DNA-PK
La DNA-PK (chinasi proteica dipendente dal DNA) è un enzima chiave coinvolto nella riparazione delle rotture a doppio filamento del DNA attraverso la via di giunzione delle estremità non omologhe (NHEJ). Gli inibitori della DNA-PK bloccano l'attività di questa chinasi, impedendo la riparazione delle rotture del DNA e portando a un aumento della morte cellulare, in particolare nelle cellule tumorali. Gli inibitori della DNA-PK sono strumenti preziosi nella ricerca e nella terapia del cancro, soprattutto in combinazione con altri trattamenti che danneggiano il DNA. Presso CymitQuimica, offriamo una gamma completa di inibitori della DNA-PK di alta qualità per supportare la tua ricerca sulla riparazione del DNA, la biologia del cancro e lo sviluppo terapeutico.
Trovati 49 prodotti di "DNA-PK"
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STL127705
CAS:STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.Formula:C22H20FN5O4Purezza:99.53% - 99.81%Colore e forma:SolidPeso molecolare:437.42Ref: TM-T13017
1mg70,00€5mg150,00€10mg219,00€25mg369,00€50mg550,00€100mg722,00€1mL*10mM (DMSO)170,00€LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Formula:C24H18N2O3SPurezza:99.34%Colore e forma:SolidPeso molecolare:414.48Ref: TM-T15789
5mg43,00€10mg71,00€25mg138,00€50mg231,00€100mg344,00€200mg505,00€1mL*10mM (DMSO)47,00€(R)-VX-984
CAS:(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.Formula:C23H21D2N7OPurezza:98%Colore e forma:SolidPeso molecolare:415.49Multi-target kinase inhibitor 4
Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.
Colore e forma:Odour SolidDNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Colore e forma:Odour SolidIC 86621
CAS:IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formula:C12H15NO3Purezza:99.68%Colore e forma:SolidPeso molecolare:221.25AMA-37
CAS:AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.Formula:C17H17NO3Purezza:98%Colore e forma:SolidPeso molecolare:283.32Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
Formula:C21H25F3N6O2Purezza:99.88%Colore e forma:SolidPeso molecolare:450.46NU 7026
CAS:NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibitionFormula:C17H15NO3Purezza:99.51% - >99.99%Colore e forma:SolidPeso molecolare:281.31CC-115 hydrochloride
CAS:CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.Formula:C16H17ClN8OColore e forma:SolidPeso molecolare:372.82PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purezza:97.79% - 99.3%Colore e forma:SolidPeso molecolare:348.36KU-57788
CAS:NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).Formula:C25H19NO3SPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:413.49AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formula:C18H20N8O2Purezza:99.03% - 99.85%Colore e forma:SolidPeso molecolare:380.4Ref: TM-T7122
1mg38,00€5mg84,00€10mg113,00€25mg177,00€50mg295,00€100mg447,00€200mg650,00€1mL*10mM (DMSO)93,00€PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Formula:C16H14BrN5O4S·HClPurezza:97.82%Colore e forma:SolidPeso molecolare:488.74PIK-90
CAS:PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
Formula:C18H17N5O3Purezza:98.25% - ≥95%Colore e forma:SolidPeso molecolare:351.36Compound 401
CAS:Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.Formula:C16H15N3O2Purezza:99.73% - 99.78%Colore e forma:SolidPeso molecolare:281.31Ref: TM-T3586
2mg33,00€5mg50,00€10mg62,00€25mg110,00€50mg203,00€100mg301,00€200mg432,00€1mL*10mM (DMSO)55,00€DMNB
CAS:DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.Formula:C9H9NO5Purezza:97.87%Colore e forma:Yellow SolidPeso molecolare:211.17PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Formula:C27H31FN6OSPurezza:99.84% - ≥95%Colore e forma:SolidPeso molecolare:506.64LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Formula:C19H17NO3Purezza:98% - 99.96%Colore e forma:Pale Yellow SolidPeso molecolare:307.34Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Formula:C24H15F3N4OPurezza:98.31% - 99.32%Colore e forma:SolidPeso molecolare:432.4
