Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2462 prodotti di "Cromatina/Epigenetica"
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BRD4770
CAS:BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.Formula:C25H23N3O3Purezza:99.82%Colore e forma:SolidPeso molecolare:413.47J-147
CAS:J-147, a curcumin derivative, is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.Formula:C18H17F3N2O2Purezza:99.61% - >99.99%Colore e forma:SolidPeso molecolare:350.33Rucaparib Phosphate
CAS:<p>Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.</p>Formula:C19H18FN3O·H3PO4Purezza:99.37%Colore e forma:SolidPeso molecolare:421.36BRD4 Inhibitor-24
CAS:<p>BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.</p>Formula:C13H14N2O4Purezza:99.66%Colore e forma:SolidPeso molecolare:262.26Ruxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formula:C17H18N6Purezza:99.37% - 99.79%Colore e forma:SolidPeso molecolare:306.36BYK204165
CAS:BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)Formula:C15H12N2O2Purezza:99.61%Colore e forma:SolidPeso molecolare:252.27Ref: TM-T7896
1mg47,00€5mg70,00€10mg96,00€25mg170,00€50mg250,00€100mg369,00€200mg540,00€1mL*10mM (DMSO)77,00€XAV-939
CAS:XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assay).Formula:C14H11F3N2OSPurezza:97.47% - 99.67%Colore e forma:SolidPeso molecolare:312.31Momelotinib HCl
CAS:Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.Formula:C23H24Cl2N6O2Colore e forma:SolidPeso molecolare:487.38CBP/EP300-IN-1
CAS:<p>CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.</p>Formula:C23H23FN2O5Purezza:99.05%Colore e forma:SolidPeso molecolare:426.44NEO2734
CAS:NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).Formula:C22H24F3N3O3Purezza:98.72% - 98.8%Colore e forma:SolidPeso molecolare:435.44Ref: TM-T8658
1mg114,00€5mg274,00€10mg454,00€25mg750,00€50mg1.026,00€100mg1.406,00€500mg2.822,00€1mL*10mM (DMSO)303,00€Talazoparib
CAS:Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).Formula:C19H14F2N6OPurezza:97.02% - 99.92%Colore e forma:SolidPeso molecolare:380.35Ref: TM-T6253
2mg42,00€5mg62,00€10mg88,00€25mg135,00€50mg187,00€100mg311,00€200mg429,00€500mg697,00€1mL*10mM (DMSO)67,00€Iso-H7 dihydrochloride
CAS:Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.Formula:C14H19Cl2N3O2SPurezza:99.53%Colore e forma:White Crystalline SolidPeso molecolare:364.29B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purezza:99.66%Colore e forma:SolidPeso molecolare:396.83BCI-121
CAS:BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.Formula:C14H18BrN3O2Purezza:99.67%Colore e forma:SolidPeso molecolare:340.22C-7280948
CAS:C-7280948 is a PRMT1 inhibitor.Formula:C14H16N2O2SPurezza:99.55% - ≥95%Colore e forma:SolidPeso molecolare:276.35Ref: TM-T2097
5mg48,00€10mg70,00€25mg115,00€50mg188,00€100mg283,00€200mg437,00€500mg705,00€1mL*10mM (DMSO)52,00€(+)-JQ-1
CAS:(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility.Formula:C23H25ClN4O2SPurezza:97.57% - 99.97%Colore e forma:SolidPeso molecolare:456.99Ref: TM-T2110
1mg35,00€2mg44,00€5mg60,00€10mg79,00€25mg96,00€50mg144,00€100mg188,00€200mg283,00€500mg512,00€1mL*10mM (DMSO)66,00€WM-8014
CAS:WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.Formula:C20H17FN2O3SPurezza:99.64%Colore e forma:SolidPeso molecolare:384.42Ref: TM-T4362
1mg57,00€2mg82,00€5mg115,00€10mg170,00€25mg334,00€50mg497,00€100mg720,00€1mL*10mM (DMSO)136,00€3-Aminobenzamide
CAS:3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction duringFormula:C7H8N2OPurezza:98.4% - 99.5%Colore e forma:White To Off-White PowderPeso molecolare:136.15SF2523
CAS:SF2523 is a highly selective and potent inhibitor.Formula:C19H17NO5SPurezza:99.1% - 99.51%Colore e forma:SolidPeso molecolare:371.41Ref: TM-T3986
1mg37,00€5mg79,00€10mg119,00€25mg274,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)87,00€MI-503
CAS:MI-503 is an efficient and selective Menin-MLL inhibitor. MI-503 has a significant inhibitory effect on human MLL leukemia cell line. Cost-effective and quality-assured.Formula:C28H27F3N8SPurezza:99.87% - 99.99%Colore e forma:SolidPeso molecolare:564.63Ref: TM-TQ0069
1mgPrezzo su richiesta2mg115,00€5mg120,00€10mg188,00€25mg354,00€50mg588,00€100mg938,00€200mg1.406,00€1mL*10mM (DMSO)149,00€Tofacitinib Citrate
CAS:Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formula:C22H28N6O8Purezza:99.19% - 99.75%Colore e forma:SolidPeso molecolare:504.49WHI-P97
CAS:WHI-P97 is a rationally designed potent inhibitor of JAK-3.Formula:C16H13Br2N3O3Purezza:99.93%Colore e forma:SolidPeso molecolare:455.1Apabetalone
CAS:<p>Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery</p>Formula:C20H22N2O5Purezza:98.08% - ≥98%Colore e forma:SolidPeso molecolare:370.4DDP-38003 trihydrochloride
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.Formula:C21H29Cl3N4OPurezza:98%Colore e forma:SolidPeso molecolare:459.84SGC2085 HCl
CAS:SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.Formula:C19H24N2O2·HClPurezza:99.91%Colore e forma:SolidPeso molecolare:348.87Ref: TM-T4013
1mg93,00€2mg150,00€5mg190,00€10mg343,00€25mg567,00€50mg825,00€100mg1.130,00€1mL*10mM (DMSO)244,00€GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Formula:C18H15N3O2Purezza:99.52%Colore e forma:SolidPeso molecolare:305.33Buformin hydrochloride
CAS:Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formula:C6H16ClN5Purezza:97.83%Colore e forma:SolidPeso molecolare:193.68BD750
CAS:BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormula:C14H13N3OSPurezza:99.02%Colore e forma:SolidPeso molecolare:271.34Phthalazinone pyrazole
CAS:Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.Formula:C18H15N5OPurezza:97.03%Colore e forma:SolidPeso molecolare:317.34JQ-1 (carboxylic acid)
CAS:JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)Formula:C19H17ClN4O2SPurezza:99.14% - 99.9%Colore e forma:SolidPeso molecolare:400.88Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formula:C27H36N6O3SPurezza:97.31% - 99.96%Colore e forma:SolidPeso molecolare:524.68Ref: TM-T1995
1g592,00€5mg50,00€10mg65,00€50mg107,00€100mg127,00€200mg205,00€500mg447,00€1mL*10mM (DMSO)54,00€BI 2536
CAS:BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.Formula:C28H39N7O3Purezza:98% - 99.88%Colore e forma:SolidPeso molecolare:521.65Ref: TM-T6173
1mg46,00€2mg59,00€5mg87,00€10mg103,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)97,00€Gandotinib
CAS:LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formula:C23H25ClFN7OPurezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:469.94Ref: TM-T2638
5mg51,00€10mg88,00€25mg160,00€50mg296,00€100mg469,00€500mg1.035,00€1mL*10mM (DMSO)57,00€JNJ-7706621
CAS:<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Formula:C15H12F2N6O3SPurezza:99.1% - 99.85%Colore e forma:SolidPeso molecolare:394.362-methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one
CAS:2-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one is ligand of CBP.Formula:C10H11NOSPurezza:99.68%Colore e forma:SolidPeso molecolare:193.271,5-Isoquinolinediol
CAS:1,5-Isoquinolinediol, a PARP1 inhibitor (IC50: 0.39 μM), is used in DNA repair and cell death studies.Formula:C9H7NO2Purezza:98.29% - 99.35%Colore e forma:Of White To White PowderPeso molecolare:161.16666-15
CAS:666-15 is a selective CREB inhibitor with an IC50 of 81 nM. 666-15 can effectively inhibit the growth of breast cancer.Cost-effective and quality-assured.Formula:C33H31Cl2N3O5Purezza:99.41% - 99.88%Colore e forma:SolidPeso molecolare:620.52Ref: TM-T5318
1mg57,00€5mg111,00€10mg170,00€25mg344,00€50mg533,00€100mg747,00€200mg1.026,00€1mL*10mM (DMSO)154,00€Fucosterol
CAS:Fucosterol, from E. stolonifera, has anti-diabetic, anti-adipogenic, anti-cancer properties; it affects PPARα and C/EBPα to control fat cell formation.Formula:C29H48OPurezza:98.39% - 99.68%Colore e forma:White PowderPeso molecolare:412.69M1001
CAS:M1001 is a HIF-2α agonist.Formula:C17H17N3O2SPurezza:98.83%Colore e forma:SolidPeso molecolare:327.4PFI-1
CAS:PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.Formula:C16H17N3O4SPurezza:98.74% - 99.19%Colore e forma:SolidPeso molecolare:347.39Acetyl Pentapeptide-1 acetate
Acetyl Pentapeptide-1 acetate is an histone deacetylase inhibitor.Formula:C34H55N9O12Purezza:99.09%Colore e forma:SolidPeso molecolare:781.86AZD1208
CAS:<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Formula:C21H21N3O2SPurezza:97.24% - 99.83%Colore e forma:SolidPeso molecolare:379.48TCS7010
CAS:TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Formula:C31H31ClFN7O2Purezza:98.49% - 99.62%Colore e forma:SolidPeso molecolare:588.07A1874
CAS:<p>A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.</p>Formula:C58H62Cl3F2N9O7SPurezza:99.52%Colore e forma:SolidPeso molecolare:1173.59Niraparib tosylate
CAS:<p>Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.</p>Formula:C19H20N4O·C7H8O3SPurezza:99.34% - 99.87%Colore e forma:SolidPeso molecolare:492.59WHI-P154
CAS:WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formula:C16H14BrN3O3Purezza:98% - 99.67%Colore e forma:SolidPeso molecolare:376.22-hexyl-4-Pentynoic Acid
CAS:2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Formula:C11H18O2Purezza:98%Colore e forma:SolidPeso molecolare:182.26Pyridone 6
CAS:Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).Formula:C18H16FN3OPurezza:97.1% - 98.74%Colore e forma:SolidPeso molecolare:309.34Ref: TM-T3080
1mg52,00€2mg74,00€5mg111,00€10mg183,00€25mg378,00€50mg620,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)116,00€5-Fluoro-2'-deoxycytidine
CAS:5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .Formula:C9H12FN3O4Purezza:97.91%Colore e forma:Fine White PowderPeso molecolare:245.21Ref: TM-T7718
2mg35,00€5mg50,00€10mg67,00€25mg96,00€50mg145,00€100mg210,00€200mg313,00€500mg525,00€1mL*10mM (DMSO)52,00€A-366
CAS:A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.Formula:C19H27N3O2Purezza:97.28% - 99.8%Colore e forma:SolidPeso molecolare:329.44Ref: TM-T3624
1mg35,00€2mg50,00€5mg74,00€10mg90,00€25mg208,00€50mg359,00€100mg530,00€1mL*10mM (DMSO)82,00€
