Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 455 prodotti di "Metiltransferasi del DNA"
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5WKS
CAS:5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.Formula:C24H36ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:462.03RSC-133
CAS:promotes the reprogramming of human somatic cells to pluripotent stem cellsFormula:C18H15N3O2Purezza:98%Colore e forma:SolidPeso molecolare:305.33WDR5-IN-4
CAS:WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.Formula:C25H22Cl2FN5OPurezza:98%Colore e forma:SolidPeso molecolare:498.38OTS186935
CAS:OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Formula:C25H26ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:463.96Guadecitabine sodium
CAS:Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .Formula:C18H24N9NaO10PPurezza:98%Colore e forma:SolidPeso molecolare:580.407TFMB-(S)-2-HG
CAS:TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.Formula:C13H11F3O4Purezza:98.07%Colore e forma:SolidPeso molecolare:288.22Ref: TM-T24871
2mg35,00€5mg52,00€10mg84,00€25mg155,00€50mg240,00€100mg358,00€500mg753,00€1mL*10mM (DMSO)51,00€UNC2327
CAS:UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).Formula:C14H17N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:319.38Arazine
CAS:Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.Formula:C20H33NO3SPurezza:90%Colore e forma:SolidPeso molecolare:367.55SKF 91488 dihydrochloride
CAS:histamine N-methyltransferase inhibitorFormula:C7H19Cl2N3SPurezza:98%Colore e forma:SolidPeso molecolare:248.22D 595
CAS:D595 is a phenethylamine-type calcium channel blocker. The most potent phenylethylamine with respect to negative inotropy was D595 (EC50: 794 nmol/l).Formula:C25H32Cl2N2O2Purezza:98%Colore e forma:SolidPeso molecolare:463.44GSK926
CAS:GSK926 is a selective, SAM-competitive, and cell-active EZH2 inhibitor.Formula:C29H35N7O2Colore e forma:SolidPeso molecolare:513.63PRMT5-IN-2
CAS:PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.Formula:C17H16ClFN4O4Purezza:98%Colore e forma:SolidPeso molecolare:394.78PDAT
CAS:PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.Formula:C15H23N3Purezza:98%Colore e forma:SolidPeso molecolare:245.36Guadecitabine
CAS:Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.Formula:C18H24N9O10PPurezza:98%Colore e forma:SolidPeso molecolare:557.41DDO-2093 dihydrochloride
DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.Formula:C29H39Cl3FN9O3Colore e forma:SolidPeso molecolare:687.04Furamidine
CAS:Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.Formula:C18H16N4OPurezza:98%Colore e forma:SolidPeso molecolare:304.35(R)-OR-S1
CAS:(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.Formula:C26H34BrN3O4Purezza:98%Colore e forma:SolidPeso molecolare:532.47UNC0379 TFA
CAS:UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Formula:C25H36F3N5O4Colore e forma:SolidPeso molecolare:527.589SGC6870
CAS:SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.Formula:C23H21BrN2O2SColore e forma:SolidPeso molecolare:469.39EZM 2302
CAS:EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.Formula:C29H37ClN6O5Purezza:97.47% - ≥98%Colore e forma:SolidPeso molecolare:585.09ZLD1039
CAS:ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.Formula:C36H48N6O3Purezza:99.5%Colore e forma:SolidPeso molecolare:612.8CMP-5 hydrochloride
CAS:CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.Formula:C21H22ClN3Purezza:98%Colore e forma:SolidPeso molecolare:351.87Dot1L-IN-2
CAS:Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectivelyFormula:C27H24N8OPurezza:98%Colore e forma:SolidPeso molecolare:476.53BIX-01338 hydrate
CAS:BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.Formula:C32H26F3N3O7Purezza:98%Colore e forma:SolidPeso molecolare:621.56GNA002
CAS:GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).Formula:C42H55NO8Purezza:98%Colore e forma:SolidPeso molecolare:701.89CM-579
CAS:CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.Formula:C29H40N4O3Purezza:99.23%Colore e forma:SolidPeso molecolare:492.65Ref: TM-T10840L
1mg52,00€5mg90,00€10mg131,00€25mg207,00€50mg303,00€100mg447,00€1mL*10mM (DMSO)117,00€MM-102
CAS:MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay.Cost-effective and quality-assured.Formula:C35H49F2N7O4Purezza:98.77% - 99.99%Colore e forma:SolidPeso molecolare:669.8Ref: TM-T6333
1mg39,00€2mg51,00€5mg105,00€10mg168,00€25mg351,00€50mg543,00€100mg777,00€1mL*10mM (DMSO)156,00€Furamidine dihydrochloride
CAS:Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.Formula:C18H18Cl2N4OPurezza:98.16%Colore e forma:SolidPeso molecolare:377.27NSC-311068
CAS:NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.Formula:C10H6N4O4SColore e forma:SolidPeso molecolare:278.24SW155246
CAS:SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).Formula:C16H11ClN2O5SPurezza:98.99%Colore e forma:SolidPeso molecolare:378.79EPZ032597
CAS:EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancerFormula:C20H23N7OPurezza:99.70%Colore e forma:SolidPeso molecolare:377.44EZH2-IN-11
CAS:EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.Formula:C28H36ClN3O5SColore e forma:SolidPeso molecolare:562.12PRMT4-IN-1
CAS:PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].Formula:C23H28FN3OPurezza:98%Colore e forma:SolidPeso molecolare:381.49EZH2-IN-3
CAS:EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.Formula:C27H28ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:490EZH2-IN-9
CAS:EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.Formula:C28H32ClF2N3O5SColore e forma:SolidPeso molecolare:596.09AA-CW236
CAS:AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).Formula:C17H16ClF3N4O2Colore e forma:SolidPeso molecolare:400.78DS-437
CAS:DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.Formula:C15H23N7O4SPurezza:98%Colore e forma:SolidPeso molecolare:397.45SMYD2-IN-1
CAS:SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).Formula:C25H25Cl2F2N7O2Purezza:98%Colore e forma:SolidPeso molecolare:564.41PRMT5:MEP50 PPI
PRMT5:MEP50 PPI inhibitor with anti-tumor and anti-proliferative effects on lung and prostate cancers.Formula:C24H22N4O4Colore e forma:SolidPeso molecolare:430.46Dot1L-IN-7
CAS:Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.Formula:C23H27N9O2Colore e forma:SolidPeso molecolare:461.526-Methyl-5-azacytidine
CAS:6-Methyl-5-azacytidine is a potent DNMT inhibitor.Formula:C9H14N4O5Purezza:98%Colore e forma:SolidPeso molecolare:258.23Tetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Formula:C9H16N2O6Purezza:98%Colore e forma:SolidPeso molecolare:248.23DC_517
CAS:DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).Formula:C33H35N3O2Colore e forma:SolidPeso molecolare:505.65PRMT5-IN-10
CAS:PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.Formula:C13H17N5O4Colore e forma:SolidPeso molecolare:307.31NSD3-IN-1
CAS:NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.Formula:C13H13N5OSColore e forma:SolidPeso molecolare:287.34EML741
CAS:<p>EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.</p>Formula:C31H49N5O2Purezza:98%Colore e forma:SolidPeso molecolare:523.75DCE_42
CAS:DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.Formula:C22H19N9O2SPurezza:98%Colore e forma:SolidPeso molecolare:473.51BI-9321
CAS:BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.Formula:C22H21FN4Purezza:98%Colore e forma:SolidPeso molecolare:360.43CARM1-IN-1
CAS:CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.Formula:C26H21Br2NO3Purezza:98.24%Colore e forma:SolidPeso molecolare:555.26Ref: TM-T10682L
1mg37,00€5mg88,00€10mg127,00€25mg250,00€50mg406,00€100mg632,00€200mg883,00€1mL*10mM (DMSO)97,00€MS0124
CAS:<p>MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.</p>Formula:C20H29N5O3Purezza:98.97%Colore e forma:SolidPeso molecolare:387.48CPUY074020
CAS:CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.Formula:C25H28N4O2Purezza:98.64%Colore e forma:SolidPeso molecolare:416.52Ref: TM-T10882
1mg74,00€5mg156,00€10mg215,00€25mg338,00€50mg475,00€100mg620,00€200mg848,00€1mL*10mM (DMSO)168,00€TM2-115
CAS:TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].Formula:C28H38N6O2Purezza:97.67%Colore e forma:SolidPeso molecolare:490.64Procainamide
CAS:Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.Formula:C13H21N3OPurezza:99.79% - 99.92%Colore e forma:SolidPeso molecolare:235.33LEM-14
CAS:<p>LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.</p>Formula:C25H26N4O4SPurezza:98.3%Colore e forma:SolidPeso molecolare:478.56Cedazuridine
CAS:Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.Formula:C9H14F2N2O5Purezza:99.66%Colore e forma:SolidPeso molecolare:268.21UNC0321
CAS:UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.Formula:C27H45N7O3Purezza:99.80%Colore e forma:SolidPeso molecolare:515.69EZH2-IN-13
CAS:EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.Formula:C34H45N5O3Purezza:98.3%Colore e forma:SolidPeso molecolare:571.75Bobcat339 hydrochloride
CAS:Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.Formula:C16H13Cl2N3OPurezza:99.22%Colore e forma:SolidPeso molecolare:334.2Ref: TM-T61012
2mg35,00€5mg52,00€10mg85,00€25mg160,00€50mg250,00€100mg373,00€200mg547,00€1mL*10mM (DMSO)58,00€DW14800
CAS:DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Formula:C31H36N4O3Purezza:99.55% - 99.68%Colore e forma:SolidPeso molecolare:512.64Ref: TM-T11131
1mg87,00€2mg130,00€5mg216,00€10mg378,00€25mg717,00€50mg948,00€100mg1.415,00€1mL*10mM (DMSO)245,00€WDR5-0102
CAS:<p>WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.</p>Formula:C18H19ClN4O3Purezza:98.03%Colore e forma:SolidPeso molecolare:374.82TNG908
CAS:TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.Formula:C21H23N5O2SPurezza:98.08% - 98.24%Colore e forma:SolidPeso molecolare:409.51Ref: TM-T73494
1mg70,00€5mg154,00€10mg235,00€25mg378,00€50mg540,00€100mg747,00€1mL*10mM (DMSO)166,00€WM-586
CAS:WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Formula:C20H20F3N5O3SPurezza:98%Colore e forma:SolidPeso molecolare:467.47Bisegliptin
CAS:Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.Formula:C18H26FN3O3Purezza:98%Colore e forma:SolidPeso molecolare:351.42MS67
CAS:MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.Formula:C52H59F4N9O7SColore e forma:SolidPeso molecolare:1030.14Compound SA91-0178
CAS:SA91-0178 (3-{[(1-methyl-2-oxo-1'-phenyl-1,2-dihydrospiro[indole-3,4'-piperidine]-5-carbonyl)amino]methyl}benzoic acid) is a specific METTL1 inhibitor and effectively alleviated tissue injury during septic inflammation.Formula:C28H27N3O4Peso molecolare:469.54GSK3368715 hydrochloride
CAS:GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.Formula:C20H38N4O2·HClColore e forma:SolidPeso molecolare:403UNC7145
CAS:UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Formula:C24H23N5O4Colore e forma:SolidPeso molecolare:445.4705MTDH-SND1 blocker 1
CAS:MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Formula:C14H13ClN4O3SColore e forma:SolidPeso molecolare:352.8GSK-2807 free base
CAS:GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Formula:C19H32N8O5Colore e forma:SolidPeso molecolare:452.51CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormula:C29H43Cl3N4O3Purezza:98%Colore e forma:SolidPeso molecolare:602.04SMYD3-IN-1
CAS:SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Formula:C28H31ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:507.02MAK683-CH2CH2COOH
CAS:MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.Formula:C23H21FN6O3Purezza:98%Colore e forma:SolidPeso molecolare:448.45GSK-3484862
CAS:Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formula:C19H19N5OSPurezza:99.87% - 99.963%Colore e forma:SolidPeso molecolare:365.45Ref: TM-T11469
1mg48,00€5mg113,00€10mg177,00€25mg318,00€50mg485,00€100mg692,00€500mg1.395,00€1mL*10mM (DMSO)203,00€UNC8153 TFA
CAS:UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFormula:C35H38F3N5O7Purezza:96.44%Colore e forma:SolidPeso molecolare:697.7CARM1-IN-3
CAS:CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFormula:C24H32N4O2Purezza:98%Colore e forma:SolidPeso molecolare:408.54PRMT5-IN-28
CAS:PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processesFormula:C18H19ClN4O5Purezza:98%Colore e forma:SolidPeso molecolare:406.82PRMT5-IN-29
CAS:PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].Formula:C18H20Cl3N5O5Purezza:98%Colore e forma:SolidPeso molecolare:492.74PRMT5-IN-25
CAS:PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1Formula:C24H21F3N6OPurezza:98%Colore e forma:SolidPeso molecolare:466.46EPZ011989 HCl(1598383-40-4 Free base)
CAS:EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.Formula:C35H51N5O4·HClColore e forma:SolidPeso molecolare:642.27DY-46-2
CAS:DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.Formula:C19H22N6O5SPurezza:99.12% - 99.12%Colore e forma:SolidPeso molecolare:446.48Ref: TM-T62643
1mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRK-701
CAS:RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.Formula:C26H30N4O3Colore e forma:SolidPeso molecolare:446.54DNMT-IN-3
CAS:DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].Formula:C37H39N7OColore e forma:SolidPeso molecolare:597.75RK-0133114
RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.Formula:C26H30N4O3Colore e forma:SolidPeso molecolare:446.54EZH2-IN-14
CAS:EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.Formula:C31H39N7O2Colore e forma:SolidPeso molecolare:541.69MS023 trihydrochloride
CAS:MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.Formula:C17H28Cl3N3OPurezza:99.81%Colore e forma:SolidPeso molecolare:396.78PRT543
CAS:PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.Formula:C17H17ClN4O4Colore e forma:SolidPeso molecolare:376.79PRMT5-IN-16
CAS:PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.Formula:C25H34N8O2Colore e forma:SolidPeso molecolare:478.59EPZ-030456
CAS:EPZ-030456 is an effective and selective inhibitor of the SMYD3.Formula:C28H34ClN5O4SColore e forma:SolidPeso molecolare:572.12GSK-A
CAS:GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.Formula:C21H25N5O2Colore e forma:SolidPeso molecolare:379.46EPZ031686
CAS:<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>Formula:C26H34ClF3N4O4SPurezza:99.67%Colore e forma:SolidPeso molecolare:591.09MS117
MS117 is a first-in-class and cell-active irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6) (IC50 = 18 nM) [1].Formula:C17H22N4OColore e forma:SolidPeso molecolare:298.38PRMT5-MTA-IN-3
CAS:PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.Formula:C19H17F3N6O3Colore e forma:SolidPeso molecolare:434.372PRMT5-IN-3
CAS:PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.Formula:C22H23F3N4O3Colore e forma:SolidPeso molecolare:448.44RU-0415529
CAS:RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.Formula:C21H29N3O4SColore e forma:SolidPeso molecolare:419.538GSK3368715
CAS:GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50sFormula:C20H38N4O2Purezza:98%Colore e forma:SolidPeso molecolare:366.54MS8815
CAS:MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.Formula:C65H87N9O8SColore e forma:SolidPeso molecolare:1154.51SARS-CoV-2 nsp14-IN-1
SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.Formula:C20H20N6O5SColore e forma:SolidPeso molecolare:456.48PF-06726304 acetate
CAS:PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.Formula:C24H25Cl2N3O5Purezza:98%Colore e forma:SolidPeso molecolare:506.38TDI-015051
CAS:TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.Formula:C22H22FN5O4SColore e forma:SolidPeso molecolare:471.505(Rac)-RG108
CAS:<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Formula:C19H14N2O4Colore e forma:SolidPeso molecolare:334.326
