Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 455 prodotti di "Metiltransferasi del DNA"
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TNG908
CAS:TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.Formula:C21H23N5O2SPurezza:98.08% - 98.24%Colore e forma:SolidPeso molecolare:409.51Ref: TM-T73494
1mg70,00€5mg154,00€10mg235,00€25mg378,00€50mg540,00€100mg747,00€1mL*10mM (DMSO)166,00€WM-586
CAS:WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Formula:C20H20F3N5O3SPurezza:98%Colore e forma:SolidPeso molecolare:467.47Bisegliptin
CAS:Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.Formula:C18H26FN3O3Purezza:98%Colore e forma:SolidPeso molecolare:351.42MS67
CAS:MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.Formula:C52H59F4N9O7SColore e forma:SolidPeso molecolare:1030.14Compound SA91-0178
CAS:SA91-0178 (3-{[(1-methyl-2-oxo-1'-phenyl-1,2-dihydrospiro[indole-3,4'-piperidine]-5-carbonyl)amino]methyl}benzoic acid) is a specific METTL1 inhibitor and effectively alleviated tissue injury during septic inflammation.Formula:C28H27N3O4Peso molecolare:469.54GSK3368715 hydrochloride
CAS:GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.Formula:C20H38N4O2·HClColore e forma:SolidPeso molecolare:403UNC7145
CAS:UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Formula:C24H23N5O4Colore e forma:SolidPeso molecolare:445.4705MTDH-SND1 blocker 1
CAS:MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Formula:C14H13ClN4O3SColore e forma:SolidPeso molecolare:352.8GSK-2807 free base
CAS:GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Formula:C19H32N8O5Colore e forma:SolidPeso molecolare:452.51CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormula:C29H43Cl3N4O3Purezza:98%Colore e forma:SolidPeso molecolare:602.04SMYD3-IN-1
CAS:SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Formula:C28H31ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:507.02MAK683-CH2CH2COOH
CAS:MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.Formula:C23H21FN6O3Purezza:98%Colore e forma:SolidPeso molecolare:448.45GSK-3484862
CAS:Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formula:C19H19N5OSPurezza:99.87% - 99.963%Colore e forma:SolidPeso molecolare:365.45Ref: TM-T11469
1mg50,00€5mg119,00€10mg187,00€25mg335,00€50mg512,00€100mg730,00€500mg1.473,00€1mL*10mM (DMSO)215,00€UNC8153 TFA
CAS:UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFormula:C35H38F3N5O7Purezza:96.44%Colore e forma:SolidPeso molecolare:697.7CARM1-IN-3
CAS:CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFormula:C24H32N4O2Purezza:98%Colore e forma:SolidPeso molecolare:408.54PRMT5-IN-28
CAS:PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processesFormula:C18H19ClN4O5Purezza:98%Colore e forma:SolidPeso molecolare:406.82PRMT5-IN-29
CAS:PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].Formula:C18H20Cl3N5O5Purezza:98%Colore e forma:SolidPeso molecolare:492.74PRMT5-IN-25
CAS:PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1Formula:C24H21F3N6OPurezza:98%Colore e forma:SolidPeso molecolare:466.46EPZ011989 HCl(1598383-40-4 Free base)
CAS:EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.Formula:C35H51N5O4·HClColore e forma:SolidPeso molecolare:642.27DY-46-2
CAS:DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.Formula:C19H22N6O5SPurezza:99.12% - 99.12%Colore e forma:SolidPeso molecolare:446.48Ref: TM-T62643
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