Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2441 prodotti di "Cromatina/Epigenetica"
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FHD-286
CAS:FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia.Formula:C24H30N6O6S2Purezza:99.73%Colore e forma:SolidPeso molecolare:562.66Ref: TM-T9749
1mg144,00€5mg283,00€10mg454,00€25mg615,00€50mg777,00€100mg1.064,00€1mL*10mM (DMSO)359,00€DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Colore e forma:Odour SolidPROTAC BRD4-DCAF1 degrader-1
CAS:PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.Formula:C60H64Cl2F2N8O9SColore e forma:SolidPeso molecolare:1182.17Bromodomain IN-2
CAS:BD-IN-1: Bromodomain inhibitor, K D 67-970nM for BRD4, CBP, etc. Antiproliferative.Formula:C16H17ClN2OColore e forma:SolidPeso molecolare:288.77BRD4 Inhibitor-16
BRD4 Inhibitor-16 (Compound 4) is a potent suppressor of BRD4 linked to cancer, aiding in research of BRD4-related treatments.Formula:C42H43N7O8SColore e forma:SolidPeso molecolare:805.9HSP70/SIRT2-IN-1
<p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>Purezza:98%Colore e forma:Odour SolidZifcasiran
CAS:Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.Formula:C737H972F20N211O349P43S8Colore e forma:SolidPeso molecolare:20339.13PROTAC BRD4 Degrader-11
PROTAC BRD4 Degrader-11 links VHL and BRD4 ligands, targeting BRD4 in PC3 cells with STEAP1/CLL1; DC50: 0.23/0.38 nM.Formula:C61H75F2N9O12S4Colore e forma:SolidPeso molecolare:1292.56N-Desmethyltamoxifen
CAS:N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.Formula:C25H27NOPurezza:98%Colore e forma:SolidPeso molecolare:357.49SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColore e forma:SolidPeso molecolare:818.95SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formula:C41H47ClN6O6SPurezza:98%Colore e forma:SolidPeso molecolare:787.37Fluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Colore e forma:SolidPARP1-IN-6
CAS:PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μMFormula:C16H11FN2OColore e forma:SolidPeso molecolare:266.27PROTAC BRD4 Degrader-7
CAS:PROTAC BRD4 Degrader-7, from patent WO2020055976A1, has IC50 of 15.5 nM (BD1) & 12.3 nM (BD2).Formula:C26H29N5O2SColore e forma:SolidPeso molecolare:475.61PROTAC BRD4-binding moiety 1
CAS:BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.Formula:C23H21N3O2Purezza:98%Colore e forma:SolidPeso molecolare:371.43(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.Formula:C41H46N6O6SColore e forma:SolidPeso molecolare:750.91PROTAC SMARCA2/4-degrader-28
CAS:PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formula:C54H68ClN9O11S2Colore e forma:SolidPeso molecolare:1118.75Malantide
CAS:Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formula:C72H124N22O21Purezza:98%Colore e forma:SolidPeso molecolare:1633.89PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Formula:C39H42FN9O7Colore e forma:SolidPeso molecolare:767.81DAO-dBET1
DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.Colore e forma:Odour Solid
