Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 459 prodotti di "Metiltransferasi del DNA"
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SMYD2-IN-1
CAS:SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).Formula:C25H25Cl2F2N7O2Purezza:98%Colore e forma:SolidPeso molecolare:564.41EML741
CAS:EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.
Formula:C31H49N5O2Purezza:98%Colore e forma:SolidPeso molecolare:523.75WDR5-IN-4
CAS:WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.Formula:C25H22Cl2FN5OPurezza:98%Colore e forma:SolidPeso molecolare:498.38EZM 2302
CAS:EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.Formula:C29H37ClN6O5Purezza:97.47% - ≥98%Colore e forma:SolidPeso molecolare:585.095WKS
CAS:5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.Formula:C24H36ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:462.03PRMT5-IN-C17
CAS:PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.Formula:C18H17N3O4SColore e forma:SolidPeso molecolare:371.41Dot1L-IN-2
CAS:Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectivelyFormula:C27H24N8OPurezza:98%Colore e forma:SolidPeso molecolare:476.53BIX-01338 hydrate
CAS:BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.Formula:C32H26F3N3O7Purezza:98%Colore e forma:SolidPeso molecolare:621.56CMP-5 hydrochloride
CAS:CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.Formula:C21H22ClN3Purezza:98%Colore e forma:SolidPeso molecolare:351.87Furamidine
CAS:Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.Formula:C18H16N4OPurezza:98%Colore e forma:SolidPeso molecolare:304.356-Methyl-5-azacytidine
CAS:6-Methyl-5-azacytidine is a potent DNMT inhibitor.Formula:C9H14N4O5Purezza:98%Colore e forma:SolidPeso molecolare:258.23Dot1L-IN-7
CAS:Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.Formula:C23H27N9O2Colore e forma:SolidPeso molecolare:461.52DS-437
CAS:DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.Formula:C15H23N7O4SPurezza:98%Colore e forma:SolidPeso molecolare:397.45SGC6870
CAS:SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.Formula:C23H21BrN2O2SColore e forma:SolidPeso molecolare:469.39UNC2327
CAS:UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).Formula:C14H17N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:319.38RSC-133
CAS:promotes the reprogramming of human somatic cells to pluripotent stem cellsFormula:C18H15N3O2Purezza:98%Colore e forma:SolidPeso molecolare:305.33DCE_42
CAS:DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.Formula:C22H19N9O2SPurezza:98%Colore e forma:SolidPeso molecolare:473.51EZH2-IN-3
CAS:EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.Formula:C27H28ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:490Guadecitabine sodium
CAS:Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .Formula:C18H24N9NaO10PPurezza:98%Colore e forma:SolidPeso molecolare:580.407OTS186935
CAS:OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Formula:C25H26ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:463.96
