Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 455 prodotti di "Metiltransferasi del DNA"
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Tazemetostat
CAS:Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.Formula:C34H44N4O4Purezza:98.24% - ≥95%Colore e forma:SolidPeso molecolare:572.74Ref: TM-T1788
2mg35,00€5mg52,00€10mg73,00€25mg92,00€50mg92,00€100mg153,00€500mg383,00€1mL*10mM (DMSO)66,00€SETDB1-TTD-IN-1
CAS:SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.Formula:C28H31N5O2Purezza:98.26% - 99.96%Colore e forma:SolidPeso molecolare:469.58HLCL-61 hydrochloride
CAS:HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.Formula:C23H24N2O·ClHPurezza:99.88% - 99.95%Colore e forma:SolidPeso molecolare:380.91MS023
CAS:MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,Formula:C17H25N3OPurezza:98.31% - 99.87%Colore e forma:SolidPeso molecolare:287.4Ref: TM-T6900
1mg39,00€2mg51,00€5mg88,00€10mg119,00€25mg243,00€50mg378,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)84,00€RG108
CAS:RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).Formula:C19H14N2O4Purezza:98% - 99.43%Colore e forma:SolidPeso molecolare:334.33Ref: TM-T2038
5mg47,00€10mg69,00€25mg117,00€50mg205,00€100mg286,00€200mg401,00€500mg652,00€1mL*10mM (DMSO)56,00€EPZ004777
CAS:EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.Formula:C28H41N7O4Purezza:98.99% - 99.32%Colore e forma:SolidPeso molecolare:539.672',3',5'-triacetyl-5-Azacytidine
CAS:2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.Formula:C14H18N4O8Purezza:98.34%Colore e forma:SolidPeso molecolare:370.31Ref: TM-T7840
2mg40,00€5mg52,00€10mg80,00€25mg129,00€50mg187,00€100mg281,00€200mg406,00€1mL*10mM (DMSO)64,00€SGC707
CAS:SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.Formula:C16H18N4O2Purezza:99.75% - 99.89%Colore e forma:SolidPeso molecolare:298.34BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Formula:C28H38N6O2Purezza:98.58% - 99.64%Colore e forma:SolidPeso molecolare:490.64Ref: TM-T7697
1mg40,00€5mg85,00€10mg117,00€25mg207,00€50mg311,00€100mg472,00€200mg642,00€1mL*10mM (DMSO)131,00€UNC1215
CAS:UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).Formula:C32H43N5O2Purezza:98% - 99.04%Colore e forma:SolidPeso molecolare:529.72MS049
CAS:MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.Formula:C15H24N2OPurezza:98.91%Colore e forma:SolidPeso molecolare:248.36Ref: TM-T4378
2mg35,00€5mg51,00€10mg85,00€25mg158,00€50mg235,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)55,00€JNJ-64619178
CAS:JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.Formula:C22H23BrN6O2Purezza:98.86% - 99.98%Colore e forma:SolidPeso molecolare:483.36Ref: TM-T15624
1mg88,00€5mg170,00€10mg274,00€25mg567,00€50mg944,00€100mg1.659,00€1mL*10mM (DMSO)182,00€Tazemetostat hydrobromide
CAS:Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).Formula:C34H45BrN4O4Purezza:99.8%Colore e forma:SolidPeso molecolare:653.65Ref: TM-T17002
2mg43,00€5mg60,00€10mg81,00€50mg96,00€100mg159,00€200mg230,00€500mg378,00€1mL*10mM (DMSO)84,00€AZ505
CAS:AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Formula:C29H38Cl2N4O4Purezza:98.18%Colore e forma:SolidPeso molecolare:577.54Ref: TM-TQ0100
1mg64,00€5mg137,00€10mg188,00€25mg311,00€50mg487,00€100mg658,00€1mL*10mM (DMSO)168,00€SGC0946
CAS:SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.Formula:C28H40BrN7O4Purezza:98% - 99.82%Colore e forma:SolidPeso molecolare:618.57WDR5-0103
CAS:WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Formula:C21H25N3O4Purezza:98% - 99.61%Colore e forma:SolidPeso molecolare:383.44A-196
CAS:A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective overFormula:C18H16Cl2N4Purezza:99.92%Colore e forma:SolidPeso molecolare:359.25Bobcat339
CAS:<p>Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.</p>Formula:C16H12ClN3OPurezza:97.79% - 99.24%Colore e forma:SolidPeso molecolare:297.74UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Formula:C36H59N7O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:621.9Gambogenic acid
CAS:Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.Formula:C38H46O8Purezza:97.47% - 99.6%Colore e forma:SolidPeso molecolare:630.77Ref: TM-T8201
1mg49,00€5mg97,00€10mg160,00€25mg283,00€50mg452,00€100mg723,00€200mg938,00€1mL*10mM (DMSO)135,00€
