Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2442 prodotti di "Cromatina/Epigenetica"
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cis-VZ 185
CAS:cis-VZ 185 is a negative control for VZ 185.Formula:C53H67FN8O8SColore e forma:SolidPeso molecolare:995.23EPZ-025654
CAS:EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.Formula:C29H33ClN8O3Colore e forma:SolidPeso molecolare:577.08PRMT5-IN-13
CAS:PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5) .Formula:C18H17ClN4O4Colore e forma:SolidPeso molecolare:388.81Hyp-dBET1
Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.Colore e forma:Odour SolidHDAC6-IN-53
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.Colore e forma:Odour SolidSAMS
CAS:SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).Formula:C74H131N29O18S2Purezza:98%Colore e forma:SolidPeso molecolare:1779.15PROTAC BRD4 Degrader-14
PROTAC BRD4 Degrader-14 binds VHL & BRD4, degrades BRD4 in PC3 cells; IC50: 1.8/1.7 nM BD1/BD2.Formula:C57H61F2N9O11S2Colore e forma:SolidPeso molecolare:1150.27HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formula:C60H69N17O11SColore e forma:SolidPeso molecolare:1236.36KAT6-IN-2
KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.Colore e forma:Odour SolidCD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Colore e forma:SolidAurora-A ligand 1
CAS:Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.Formula:C21H23N5O3Colore e forma:SolidPeso molecolare:393.4393',4'-Dimethoxyflavone
CAS:3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities.Formula:C17H14O4Purezza:98.05%Colore e forma:SolidPeso molecolare:282.29PBRM1-BD2-IN-7
CAS:PBRM1-BD2-IN-7, a PBRM1 bromodomain inhibitor with an IC50 of 0.29 μM, is used in cancer research.Formula:C16H15ClN2OPurezza:99.31% - 99.41%Colore e forma:SoildPeso molecolare:286.76Ref: TM-T60155
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)240,00€HLB-0532259
CAS:<p>HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)</p>Formula:C40H44N8O7Colore e forma:SolidPeso molecolare:748.827Myelin Basic Protein
CAS:Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Formula:C60H103N21O17Purezza:98%Colore e forma:SolidPeso molecolare:1390.59TNKS-2-IN-2
CAS:TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formula:C26H23N3O6Purezza:99.45%Colore e forma:SoildPeso molecolare:473.48Menin-MLL inhibitor 21
CAS:Menin-mll inhibitor 21 is a selective, oral and irreversible Menin inhibitor. Menin-MLL inhibitor 21 promotes selective proliferation of β cells and improvement of β cell function in human islet cultures in vitro. Menin-MLL inhibitor 21 enhances glycemic control in animal models of diabetes. Menin-MLL inhibitor 21 induced a dose-dependent increase in insulin secretion that was augmented by a GLP-1 receptor agonist (RA).Formula:C31H34N8O3Purezza:99.95%Colore e forma:SoildPeso molecolare:566.65iHAC
iHAC is an inhibitor-HSP90 anchoring chimera that covalently binds to the BRD4 ligand (+)-JQ-1, targeting HSP90 and thereby inhibiting cancer cell proliferation. This compound also triggers an anti-tumor immune response and is effective in suppressing the recurrence and metastasis of 4T1 breast cancer in mouse models.Formula:C50H46ClIN16O7S3Colore e forma:SolidPeso molecolare:1241.56RMM23
RMM23 is an inhibitor that targets PfBDP1, exhibiting a Kd of 1.24 μM. In vitro, it shows EC50 values of 18 μM against the 3D7 wild-type strain, 14 μM against the NF54 wild-type strain, and 20 μM against the multidrug-resistant K1 strain during the blood stage.Colore e forma:Odour SolidThalidomide-NH-CBP/p300 ligand 2
CAS:Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).Formula:C48H57F2N11O6Colore e forma:SolidPeso molecolare:922.052Dihydrochlamydocin analog-1
CAS:Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.Formula:C28H40N4O6Colore e forma:SolidPeso molecolare:528.64EZH2-IN-5
CAS:EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Formula:C26H37BrN4O2Colore e forma:SolidPeso molecolare:517.512Antidiabetic agent 7
Antidiabetic agent 7 (Compound 5m) functions as a potent hyperglycemia inhibitor. It effectively stimulates GLUT4 translocation in skeletal muscle cells by activating the AMPK-dependent pathway. Additionally, this compound is capable of reducing blood glucose levels and exhibits favorable pharmacokinetic properties. Antidiabetic agent 7 is suitable for research related to antihyperglycemic treatments.Formula:C27H21Cl2N5O3Colore e forma:SolidPeso molecolare:534.39NCT-TFP
CAS:NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors[1].Formula:C41H34F4N2O5Colore e forma:SolidPeso molecolare:710.71CPI-268456
CAS:CPI-268456 is a compound which has bioactive.Formula:C20H15Cl2N3O2Colore e forma:SolidPeso molecolare:400.26ISM012-042
ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.Formula:C26H28N6O4Colore e forma:SolidPeso molecolare:488.538EZH2-IN-15
CAS:A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.Formula:C32H44N4O4Purezza:99.88%Colore e forma:SolidPeso molecolare:548.72Ref: TM-T67883
1mg143,00€5mg344,00€10mg525,00€25mg833,00€50mg1.121,00€100mg1.510,00€200mg2.023,00€1mL*10mM (DMSO)418,00€MS479
MS479 is a BRD4 PROTAC degrader that binds with high affinity to BRD4-BD2 and GLP (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM). It effectively reduces the protein levels of BRD4 short isoforms. By directly binding to its substrate GLP, MS479 recruits the E3 ligase SPOP as a bridging protein. Additionally, MS479 can be utilized to inhibit the proliferation of colorectal cancer cells.Colore e forma:Odour SolidDC-S239
CAS:Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Formula:C15H15N3O5SPurezza:99.37%Colore e forma:SolidPeso molecolare:349.36Ref: TM-T60002
2mg46,00€5mg70,00€10mg101,00€25mg197,00€50mg320,00€100mg509,00€200mg695,00€1mL*10mM (DMSO)77,00€PROTAC BET Degrader-10
CAS:PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon ligands.Formula:C39H39ClN8O6SColore e forma:SolidPeso molecolare:783.3Ref: TM-T39374
5mg236,00€10mg379,00€25mg710,00€50mg1.054,00€100mg1.568,00€200mgPrezzo su richiesta500mgPrezzo su richiesta1mL*10mM (DMSO)326,00€JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Formula:C30H33FN4O3SColore e forma:SolidPeso molecolare:548.67Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Formula:C122H203N45O36S2Purezza:98.92%Colore e forma:SolidPeso molecolare:2940.33Ref: TM-T11740L
1mg170,00€2mg225,00€5mg329,00€10mg467,00€25mg677,00€50mg929,00€100mg1.244,00€200mg1.681,00€7-Hydroxyneolamellarin A
CAS:7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.Formula:C24H19NO5Colore e forma:SolidPeso molecolare:401.41ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Colore e forma:Odour SolidPRMT5 ligand 1
CAS:PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Formula:C20H26N6O2Colore e forma:SolidPeso molecolare:382.459dBAZ2
dBAZ2 is a pioneering PROTAC degrader targeting BAZ2A and BAZ2B, with DC50 values of 180 nM for BAZ2A and 250 nM for BAZ2B.Formula:C54H64FN11O5S2Colore e forma:SolidPeso molecolare:1030.29HDAC11-IN-1
HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.Formula:C43H63F3N6O6S2Colore e forma:SolidPeso molecolare:881.12CARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formula:C27H35ClN6O3Colore e forma:SolidPeso molecolare:527.06HSP70/SIRT2-IN-1
<p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>Purezza:98%Colore e forma:Odour SolidJPS035
CAS:JPS035: potent benzamide-based VHL E3 ligase PROTAC, degrades HDAC1/2, increases gene expression and apoptosis in HCT116 cells.Formula:C49H65N7O7SColore e forma:SolidPeso molecolare:896.15HLDA-221
HLDA-221 is a heterobifunctional small molecule known as a Regulated Induced Proximity Targeting Chimera (RIPTAC).Colore e forma:Odour SolidLSQ-28
LSQ-28 is an orally active HDAC3 inhibitor with an IC50 of 42 nM, demonstrating significant anticancer, antiproliferative, anti-migration, anti-invasion, and anti-wound healing activities. LSQ-28 is suitable for cancer research.Formula:C31H27N5OColore e forma:SolidPeso molecolare:485.579SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formula:C41H47ClN6O6SPurezza:98%Colore e forma:SolidPeso molecolare:787.37DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Colore e forma:Odour SolidZSNI-21
ZSNI-21 is a dual inhibitor targeting ADAM17 and HDAC2. It effectively suppresses the proliferation of Bel-7402 cells and exhibits significant anti-metastatic properties against HCC-LM3 cells, making it a promising candidate for hepatocellular carcinoma (HCC) research.Formula:C26H25N3O5Colore e forma:SolidPeso molecolare:459.49M-1211
CAS:M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.Formula:C42H57FN6O6SColore e forma:SolidPeso molecolare:793.01UNC10013
UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.Colore e forma:Odour SolidPROTAC BRD4-DCAF1 degrader-1
CAS:PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.Formula:C60H64Cl2F2N8O9SColore e forma:SolidPeso molecolare:1182.17PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Formula:C39H42FN9O7Colore e forma:SolidPeso molecolare:767.81PROTAC BRM degrader-1
CAS:PROTAC BRM degrader-1 (compound 17) serves as a PROTAC-based degrader targeting both BRM and BRG1, exhibiting DC50 values of 93 pM and 4.9 nM, respectively [1].Formula:C57H69N11O8SColore e forma:SolidPeso molecolare:1068.29G9a-IN-3
G9a-IN-3 (compound 16g) is a potent G9a inhibitor with an IC50 of 0.002 μM. It is applicable for research in sickle cell disease.Formula:C26H29N5O3Colore e forma:SolidPeso molecolare:459.22704Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Colore e forma:Odour SolidCAY10591
CAS:<p>SIRT1 activated by CAY10591, mimics caloric restriction, extends lifespan, inhibits apoptosis, suppresses TNF-α, and promotes fat mobilization.</p>Formula:C20H25N5O2Colore e forma:SolidPeso molecolare:367.44HDAC6 ligand-3
HDAC6ligand-3 serves as a ligand for HDAC6 and can be utilized as a target protein ligand in the synthesis of [PROTAC] HDAC6 degrader4.Formula:C20H21N3O3Colore e forma:SolidPeso molecolare:351.399DS-103
DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.Formula:C28H33N5O3Colore e forma:SolidPeso molecolare:487.59Echinomycin
CAS:Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.Formula:C51H64N12O12S2Purezza:95%Colore e forma:SolidPeso molecolare:1101.26Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formula:C63H107N19O20S2Purezza:98%Colore e forma:SolidPeso molecolare:1514.77(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.Formula:C41H46N6O6SColore e forma:SolidPeso molecolare:750.91PROTAC SMARCA2/4-degrader-28
CAS:PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formula:C54H68ClN9O11S2Colore e forma:SolidPeso molecolare:1118.75SJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Formula:C36H36N10O5Colore e forma:SolidPeso molecolare:688.74PROTAC BRD4-binding moiety 1
CAS:BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.Formula:C23H21N3O2Purezza:98%Colore e forma:SolidPeso molecolare:371.43Malantide TFA
Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.Formula:C74H125F3N22O23Colore e forma:SolidPeso molecolare:1747.91Go6976
CAS:Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.Formula:C24H18N4OPurezza:95.89%Colore e forma:Off-White To Yellow SolidPeso molecolare:378.43MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Colore e forma:Odour SolidCM112
CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.Formula:C39H61N5O7Colore e forma:SolidPeso molecolare:711.4571SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formula:C14H16N2OPurezza:99.58%Colore e forma:SolidPeso molecolare:228.29Ref: TM-T9648
1mg96,00€5mg202,00€10mg311,00€25mg533,00€50mg747,00€100mg1.017,00€200mg1.359,00€1mL*10mM (DMSO)207,00€PROTAC HDAC6 degrader 3
PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]Formula:C46H56F2N10O9SColore e forma:SolidPeso molecolare:963.06SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formula:C24H29ClN8O4SPurezza:98.68%Colore e forma:SolidPeso molecolare:561.06VinSpinIn
CAS:VinSpinIn is a probe for the Spin family proteins.Formula:C42H58N8O4Colore e forma:SolidPeso molecolare:738.98FKBP12 PROTAC dTAG-7
CAS:dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Formula:C63H79N5O19Purezza:98%Colore e forma:SolidPeso molecolare:1210.32PROTAC BRD4 Degrader-26
CAS:PROTACBRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC designed to degrade BRD4, achieving 80% degradation efficiency at a concentration of 1 μM. This compound can be inactivated by ultraviolet light.Formula:C46H45ClN10O10SPeso molecolare:965.43SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formula:C22H25ClN8O2SPurezza:99.56%Colore e forma:SolidPeso molecolare:501coumarin-SAHA
CAS:SAHA inhibits class I/II HDAC; c-SAHA, a fluorescent derivative, excites at 325 nm and emits at 400 nm.Formula:C18H22N2O5Colore e forma:SolidPeso molecolare:346.383SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColore e forma:SolidPeso molecolare:818.95JWZ-7-7-Neg1
CAS:JWZ-7-7-Neg1, a neighboring transcription chemical inducer (TCIP), serves as a negative control. It exhibits reduced binding capabilities to BRD4 or BCL6 compared to JWZ-7-7, resulting in lower cytotoxicity towards DLBCL cells.Formula:C50H58Cl2N12O6SColore e forma:SolidPeso molecolare:1026.04PROTAC BRD4 Degrader-32
<p>PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.</p>Formula:C42H42ClN5O5Colore e forma:SolidPeso molecolare:731.28745PARP1-IN-38
PARP1-IN-38 (compound ent-6_P) is a potent PARP1 inhibitor with an IC50 value of 10 μM. It exhibits selective cytotoxic activity in BRCA-mutant cancer cells.Formula:C16H10FN3OColore e forma:SolidPeso molecolare:279.08079JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Colore e forma:Odour SolidBryostatin 3
CAS:Bryostatin 3 is a protein kinase C activator.Formula:C46H64O17Purezza:98%Colore e forma:SolidPeso molecolare:888.99PROTAC BRD4 Degrader-10
CAS:Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.Formula:C59H71F2N9O15S4Colore e forma:SolidPeso molecolare:1312.5α-Hydroxyglutaric Acid
CAS:α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.Formula:C5H8O5Colore e forma:SolidPeso molecolare:148.114Fluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Colore e forma:SolidiRucaparib-AP6
CAS:iRucaparib-AP6: a specific, non-trapping PARP1 degrader; inhibits the enzyme's activity and scaffolding.Formula:C46H55FN6O11Purezza:98%Colore e forma:SolidPeso molecolare:886.96(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Colore e forma:SolidJPS036
CAS:JPS036, a benzamide-based VHL E3-ligase PROTAC, potently degrades HDAC1/2, increasing gene expression and apoptosis in HCT116 cells.Formula:C51H66FN7O7SColore e forma:SolidPeso molecolare:940.18R 8605
CAS:R 8605 is a third-generation retinoid.Formula:C22H27NO4Colore e forma:SolidPeso molecolare:369.45BTR2004
BTR2004 is a selective PROTAC degrader targeting the BET family (BRD2/3/4) proteins. It facilitates the formation of a ternary complex with BRD proteins and KLHL20, leading to ubiquitination and proteasomal degradation via the UPS pathway. BTR2004 shows potential for research in PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.Colore e forma:Odour SolidPROTAC CBP/P300 Degrader-1
CAS:PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.Formula:C46H53F2N11O6Colore e forma:SolidPeso molecolare:893.998NF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Formula:C24H27N7O4Colore e forma:SolidPeso molecolare:477.21245PROTAC BRD4 Degrader-20
CAS:PROTAC BRD4 Degrader-20 (compound 195) is a bifunctional degrader of BRD4 [1].Formula:C55H58ClN9O7S2Colore e forma:SolidPeso molecolare:1056.69PRMT5-IN-15
CAS:PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.Formula:C24H23F3N6O2Colore e forma:SolidPeso molecolare:484.483DAO-dBET1
DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.Colore e forma:Odour SolidGSK097
CAS:GSK097: Potent, selective BD2 inhibitor in BET proteins; 2000x more selective for BD2 than BD1; soluble >1 mg/mL in FaSSIF.Formula:C19H21N3O3Colore e forma:SolidPeso molecolare:339.395AUR1545
CAS:AUR1545 is a selective KAT2A/KAT2B degradator, inhibitory against AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.Formula:C41H50BrN9O5Purezza:98.84%Colore e forma:SolidPeso molecolare:828.8HDAC8-IN-10
HDAC8-IN-10 (compound 15) serves as a potent inhibitor of HDAC8, exhibiting an IC50 value of 7.6 nM. It also acts as a ligand for the HDAC8 target protein, utilized in the synthesis of PROTAC YX862.Colore e forma:Odour SolidPF-03622905
CAS:PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.Formula:C24H35N7O3Colore e forma:SolidPeso molecolare:469.59BRD4-IN-4
CAS:BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFormula:C17H18N2O3SPurezza:99.97%Colore e forma:SolidPeso molecolare:330.4Protein Kinase C (19-31)
CAS:Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.Formula:C67H118N26O16Purezza:98%Colore e forma:Lyophilized PowderPeso molecolare:1543.82MACTIDE-V
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.Formula:C109H156N22O27S2Colore e forma:SolidPeso molecolare:2269.09517
