Recettore degli androgeni
Il recettore degli androgeni (AR) è un recettore ormonale nucleare che viene attivato dal legame con gli androgeni, come il testosterone e il diidrotestosterone. Questo recettore svolge un ruolo cruciale nello sviluppo e nel mantenimento delle caratteristiche maschili, nonché nella regolazione di diversi processi fisiologici, tra cui la crescita muscolare, la libido e la densità ossea. Gli inibitori del recettore degli androgeni sono ampiamente studiati nel contesto del cancro alla prostata, dove la segnalazione dell'AR è spesso sovraregolata. Presso CymitQuimica, offriamo una gamma di modulatori del recettore degli androgeni di alta qualità per supportare la tua ricerca in endocrinologia, biologia del cancro e regolazione ormonale.
Trovati 229 prodotti di "Recettore degli androgeni"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Galloylalbiflorin
CAS:Galloylalbiflorin, an AR antagonist with IC50 53.3μM, is sourced from Paeonia lactiflora roots, exhibiting anti-androgenic properties.Formula:C30H32O15Colore e forma:SolidPeso molecolare:632.57MTX-23
CAS:MTX-23, an AR-targeted Proteolysis Targeting Chimera (PROTAC), effectively degrades both AR-V7 and AR-FL, inhibiting the proliferation of CaP cells and inducingFormula:C43H53F2N7O7S2Colore e forma:SolidPeso molecolare:882.05K2-B4-5e
K2-B4-5e is a PROTAC compound designed to target the degradation of BRD4 and androgen receptor (AR) through a KLHDC2-based E3 ligase mechanism. It effectively induces rapid and potent degradation of BET family proteins and AR within cells.Formula:C52H49ClN8O6SPeso molecolare:948.3184317β-hydroxy Exemestane
CAS:17β-hydroxy Exemestane is the primary active metabolite of exemestane .Formula:C20H26O2Colore e forma:SolidPeso molecolare:298.42Gridegalutamide
CAS:Gridegalutamide exhibits anti-androgen and anti-tumor activities.Formula:C41H45F3N8O5SColore e forma:SolidPeso molecolare:818.91PROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.Formula:C45H68F3N3O11Colore e forma:SolidPeso molecolare:884.03ARD-69
ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.Formula:C62H74ClFN8O7SColore e forma:SolidPeso molecolare:1129.83Dipropyl phthalate
CAS:Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.Formula:C14H18O4Purezza:98.62%Colore e forma:SolidPeso molecolare:250.29PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Formula:C43H49ClN6O5Colore e forma:SolidPeso molecolare:765.339Faznolutamide
CAS:Faznolutamide is an antiandrogen agent [1] [2] .Formula:C19H17FN4O2SColore e forma:SolidPeso molecolare:384.43PROTAC AR Degrader-8
CAS:PROTAC AR Degrader-8 (Compound NP18) functions as a PROTAC degrader targeting the androgen receptor (AR) and effectively degrades AR-FL in both 22Rv1 and LNCaP cells with DC50 values of 0.018 μM and 0.14 μM, respectively. It also degrades AR-V7 in 22Rv1 cells with a DC50 of 0.026 μM. Additionally, PROTAC AR Degrader-8 inhibits the proliferation of 22Rv1 and LNCaP cancer cells, exhibiting IC50 values of 0.038 μM and 1.11 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in 22Rv1 cells (apoptosis). Demonstrating anticancer efficacy, PROTAC AR Degrader-8 shows activity in both mouse and zebrafish models. [Pink: ligand for target protein AR ligand-33; Black: linker; Blue: ligand for E3 ligase Cereblon]Formula:C40H41N5O7Colore e forma:SolidPeso molecolare:703.7833-Cl-Pyridine-amide-acrylaldehyde-piperazine
3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.Colore e forma:Odour SolidARD-2051
CAS:ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading ARFormula:C43H45ClN8O5Purezza:98%Colore e forma:SolidPeso molecolare:789.32Lambertianic acid
CAS:Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Formula:C20H28O3Purezza:98%Colore e forma:SolidPeso molecolare:316.4419,10-Dihydrophenanthrene
CAS:9,10-Dihydrophenanthrene has inhibitory activity against the androgen receptor and can be used in related research in the field of life sciences.Formula:C14H12Purezza:98.76%Colore e forma:SolidPeso molecolare:180.25Linuron
CAS:Linuron herbicide disrupts photosynthesis and acts as an androgen receptor antagonist.Formula:C9H10Cl2N2O2Purezza:99.08%Colore e forma:White Crystalline Solid Linuron Is A Colorless Crystals Non Corrosive Used As An HerbicidePeso molecolare:249.09LO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Colore e forma:Odour SolidCl-4AS-1
CAS:steroidal androgen receptor agonistFormula:C26H33ClN2O2Purezza:98%Colore e forma:SolidPeso molecolare:441.01PROTAC AR Degrader-10
PROTACAR Degrader-10 is a protein degrader targeting androgen receptors (AR) with a DC50 value of ≤100 nM, and can be used in prostate cancer research.6-Amino-5-bromoquinoxaline
CAS:Compound PDK0245, with CAS No. 50358-63-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0245 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C8H6BrN3Peso molecolare:224.05
