Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 455 prodotti di "Metiltransferasi del DNA"
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EPZ005687
CAS:EPZ005687 is a potent and selective inhibitor of EZH2.Formula:C32H37N5O3Purezza:97.06% - 99.64%Colore e forma:SolidPeso molecolare:539.67Piribedil
CAS:Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.Formula:C16H18N4O2Purezza:99.79% - 99.82%Colore e forma:SolidPeso molecolare:298.34C-7280948
CAS:C-7280948 is a PRMT1 inhibitor.Formula:C14H16N2O2SPurezza:99.55% - ≥95%Colore e forma:SolidPeso molecolare:276.35Ref: TM-T2097
5mg48,00€10mg70,00€25mg115,00€50mg188,00€100mg283,00€200mg437,00€500mg705,00€1mL*10mM (DMSO)52,00€WDR5-0103
CAS:WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Formula:C21H25N3O4Purezza:98% - 99.61%Colore e forma:SolidPeso molecolare:383.44A-196
CAS:A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective overFormula:C18H16Cl2N4Purezza:99.92%Colore e forma:SolidPeso molecolare:359.25UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Formula:C36H59N7O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:621.9AZ505
CAS:AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Formula:C29H38Cl2N4O4Purezza:98.18%Colore e forma:SolidPeso molecolare:577.54Ref: TM-TQ0100
1mg60,00€5mg130,00€10mg178,00€25mg295,00€50mg462,00€100mg623,00€1mL*10mM (DMSO)165,00€Tazemetostat hydrobromide
CAS:Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).Formula:C34H45BrN4O4Purezza:99.8%Colore e forma:SolidPeso molecolare:653.65Ref: TM-T17002
2mg43,00€5mg60,00€10mg81,00€50mg96,00€100mg159,00€200mg230,00€500mg378,00€1mL*10mM (DMSO)84,00€SGC0946
CAS:SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.Formula:C28H40BrN7O4Purezza:98% - 99.82%Colore e forma:SolidPeso molecolare:618.57Gambogenic acid
CAS:Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.Formula:C38H46O8Purezza:97.47% - 99.6%Colore e forma:SolidPeso molecolare:630.77Ref: TM-T8201
1mg47,00€5mg92,00€10mg152,00€25mg268,00€50mg429,00€100mg685,00€200mg888,00€1mL*10mM (DMSO)128,00€BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Formula:C28H38N6O2Purezza:98.58% - 99.64%Colore e forma:SolidPeso molecolare:490.64Ref: TM-T7697
1mg40,00€5mg85,00€10mg117,00€25mg207,00€50mg311,00€100mg472,00€200mg642,00€1mL*10mM (DMSO)131,00€UNC1215
CAS:UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).Formula:C32H43N5O2Purezza:98% - 99.04%Colore e forma:SolidPeso molecolare:529.72EPZ004777
CAS:EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.Formula:C28H41N7O4Purezza:98.99% - 99.32%Colore e forma:SolidPeso molecolare:539.67MS049
CAS:MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.Formula:C15H24N2OPurezza:98.91%Colore e forma:SolidPeso molecolare:248.36Ref: TM-T4378
2mg35,00€5mg51,00€10mg85,00€25mg158,00€50mg235,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)55,00€SGC707
CAS:SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.Formula:C16H18N4O2Purezza:99.75% - 99.89%Colore e forma:SolidPeso molecolare:298.34SETDB1-TTD-IN-1
CAS:SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.Formula:C28H31N5O2Purezza:98.26% - 99.96%Colore e forma:SolidPeso molecolare:469.58HLCL-61 hydrochloride
CAS:HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.Formula:C23H24N2O·ClHPurezza:99.88% - 99.95%Colore e forma:SolidPeso molecolare:380.91BRD9539
CAS:BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μMFormula:C24H21N3O3Purezza:98% - 99.57%Colore e forma:SolidPeso molecolare:399.44LLY-507
CAS:LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Formula:C36H42N6OPurezza:99.58% - 99.93%Colore e forma:SolidPeso molecolare:574.76Ref: TM-T6879
1mg44,00€2mg55,00€5mg85,00€10mg138,00€25mg304,00€50mg552,00€100mg787,00€1mL*10mM (DMSO)110,00€OICR-9429
CAS:<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Formula:C29H32F3N5O3Purezza:97.07% - 99.93%Colore e forma:SolidPeso molecolare:555.59Tazemetostat
CAS:Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.Formula:C34H44N4O4Purezza:98.24% - ≥95%Colore e forma:SolidPeso molecolare:572.74Ref: TM-T1788
2mg35,00€5mg52,00€10mg73,00€25mg92,00€50mg92,00€100mg153,00€500mg383,00€1mL*10mM (DMSO)66,00€MRTX9768
CAS:MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.Formula:C24H17FN6OPurezza:97.02%Colore e forma:SolidPeso molecolare:424.43Pinometostat
CAS:Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.Formula:C30H42N8O3Purezza:99.19% - 99.86%Colore e forma:SolidPeso molecolare:562.71TP-064
CAS:TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.Formula:C28H34N4O2Purezza:97.85%Colore e forma:SolidPeso molecolare:458.6Ref: TM-T28996
1mg38,00€2mg49,00€5mg79,00€10mg119,00€25mg245,00€50mg487,00€100mg710,00€1mL*10mM (DMSO)80,00€AMI-1
CAS:<p>AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).</p>Formula:C21H14N2Na2O9S2Purezza:97.53% - 99.9%Colore e forma:DrypowderPeso molecolare:548.45GSK591
CAS:GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).Formula:C22H28N4O2Purezza:99.35% - 99.45%Colore e forma:SolidPeso molecolare:380.48Ref: TM-T6853
1mg46,00€2mg58,00€5mg95,00€10mg137,00€25mg268,00€50mg404,00€100mg567,00€1mL*10mM (DMSO)101,00€3-deazaneplanocin A HCl
CAS:3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.Formula:C12H15ClN4O3Purezza:93.24% - 98.9%Colore e forma:SolidPeso molecolare:298.73MS023
CAS:MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,Formula:C17H25N3OPurezza:98.31% - 99.87%Colore e forma:SolidPeso molecolare:287.4Ref: TM-T6900
1mg39,00€2mg51,00€5mg88,00€10mg119,00€25mg243,00€50mg378,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)84,00€MR837
CAS:MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.Formula:C16H14N2OSPurezza:99.77% - 99.85%Colore e forma:SolidPeso molecolare:282.36Ref: TM-T8879
2mg40,00€5mg58,00€10mg96,00€25mg145,00€50mg255,00€100mg375,00€200mg530,00€1mL*10mM (DMSO)70,00€SGC2085
CAS:SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).Formula:C19H24N2O2Purezza:99.61% - 99.71%Colore e forma:SolidPeso molecolare:312.41Ref: TM-T7089
1mg88,00€2mg119,00€5mg227,00€10mg341,00€25mg563,00€50mg820,00€100mg1.130,00€1mL*10mM (DMSO)160,00€BRD4770
CAS:BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.Formula:C25H23N3O3Purezza:99.82%Colore e forma:SolidPeso molecolare:413.47GSK503
CAS:GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.Formula:C31H38N6O2Purezza:98% - 99.89%Colore e forma:SolidPeso molecolare:526.676-Thioguanine
CAS:6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Formula:C5H5N5SPurezza:98.75% - >99.99%Colore e forma:Odorless Or Almost Odorless Pale Yellow Crystalline PowderPeso molecolare:167.195-Methyl-2'-deoxycytidine
CAS:5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.Formula:C10H15N3O4Purezza:99.18% - 99.69%Colore e forma:SolidPeso molecolare:241.245-Fluoro-2'-deoxycytidine
CAS:5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .Formula:C9H12FN3O4Purezza:97.91%Colore e forma:Fine White PowderPeso molecolare:245.21Ref: TM-T7718
2mg35,00€5mg50,00€10mg67,00€25mg96,00€50mg145,00€100mg210,00€200mg313,00€500mg525,00€1mL*10mM (DMSO)52,00€UNC3866 TFA(1872382-47-2 free base)
CAS:UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formula:C45H67F3N6O10Purezza:98.43%Colore e forma:SolidPeso molecolare:909.04GSK343
CAS:GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity againstFormula:C31H39N7O2Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:541.69GSK126
CAS:GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).Formula:C31H38N6O2Purezza:98% - 99.67%Colore e forma:SolidPeso molecolare:526.67Ref: TM-T2079
2mg44,00€5mg65,00€10mg88,00€25mg152,00€50mg227,00€100mg349,00€200mg455,00€1mL*10mM (DMSO)74,00€UNC3866
CAS:UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formula:C43H66N6O8Purezza:88.06% - 99.62%Colore e forma:SolidPeso molecolare:795.02Amodiaquine
CAS:Amodiaquine is a synthetic aminoquinoline, used to treat malaria.Formula:C20H22ClN3OPurezza:99.78% - 99.99%Colore e forma:Crystals From Absolute Ethanol SolidPeso molecolare:355.86Ref: TM-T8381
1mg52,00€2mg70,00€5mg96,00€10mg173,00€25mg304,00€50mg452,00€100mg647,00€1mL*10mM (DMSO)120,00€JNJ-64619178
CAS:JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.Formula:C22H23BrN6O2Purezza:98.86% - 99.98%Colore e forma:SolidPeso molecolare:483.36Ref: TM-T15624
1mg88,00€5mg170,00€10mg274,00€25mg567,00€50mg944,00€100mg1.659,00€1mL*10mM (DMSO)182,00€GSK3326595
CAS:GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).Formula:C24H32N6O3Purezza:98.88% - 99.63%Colore e forma:SolidPeso molecolare:452.55SGI-1027
CAS:SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT).Formula:C27H23N7OPurezza:99.45% - 99.78%Colore e forma:SolidPeso molecolare:461.52Ref: TM-T1904
5mg58,00€10mg94,00€25mg163,00€50mg296,00€100mg467,00€500mg1.035,00€1mL*10mM (DMSO)74,00€RG108
CAS:RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).Formula:C19H14N2O4Purezza:98% - 99.43%Colore e forma:SolidPeso molecolare:334.33Ref: TM-T2038
5mg47,00€10mg69,00€25mg117,00€50mg205,00€100mg286,00€200mg401,00€500mg652,00€1mL*10mM (DMSO)56,00€Metoprine
CAS:Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.Formula:C11H10Cl2N4Purezza:98.42%Colore e forma:SolidPeso molecolare:269.13BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Formula:C28H38N6O2·3HClPurezza:99.41% - 99.95%Colore e forma:SolidPeso molecolare:600.02Ref: TM-T1959
2mg52,00€5mg71,00€10mg107,00€25mg192,00€50mg274,00€100mg472,00€200mg642,00€1mL*10mM (DMSO)111,00€MS37452
CAS:MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).Formula:C22H26N2O5Purezza:99.39%Colore e forma:SolidPeso molecolare:398.45Ref: TM-T21767
5mg51,00€10mg88,00€25mg170,00€50mg305,00€100mg527,00€500mg1.121,00€1mL*10mM (DMSO)57,00€EPZ004777 hydrochloride
CAS:EPZ004777 hydrochloride (EPZ004777 HCl) is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.Formula:C28H42ClN7O4Colore e forma:SolidPeso molecolare:576.13UNC6934
CAS:UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Formula:C24H21N5O4Purezza:98.67%Colore e forma:SolidPeso molecolare:443.45Ref: TM-T9584
1mg49,00€5mg97,00€10mg160,00€25mg344,00€50mg512,00€100mg707,00€200mg938,00€1mL*10mM (DMSO)106,00€UNC0638
CAS:UNC0638 inhibits G9a and GLP lysine methyltransferases with IC50 <15 nM and 19 nM, respectively, showing high selectivity.Formula:C30H47N5O2Purezza:98.88% - 99.53%Colore e forma:SolidPeso molecolare:509.73
