Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2442 prodotti di "Cromatina/Epigenetica"
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Amifostine sodium
CAS:Amifostine sodium is a phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.Formula:C5H15N2NaO3PSColore e forma:SolidPeso molecolare:237.21BAZ1A-IN-1
CAS:BAZ1A-IN-1, a potent inhibitor, KD 0.52 μM against BAZ1A, is effective in high-BAZ1A cancer cells, not in low-BAZ1A ones.Formula:C16H12N4O3SPurezza:99.87%Colore e forma:SolidPeso molecolare:340.36Ref: TM-T9552
1mg88,00€5mg187,00€10mg283,00€25mg567,00€50mg848,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)207,00€MS31 trihydrochloride
MS31 trihydrochloride: a selective SPIN1 inhibitor, binds H3K4me3 (IC50: 77-243 nM), non-toxic to healthy cells.Formula:C20H30Cl3N3O2Colore e forma:SolidPeso molecolare:450.83Menin-MLL inhibitor 20
CAS:Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.Formula:C33H40N8O4Purezza:97.77%Colore e forma:SolidPeso molecolare:612.72Ref: TM-T9399
1mg40,00€5mg90,00€10mg135,00€25mg264,00€50mg390,00€100mg555,00€200mg752,00€1mL*10mM (DMSO)90,00€I-CBP112
CAS:I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.Formula:C27H36N2O5Purezza:98.18%Colore e forma:SolidPeso molecolare:468.59Ref: TM-T3969
1mg34,00€2mg52,00€5mg97,00€10mg170,00€25mg313,00€50mg449,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)97,00€Buformin hydrochloride
CAS:Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formula:C6H16ClN5Purezza:97.83%Colore e forma:SolidPeso molecolare:193.68GSK503
CAS:GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.Formula:C31H38N6O2Purezza:98% - 99.89%Colore e forma:SolidPeso molecolare:526.67CPI-455
CAS:<p>CPI-455 is a specific KDM5 inhibitor.</p>Formula:C16H14N4OPurezza:97.87% - 99.03%Colore e forma:SolidPeso molecolare:278.31Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purezza:97.47% - 99.8%Colore e forma:SolidPeso molecolare:178.14A-769662
CAS:A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).Formula:C20H12N2O3SPurezza:97.52% - 99.58%Colore e forma:SolidPeso molecolare:360.39Ref: TM-T2468
2mg39,00€5mg57,00€10mg79,00€25mg142,00€50mg256,00€100mg465,00€500mg1.017,00€1mL*10mM (DMSO)59,00€ASP4132
CAS:ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.Formula:C46H51F3N6O8S2Purezza:98.34%Colore e forma:SolidPeso molecolare:937.06Ref: TM-T8432
1mg52,00€5mg120,00€10mg187,00€25mg339,00€50mg509,00€100mg715,00€200mg979,00€1mL*10mM (DMSO)195,00€Abrocitinib
CAS:Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formula:C14H21N5O2SPurezza:99.09% - 99.91%Colore e forma:SolidPeso molecolare:323.41Ref: TM-TQ0037
1mg35,00€2mg48,00€5mg70,00€10mg111,00€25mg255,00€50mg465,00€100mg838,00€200mg1.130,00€1mL*10mM (DMSO)78,00€3-methyl-1,2,3,4-tetrahydroquinazolin-2-one
CAS:3-methyl-1,2,3,4-tetrahydroquinazolin-2-one is a inhibitor of BRD4 .Formula:C9H10N2OPurezza:99.3% - 99.64%Colore e forma:SolidPeso molecolare:162.19Ref: TM-T50006
2mg39,00€5mg55,00€10mg82,00€25mg126,00€50mg182,00€100mg273,00€500mg677,00€1mL*10mM (DMSO)59,00€Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurezza:98% - 99.45%Colore e forma:SolidPeso molecolare:393.49Ref: TM-T1825
1mg38,00€2mg49,00€5mg70,00€10mg88,00€25mg164,00€50mg224,00€100mg393,00€1mL*10mM (DMSO)70,00€Tubacin
CAS:Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.Formula:C41H43N3O7SPurezza:97.62% - 98.75%Colore e forma:SolidPeso molecolare:721.86Alobresib
CAS:Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.Formula:C26H23N5O2Purezza:97.63%Colore e forma:SolidPeso molecolare:437.49Ref: TM-T8495
1mg73,00€2mg93,00€5mg144,00€10mg274,00€25mg535,00€50mg753,00€100mg1.035,00€1mL*10mM (DMSO)159,00€SHR0302
CAS:SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formula:C18H22N8O2SPurezza:99.11%Colore e forma:SolidPeso molecolare:414.48Ref: TM-T9195
1mg80,00€5mg183,00€10mg298,00€25mg512,00€50mg817,00€100mg1.311,00€1mL*10mM (DMSO)167,00€J-147
CAS:J-147, a curcumin derivative, is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.Formula:C18H17F3N2O2Purezza:99.61% - >99.99%Colore e forma:SolidPeso molecolare:350.33653-47 hydrochloride
CAS:653-47 hydrochloride boosts CREB inhibition by 666-15 and weakly inhibits CREB itself (IC50: 26.3 μM).Formula:C20H20Cl2N2O3Purezza:99.14%Colore e forma:SolidPeso molecolare:407.29Ref: TM-T8890
1mg92,00€5mg187,00€10mg354,00€25mg597,00€50mg852,00€100mg1.159,00€500mg2.327,00€1mL*10mM (DMSO)215,00€Rucaparib Phosphate
CAS:<p>Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.</p>Formula:C19H18FN3O·H3PO4Purezza:99.37%Colore e forma:SolidPeso molecolare:421.36GSK199
CAS:GSK199 is a selective PAD4 inhibitor(IC50 of 200 nM in the absence of calcium).Formula:C24H29ClN6O2Purezza:99.44%Colore e forma:SolidPeso molecolare:468.98Ref: TM-T8861
1mg65,00€5mg140,00€10mg226,00€25mg371,00€50mg520,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)164,00€PF-06409577
CAS:PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).Formula:C19H16ClNO3Purezza:95.17% - 98.21%Colore e forma:SolidPeso molecolare:341.79Ref: TM-T4427
1mg35,00€2mg46,00€5mg66,00€10mg105,00€25mg210,00€50mg354,00€100mg567,00€200mgPrezzo su richiesta1mL*10mM (DMSO)74,00€Ruxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formula:C17H18N6Purezza:99.37% - 99.79%Colore e forma:SolidPeso molecolare:306.36BYK204165
CAS:BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)Formula:C15H12N2O2Purezza:99.61%Colore e forma:SolidPeso molecolare:252.27Ref: TM-T7896
1mg47,00€5mg70,00€10mg96,00€25mg170,00€50mg250,00€100mg369,00€200mg540,00€1mL*10mM (DMSO)77,00€AMI-1
CAS:<p>AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).</p>Formula:C21H14N2Na2O9S2Purezza:97.53% - 99.9%Colore e forma:DrypowderPeso molecolare:548.45XAV-939
CAS:XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assay).Formula:C14H11F3N2OSPurezza:97.47% - 99.67%Colore e forma:SolidPeso molecolare:312.31Momelotinib HCl
CAS:Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.Formula:C23H24Cl2N6O2Colore e forma:SolidPeso molecolare:487.38Delgocitinib EtOH
CAS:Delgocitinib (LEO-124249/JTE052) is a selective JAK inhibitor used for reducing skin inflammation and treating chronic dermatitis.Formula:C18H24N6O2Colore e forma:SolidPeso molecolare:356.43BEBT-908
CAS:BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).Formula:C23H25N9O3SPurezza:99.67%Colore e forma:SolidPeso molecolare:507.57Ref: TM-T16529
1mg99,00€5mg235,00€10mg354,00€25mg593,00€50mg847,00€100mg1.121,00€200mg1.539,00€1mL*10mM (DMSO)263,00€Iso-H7 dihydrochloride
CAS:Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.Formula:C14H19Cl2N3O2SPurezza:99.53%Colore e forma:White Crystalline SolidPeso molecolare:364.29dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Formula:C5H8N2O5Purezza:99.93% - ≥95%Colore e forma:SolidPeso molecolare:176.13Ref: TM-TL0001
1mg48,00€5mg92,00€10mg160,00€25mg349,00€50mg520,00€100mg740,00€200mg1.026,00€1mL*10mM (DMSO)97,00€BCI-121
CAS:BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.Formula:C14H18BrN3O2Purezza:99.67%Colore e forma:SolidPeso molecolare:340.22Bobcat339
CAS:<p>Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.</p>Formula:C16H12ClN3OPurezza:97.79% - 99.24%Colore e forma:SolidPeso molecolare:297.74Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formula:C20H26O5Purezza:99.97% - >99.99%Colore e forma:SolidPeso molecolare:346.42Ref: TM-T4672
1mg96,00€5mg215,00€10mg369,00€25mg610,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)235,00€γ-Oryzanol
CAS:γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in theFormula:C40H58O4Purezza:mixture - mixtureColore e forma:White Or White Crystalline Powder OdourlessPeso molecolare:602.9GSK126
CAS:GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).Formula:C31H38N6O2Purezza:98% - 99.67%Colore e forma:SolidPeso molecolare:526.67Ref: TM-T2079
2mg44,00€5mg65,00€10mg88,00€25mg152,00€50mg227,00€100mg349,00€200mg455,00€1mL*10mM (DMSO)74,00€Tofacitinib Citrate
CAS:Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formula:C22H28N6O8Purezza:99.19% - 99.75%Colore e forma:SolidPeso molecolare:504.49EPZ005687
CAS:EPZ005687 is a potent and selective inhibitor of EZH2.Formula:C32H37N5O3Purezza:97.06% - 99.64%Colore e forma:SolidPeso molecolare:539.67DDP-38003 trihydrochloride
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.Formula:C21H29Cl3N4OPurezza:98%Colore e forma:SolidPeso molecolare:459.84SGC2085 HCl
CAS:SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.Formula:C19H24N2O2·HClPurezza:99.91%Colore e forma:SolidPeso molecolare:348.87Ref: TM-T4013
1mg93,00€2mg150,00€5mg190,00€10mg343,00€25mg567,00€50mg825,00€100mg1.130,00€1mL*10mM (DMSO)244,00€WH-4-025
CAS:WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.Formula:C39H38F3N7O5Purezza:99.41%Colore e forma:SolidPeso molecolare:741.76Ref: TM-T9219
1mg40,00€2mg52,00€5mg88,00€10mg137,00€25mg264,00€50mg419,00€100mg617,00€1mL*10mM (DMSO)87,00€4-Phenylbutyric acid
CAS:4-Phenylbutyric acid (Benzenebutyric acid) is a HDAC inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. Cost-effective and quality-assured.Formula:C10H12O2Purezza:98.40% - 99.76%Colore e forma:SolidPeso molecolare:164.2Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formula:C27H36N6O3SPurezza:97.31% - 99.96%Colore e forma:SolidPeso molecolare:524.68Ref: TM-T1995
1g625,00€5mg49,00€10mg69,00€50mg113,00€100mg134,00€200mg216,00€500mg472,00€1mL*10mM (DMSO)57,00€BI 2536
CAS:BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.Formula:C28H39N7O3Purezza:98% - 99.88%Colore e forma:SolidPeso molecolare:521.65Ref: TM-T6173
1mg46,00€2mg59,00€5mg87,00€10mg103,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)97,00€Gandotinib
CAS:LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formula:C23H25ClFN7OPurezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:469.94Ref: TM-T2638
5mg51,00€10mg88,00€25mg160,00€50mg296,00€100mg469,00€500mg1.035,00€1mL*10mM (DMSO)57,00€3-deazaneplanocin A HCl
CAS:3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.Formula:C12H15ClN4O3Purezza:93.24% - 98.9%Colore e forma:SolidPeso molecolare:298.73MS37452
CAS:MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).Formula:C22H26N2O5Purezza:99.39%Colore e forma:SolidPeso molecolare:398.45Ref: TM-T21767
5mg51,00€10mg88,00€25mg170,00€50mg305,00€100mg527,00€500mg1.121,00€1mL*10mM (DMSO)57,00€YF-2
CAS:YF-2 activates histone acetyltransferases (H3, CBP, PCAF, GCN5) across the blood-brain barrier; EC50s: 2.75-49.31 μM.Formula:C20H22ClF3N2O3Purezza:99.33%Colore e forma:SolidPeso molecolare:430.85PFI-1
CAS:PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.Formula:C16H17N3O4SPurezza:98.74% - 99.19%Colore e forma:SolidPeso molecolare:347.39Acetyl Pentapeptide-1 acetate
Acetyl Pentapeptide-1 acetate is an histone deacetylase inhibitor.Formula:C34H55N9O12Purezza:99.09%Colore e forma:SolidPeso molecolare:781.86
