradation via the UPS pathway. BTR2004 shows potential for research in PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.Colore e forma:Odour SolidZMF-23
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis andFormula:C22H23Cl2N5O3Purezza:98%Colore e forma:SolidPeso molecolare:476.36VinSpinIn
CAS:VinSpinIn is a probe for the Spin family proteins.Formula:C42H58N8O4Colore e forma:SolidPeso molecolare:738.98HDAC1-IN-9
HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 μM. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.Formula:C17H17N3O3Colore e forma:SolidPeso molecolare:311.34SJ1008030
CAS:<p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>Formula:C42H43N13O7SColore e forma:SolidPeso molecolare:873.94mTOR/HDAC-IN-1
CAS:mTOR/HDAC-IN-1, a dual inhibitor for mTOR & HDAC1 with IC50s 0.49 & 0.91 nM, potential anti-cancer agent.Formula:C23H23N11O3Colore e forma:SolidPeso molecolare:501.5SAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Formula:C155H256N48O40Purezza:98%Colore e forma:SolidPeso molecolare:3432.05PROTAC BRD4 Degrader-10
CAS:Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.Formula:C59H71F2N9O15S4Colore e forma:SolidPeso molecolare:1312.5JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Colore e forma:Odour SolidHyp-dBET1
Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.Colore e forma:Odour SolidGSK3735967
CAS:GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formula:C25H31N7OSColore e forma:SolidPeso molecolare:477.62PROTAC BRD4 Degrader-13
CAS:PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Formula:C68H85F2N11O17P2S2Colore e forma:SolidPeso molecolare:1492.55E67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Formula:C21H36N6O2Colore e forma:SolidPeso molecolare:404.559MT1
CAS:MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).Formula:C54H66Cl2N10O9S2Colore e forma:SolidPeso molecolare:1134.2Ep300/CREBBP-IN-3
CAS:Ep300/CREBBP-IN-3 inhibits Ep300 & CREBBP (IC50: 0.056 & 0.095 μM respectively); potential for cancer research.Formula:C26H25F4N5O3Colore e forma:SolidPeso molecolare:531.50CPI-1328
CAS:CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.Formula:C28H36ClN3O4SColore e forma:SolidPeso molecolare:546.12PROTAC BRD4 Degrader-28
<p>PROTAC BRD4 Degrader-28 (Compound 4) is a PROTAC degrader specifically targeting BRD4, and it holds potential for cancer research.</p>Formula:C38H36ClN7O8SColore e forma:SolidPeso molecolare:786.25PAD2-IN-2 TFA
PAD2-IN-2 (cis-isomer of 1) TFA is an inhibitor of protein arginine deiminase 2 (PAD2). This molecule features an azobenzene photoswitch, enabling the optical regulation of PAD activity. Additionally, PAD2-IN-2 TFA inhibits the citrullination of histone H3.Formula:C28H27ClF3N7O3Colore e forma:SolidPeso molecolare:602.01MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formula:C15H26Cl2N2OPurezza:99.9%Colore e forma:SolidPeso molecolare:321.28SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formula:C22H25ClN8O2SPurezza:99.56%Colore e forma:SolidPeso molecolare:501FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidFKBP12 PROTAC dTAG-7
CAS:dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Formula:C63H79N5O19Purezza:98%Colore e forma:SolidPeso molecolare:1210.32Okicenone
CAS:<p>Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.</p>Formula:C15H14O4Colore e forma:SolidPeso molecolare:258.27PROTAC BRD4 Degrader-12
CAS:PROTAC BRD4 Degrader-12 targets BRD4 in PC3 cells; conjugates with STEAP1, CLL1; DC50: 0.39/0.24 nM.Formula:C62H77F2N9O12S4Colore e forma:SolidPeso molecolare:1306.58HDAC8-IN-10
HDAC8-IN-10 (compound 15) serves as a potent inhibitor of HDAC8, exhibiting an IC50 value of 7.6 nM. It also acts as a ligand for the HDAC8 target protein, utilized in the synthesis of PROTAC YX862.Colore e forma:Odour SolidSIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formula:C24H29ClN8O4SPurezza:98.68%Colore e forma:SolidPeso molecolare:561.06PKCδ Peptide Substrate
CAS:PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) andFormula:C109H191N35O29SColore e forma:SolidPeso molecolare:2487.97PROTAC HDAC6 degrader 3
PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]Formula:C46H56F2N10O9SColore e forma:SolidPeso molecolare:963.06coumarin-SAHA
CAS:SAHA inhibits class I/II HDAC; c-SAHA, a fluorescent derivative, excites at 325 nm and emits at 400 nm.Formula:C18H22N2O5Colore e forma:SolidPeso molecolare:346.383IQZ23
CAS:IQZ23 inhibits fat cell formation, activates AMPK, cuts triglycerides (EC50=0.033 μM), may aid obesity/metabolic study.Formula:C26H29N5O2Colore e forma:SolidPeso molecolare:443.551Dot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formula:C34H37ClF3N9O4SColore e forma:SolidPeso molecolare:760.23RMM23
RMM23 is an inhibitor that targets PfBDP1, exhibiting a Kd of 1.24 μM. In vitro, it shows EC50 values of 18 μM against the 3D7 wild-type strain, 14 μM against the NF54 wild-type strain, and 20 μM against the multidrug-resistant K1 strain during the blood stage.Colore e forma:Odour SolidLyngbyatoxin A
CAS:<p>Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as &quot;swimmers' itch&quot; in Hawaii.</p>Formula:C27H39N3O2Colore e forma:SolidPeso molecolare:437.62DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Colore e forma:Odour SolidKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Colore e forma:Odour SolidRef: TM-L1600
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaTyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedColore e forma:Odour SolidRef: TM-L2200
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaLSD1-IN-32
<p>LSD1-IN-32 (compound 11e) is a potent inhibitor of LSD1, with an IC50 value of 0.99 µM. It effectively impedes RANKL-induced osteoclastogenesis, bone resorption, and F-actin ring formation, indicating its potential use in osteoporosis research.</p>Formula:C36H56N2O3Si2Peso molecolare:620.38295Pumecitinib
CAS:<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Formula:C17H20N8O2SPurezza:99.94%Colore e forma:SoildPeso molecolare:400.46BRD4-IN-2
CAS:BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC 50 value of 9.9 nM.Formula:C43H48N8O11Colore e forma:SolidPeso molecolare:852.902FTX-6058 hydrochloride
CAS:FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Formula:C22H19ClFN5O2Colore e forma:SolidPeso molecolare:439.87MS33
CAS:MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formula:C64H84F3N11O7SColore e forma:SolidPeso molecolare:1208.5PROTAC BET Degrader-10
CAS:PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon ligands.Formula:C39H39ClN8O6SColore e forma:SolidPeso molecolare:783.3Ref: TM-T39374
5mg236,00€10mg379,00€25mg710,00€50mg1.054,00€100mg1.568,00€200mgPrezzo su richiesta500mgPrezzo su richiesta1mL*10mM (DMSO)326,00€JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formula:C43H45ClFN7O10SColore e forma:SolidPeso molecolare:906.375MACTIDE-V
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.Formula:C109H156N22O27S2Colore e forma:SolidPeso molecolare:2269.09517XF067-68
CAS:XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formula:C52H59F4N9O7SColore e forma:SolidPeso molecolare:1030.14(S)-GNE-987
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).Formula:C56H67F2N9O8S2Purezza:98%Colore e forma:SolidPeso molecolare:1096.31Go6976
CAS:Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.Formula:C24H18N4OPurezza:95.89%Colore e forma:Off-White To Yellow SolidPeso molecolare:378.43SJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Formula:C36H36N10O5Colore e forma:SolidPeso molecolare:688.74KB02-JQ1
CAS:KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.Formula:C38H43Cl2N7O6SPurezza:98%Colore e forma:SoildPeso molecolare:796.76MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Colore e forma:Odour SolidNSC 370284
CAS:NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formula:C21H25NO6Purezza:99.74%Colore e forma:SolidPeso molecolare:387.43KDM1A-IN-29
CAS:<p>KDM1A-IN-29 is a histone demethylase inhibitor.</p>Formula:C16H16ClN3O4SColore e forma:SoildPeso molecolare:381.83NF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Formula:C24H27N7O4Colore e forma:SolidPeso molecolare:477.21245Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formula:C63H107N19O20S2Purezza:98%Colore e forma:SolidPeso molecolare:1514.77Axl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptorFormula:C14H19ClO8Purezza:98%Colore e forma:SolidPeso molecolare:350.75ZL0590
CAS:ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.Formula:C23H27F3N4O4SPurezza:99.77%Colore e forma:SoildPeso molecolare:512.55Ref: TM-T60072
1mg74,00€5mg160,00€10mg235,00€25mg424,00€50mg635,00€100mg935,00€1mL*10mM (DMSO)177,00€SNIPER(BRD)-1
CAS:SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.Formula:C53H66ClN9O8S2Purezza:98%Colore e forma:SolidPeso molecolare:1056.73Kiss2 peptide
CAS:Kiss2 peptide functions as a positive regulator of reproductive behavior. In COS-7 cells, it binds to its homologous G-protein coupled receptor Kiss2R (GPR54), activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).Formula:C63H84N16O12Peso molecolare:1257.44Namoline
CAS:Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Formula:C10H3ClF3NO4Colore e forma:SolidPeso molecolare:293.58GSK J5
CAS:GSK J5: schistosome, helminth inhibitor; trematode insecticide; boosts schistosome death dose/time-wise.Formula:C24H27N5O2Purezza:99.94%Colore e forma:SolidPeso molecolare:417.5Ref: TM-T22821
1mg47,00€5mg126,00€10mg202,00€25mg449,00€50mg655,00€100mg934,00€500mg1.872,00€1mL*10mM (DMSO)117,00€Vanicoside A
CAS:Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .Formula:C51H50O21Colore e forma:SolidPeso molecolare:998.93NCT-TFP
CAS:NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors[1].Formula:C41H34F4N2O5Colore e forma:SolidPeso molecolare:710.71NP213
CAS:NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).Formula:C42H84N28O7Purezza:98%Colore e forma:SolidPeso molecolare:1093.3MOCPAC
CAS:MOCPAC is an HDAC1 specific substrate [1] .Formula:C27H31N3O6Colore e forma:SolidPeso molecolare:493.55JPS016
CAS:JPS016: benzamide VHL E3-ligase PROTAC, degrades HDAC1/2, triggers apoptosis in HCT116 cells.Formula:C48H63N7O8SColore e forma:SolidPeso molecolare:898.12GSK040
CAS:GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Formula:C29H34N4O4Colore e forma:SolidPeso molecolare:502.6SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.Purezza:98%Colore e forma:Odour SolidUzansertib
CAS:Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.Formula:C26H26F3N5O3Colore e forma:SolidPeso molecolare:513.51PROTAC BRD4 Degrader-19
CAS:PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utilityFormula:C44H38N8O5S2Colore e forma:SolidPeso molecolare:822.95GSK8573
CAS:GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formula:C20H21NO3Purezza:99.97%Colore e forma:SolidPeso molecolare:323.39BRD7-IN-1 free base
CAS:BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formula:C22H26N4O3Purezza:98%Colore e forma:SolidPeso molecolare:394.47TNKS-2-IN-2
CAS:TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formula:C26H23N3O6Purezza:99.45%Colore e forma:SoildPeso molecolare:473.48MNK/PIM-IN-1
CAS:MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.Formula:C27H27FN6O2Colore e forma:SolidPeso molecolare:486.551PROTAC BRD4 Degrader-32
<p>PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.</p>Formula:C42H42ClN5O5Colore e forma:SolidPeso molecolare:731.28745MS479
MS479 is a BRD4 PROTAC degrader that binds with high affinity to BRD4-BD2 and GLP (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM). It effectively reduces the protein levels of BRD4 short isoforms. By directly binding to its substrate GLP, MS479 recruits the E3 ligase SPOP as a bridging protein. Additionally, MS479 can be utilized to inhibit the proliferation of colorectal cancer cells.Colore e forma:Odour SolidDot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Colore e forma:Odour Solid2-Methylquinazolin-4-ol
CAS:Compound 1769-24-0 is a natural product for research related to life sciences. The catalog number is TPL0186 and the CAS number is 1769-24-0.Formula:C9H8N2OPurezza:99.98%Colore e forma:SolidPeso molecolare:160.17dBAZ2
dBAZ2 is a pioneering PROTAC degrader targeting BAZ2A and BAZ2B, with DC50 values of 180 nM for BAZ2A and 250 nM for BAZ2B.Formula:C54H64FN11O5S2Colore e forma:SolidPeso molecolare:1030.29JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidCBP/p300-IN-8
CAS:CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.Formula:C27H31N3O4Colore e forma:SolidPeso molecolare:461.562(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Colore e forma:SolidBETd-246
CAS:BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.Formula:C48H55N11O10Purezza:98%Colore e forma:SolidPeso molecolare:946.02Ref: TM-T14549
5mg512,00€10mg750,00€25mg1.529,00€50mg2.318,00€100mgPrezzo su richiesta200mgPrezzo su richiesta3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS:<p>3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.</p>Formula:C30H52O4Colore e forma:SolidPeso molecolare:476.742Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Formula:C122H203N45O36S2Purezza:98.92%Colore e forma:SolidPeso molecolare:2940.33Ref: TM-T11740L
1mg170,00€2mg225,00€5mg329,00€10mg467,00€25mg677,00€50mg929,00€100mg1.244,00€200mg1.681,00€
