Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2462 prodotti di "Cromatina/Epigenetica"
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PROTAC BET Degrader-13
PROTACBET Degrader-13 (Compound 34) is a TRIM21-based PROTAC (TRIMTAC) degrader that targets BET proteins. It effectively degrades the PML-eGFP-BRD4 fusion protein, causing a near-complete loss of EGFP+ nuclear foci with an EC50 of 1.4 μM.Colore e forma:Odour SolidBiguanide
CAS:Biguanide can reduce oxidative stress in rats with hyperglycemia.Formula:C2H7N5Colore e forma:SolidPeso molecolare:101.11BRD3067
CAS:BRD3067, a Tubacin derivative, inhibits HDAC6 (IC50 15 nM) and acts as a negative control for Tubacin A, showing anticancer and anti-inflammatory effects.Formula:C21H23N3O2Purezza:98%Colore e forma:SolidPeso molecolare:349.43Bryostatin 3
CAS:Bryostatin 3 is a protein kinase C activator.Formula:C46H64O17Purezza:98%Colore e forma:SolidPeso molecolare:888.99MSC2504877
CAS:<p>MSC2504877 inhibits tankyrase, boosts CDK4/6 inhibitors, blocks Cyclin D2/E2 upregulation, and strengthens phospho-Rb suppression.</p>Formula:C17H18N2O2Purezza:99.72%Colore e forma:SoildPeso molecolare:282.34pan-BET/BD2-IN-1
Pan-BET/BD2-IN-1 (compound 6b) is a selective BET protein inhibitor with BRDT-1Ki of 1.05 μM and BRD4-1Ki of 0.68 μM. It effectively inhibits the growth of MM.1S cancer cells with an IC50 value of 2.6 μM.Colore e forma:Odour SolidPOI ligand 1
POI ligand 1 serves as a template for the non-selective HDAC inhibitor Vorinostat. It functions as a target protein ligand (PROTAC target protein ligand) in the creation of PROTAC HDAC degraders with anti-tumor properties. Additionally, POI ligand 1 is utilized in the synthesis of FF2049.Formula:C14H21N3O3Colore e forma:SolidPeso molecolare:279.335SJ1008030
CAS:<p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>Formula:C42H43N13O7SColore e forma:SolidPeso molecolare:873.94PROTAC BRD4 Degrader-15
CAS:PROTAC BRD4 Degrader-15 targets von Hippel-Lindau and BRD4 with IC50s 7.2/8.1 nM and degrades BRD4 in cancer cells.Formula:C57H62F2N10O10S2Colore e forma:SolidPeso molecolare:1149.3Malantide
CAS:Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formula:C72H124N22O21Purezza:98%Colore e forma:SolidPeso molecolare:1633.89PROTAC SMARCA2/4-degrader-28
CAS:PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formula:C54H68ClN9O11S2Colore e forma:SolidPeso molecolare:1118.75Myelin Basic Protein
CAS:Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Formula:C60H103N21O17Purezza:98%Colore e forma:SolidPeso molecolare:1390.59CPI-268456
CAS:CPI-268456 is a compound which has bioactive.Formula:C20H15Cl2N3O2Colore e forma:SolidPeso molecolare:400.26SJ44236
SJ44236 is a BET PROTAC degrader capable of degrading BRD2 (DC50 = 0.127 nM), BRD3, and BRD4. It shows cytotoxicity in MV4-11 and HD-MB03 cells with IC50 values of 0.12 nM and 0.92 nM, respectively. The compound downregulates c-Myc expression and upregulates p53 expression. In mice, SJ44236 demonstrates good oral bioavailability (45%). [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonE3ligaseLigand 54]Formula:C40H45ClN8O3SColore e forma:SolidPeso molecolare:753.36HDAC-IN-26
CAS:HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Formula:C24H28FN5O3Colore e forma:SolidPeso molecolare:453.518WDR5-MYC-IN-1
WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.Colore e forma:Odour SolidMZP-55
CAS:MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)Formula:C57H70ClN7O10SPurezza:98%Colore e forma:SolidPeso molecolare:1080.73Ref: TM-T13786
5mg434,00€10mg663,00€25mg1.254,00€50mgPrezzo su richiesta100mgPrezzo su richiesta1mL*10mM (DMSO)472,00€TAT-P4-(DATC5)2 TFA
TAT-P4-(DATC5)2 TFA, a high-affinity peptide inhibitor targeting the PDZ domain of protein interacting with C kinase-1 (PICK1), exhibits a K i of 1.7 nM andColore e forma:Odour SolidSirReal1-O-propargyl
CAS:SirReal1-O-propargyl is a selective Sirtuin 2 inhibitor (IC50=2.4 μM) and PROTAC ligand. Its propargyl group enables click chemistry reactions such as CuAAc.Formula:C21H20N4O2S2Purezza:99.97%Colore e forma:SolidPeso molecolare:424.542-PADQZ hydrochloride
CAS:2-PADQZ hydrochloride shows antiviral activity and targets influenza A virus RNA promoter.Formula:C15H21ClN4O2Purezza:99.61%Colore e forma:SolidPeso molecolare:324.81PBRM1-BD2-IN-5
CAS:PBRM1-BD2-IN-5 is a potent inhibitor of the PBRM1 Bromodomain, demonstrating dissociation constant (Kd) values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5Formula:C15H13ClN2OPurezza:99.51%Colore e forma:SoildPeso molecolare:272.73Ref: TM-T60159
1mg88,00€5mg187,00€10mg274,00€25mg454,00€50mg605,00€100mg837,00€200mg1.121,00€1mL*10mM (DMSO)180,00€HDAC3/BRD4-IN-1
HDAC3/BRD4-IN-1 (compound 26n) is an inhibitor of HDAC3/BRD4, exhibiting an IC50 of 8 nM for HDAC3, while its IC50 values for HDAC1 and HDAC2 are 220 nM and 120 nM, respectively. It displays anti-tumor and anti-proliferative effects by upregulating Ac-H3 and downregulating c-Myc. The half-life of HDAC3/BRD4-IN-1 in human liver microsomes is 29.36 minutes.Formula:C31H35N5O4Colore e forma:SolidPeso molecolare:541.64PRMT5-MTA-IN-2
PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.Formula:C30H25F2N7O2Colore e forma:SolidPeso molecolare:553.567-oxo Staurosporine
CAS:Antibiotic 7-oxo Staurosporine from S. platensis blocks various kinases, induces G2/M arrest in K562 cells, is cytotoxic, and impedes mycelial growth.Formula:C28H24N4O4Colore e forma:SolidPeso molecolare:480.51(S,R,S)-AHPC-C5-COOH
CAS:E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.Formula:C29H42N4O5SPurezza:98%Colore e forma:SolidPeso molecolare:558.73Dihydrochlamydocin analog-1
CAS:Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.Formula:C28H40N4O6Colore e forma:SolidPeso molecolare:528.64PROTAC SMARCA2/4-degrader-27
CAS:PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.Formula:C49H58FN9O6SColore e forma:SolidPeso molecolare:920.11UNC6864 (Kei)
UNC6864, an ethylisopropyllysine-containing ligand, exhibits binding affinity to wild-type CBX5, demonstrating a dissociation constant (K D) of 3.3 μM.Formula:C42H59N7O11Colore e forma:SolidPeso molecolare:837.96PROTAC BRD4 Degrader-11
PROTAC BRD4 Degrader-11 links VHL and BRD4 ligands, targeting BRD4 in PC3 cells with STEAP1/CLL1; DC50: 0.23/0.38 nM.Formula:C61H75F2N9O12S4Colore e forma:SolidPeso molecolare:1292.56SIRT1/2/3-IN-1
CAS:Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.Formula:C46H63N9O8S2Colore e forma:SolidPeso molecolare:934.18QA-68
QA-68 is a potent BRD9 degrader, inhibits cell growth, and has anti-leukemic properties.Formula:C61H72N10O10S2Colore e forma:SolidPeso molecolare:1169.42NF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Formula:C24H27N7O4Colore e forma:SolidPeso molecolare:477.21245AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formula:C28H32FN9O2Colore e forma:SolidPeso molecolare:545.61TP-472N
CAS:TP-472N serves as a negative control probe for TP-472, which is a specific and effective BRD7/9 probe.Formula:C19H18N2O2Colore e forma:SolidPeso molecolare:306.36Ep300/CREBBP-IN-8
CAS:Ep300/CREBBP-IN-8, IC50: 0.014/0.018 μM, potent Ep300/CREBBP inhibitor, oral, for cancer research.Formula:C25H27F2N5O3Colore e forma:SolidPeso molecolare:483.51PROTAC SMARCA2/4-degrader-31
CAS:PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Colore e forma:SolidPeso molecolare:797.95PRMT5-IN-15
CAS:PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.Formula:C24H23F3N6O2Colore e forma:SolidPeso molecolare:484.483OKI-006
CAS:OKI-006 is an oral HDAC inhibitor with potential for cancer research, derived from largazole.Formula:C21H30N4O5S2Colore e forma:SolidPeso molecolare:482.62TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purezza:99.65%Colore e forma:SolidPeso molecolare:506.36Ref: TM-T34787
1mg97,00€5mg235,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€1mL*10mM (DMSO)261,00€Neuropeptide DF2
CAS:Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish.Formula:C44H67N15O10Purezza:98%Colore e forma:SolidPeso molecolare:966.1PROTAC BRM degrader-1
CAS:PROTAC BRM degrader-1 (compound 17) serves as a PROTAC-based degrader targeting both BRM and BRG1, exhibiting DC50 values of 93 pM and 4.9 nM, respectively [1].Formula:C57H69N11O8SColore e forma:SolidPeso molecolare:1068.29coumarin-SAHA
CAS:SAHA inhibits class I/II HDAC; c-SAHA, a fluorescent derivative, excites at 325 nm and emits at 400 nm.Formula:C18H22N2O5Colore e forma:SolidPeso molecolare:346.383(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Colore e forma:SolidKDM4 ligand-1
KDM4ligand-1 is a ligand targeting the protein (histone lysine demethylase KDM4) in PROTACs. It can be utilized for the synthesis of PROTACs.Colore e forma:Odour SolidUNC10013
UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.Colore e forma:Odour SolidSJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColore e forma:SolidPeso molecolare:818.95PROTAC SMARCA2/4-degrader-30
CAS:Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Colore e forma:SolidPeso molecolare:797.95EPZ-719
CAS:EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.Formula:C22H31FN4O3SColore e forma:SolidPeso molecolare:450.57PRMT1-IN-1
CAS:<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Formula:C20H7Br6NO5Colore e forma:SolidPeso molecolare:820.702Nicotinamide riboside tartrate
CAS:NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.Formula:C15H20N2O11Colore e forma:SolidPeso molecolare:404.33EP300/CBP ligand 2
<p>EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.</p>Formula:C20H18N6OColore e forma:SolidPeso molecolare:358.4ACBI2
CAS:ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.Formula:C56H68BrFN8O5SColore e forma:SolidPeso molecolare:1064.16CREBtide
CAS:CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).Formula:C73H129N29O19Purezza:98%Colore e forma:SolidPeso molecolare:1716.99PAD2-IN-2 TFA
PAD2-IN-2 (cis-isomer of 1) TFA is an inhibitor of protein arginine deiminase 2 (PAD2). This molecule features an azobenzene photoswitch, enabling the optical regulation of PAD activity. Additionally, PAD2-IN-2 TFA inhibits the citrullination of histone H3.Formula:C28H27ClF3N7O3Colore e forma:SolidPeso molecolare:602.01UNC-4219 TFA
CAS:UNC4219 is a control for UNC3866, blocking Kme reader function in CBX & CDY chromodomains.Formula:C46H69F3N6O10Purezza:98%Colore e forma:SolidPeso molecolare:923.0855H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE
CAS:Formula:C12H9N3OColore e forma:SolidPeso molecolare:211.21PROTAC SMARCA2/4-degrader-29
CAS:PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.Formula:C44H51N11O4Colore e forma:SolidPeso molecolare:797.95LSD1-IN-27
CAS:LSD1-IN-27 inhibits LSD1 (IC50=13 nM), blocks gastric cancer cell stemness/migration, reduces PD-L1, and boosts T-cell response.Formula:C24H25N3Purezza:99.98%Colore e forma:SoildPeso molecolare:355.48HIF-PHD-IN-4
HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.Colore e forma:Odour Solid2-Methylquinazolin-4-ol
CAS:Compound 1769-24-0 is a natural product for research related to life sciences. The catalog number is TPL0186 and the CAS number is 1769-24-0.Formula:C9H8N2OPurezza:99.98%Colore e forma:SolidPeso molecolare:160.17Protein Kinase C (19-36)
CAS:Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Formula:C93H159N35O24Purezza:98%Colore e forma:SolidPeso molecolare:2151.48PIM-IN-1
CAS:PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).Formula:C15H18ClFN4OColore e forma:SolidPeso molecolare:324.78Fluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Colore e forma:SolidJAK1/TYK2-IN-1
CAS:JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).Formula:C18H20F3N7OColore e forma:SolidPeso molecolare:407.401PROTAC BRD4 Degrader-1
CAS:PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).Formula:C40H37N9O8Purezza:98%Colore e forma:SolidPeso molecolare:771.78FTX-6058 hydrochloride
CAS:FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Formula:C22H19ClFN5O2Colore e forma:SolidPeso molecolare:439.87Adenosine receptor modulator 1
Adenosine receptor modulator 1 acts as an inducer of collagen VII (C7). It enhances the expression of COL7A1 mRNA in donor-derived keratinocytes and, in synergy with Gentamicin, increases the overall levels of C7.Formula:C25H28N6O3Colore e forma:SolidPeso molecolare:460.53α-Hydroxyglutaric Acid
CAS:α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.Formula:C5H8O5Colore e forma:SolidPeso molecolare:148.114PROTAC BRD4 Degrader-32
<p>PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.</p>Formula:C42H42ClN5O5Colore e forma:SolidPeso molecolare:731.28745C 21
CAS:PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Formula:C90H161ClN36O24Purezza:98%Colore e forma:SolidPeso molecolare:2166.94iHAC
iHAC is an inhibitor-HSP90 anchoring chimera that covalently binds to the BRD4 ligand (+)-JQ-1, targeting HSP90 and thereby inhibiting cancer cell proliferation. This compound also triggers an anti-tumor immune response and is effective in suppressing the recurrence and metastasis of 4T1 breast cancer in mouse models.Formula:C50H46ClIN16O7S3Colore e forma:SolidPeso molecolare:1241.56PAD2-IN-1
CAS:PAD2-IN-1 is a selective benzimidazole-derived inhibitor with a 95-fold and 79-fold higher affinity for PAD2 over PAD4 and PAD3, respectively.Formula:C25H29FN6O3Colore e forma:SolidPeso molecolare:480.544GXH-II-052
GXH-II-052: Potent BET inhibitor, binds BRD4/BRDT (Kd 0.6-28 nM), anti-proliferative, reduces c-Myc expression.Formula:C62H76Cl2F2N14O11S2Colore e forma:SolidPeso molecolare:1366.39SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Formula:C45H62Cl3N7O8Colore e forma:SolidPeso molecolare:935.37Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
CAS:<p>Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.</p>Formula:C88H138N20O34P2Purezza:98%Colore e forma:SolidPeso molecolare:2082.1PROTAC BRD4 Degrader-7
CAS:PROTAC BRD4 Degrader-7, from patent WO2020055976A1, has IC50 of 15.5 nM (BD1) & 12.3 nM (BD2).Formula:C26H29N5O2SColore e forma:SolidPeso molecolare:475.61AUR1545
CAS:AUR1545 is a selective KAT2A/KAT2B degradator, inhibitory against AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.Formula:C41H50BrN9O5Purezza:98.84%Colore e forma:SolidPeso molecolare:828.8PRMT5-IN-11
CAS:PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Formula:C13H17N5O4Colore e forma:SolidPeso molecolare:307.31Foenumoside B
CAS:Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotesFormula:C60H96O25Purezza:98%Colore e forma:SolidPeso molecolare:1217.39BBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Formula:C37H47N5O5SColore e forma:SolidPeso molecolare:673.32979BETd-246
CAS:BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.Formula:C48H55N11O10Purezza:98%Colore e forma:SolidPeso molecolare:946.02Ref: TM-T14549
5mg512,00€10mg750,00€25mg1.529,00€50mg2.318,00€100mgPrezzo su richiesta200mgPrezzo su richiestaJMJD6 inhibitor WL12
CAS:<p>WL12 (ZINC6733033): First-in-class JMJD6 inhibitor; halts JMJD6-dependent cervical/liver cancer cell growth.</p>Formula:C16H11N3O2Purezza:98.57%Colore e forma:SolidPeso molecolare:277.28FTX-6058
CAS:FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Formula:C22H18FN5O2Colore e forma:SolidPeso molecolare:403.417Protein Kinase C (19-31)
CAS:Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.Formula:C67H118N26O16Purezza:98%Colore e forma:Lyophilized PowderPeso molecolare:1543.82GSK232
CAS:GSK232 is a highly selective and cellularly penetrant inhibitor of CECR2 with outstanding physicochemical properties.Formula:C21H27ClN6O3SColore e forma:SolidPeso molecolare:479.0TO-1187
TO-1187 is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It enhances the ubiquitination and subsequent degradation of HDAC6, making it useful for research in hematological malignancies and solid tumors.Colore e forma:Odour SolidPROTAC BRD4 Degrader-2
CAS:PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).Formula:C40H39N9O7Purezza:98%Colore e forma:SolidPeso molecolare:757.79BRD4-IN-4
CAS:BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFormula:C17H18N2O3SPurezza:99.97%Colore e forma:SolidPeso molecolare:330.4EML734
CAS:EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.Formula:C27H32N10O7Purezza:98%Colore e forma:SolidPeso molecolare:608.61Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurezza:99.92% - 99.97%Colore e forma:SolidPeso molecolare:587.54PROTAC BRD2/BRD4 degrader-1
Compound 15: Potent PROTAC, selectively degrades BRD4/BRD2, has low toxicity, and is built of a BET inhibitor, linker, and CRBN ligand.Formula:C39H38N6O9SPurezza:98%Colore e forma:SolidPeso molecolare:766.82XF056-132
CAS:XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .Formula:C51H57F4N9O7SColore e forma:SolidPeso molecolare:1016.11AS2553627
CAS:AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.Formula:C18H19N5OColore e forma:SolidPeso molecolare:321.38Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formula:C27H49NO5SPurezza:>99.99% - >99.99%Colore e forma:SoildPeso molecolare:499.75mTOR/HDAC-IN-1
CAS:mTOR/HDAC-IN-1, a dual inhibitor for mTOR & HDAC1 with IC50s 0.49 & 0.91 nM, potential anti-cancer agent.Formula:C23H23N11O3Colore e forma:SolidPeso molecolare:501.5JAK-IN-15
CAS:JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Formula:C22H23FN4O3SColore e forma:SolidPeso molecolare:442.51Bisindolylmaleimide XI hydrochloride
CAS:Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is an orally active pan-PKC inhibitor that inhibits PKCα, PKCβI, PKCβII, and PKCγ.Formula:C28H29ClN4O2Purezza:99.45%Colore e forma:SolidPeso molecolare:489.01CW-3308
<p>CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.</p>Formula:C45H48N6O8Colore e forma:SolidPeso molecolare:800.9BRD4 Inhibitor-27
CAS:<p>BRD4 Inhibitor-27 is a potent BRD4 inhibitor that inhibits BRD4 BD1 and BRD4 BD2 with IC50s of 9.6 and 11.3 μM, respectively.BRD4 Inhibitor-27 has anticancer</p>Formula:C16H13F3N6Purezza:99.22%Colore e forma:SolidPeso molecolare:346.31Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formula:C63H118N18O14SPurezza:98%Colore e forma:SolidPeso molecolare:1383.8Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS:Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].Formula:C34H43N3O7Colore e forma:SolidPeso molecolare:605.72JHDM-IN-1
CAS:JHDM-IN-1 inhibits JHDMs; IC50: 3.4 μM JMJD2C, 4.3 μM JMJD2A, 5.9 μM JMJD2E, 10 μM PHF8, 43 μM JMJD3.Formula:C27H29N3O6Colore e forma:SolidPeso molecolare:491.54SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Formula:C44H64N6O9Purezza:98%Colore e forma:SoildPeso molecolare:821.01N-Desmethyltamoxifen
CAS:N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.Formula:C25H27NOPurezza:98%Colore e forma:SolidPeso molecolare:357.49BI01826025
BI01826025 (pArg-JQ1), a BRDT BD1 bromodomain PROTAC degrader, tests ClpC2's effect on ClpC1P1P2 protease.Formula:C31H42ClN10O7PSColore e forma:SolidPeso molecolare:765.22MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Colore e forma:SolidSAMβA TFA
SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improvesFormula:C50H73N17O16·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:1168.22 (free acid)DAO-dBET1
DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.Colore e forma:Odour SolidPROTAC BRD4 Degrader-35
CAS:PROTACBRD4 Degrader-35 (Compound 17) is a PROTAC degrader targeting BRD4. It is utilized in cancer research.Formula:C47H53ClN10O4SColore e forma:SolidPeso molecolare:889.51TCIP3
CAS:TCIP3 is a bivalent molecular glue (molecular glue) that can simultaneously bind to both p300/CBP and BCL6. It redirects p300 and CBP to activate programmed cell death genes, which are typically repressed by the oncogenic driver BCL6. TCIP3 is useful for studying diffuse large B-cell lymphoma (DLBCL) and is not toxic to untransformed tonsil lymphocytes or fibroblasts.Formula:C58H71ClF2N16O7Colore e forma:SolidPeso molecolare:1177.74LSD1/HDAC6-IN-1
LSD1/HDAC6-IN-1 is an oral dual inhibitor of LSD1/HDAC6 with anti-tumor effects, useful for multiple myeloma research.Colore e forma:SolidJPS036
CAS:JPS036, a benzamide-based VHL E3-ligase PROTAC, potently degrades HDAC1/2, increasing gene expression and apoptosis in HCT116 cells.Formula:C51H66FN7O7SColore e forma:SolidPeso molecolare:940.18HDAC6 degrader-3
CAS:HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.Formula:C41H41F4N7O11Colore e forma:SolidPeso molecolare:883.8HSP70/SIRT2-IN-1
<p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>Purezza:98%Colore e forma:Odour SolidPROTAC BRD4-binding moiety 1
CAS:BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.Formula:C23H21N3O2Purezza:98%Colore e forma:SolidPeso molecolare:371.43HIV-1 inhibitor-65
HIV-1inhibitor-65 (compound 3c) is an inhibitor of HIV-1 with an EC50 of 2.9 nM and serves as an activator of protein kinase C (PKC). It effectively hinders syncytium formation with an EC50 of 7.0 nM, and prevents HIV-1 entry as well as the action of HIV-1 reverse transcriptase.Formula:C40H53FO6Peso molecolare:648.38262BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Formula:C61H71BClN9O7S2Colore e forma:SolidPeso molecolare:1152.67CBP/p300-IN-14
CAS:CBP/p300-IN-14, patent WO2021213521A1's compound 27, inhibits CBP/EP300 with 3.3 nM IC50.Formula:C30H31F2N7O2Colore e forma:SolidPeso molecolare:559.622PRMT5-IN-41
CAS:PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.Formula:C22H16F5N5O2Peso molecolare:477.39WQQ-345
WQQ-345, a BCAT1 inhibitor, exhibits an IC50 of 10.8 mM. In 67R cells, it reduces α-KG levels and upregulates H3K27me3 expression while downregulating the expression of glycolytic enzymes (PFKP and LDHA), leading to impaired glycolytic activity. Additionally, WQQ-345 demonstrates tumor-suppressive activity in a 67R subcutaneous xenograft model.Formula:C10H17NO2Colore e forma:SolidPeso molecolare:183.25Protein Kinase C Peptide Substrate
CAS:PKC Peptide Substrate acts on cell spacers, driven by second messengers/adaptors due to external signals via g protein/tyrosine kinase receptors.Formula:C83H155N39O21SPurezza:98%Colore e forma:SolidPeso molecolare:2067.43Menin-KMT2A-IN-1
Menin–KMT2A-IN-1 (Compound 20) is an inhibitor of menin–KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 μM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin–KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.Formula:C28H35FN6O3Colore e forma:SolidPeso molecolare:522.61CPI-1328
CAS:CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.Formula:C28H36ClN3O4SColore e forma:SolidPeso molecolare:546.12Pulrodemstat HCl
CAS:Pulrodemstat HCl is an LSD1 inhibitor and a KDM1A inhibitor with anticancer anti, proliferative activity.Formula:C24H24ClF2N5O2Purezza:97.87% - 99.16%Colore e forma:SoildPeso molecolare:487.93Kiss2 peptide acetate
Kiss2 peptide acetate is the acetate form of Kiss2 peptide, serving as a positive regulator of reproduction. It binds to its homologous receptor Kiss2R (GPR54) in COS-7 cells, activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This activation enhances the activity of both cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).Formula:C63H84N16O12·xC2H4O2Colore e forma:SolidPeso molecolare:1257.44 (free base)AS-254s
AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.Formula:C36H41ClN6O3S2Colore e forma:SolidPeso molecolare:705.332SMD-3236
CAS:SMD-3236 is a PRAOTAC degrader targeting SMARCA2, designed using SMARCA ligand and VHL-1 ligand, and exhibits prolonged anti-tumor activity in vivo. SMARCA2 acts as a synthetic lethal target in cancer cells lacking SMARCA4, with SMD-3236 showing 2000-fold selectivity for SMARCA2 over SMARCA4, having a DC50 of less than 1 nM and a Dmax of over 95%. In the human cancer xenograft models deficient in SMARCA4, notably the H838 model, SMD-3236 effectively induces loss of SMARCA2 in tumor tissue while sparing the SMARCA4 protein, thereby inhibiting tumor growth. The compound consists of a target protein ligand (red part) SMI-1074, a PROTAC linker (black part) (trans-4-Ethynylcyclohexyl)methyl methanesulfonate, and an E3 ligase ligand (blue part) SMARCA2 ligand-14, forming the E3LigaseLigand-linker Conjugate 159.Formula:C61H75ClN10O5SColore e forma:SolidPeso molecolare:1095.83HDAC1-IN-9
HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 μM. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.Formula:C17H17N3O3Colore e forma:SolidPeso molecolare:311.34PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Colore e forma:Odour SolidAxltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formula:C63H107N19O20S2Purezza:98%Colore e forma:SolidPeso molecolare:1514.77PARP1-IN-38
PARP1-IN-38 (compound ent-6_P) is a potent PARP1 inhibitor with an IC50 value of 10 μM. It exhibits selective cytotoxic activity in BRCA-mutant cancer cells.Formula:C16H10FN3OColore e forma:SolidPeso molecolare:279.08079AMPK activator 13
AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygenPurezza:98%Colore e forma:Odour SolidPim-1 kinase inhibitor 11
<p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>Colore e forma:Odour SolidLys-CoA TFA
Lys-CoA TFA: p300 HAT inhibitor, IC50 50-500 nM, >100x selective vs PCAF, inhibits p300-dependent transcription.Formula:C33H54F3N10O21P3SColore e forma:SolidPeso molecolare:1108.82PROTAC BRD9-binding moiety 5
CAS:PROTAC BRD9 binder moiety 5 selectively binds BRD9 with IC50 4.20μM, used in PROTAC synthesis, shows cancer cell antiproliferative activity.Formula:C19H18N6OColore e forma:SolidPeso molecolare:346.39PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8: BRD4 inhibitor with IC50s of 1.1/1.4 nM for BD1/BD2, degrades BRD4 in PC3 cells.Colore e forma:LiquidEldocasiran
CAS:Eldocasiran, a micro-RNA-193a-3p analogue, exhibits anticancer properties. It is utilized in cancer research [1].Formula:C423H529N161O305P42Colore e forma:SolidPeso molecolare:14049.5Transcriptional Intermediary Factor 2 (TIF2) (740-753)
CAS:TIF2 (740-753) is a 14-amino acid peptide, a coactivator for TIF-2 covering residues 740-753.Formula:C75H124N20O25Peso molecolare:1705.932PROTAC TYK2 degrader-1
CAS:PROTAC TYK2 degrader-1 (CPD-155) functions as a selective degrader of TYK2, demonstrating a degradation maximum (D max) greater than 60%. This compound effectively targets TYK2 for degradation, utilizing a linker to connect the TYK2 ligand with the VHL ligand Thalidomide, each color-coded for identification.Formula:C40H41N13O7Peso molecolare:815.84PRO-HD2
PRO-HD2 is a selective, PROTAC-based degrader of HDAC6 [1].Purezza:98%Colore e forma:Odour SolidCAY10591
CAS:<p>SIRT1 activated by CAY10591, mimics caloric restriction, extends lifespan, inhibits apoptosis, suppresses TNF-α, and promotes fat mobilization.</p>Formula:C20H25N5O2Colore e forma:SolidPeso molecolare:367.44GSK9311 hydrochloride
CAS:GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).Formula:C24H32ClN5O3Purezza:98%Colore e forma:SolidPeso molecolare:474ZLN 024 hydrochloride
CAS:ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).Formula:C13H14BrClN2OSPurezza:98.541%Colore e forma:SolidPeso molecolare:361.68N-acetyl-S-geranylgeranyl-L-Cysteine
CAS:N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic inhibitor for protein methyltransferase.Formula:C25H41NO3SColore e forma:SolidPeso molecolare:435.67HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formula:C60H69N17O11SColore e forma:SolidPeso molecolare:1236.36Ep300/CREBBP-IN-2
CAS:Ep300/CREBBP-IN-2: Potent, oral Ep300 & CREBBP inhibitor; IC50s: 0.052μM & 0.148μM; cancer research.Formula:C26H27F3N4O4Colore e forma:SolidPeso molecolare:516.51CB1R/AMPK modulator 1
Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.Formula:C25H22Cl2N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:557.45PRMT5-IN-4
CAS:PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Formula:C11H13N3O4SColore e forma:SolidPeso molecolare:283.3TDI-012804
TDI-012804 is a TNKS2 inhibitor that selectively inhibits endogenous TNKS2 protein within cells. It enhances the expression of AXIN1 protein in Tnks1 heterozygous (Tnks1HET) and knockout (Tnks1KO) cells. TDI-012804 suppresses the proliferation of ApcQ1405X/Tnks1KO organoids with an EC50 of 59.1 nM and exhibits selective toxicity towards Tnks1KO AKP-G12D and AKP-G13D organoids.Colore e forma:Odour SolidZIP
CAS:Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Formula:C90H154N30O17Purezza:98%Colore e forma:SolidPeso molecolare:1928.4UNC10142
UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.Formula:C33H52N6O3Colore e forma:SolidPeso molecolare:580.8SAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Formula:C155H256N48O40Purezza:98%Colore e forma:SolidPeso molecolare:3432.05PKCδ Peptide Substrate
CAS:PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) andFormula:C109H191N35O29SColore e forma:SolidPeso molecolare:2487.97PROTAC SMARCA2 degrader-26
CAS:PROTAC SMARCA2 degrader-26 (compound 45) is an effective degrader of SMARCA2 using the PROTAC technology. It induces degradation of SMARCA2 and SMARCA4 in VCaP cells, with degradation percentages of 94% and 57%, respectively. Additionally, PROTAC SMARCA2 degrader-26 demonstrates antiproliferative activity.Formula:C46H54N8O5SColore e forma:SolidPeso molecolare:831.04CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formula:C27H37Cl3N8O4Purezza:98%Colore e forma:SoildPeso molecolare:643.99Ref: TM-T10699L2
2mg138,00€5mg197,00€10mg299,00€50mg702,00€100mg1.090,00€200mgPrezzo su richiesta500mgPrezzo su richiesta1mL*10mM (DMSO)279,00€Protein kinase C α peptide TFA
CAS:Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.Formula:C68H115F3N24O26SColore e forma:SolidPeso molecolare:1773.85PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formula:C55H60FN11O8SPurezza:98%Colore e forma:SolidPeso molecolare:1054.2dAURK-4
CAS:dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H52ClFN8O12Colore e forma:SolidPeso molecolare:1035.47Anemonin (6CI)
CAS:Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.Formula:C10H8O4Colore e forma:SolidPeso molecolare:192.17PROTAC SMARCA2 degrader-21
CAS:PROTAC SMARCA2 degrader-21 (Compound I-5) acts as a degrader of SMARCA2 in A549 cells, with a DC50 range of 10-50 nM, and additionally degrades both SMARCA2 and SMARCA4 in MV411 cells, with respective DC50 values of <1 nM and >100 nM.Formula:C54H66N12O5SColore e forma:SolidPeso molecolare:995.24TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Colore e forma:Odour SolidPROTAC SMARCA2/4-degrader-34
PROTAC SMARCA2/4-degrader-34 (compound 38) serves as an effective degrader of both SMARCA2 and SMARCA4. It demonstrates binding affinity to PXR with a DC50 value of 85.1 nM and reduces the protein expression of 3xFLAG-PXR.Formula:C58H78N8O13SColore e forma:SolidPeso molecolare:1127.35HD-TAC7
CAS:HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB p65; researched for asthma, COPD.Formula:C33H32FN7O7Colore e forma:SolidPeso molecolare:657.65PROTAC BRD4 Degrader-30
PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.Colore e forma:Odour SolidR8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Formula:C111H211N59O26SPurezza:98%Colore e forma:SolidPeso molecolare:2820.33(R)-SKBG-1
CAS:(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNAFormula:C22H26ClN3O6SPurezza:97.25%Colore e forma:SolidPeso molecolare:495.98EXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Formula:C18H17N3O3Colore e forma:SolidPeso molecolare:323.35GSK 591 dihydrochloride
CAS:Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.Formula:C22H30Cl2N4O2Colore e forma:SolidPeso molecolare:453.41PROTAC BET degrader-2
CAS:PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).Formula:C41H42N10O6Purezza:98%Colore e forma:SolidPeso molecolare:770.84Ref: TM-T12559
5mg379,00€10mg600,00€25mg1.111,00€50mgPrezzo su richiesta100mgPrezzo su richiesta1mL*10mM (DMSO)605,00€GSK023
GSK023 (compound 31) is a selective chemical probe that targets the BET BD1 domain.Formula:C29H39N5O2Peso molecolare:489.31038HSP90/LSD1-IN-1
HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.Colore e forma:Odour SolidGSK973
CAS:<p>GSK973 is a selective oral BET inhibitor, 1600x more for BRD4 BD2 (pIC50 7.8, pKd 8.7) than BD1, effective against other BD2s.</p>Formula:C23H23FN2O4Colore e forma:SolidPeso molecolare:410.445HDAC-IN-89
<p>HDAC-IN-89 is an inhibitor of HDAC1 (IC50: 0.95 nM), HDAC2 (IC50: 0.86 nM), HDAC3 (IC50: 1.06 nM), and HDAC8 (IC50: 4.24 nM). It can disrupt the cell cycle and induce apoptosis. Additionally, HDAC-IN-89 exhibits antitumor activity.</p>Colore e forma:Odour SolidmUNO
CAS:mUNO is a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically binds to murine CD206, targeting tumor-associated macrophages that express CD206/MRC1. Additionally, mUNO can interact with human recombinant CD206.Formula:C22H39N7O8SColore e forma:SolidPeso molecolare:561.652S-Ruxolitinib
CAS:<p>S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.</p>Formula:C17H18N6Purezza:98%Colore e forma:SolidPeso molecolare:306.37PROTAC SMARCA2 degrader-24
CAS:PROTAC SMARCA2 degrader-24 (Compound 34) is a SMARCA2 PROTAC degrader with a DC50 of less than 0.1 µM in HeLa cells. It also degrades SMARCA4 in HeLa cells, exhibiting a DC50 greater than 10 µM.Formula:C45H56N10O5SColore e forma:SolidPeso molecolare:849.06TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Formula:C23H21FN4O2Colore e forma:SolidPeso molecolare:404.16485CP 46665
CAS:CP 46665 is a bio-active chemical.Formula:C35H66Cl2N2O2Colore e forma:SolidPeso molecolare:617.82Psychosine
CAS:Psychosine (Galactosylsphingosine) is a PKC inhibitor, and is highly cytotoxic, inducing cell death in a variety of cells.Formula:C24H47NO7Purezza:98%Colore e forma:White PowderPeso molecolare:461.63YCH1899
YCH1899, an orally active PARP inhibitor, demonstrates potent inhibition of PARP1/2 with an IC50 of less than 0.001 nM.Formula:C25H18BrFN6O3Purezza:98%Colore e forma:SolidPeso molecolare:549.35Cath-L-dBET1
Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 μM in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.Colore e forma:Odour SolidHIF-1α-IN-6
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.Purezza:98%Colore e forma:Odour SolidHDAC/CD13-IN-1
HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μMFormula:C27H41Cl2N5O4Purezza:98%Colore e forma:SolidPeso molecolare:570.55PRMT4-IN-3
<p>PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37</p>Formula:C23H29N7OPurezza:98%Colore e forma:SolidPeso molecolare:419.52Mz325
Mz325 serves as a dual inhibitor of both HDAC and Sirt2, exhibiting an IC50 of 9.7 µM against Sirt2, which are implicated in the pathogenesis of cancer andPurezza:98%Colore e forma:Odour SolidPROTAC BRD3/BRD4-L degrader-2
PROTAC BRD3/BRD4-L degrader-2, a PROTAC molecule, selectively degrades cellular BRD3 and BRD4-L with K i values of 16.91 and 2.8 nM, respectively, and exhibitsFormula:C43H44ClN7O3Purezza:98%Colore e forma:SolidPeso molecolare:742.31MC4171
MC4171 is a selective KAT8 inhibitor with antiproliferative activity and can be used to study cancer.Formula:C21H15N3O3Purezza:99.56%Colore e forma:SolidPeso molecolare:357.36PCAF-IN-1
CAS:PCAF-IN-1 is a highly selective PCAF inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects.Formula:C15H11ClN6Colore e forma:SolidPeso molecolare:310.74DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formula:C26H35N7O5Colore e forma:SolidPeso molecolare:525.6KDM4C-IN-1
CAS:KDM4C-IN-1 is aKDM4C inhibitor withial anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.Formula:C15H14N4O3Purezza:99.33%Colore e forma:SolidPeso molecolare:298.3GSK2879552
CAS:GSK2879552: oral, irreversible LSD1 inhibitor with potential cancer-fighting properties.Formula:C23H28N2O2Purezza:99.22%Colore e forma:SolidPeso molecolare:364.48(2R)-Octyl-α-hydroxyglutarate
CAS:(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.Formula:C13H24O5Colore e forma:SolidPeso molecolare:260.33SGC-iMLLT
CAS:SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular targetFormula:C22H24N6OPurezza:99.21% - 99.92%Colore e forma:SolidPeso molecolare:388.47AZ505 ditrifluoroacetate
CAS:AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Formula:C33H40Cl2F6N4O8Colore e forma:SolidPeso molecolare:805.59T-448
CAS:T-448 is a lysine-specific demethylase 1 inhibitor (IC50: 22 nM) that improves learning function in mice.T-448 can be used to study memory deficits.Formula:C19H22N4O3SPurezza:97% - 98.63%Colore e forma:SolidPeso molecolare:386.47GSK778
CAS:GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.Formula:C30H33N5O3Purezza:98.42%Colore e forma:SolidPeso molecolare:511.61Ref: TM-T9703
1mg160,00€5mg311,00€10mg502,00€25mg1.008,00€50mg1.596,00€100mg2.213,00€1mL*10mM (DMSO)47,00€KDM4-IN-3
CAS:KDM4-IN-3 is a KDM4 inhibitor that is cell-permeable and kills prostate cancer cells at low micromolar concentrations.Formula:C17H14N4OColore e forma:SolidPeso molecolare:290.32
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