Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 457 prodotti di "Metiltransferasi del DNA"
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SMYD2-IN-1
CAS:SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).Formula:C25H25Cl2F2N7O2Purezza:98%Colore e forma:SolidPeso molecolare:564.41EML741
CAS:EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.
Formula:C31H49N5O2Purezza:98%Colore e forma:SolidPeso molecolare:523.75EZM 2302
CAS:EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.Formula:C29H37ClN6O5Purezza:97.47% - ≥98%Colore e forma:SolidPeso molecolare:585.09Dot1L-IN-2
CAS:Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectivelyFormula:C27H24N8OPurezza:98%Colore e forma:SolidPeso molecolare:476.53Guadecitabine sodium
CAS:Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .Formula:C18H24N9NaO10PPurezza:98%Colore e forma:SolidPeso molecolare:580.407GNA002
CAS:GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).Formula:C42H55NO8Purezza:98%Colore e forma:SolidPeso molecolare:701.89ZLD1039
CAS:ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.Formula:C36H48N6O3Purezza:99.5%Colore e forma:SolidPeso molecolare:612.8PRMT5-IN-2
CAS:PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.Formula:C17H16ClFN4O4Purezza:98%Colore e forma:SolidPeso molecolare:394.78Tetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Formula:C9H16N2O6Purezza:98%Colore e forma:SolidPeso molecolare:248.23DC_517
CAS:DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).Formula:C33H35N3O2Colore e forma:SolidPeso molecolare:505.65Cedazuridine
CAS:Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.Formula:C9H14F2N2O5Purezza:99.66%Colore e forma:SolidPeso molecolare:268.21CARM1-IN-1
CAS:CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.Formula:C26H21Br2NO3Purezza:98.24%Colore e forma:SolidPeso molecolare:555.26Ref: TM-T10682L
1mg37,00€5mg88,00€10mg127,00€25mg250,00€50mg406,00€100mg632,00€200mg883,00€1mL*10mM (DMSO)97,00€Bobcat339 hydrochloride
CAS:Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.Formula:C16H13Cl2N3OPurezza:99.22%Colore e forma:SolidPeso molecolare:334.2Ref: TM-T61012
2mg34,00€5mg50,00€10mg80,00€25mg152,00€50mg236,00€100mg353,00€200mg517,00€1mL*10mM (DMSO)55,00€EZH2-IN-13
CAS:EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.Formula:C34H45N5O3Purezza:98.3%Colore e forma:SolidPeso molecolare:571.75DW14800
CAS:DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Formula:C31H36N4O3Purezza:99.55% - 99.68%Colore e forma:SolidPeso molecolare:512.64Ref: TM-T11131
1mg87,00€2mg130,00€5mg216,00€10mg378,00€25mg717,00€50mg948,00€100mg1.415,00€1mL*10mM (DMSO)245,00€LEM-14
CAS:LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.
Formula:C25H26N4O4SPurezza:98.3%Colore e forma:SolidPeso molecolare:478.56CPUY074020
CAS:CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.Formula:C25H28N4O2Purezza:98.64%Colore e forma:SolidPeso molecolare:416.52Ref: TM-T10882
1mg71,00€5mg147,00€10mg205,00€25mg319,00€50mg450,00€100mg587,00€200mg803,00€1mL*10mM (DMSO)159,00€TM2-115
CAS:TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].Formula:C28H38N6O2Purezza:97.67%Colore e forma:SolidPeso molecolare:490.64TNG908
CAS:TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.Formula:C21H23N5O2SPurezza:98.08% - 98.24%Colore e forma:SolidPeso molecolare:409.51Ref: TM-T73494
1mg70,00€5mg154,00€10mg235,00€25mg378,00€50mg540,00€100mg747,00€1mL*10mM (DMSO)166,00€UNC0321
CAS:UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.Formula:C27H45N7O3Purezza:99.80%Colore e forma:SolidPeso molecolare:515.69
