Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2462 prodotti di "Cromatina/Epigenetica"
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PRO-HD1
PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50Purezza:98%Colore e forma:Odour SolidBiguanide
CAS:Biguanide can reduce oxidative stress in rats with hyperglycemia.Formula:C2H7N5Colore e forma:SolidPeso molecolare:101.11BRD3067
CAS:BRD3067, a Tubacin derivative, inhibits HDAC6 (IC50 15 nM) and acts as a negative control for Tubacin A, showing anticancer and anti-inflammatory effects.Formula:C21H23N3O2Purezza:98%Colore e forma:SolidPeso molecolare:349.43Bryostatin 3
CAS:Bryostatin 3 is a protein kinase C activator.Formula:C46H64O17Purezza:98%Colore e forma:SolidPeso molecolare:888.99MSC2504877
CAS:<p>MSC2504877 inhibits tankyrase, boosts CDK4/6 inhibitors, blocks Cyclin D2/E2 upregulation, and strengthens phospho-Rb suppression.</p>Formula:C17H18N2O2Purezza:99.72%Colore e forma:SoildPeso molecolare:282.34pan-BET/BD2-IN-1
Pan-BET/BD2-IN-1 (compound 6b) is a selective BET protein inhibitor with BRDT-1Ki of 1.05 μM and BRD4-1Ki of 0.68 μM. It effectively inhibits the growth of MM.1S cancer cells with an IC50 value of 2.6 μM.Colore e forma:Odour SolidFluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Colore e forma:SolidSJ1008030
CAS:<p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>Formula:C42H43N13O7SColore e forma:SolidPeso molecolare:873.94α-Hydroxyglutaric Acid
CAS:α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.Formula:C5H8O5Colore e forma:SolidPeso molecolare:148.114Malantide
CAS:Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formula:C72H124N22O21Purezza:98%Colore e forma:SolidPeso molecolare:1633.89N-Desmethyltamoxifen
CAS:N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.Formula:C25H27NOPurezza:98%Colore e forma:SolidPeso molecolare:357.49PRMT1-IN-1
CAS:<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Formula:C20H7Br6NO5Colore e forma:SolidPeso molecolare:820.702E67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Formula:C21H36N6O2Colore e forma:SolidPeso molecolare:404.559mTOR/HDAC-IN-1
CAS:mTOR/HDAC-IN-1, a dual inhibitor for mTOR & HDAC1 with IC50s 0.49 & 0.91 nM, potential anti-cancer agent.Formula:C23H23N11O3Colore e forma:SolidPeso molecolare:501.5HDAC-IN-26
CAS:HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Formula:C24H28FN5O3Colore e forma:SolidPeso molecolare:453.518SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formula:C41H47ClN6O6SPurezza:98%Colore e forma:SolidPeso molecolare:787.37MZP-55
CAS:MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)Formula:C57H70ClN7O10SPurezza:98%Colore e forma:SolidPeso molecolare:1080.73Ref: TM-T13786
5mg434,00€10mg663,00€25mg1.254,00€50mgPrezzo su richiesta100mgPrezzo su richiesta1mL*10mM (DMSO)472,00€OARV-771
CAS:OARV-771: VHL-based PROTAC targeting BET; DC50: Brd4-6nM, Brd2-1nM, Brd3-4nM; enhanced cell permeability.Formula:C49H59ClN8O8S2Colore e forma:SolidPeso molecolare:987.62PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Formula:C38H47N9O5SColore e forma:SolidPeso molecolare:741.9JAK-IN-15
CAS:JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Formula:C22H23FN4O3SColore e forma:SolidPeso molecolare:442.51Mz325
Mz325 serves as a dual inhibitor of both HDAC and Sirt2, exhibiting an IC50 of 9.7 µM against Sirt2, which are implicated in the pathogenesis of cancer andPurezza:98%Colore e forma:Odour SolidTYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Formula:C23H21FN4O2Colore e forma:SolidPeso molecolare:404.16485HDAC8-IN-10
HDAC8-IN-10 (compound 15) serves as a potent inhibitor of HDAC8, exhibiting an IC50 value of 7.6 nM. It also acts as a ligand for the HDAC8 target protein, utilized in the synthesis of PROTAC YX862.Colore e forma:Odour SolidSJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFormula:C43H45N13O9SPurezza:98%Colore e forma:SolidPeso molecolare:919.96(S,R,S)-AHPC-C5-COOH
CAS:E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.Formula:C29H42N4O5SPurezza:98%Colore e forma:SolidPeso molecolare:558.73Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formula:C63H118N18O14SPurezza:98%Colore e forma:SolidPeso molecolare:1383.8PROTAC SMARCA2/4-degrader-27
CAS:PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.Formula:C49H58FN9O6SColore e forma:SolidPeso molecolare:920.11Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formula:C22H28ClN3O4Purezza:99.95%Colore e forma:SolidPeso molecolare:433.93Ref: TM-T64336
5mg43,00€10mg60,00€25mg103,00€50mg166,00€100mg259,00€200mg378,00€1mL*10mM (DMSO)47,00€RJW100
CAS:RJW100 is a potent LRH-1 & SF-1 agonist with pEC50 of 6.6 & 7.5, also activates miR-200c promoter.Formula:C28H34OPurezza:99.45%Colore e forma:SolidPeso molecolare:386.57SIRT1/2/3-IN-1
CAS:Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.Formula:C46H63N9O8S2Colore e forma:SolidPeso molecolare:934.18RK 286D
CAS:<p>RK 286D is an indolocarbazole antibiotic.</p>Formula:C26H23N3O4Colore e forma:SolidPeso molecolare:441.48NF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Formula:C24H27N7O4Colore e forma:SolidPeso molecolare:477.21245AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formula:C28H32FN9O2Colore e forma:SolidPeso molecolare:545.61MS2133
MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.Formula:C58H66ClF3N14O11S2Colore e forma:SolidPeso molecolare:1290.41175(rel)-Tranylcypromine D5 hydrochloride
CAS:(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.Formula:C9H12ClNPurezza:98%Colore e forma:SolidPeso molecolare:174.682PROTAC SMARCA2/4-degrader-31
CAS:PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Colore e forma:SolidPeso molecolare:797.95JHDM-IN-1
CAS:JHDM-IN-1 inhibits JHDMs; IC50: 3.4 μM JMJD2C, 4.3 μM JMJD2A, 5.9 μM JMJD2E, 10 μM PHF8, 43 μM JMJD3.Formula:C27H29N3O6Colore e forma:SolidPeso molecolare:491.54INCB059872
CAS:INCB059872: potent, oral, selective LSD1 inhibitor for myeloid leukemia research.Formula:C23H34N2O3Colore e forma:SolidPeso molecolare:386.536TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purezza:99.65%Colore e forma:SolidPeso molecolare:506.36Ref: TM-T34787
1mg97,00€5mg235,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€1mL*10mM (DMSO)261,00€Dot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formula:C34H37ClF3N9O4SColore e forma:SolidPeso molecolare:760.23PROTAC BRD4 Degrader-12
CAS:PROTAC BRD4 Degrader-12 targets BRD4 in PC3 cells; conjugates with STEAP1, CLL1; DC50: 0.39/0.24 nM.Formula:C62H77F2N9O12S4Colore e forma:SolidPeso molecolare:1306.58SYY-B085-1
CAS:SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor.Formula:C27H23F4N5O4Colore e forma:SolidPeso molecolare:557.506(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Colore e forma:SolidKDM4 ligand-1
KDM4ligand-1 is a ligand targeting the protein (histone lysine demethylase KDM4) in PROTACs. It can be utilized for the synthesis of PROTACs.Colore e forma:Odour SolidTubulin/HDAC-IN-3
Tubulin/HDAC-IN-3 (compound 12a) serves as a potent dual inhibitor of tubulin polymerization and HDAC1/8, exhibiting IC50 values of 5.4 μM for tubulinFormula:C28H28N2O10Colore e forma:SolidPeso molecolare:552.53AUR1545
CAS:AUR1545 is a selective KAT2A/KAT2B degradator, inhibitory against AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.Formula:C41H50BrN9O5Purezza:98.84%Colore e forma:SolidPeso molecolare:828.8PROTAC SMARCA2/4-degrader-30
CAS:Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Colore e forma:SolidPeso molecolare:797.95Protein Kinase C (19-31)
CAS:Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.Formula:C67H118N26O16Purezza:98%Colore e forma:Lyophilized PowderPeso molecolare:1543.82
