Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2540 prodotti di "Cromatina/Epigenetica"
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(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Colore e forma:SolidTAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purezza:99.65%Colore e forma:SolidPeso molecolare:506.36Ref: TM-T34787
1mg97,00€5mg235,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€1mL*10mM (DMSO)261,00€DW71177
CAS:DW71177 is a BET inhibitor with potent anti-leukemic activity for the study of leukemia.Formula:C20H28N6O2Purezza:98.13%Colore e forma:SoildPeso molecolare:384.48Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS:Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].Formula:C34H43N3O7Colore e forma:SolidPeso molecolare:605.72Nicotinamide riboside tartrate
CAS:NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.Formula:C15H20N2O11Colore e forma:SolidPeso molecolare:404.33SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFormula:C43H45N13O9SPurezza:98%Colore e forma:SolidPeso molecolare:919.96PRMT1-IN-1
CAS:PRMT1-IN-1 is a PRMT1 inhibitor.
Formula:C20H7Br6NO5Colore e forma:SolidPeso molecolare:820.702C 21
CAS:PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Formula:C90H161ClN36O24Purezza:98%Colore e forma:SolidPeso molecolare:2166.94Bisindolylmaleimide XI hydrochloride
CAS:Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is an orally active pan-PKC inhibitor that inhibits PKCα, PKCβI, PKCβII, and PKCγ.Formula:C28H29ClN4O2Purezza:99.45%Colore e forma:SolidPeso molecolare:489.01ACBI2
CAS:ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.Formula:C56H68BrFN8O5SColore e forma:SolidPeso molecolare:1064.16EP300/CBP ligand 2
EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.
Formula:C20H18N6OColore e forma:SolidPeso molecolare:358.4R8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Formula:C111H211N59O26SPurezza:98%Colore e forma:SolidPeso molecolare:2820.33PARP/HDAC-IN-1
PARP/HDAC-IN-1 is a PARP and HDAC inhibitor that inhibits PARP1, PARP2, and HDAC1, and may be used to study pancreatic cancer.Formula:C36H32F2N6O3Purezza:95.00%Colore e forma:SolidPeso molecolare:634.67SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColore e forma:SolidPeso molecolare:818.95PROTAC SMARCA2/4-degrader-29
CAS:PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.Formula:C44H51N11O4Colore e forma:SolidPeso molecolare:797.95Protein Kinase C (19-36)
CAS:Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Formula:C93H159N35O24Purezza:98%Colore e forma:SolidPeso molecolare:2151.48PAD2-IN-1
CAS:PAD2-IN-1 is a selective benzimidazole-derived inhibitor with a 95-fold and 79-fold higher affinity for PAD2 over PAD4 and PAD3, respectively.Formula:C25H29FN6O3Colore e forma:SolidPeso molecolare:480.544PROTAC BRD9-binding moiety 5
CAS:PROTAC BRD9 binder moiety 5 selectively binds BRD9 with IC50 4.20μM, used in PROTAC synthesis, shows cancer cell antiproliferative activity.Formula:C19H18N6OColore e forma:SolidPeso molecolare:346.39Fluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Colore e forma:Solid
