Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 457 prodotti di "Metiltransferasi del DNA"
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PRMT5-IN-17
CAS:PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.Formula:C26H33N7O2Colore e forma:SolidPeso molecolare:475.59BAY-598 R-isomer
CAS:BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.Formula:C22H20Cl2F2N6O3Colore e forma:SolidPeso molecolare:525.34CPI-905
CAS:CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.Formula:C18H20N2O5Colore e forma:SolidPeso molecolare:344.36DNMT3A-IN-1
CAS:DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).Formula:C30H38N6O4Colore e forma:SolidPeso molecolare:546.66CM-579
CAS:CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.Formula:C29H40N4O3Purezza:99.23%Colore e forma:SolidPeso molecolare:492.65Ref: TM-T10840L
1mg52,00€5mg90,00€10mg131,00€25mg207,00€50mg303,00€100mg447,00€1mL*10mM (DMSO)117,00€NSC-311068
CAS:NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.Formula:C10H6N4O4SColore e forma:SolidPeso molecolare:278.24EZH2-IN-11
CAS:EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.Formula:C28H36ClN3O5SColore e forma:SolidPeso molecolare:562.12EZH2-IN-9
CAS:EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.Formula:C28H32ClF2N3O5SColore e forma:SolidPeso molecolare:596.09AA-CW236
CAS:AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).Formula:C17H16ClF3N4O2Colore e forma:SolidPeso molecolare:400.78NSD3-IN-1
CAS:NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.Formula:C13H13N5OSColore e forma:SolidPeso molecolare:287.34BI-9321
CAS:BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.Formula:C22H21FN4Purezza:98%Colore e forma:SolidPeso molecolare:360.43UNC0379 TFA
CAS:UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Formula:C25H36F3N5O4Colore e forma:SolidPeso molecolare:527.589DDO-2093 dihydrochloride
DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.Formula:C29H39Cl3FN9O3Colore e forma:SolidPeso molecolare:687.04PRMT5-IN-10
CAS:PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.Formula:C13H17N5O4Colore e forma:SolidPeso molecolare:307.31EZH2-IN-7
CAS:EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.Formula:C31H37D2N5O3SColore e forma:SolidPeso molecolare:563.755-Aza-4'-thio-2'-deoxycytidine
CAS:5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].Formula:C8H12N4O3SColore e forma:SolidPeso molecolare:244.27G9a-IN-2
CAS:G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).Formula:C30H42N4O4Colore e forma:SolidPeso molecolare:522.68Lobelane Hydrochloride
CAS:Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.Formula:C22H30ClNColore e forma:SolidPeso molecolare:343.93Fagaronine chloride
CAS:Fagaronine chloride is a potent inhibitor of Topoisomerases I.Formula:C21H20ClNO4Colore e forma:SolidPeso molecolare:385.84DC_501
CAS:DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.Formula:C25H23Cl2N3OPurezza:98%Colore e forma:SolidPeso molecolare:452.38
