Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2490 prodotti di "Cromatina/Epigenetica"
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HIF-PHD-IN-1
CAS:HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.Formula:C17H12Cl2N6O3Colore e forma:SolidPeso molecolare:419.22Amredobresib
CAS:Amredobresib is a potent BET inhibitor that impedes the interaction between bromodomains and acetylated lysines on histone H3 and H4, thereby serving as crucial regulators of gene transcription. It proves valuable in the investigation of acute myeloid leukemia (AML) and cancer.Formula:C26H29N9Colore e forma:SolidPeso molecolare:467.581BD-9136
BD-9136, a highly selective BRD4 degrader, demonstrates the capability to inhibit tumor growth without inducing adverse effects in mice, showing potential forFormula:C44H44N10O5SPurezza:98%Colore e forma:SolidPeso molecolare:824.95YF-2 hydrochloride
CAS:YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties.Formula:C20H23Cl2F3N2O3Colore e forma:SolidPeso molecolare:467.31Cercosporin
CAS:Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).Formula:C29H26O10Purezza:98%Colore e forma:SolidPeso molecolare:534.51CARM1-IN-1 hydrochloride
CAS:CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with minimal inhibition of PRMT1 and SET7.Formula:C26H22Br2ClNO3Colore e forma:SolidPeso molecolare:591.72HJB97
CAS:HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively).Formula:C26H28N8O3Purezza:98%Colore e forma:SolidPeso molecolare:500.55Ref: TM-T15484
Prodotto fuori produzioneDesidustat
CAS:Desidustat is an inhibitor of HIF hydroxylase.
Formula:C16H16N2O6Purezza:98%Colore e forma:SolidPeso molecolare:332.31CTB
CAS:CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
Formula:C16H13ClF3NO2Purezza:99.82%Colore e forma:SolidPeso molecolare:343.73PF-03814735
CAS:PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formula:C23H25F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:474.48BLL5 Maleate
CAS:BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.Formula:C21H21N3Purezza:98%Colore e forma:SolidPeso molecolare:315.41JAK2-IN-9
CAS:Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM.
Formula:C20H24N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:412.51Ref: TM-T79581
Prodotto fuori produzioneAMPK activator C2
CAS:AMPK activator C2 is an AMPK allosteric activator.Formula:C7H6NO6PPurezza:98%Colore e forma:SolidPeso molecolare:231.1Ref: TM-T23734
Prodotto fuori produzioneBisindolylmaleimide I HCl
CAS:Bisindolylmaleimide I HCl is a specific ATP-competitive PKC inhibitor.Formula:C25H25ClN4O2Purezza:98%Colore e forma:SolidPeso molecolare:448.95BET-IN-15
CAS:BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2.
Formula:C21H18F2N4O3SPurezza:98%Colore e forma:SolidPeso molecolare:444.45Ref: TM-T79167
Prodotto fuori produzioneAntitumor agent-104
CAS:Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme
Formula:C31H33FN6O3Purezza:98%Colore e forma:SolidPeso molecolare:556.63JAK1-IN-10
CAS:JAK1-IN-10 (compound 9), a cyano-substituted cyclic hydrazine derivative, functions as a potent and selective inhibitor of JAK1 [1].
Formula:C15H17N7Purezza:98%Colore e forma:SolidPeso molecolare:295.34JAK-IN-27
CAS:JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nM
Formula:C20H21F2N7OPurezza:98%Colore e forma:SolidPeso molecolare:413.42BAZ2-ICR
CAS:BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains.Formula:C20H19N7Purezza:98%Colore e forma:SolidPeso molecolare:357.41STAT3-IN-18
CAS:STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and
Formula:C18H24Cl2N2O6PtPurezza:98%Colore e forma:SolidPeso molecolare:630.38
