Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 451 prodotti di "Metiltransferasi del DNA"
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A-395
CAS:<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Formula:C26H35FN4O2SPurezza:98.43%Colore e forma:SolidPeso molecolare:486.65Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS:Formula:C8H9ClN4Purezza:98%Colore e forma:SolidPeso molecolare:196.6369(E)-3,4-dihydroxycinnamic acid
CAS:Formula:C9H8O4Purezza:98%Colore e forma:SolidPeso molecolare:180.1574Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Formula:C9H16N4O7Purezza:>99.99%Colore e forma:SolidPeso molecolare:292.25Procaine Hydrochloride
CAS:Formula:C13H21ClN2O2Purezza:98%Colore e forma:SolidPeso molecolare:272.7710Decitabine
CAS:Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.Formula:C8H12N4O4Purezza:98.06% - 99.87%Colore e forma:Physical Description Fine White Crystalline Powder Used As A DrugPeso molecolare:228.21Diperodon hydrochloride
CAS:Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.Formula:C22H28ClN3O4Purezza:99.91%Colore e forma:SolidPeso molecolare:433.93EBI-2511
CAS:EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Formula:C34H48N4O4Purezza:99.74%Colore e forma:SolidPeso molecolare:576.77DC-05
CAS:<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Formula:C25H25N3OPurezza:98.95%Colore e forma:SolidPeso molecolare:383.49iso-Azalansta
CAS:(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Formula:C22H24ClN3O2SPurezza:99.53% - 99.89%Colore e forma:SoildPeso molecolare:429.96N-Phthalyl-L-tryptophan
CAS:Formula:C19H14N2O4Purezza:95%Colore e forma:SolidPeso molecolare:334.3255BVT948
CAS:BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.Formula:C14H11NO3Purezza:98.87%Colore e forma:SolidPeso molecolare:241.24(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid
CAS:Formula:C16H18O9Purezza:98%Colore e forma:SolidPeso molecolare:354.3087Ref: IN-DA00I681
1g30,00€5g52,00€10g75,00€1kgPrezzo su richiesta25g153,00€100g489,00€250gPrezzo su richiesta500gPrezzo su richiesta50kg41.345,00€250mg26,00€DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Colore e forma:Odour SolidE67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Formula:C21H36N6O2Colore e forma:SolidPeso molecolare:404.559EZH2-IN-5
CAS:EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Formula:C26H37BrN4O2Colore e forma:SolidPeso molecolare:517.512MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Formula:C58H66ClF3N14O11S2Colore e forma:SolidPeso molecolare:1290.41175Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formula:C27H49NO5SPurezza:>99.99% - >99.99%Colore e forma:SoildPeso molecolare:499.75
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