Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2440 prodotti di "Cromatina/Epigenetica"
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GSK040
CAS:GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Formula:C29H34N4O4Colore e forma:SolidPeso molecolare:502.6SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.Purezza:98%Colore e forma:Odour SolidUzansertib
CAS:Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.Formula:C26H26F3N5O3Colore e forma:SolidPeso molecolare:513.51PROTAC BRD4 Degrader-19
CAS:PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utilityFormula:C44H38N8O5S2Colore e forma:SolidPeso molecolare:822.95GSK8573
CAS:GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formula:C20H21NO3Purezza:99.97%Colore e forma:SolidPeso molecolare:323.39BRD7-IN-1 free base
CAS:BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formula:C22H26N4O3Purezza:98%Colore e forma:SolidPeso molecolare:394.47TNKS-2-IN-2
CAS:TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formula:C26H23N3O6Purezza:99.45%Colore e forma:SoildPeso molecolare:473.48MNK/PIM-IN-1
CAS:MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.Formula:C27H27FN6O2Colore e forma:SolidPeso molecolare:486.551PROTAC BRD4 Degrader-32
<p>PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.</p>Formula:C42H42ClN5O5Colore e forma:SolidPeso molecolare:731.28745MS479
MS479 is a BRD4 PROTAC degrader that binds with high affinity to BRD4-BD2 and GLP (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM). It effectively reduces the protein levels of BRD4 short isoforms. By directly binding to its substrate GLP, MS479 recruits the E3 ligase SPOP as a bridging protein. Additionally, MS479 can be utilized to inhibit the proliferation of colorectal cancer cells.Colore e forma:Odour SolidDot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Colore e forma:Odour Solid2-Methylquinazolin-4-ol
CAS:Compound 1769-24-0 is a natural product for research related to life sciences. The catalog number is TPL0186 and the CAS number is 1769-24-0.Formula:C9H8N2OPurezza:99.98%Colore e forma:SolidPeso molecolare:160.17dBAZ2
dBAZ2 is a pioneering PROTAC degrader targeting BAZ2A and BAZ2B, with DC50 values of 180 nM for BAZ2A and 250 nM for BAZ2B.Formula:C54H64FN11O5S2Colore e forma:SolidPeso molecolare:1030.29JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidCBP/p300-IN-8
CAS:CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.Formula:C27H31N3O4Colore e forma:SolidPeso molecolare:461.562(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Colore e forma:SolidBETd-246
CAS:BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.Formula:C48H55N11O10Purezza:98%Colore e forma:SolidPeso molecolare:946.02Ref: TM-T14549
5mg512,00€10mg750,00€25mg1.529,00€50mg2.318,00€100mgPrezzo su richiesta200mgPrezzo su richiesta3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS:<p>3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.</p>Formula:C30H52O4Colore e forma:SolidPeso molecolare:476.742Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Formula:C122H203N45O36S2Purezza:98.92%Colore e forma:SolidPeso molecolare:2940.33Ref: TM-T11740L
1mg170,00€2mg225,00€5mg329,00€10mg467,00€25mg677,00€50mg929,00€100mg1.244,00€200mg1.681,00€
