Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 451 prodotti di "Metiltransferasi del DNA"
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SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Formula:C45H62Cl3N7O8Colore e forma:SolidPeso molecolare:935.37SAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Formula:C155H256N48O40Purezza:98%Colore e forma:SolidPeso molecolare:3432.05PRMT5-IN-9
CAS:<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Formula:C25H23F3N6OColore e forma:SolidPeso molecolare:480.495WDR5-47
CAS:WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.Formula:C19H20ClFN4O3Purezza:98.15%Colore e forma:SoildPeso molecolare:406.84Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Colore e forma:Odour SolidML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Colore e forma:Odour SolidUNC6852
CAS:<p>UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.</p>Formula:C43H48N10O6SPurezza:96.64%Colore e forma:SolidPeso molecolare:832.97MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Formula:C58H66ClF3N14O11S2Colore e forma:SolidPeso molecolare:1290.41175BBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Formula:C37H47N5O5SColore e forma:SolidPeso molecolare:673.32979TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Colore e forma:Odour SolidLarsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formula:C27H49NO5SPurezza:>99.99% - >99.99%Colore e forma:SoildPeso molecolare:499.75MS33
CAS:MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formula:C64H84F3N11O7SColore e forma:SolidPeso molecolare:1208.5EPZ-719
CAS:EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.Formula:C22H31FN4O3SColore e forma:SolidPeso molecolare:450.57MAK683-CH2CH2COOH hydrochloride
MAK683-CH2CH2COOH, an EED binder, was key in crafting PROTAC EED degrader-1 and -2 targeting VHL-E3 ligase.Formula:C23H22ClFN6O3Colore e forma:SolidPeso molecolare:484.91SGC3027
<p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>Formula:C41H47ClN6O6SPurezza:98%Colore e forma:SolidPeso molecolare:787.37PRMT5-IN-11
CAS:PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Formula:C13H17N5O4Colore e forma:SolidPeso molecolare:307.31FTX-6058 hydrochloride
CAS:FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Formula:C22H19ClFN5O2Colore e forma:SolidPeso molecolare:439.87XF056-132
CAS:XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .Formula:C51H57F4N9O7SColore e forma:SolidPeso molecolare:1016.11E67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Formula:C21H36N6O2Colore e forma:SolidPeso molecolare:404.559
