Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2442 prodotti di "Cromatina/Epigenetica"
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PF-CBP1
CAS:PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).Formula:C29H36N4O3Purezza:99.45%Colore e forma:SolidPeso molecolare:488.62BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Formula:C28H38N6O2Purezza:98.58% - 99.64%Colore e forma:SolidPeso molecolare:490.64Ref: TM-T7697
1mg40,00€5mg85,00€10mg117,00€25mg207,00€50mg311,00€100mg472,00€200mg642,00€1mL*10mM (DMSO)131,00€PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formula:C22H26N4O3Purezza:98.82%Colore e forma:SolidPeso molecolare:394.473-methyl-1,2-dihydroquinolin-2-one
CAS:3-methyl-1,2-dihydroquinolin-2-one is the first known micromolar inhibitors of the ATAD2 bromodomain.Formula:C10H9NOPurezza:99.62%Colore e forma:SolidPeso molecolare:159.18Ref: TM-T50035
1mg38,00€5mg81,00€10mg108,00€25mg178,00€50mg264,00€100mg374,00€200mg507,00€1mL*10mM (DMSO)65,00€Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formula:C21H18F3N5OPurezza:98.91%Colore e forma:SolidPeso molecolare:413.4Ref: TM-T5524
1mg70,00€2mg95,00€5mg160,00€10mg250,00€25mg424,00€50mg612,00€100mg842,00€200mg1.159,00€1mL*10mM (DMSO)170,00€NSC 228155
CAS:NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Formula:C11H6N4O4SPurezza:99.84%Colore e forma:SolidPeso molecolare:290.25Ref: TM-T6908
2mg35,00€5mg50,00€10mg66,00€25mg124,00€50mg188,00€100mg354,00€200mg495,00€1mL*10mM (DMSO)52,00€653-47
CAS:653-47 enhances the effects of 666-15 on inhibiting CREB and is a mild CREB inhibitor itself (IC50: 26.3μM).Formula:C20H19ClN2O3Colore e forma:SolidPeso molecolare:370.83BI-9564
CAS:<p>BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.</p>Formula:C20H23N3O3Purezza:99.38%Colore e forma:SolidPeso molecolare:353.41Senaparib hydrochloride
CAS:Senaparib hydrochloride is a potent and selective oral PARP1/2 inhibitor with strong antitumor activity.Formula:C24H21ClF2N6O3Colore e forma:SolidPeso molecolare:514.92Hesperadin
CAS:Hesperadin(IC50=250 nM) effectively inhibits Aurora B.Formula:C29H32N4O3SPurezza:98.04% - 99.44%Colore e forma:SolidPeso molecolare:516.65Ritlecitinib
CAS:Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Formula:C15H19N5OPurezza:98.82% - 99.92%Colore e forma:SolidPeso molecolare:285.34Ref: TM-T5382
2mg39,00€5mg56,00€10mg96,00€25mg216,00€50mg306,00€100mg430,00€200mg628,00€1mL*10mM (DMSO)77,00€Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurezza:98.53% - 99.94%Colore e forma:SolidPeso molecolare:248.71Ref: TM-T6111
5mg50,00€10mg57,00€25mg93,00€50mg140,00€100mg235,00€200mg349,00€500mg565,00€1mL*10mM (DMSO)52,00€6-Bromo-3-methyl-1,4-dihydroquinazolin-2-one
CAS:CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).Formula:C9H9BrN2OPurezza:99.28%Colore e forma:SolidPeso molecolare:241.08Ref: TM-T8609
1mg62,00€5mg123,00€10mg180,00€25mg298,00€50mg419,00€100mg567,00€200mg752,00€1mL*10mM (DMSO)113,00€Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formula:C51H82O21Purezza:99.51% - 99.63%Colore e forma:SolidPeso molecolare:1031.18UNC1079
CAS:<p>UNC1079 is an selective L3MBTL3 domain inhibitor</p>Formula:C28H42N4O2Purezza:99.48%Colore e forma:SolidPeso molecolare:466.66Senaparib
CAS:Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.Formula:C24H20F2N6O3Purezza:99.8%Colore e forma:SolidPeso molecolare:478.45Ref: TM-T9593
1mg46,00€2mg59,00€5mg87,00€10mg153,00€25mg274,00€50mg432,00€100mg638,00€1mL*10mM (DMSO)96,00€O-304
CAS:O-304 is a pan-activator of AMP-activated protein kinase (AMPK).Formula:C16H11Cl2N3O2SPurezza:99.84% - ≥98%Colore e forma:SolidPeso molecolare:380.25Ref: TM-T7362
1mg66,00€2mg96,00€5mg144,00€10mg216,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)159,00€WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Formula:C16H14Br2ClN3O3Purezza:99.49%Colore e forma:SolidPeso molecolare:491.56Ref: TM-T4657L
2mg37,00€5mg50,00€10mg90,00€25mg145,00€50mg192,00€100mg276,00€200mg393,00€1mL*10mM (DMSO)77,00€KDM4D-IN-1
CAS:KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).Formula:C11H7N5OPurezza:99.51% - >99.99%Colore e forma:SolidPeso molecolare:225.21Ref: TM-T4214
1mg77,00€5mg166,00€10mg259,00€25mg522,00€50mg838,00€100mg1.225,00€1mL*10mM (DMSO)177,00€EPZ015666
CAS:EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.Formula:C20H25N5O3Purezza:98% - 99.64%Colore e forma:SolidPeso molecolare:383.44PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formula:C22H25N7O2Purezza:97.58% - 99.94%Colore e forma:SolidPeso molecolare:419.48LLY-507
CAS:LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Formula:C36H42N6OPurezza:99.58% - 99.93%Colore e forma:SolidPeso molecolare:574.76Ref: TM-T6879
1mg44,00€2mg55,00€5mg85,00€10mg138,00€25mg304,00€50mg552,00€100mg787,00€1mL*10mM (DMSO)110,00€UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Formula:C36H59N7O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:621.93,6-Dihydroxyflavone
CAS:3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.Formula:C15H10O4Purezza:99.92%Colore e forma:SolidPeso molecolare:254.244-amino-1,8-Naphthalimide
CAS:4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nMFormula:C12H8N2O2Purezza:95.13%Colore e forma:Yellow Solid PowderPeso molecolare:212.2EX229
CAS:EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.Formula:C24H18ClN3O3Purezza:99.20% - 99.36%Colore e forma:SolidPeso molecolare:431.87Ref: TM-TQ0028
1mg37,00€2mg52,00€5mg74,00€10mg111,00€25mg221,00€50mg376,00€100mg565,00€1mL*10mM (DMSO)85,00€PFI-2 hydrochloride
CAS:PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM),Formula:C23H26ClF4N3O3SPurezza:99.31% - 99.91%Colore e forma:SolidPeso molecolare:535.98Ref: TM-T4583
1mg40,00€2mg51,00€5mg85,00€10mg117,00€25mg212,00€50mg378,00€100mg552,00€500mg1.169,00€1mL*10mM (DMSO)128,00€ML324
CAS:ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).Formula:C21H23N3O2Purezza:98.22% - 98.57%Colore e forma:SolidPeso molecolare:349.43Ref: TM-T6593
2mg35,00€5mg51,00€10mg79,00€25mg128,00€50mg216,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)84,00€Niraparib tosylate monohyrate
CAS:Niraparib (MK-4827), a PARP inhibitor, boosts DNA breaks to trigger genomic instability and apoptosis, offering anti-cancer effects.Formula:C26H30N4O5SPurezza:97.7% - 99.99%Colore e forma:SolidPeso molecolare:510.61Ref: TM-T9497
5mg60,00€10mg87,00€25mg117,00€50mg144,00€100mg216,00€200mg325,00€500mg545,00€1mL*10mM (DMSO)70,00€BMS-P5 free base
CAS:BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor.Formula:C27H32N6O2Purezza:99.88%Colore e forma:SolidPeso molecolare:472.58BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Formula:C26H26F3N7O2Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:525.53Ref: TM-T2488
1mg35,00€2mg43,00€5mg63,00€10mg101,00€25mg212,00€50mg351,00€100mg588,00€1mL*10mM (DMSO)73,00€ARN-3236
CAS:ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nMFormula:C19H16N2O2SPurezza:98.89% - 99.7%Colore e forma:SolidPeso molecolare:336.41Ref: TM-T5993
1mg60,00€5mg97,00€10mg160,00€25mg264,00€50mg354,00€100mg540,00€200mg777,00€1mL*10mM (DMSO)150,00€HNHA
CAS:HNHA is an inhibitor of HDAC.Formula:C17H21NO2SPurezza:98.04%Colore e forma:SolidPeso molecolare:303.42Ref: TM-T21806
1mg44,00€5mg84,00€10mg135,00€25mg279,00€50mg445,00€100mg640,00€200mg879,00€1mL*10mM (DMSO)90,00€IOX2
CAS:IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.Formula:C19H16N2O5Purezza:98% - 99.59%Colore e forma:SolidPeso molecolare:352.34URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formula:C27H27N5Purezza:99.32% - 99.98%Colore e forma:SolidPeso molecolare:421.544-Phenylbutyric acid
CAS:4-Phenylbutyric acid (Benzenebutyric acid) is a HDAC inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. Cost-effective and quality-assured.Formula:C10H12O2Purezza:98.40% - 99.76%Colore e forma:SolidPeso molecolare:164.2Eicosapentaenoic Acid sodium
CAS:EPA sodium, an oral omega-3, demethylates DNA, reactivates tumor suppressors, and induces vasodilation.Formula:C20H29NaO2Colore e forma:SolidPeso molecolare:324.43TIQ-A
CAS:TIQ-A blocks PARP1 to prevent excessive DNA damage response, implicated in ischemia, asthma, and atherosclerosis.Formula:C11H7NOSPurezza:99.75%Colore e forma:SolidPeso molecolare:201.24Ref: TM-T50098
1mg50,00€5mg97,00€10mg170,00€25mg306,00€50mg437,00€100mg562,00€200mg777,00€1mL*10mM (DMSO)101,00€OTS186935 hydrochloride
OTS186935 HCl inhibits SUV39H2 (IC50 6.49 nM), curbs tumor growth in mice, and modulates γ-H2AX in cancer cells.Formula:C25H27Cl2N5O2Colore e forma:SolidPeso molecolare:522.31SAR-20347
CAS:SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).Formula:C21H18ClFN4O4Purezza:98.99% - 99.77%Colore e forma:SolidPeso molecolare:444.84Ref: TM-T4210
1mg35,00€5mg80,00€10mg116,00€25mg227,00€50mg354,00€100mg588,00€200mg818,00€1mL*10mM (DMSO)88,00€4'-Methoxychalcone
CAS:4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.Formula:C16H14O2Purezza:99.86%Colore e forma:SolidPeso molecolare:238.28NCGC00244536
CAS:NCGC00244536 (KDM4B Inhibitor B3) is a potent KDM4B inhibitor (IC50: 10 nM).Formula:C25H22N2O2Purezza:97.2% - 99.72%Colore e forma:SolidPeso molecolare:382.45Ref: TM-TQ0050
1mg96,00€5mg279,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€1mL*10mM (DMSO)240,00€Perindopril
CAS:Perindopril, an ACE inhibitor, treats hypertension, heart failure, and coronary artery disease; available as arginine or erbumine.Formula:C19H32N2O5Colore e forma:White PowderPeso molecolare:368.47Lomeguatrib
CAS:Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .Formula:C10H8BrN5OSPurezza:99.26% - >99.99%Colore e forma:SolidPeso molecolare:326.17FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Formula:C12H9ClN2O4Purezza:97.1% - >99.99%Colore e forma:SolidPeso molecolare:280.66TG101209
CAS:TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.Formula:C26H35N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:509.67GSK-J1
CAS:GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively.Formula:C22H23N5O2Purezza:99.23% - 99.67%Colore e forma:SolidPeso molecolare:389.45BMS-P5
CAS:BMS-P5 is a specific and orally active Peptidylarginine Deiminase 4 (PAD4) inhibitor.Formula:C27H33ClN6O2Purezza:99.88%Colore e forma:SolidPeso molecolare:509.04Ref: TM-T22277
2mg47,00€5mg90,00€10mg143,00€25mg283,00€50mg505,00€100mg802,00€200mg1.074,00€1mL*10mM (DMSO)92,00€GSK-J4 Hydrochloride
CAS:GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. It is an ethyl ester derivative of the GSK-J1.Formula:C24H28ClN5O2Purezza:97.95% - 98.23%Colore e forma:SolidPeso molecolare:453.97Ref: TM-T4383
1mg40,00€2mg52,00€5mg88,00€10mg127,00€25mg217,00€50mg363,00€100mg533,00€200mg745,00€1mL*10mM (DMSO)139,00€PJ34 hydrochloride
CAS:PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2.Formula:C17H18ClN3O2Purezza:98.87% - ≥95%Colore e forma:SolidPeso molecolare:331.8
