Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 459 prodotti per "Metiltransferasi del DNA".
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SKLB-03220
CAS:SKLB-03220 is an oral covalent EZH2 inhibitor, abolishing H3K27me3 marks and serving as a potent small-molecule tool for cancer epigenetics research.Formula:C33H40N4O4Purezza:97.01%Colore e forma:Yellow SolidPeso molecolare:556.71Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Colore e forma:Odour SolidSAH-EZH2
CAS:EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Formula:C155H256N48O40Purezza:98%Colore e forma:SolidPeso molecolare:3432.05EZH2-IN-5
CAS:EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Formula:C26H37BrN4O2Colore e forma:SolidPeso molecolare:517.512PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formula:C55H60FN11O8SPurezza:98%Colore e forma:SolidPeso molecolare:1054.2UNC4976 TFA
UNC4976 TFA boosts CBX7 chromodomain interaction with nucleic acids and blocks gene-specific H3K27me3 binding, while enhancing DNA/RNA attachment.Formula:C49H71F3N6O10Colore e forma:SolidPeso molecolare:961.12PRMT5-IN-43
CAS:PRMT5-IN-43 (compound 4A) is an inhibitor of PRMT5, primarily utilized in cancer research.Formula:C22H17ClF3N5O2Colore e forma:SolidPeso molecolare:475.85EEDi-5285
CAS:EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Formula:C24H22FN5O3SPurezza:>99.99%Colore e forma:SolidPeso molecolare:479.53Ref: TM-T22322
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta5mg2.700,00€1mL*10mM (DMSO)3.060,00€AS-99 TFA
CAS:AS-99 TFA is an ASH1L inhibitor (IC50=0.79 μM) with anti-leukemic activity. It induces apoptosis, downregulates MLL target genes, and reduces leukemia burden in vivo.Formula:C29H31F6N5O5S2Colore e forma:Yellow SolidPeso molecolare:707.71Tet1
CAS:Tet1 is a peptide with the sequence HLNILSTLWKYRC. It specifically binds to the neuronal ganglioside receptor GT1b, which gives it the ability to target neurons. Tet1 is suitable for research related to drug delivery.Formula:C76H119N21O18SColore e forma:SolidPeso molecolare:1646.95G9D-4
G9D-4 is an effective degrader of G9a with a DC50 value of 0.1 μM in PANC-1 cells, and it does not directly interfere with GLP proteins (DC50 greater than 10 μM). This compound plays a significant role in pancreatic cancer research.Colore e forma:Odour SolidBBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Formula:C37H47N5O5SColore e forma:SolidPeso molecolare:673.32979MS-8709
CAS:MS-8709 is a potent and selective G9a/GLP PROTAC Degrader with a DC50(G9a) of 274 nM and a DC50(GLP) of 260 nM. It induces G9a/GLP protein degradation in a concentration-dependent and time-dependent manner via the ubiquitin-proteasome system, without affecting mRNA expression levels. MS-8709 demonstrates superior cell growth inhibition compared to the parent compound UNC0642 in prostate cancer, leukemia, and lung cancer cell models, and exhibits mouse pharmacokinetic characteristics suitable for in vivo efficacy studies.Formula:C64H95F2N11O7SPurezza:99.98%Colore e forma:White SolidPeso molecolare:1200.57LLC0424
LLC0424 is a potent and selective degrader of the nuclear receptor-binding SET domain 2 (NSD2), with a DC50 of 20 nM. It reduces H3K36me2 levels and inhibits the growth of acute lymphoblastic leukemia (ALL) cell lines, making it useful for research in ALL.Colore e forma:Odour SolidEPZ-719
CAS:EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Formula:C22H31FN4O3SPurezza:99.95%Colore e forma:White SolidPeso molecolare:450.57A-893
CAS:A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formula:C29H38Cl2N4O4Colore e forma:SolidPeso molecolare:577.54PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Colore e forma:Odour SolidDNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Colore e forma:Odour SolidLarsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formula:C27H49NO5SPurezza:>99.99% - >99.99%Colore e forma:SolidPeso molecolare:499.75UNC2399
CAS:UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its ICFormula:C67H104N10O17SColore e forma:SolidPeso molecolare:1353.68
