Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2490 prodotti di "Cromatina/Epigenetica"
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Pumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Formula:C17H20N8O2SPurezza:99.94%Colore e forma:SoildPeso molecolare:400.46Go6976
CAS:Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.Formula:C24H18N4OPurezza:95.89%Colore e forma:Off-White To Yellow SolidPeso molecolare:378.43JPS016
CAS:JPS016: benzamide VHL E3-ligase PROTAC, degrades HDAC1/2, triggers apoptosis in HCT116 cells.Formula:C48H63N7O8SColore e forma:SolidPeso molecolare:898.12MS33
CAS:MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formula:C64H84F3N11O7SColore e forma:SolidPeso molecolare:1208.5JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formula:C43H45ClFN7O10SColore e forma:SolidPeso molecolare:906.375PROTAC BET Degrader-10
CAS:PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon ligands.Formula:C39H39ClN8O6SColore e forma:SolidPeso molecolare:783.3Ref: TM-T39374
5mg236,00€10mg379,00€25mg710,00€50mg1.054,00€100mg1.568,00€200mgPrezzo su richiesta500mgPrezzo su richiesta1mL*10mM (DMSO)326,00€XF067-68
CAS:XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formula:C52H59F4N9O7SColore e forma:SolidPeso molecolare:1030.14CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Colore e forma:Solid(S)-GNE-987
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).Formula:C56H67F2N9O8S2Purezza:98%Colore e forma:SolidPeso molecolare:1096.31PRO-HD3
PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].Purezza:98%Colore e forma:Odour SolidKB02-JQ1
CAS:KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.Formula:C38H43Cl2N7O6SPurezza:98%Colore e forma:SoildPeso molecolare:796.76MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Colore e forma:Odour SolidMOCPAC
CAS:MOCPAC is an HDAC1 specific substrate [1] .Formula:C27H31N3O6Colore e forma:SolidPeso molecolare:493.55M-1211
CAS:M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.Formula:C42H57FN6O6SColore e forma:SolidPeso molecolare:793.01SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formula:C24H29ClN8O4SPurezza:98.68%Colore e forma:SolidPeso molecolare:561.067-Hydroxyneolamellarin A
CAS:7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.Formula:C24H19NO5Colore e forma:SolidPeso molecolare:401.41Axl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptorFormula:C14H19ClO8Purezza:98%Colore e forma:SolidPeso molecolare:350.75EZH2-IN-5
CAS:EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Formula:C26H37BrN4O2Colore e forma:SolidPeso molecolare:517.512SNIPER(BRD)-1
CAS:SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.Formula:C53H66ClN9O8S2Purezza:98%Colore e forma:SolidPeso molecolare:1056.73Namoline
CAS:Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Formula:C10H3ClF3NO4Colore e forma:SolidPeso molecolare:293.58NP213
CAS:NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).Formula:C42H84N28O7Purezza:98%Colore e forma:SolidPeso molecolare:1093.3Vanicoside A
CAS:Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .Formula:C51H50O21Colore e forma:SolidPeso molecolare:998.93HIF-1 α (556-574)
CAS:HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.Formula:C101H150D2N20O34S2Purezza:98%Colore e forma:SolidPeso molecolare:2254.6ZL0590
CAS:ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.Formula:C23H27F3N4O4SPurezza:99.77%Colore e forma:SoildPeso molecolare:512.55Ref: TM-T60072
1mg74,00€5mg160,00€10mg235,00€25mg424,00€50mg635,00€100mg935,00€1mL*10mM (DMSO)177,00€Dihydrochlamydocin analog-1
CAS:Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.Formula:C28H40N4O6Colore e forma:SolidPeso molecolare:528.64IQZ23
CAS:IQZ23 inhibits fat cell formation, activates AMPK, cuts triglycerides (EC50=0.033 μM), may aid obesity/metabolic study.Formula:C26H29N5O2Colore e forma:SolidPeso molecolare:443.551GSK040
CAS:GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Formula:C29H34N4O4Colore e forma:SolidPeso molecolare:502.6SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.Purezza:98%Colore e forma:Odour SolidPROTAC BRD4 Degrader-19
CAS:PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utilityFormula:C44H38N8O5S2Colore e forma:SolidPeso molecolare:822.95PROTAC HDAC6 degrader 3
PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]Formula:C46H56F2N10O9SColore e forma:SolidPeso molecolare:963.06GSK8573
CAS:GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formula:C20H21NO3Purezza:99.97%Colore e forma:SolidPeso molecolare:323.39BRD7-IN-1 free base
CAS:BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formula:C22H26N4O3Purezza:98%Colore e forma:SolidPeso molecolare:394.47BETd-246
CAS:BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.Formula:C48H55N11O10Purezza:98%Colore e forma:SolidPeso molecolare:946.02Ref: TM-T14549
5mg485,00€10mg710,00€25mg1.449,00€50mg2.197,00€100mgPrezzo su richiesta200mgPrezzo su richiestaLT-630
LT-630 is an inhibitor of HDAC6. It alleviates liver damage by reducing oxidative stress injury.Formula:C19H17FN4O3Peso molecolare:368.12847MNK/PIM-IN-1
CAS:MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.Formula:C27H27FN6O2Colore e forma:SolidPeso molecolare:486.551RMM23
RMM23 is an inhibitor that targets PfBDP1, exhibiting a Kd of 1.24 μM. In vitro, it shows EC50 values of 18 μM against the 3D7 wild-type strain, 14 μM against the NF54 wild-type strain, and 20 μM against the multidrug-resistant K1 strain during the blood stage.Colore e forma:Odour SolidC 21
CAS:PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Formula:C90H161ClN36O24Purezza:98%Colore e forma:SolidPeso molecolare:2166.94dBAZ2
dBAZ2 is a pioneering PROTAC degrader targeting BAZ2A and BAZ2B, with DC50 values of 180 nM for BAZ2A and 250 nM for BAZ2B.Formula:C54H64FN11O5S2Colore e forma:SolidPeso molecolare:1030.29PRMT5-IN-4
CAS:PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Formula:C11H13N3O4SColore e forma:SolidPeso molecolare:283.3PROTAC BRD4 Degrader-12
CAS:PROTAC BRD4 Degrader-12 targets BRD4 in PC3 cells; conjugates with STEAP1, CLL1; DC50: 0.39/0.24 nM.Formula:C62H77F2N9O12S4Colore e forma:SolidPeso molecolare:1306.58CBPD-409
CBPD-409 is an orally active CBP/p300 degrader with a DC50 of 0.2–0.4 nM. It exhibits antiproliferative effects in AR+ prostate cancer cell lines VCaP, LNCaP, and 22Rv1, with an IC50 of 1.2–2.0 nM. Additionally, CBPD-409 shows antitumor activity.Formula:C46H52F2N10O5Peso molecolare:862.40902CBP/p300-IN-8
CAS:CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.Formula:C27H31N3O4Colore e forma:SolidPeso molecolare:461.562JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;
Colore e forma:Odour SolidPROTAC BRD4 Degrader-5
CAS:PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Formula:C50H62ClN9O8S2Colore e forma:SolidPeso molecolare:1016.673β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS:3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.
Formula:C30H52O4Colore e forma:SolidPeso molecolare:476.742Curcuphenol
CAS:Curcuphenol in concentrations in the range of 29-116 μg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner.Formula:C15H22OPurezza:98%Colore e forma:SolidPeso molecolare:218.33Deuruxolitinib
CAS:Deuruxolitinib functions as an inhibitor of JAK1/2.Formula:C17H18N6Colore e forma:SolidPeso molecolare:314.41DBL-6-13
DBL-6-13 is an inhibitor of WDR5, displaying moderate binding affinity with dissociation constants (Kd) of 6.8 μM and 9.1 μM as determined by microscale thermophoresis analysis and fluorescence polarization analysis, respectively.Formula:C25H38N4O3Colore e forma:SolidPeso molecolare:442.59SYY-B085-1
CAS:SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor.Formula:C27H23F4N5O4Colore e forma:SolidPeso molecolare:557.506
