Recettore degli androgeni
Il recettore degli androgeni (AR) è un recettore ormonale nucleare che viene attivato dal legame con gli androgeni, come il testosterone e il diidrotestosterone. Questo recettore svolge un ruolo cruciale nello sviluppo e nel mantenimento delle caratteristiche maschili, nonché nella regolazione di diversi processi fisiologici, tra cui la crescita muscolare, la libido e la densità ossea. Gli inibitori del recettore degli androgeni sono ampiamente studiati nel contesto del cancro alla prostata, dove la segnalazione dell'AR è spesso sovraregolata. Presso CymitQuimica, offriamo una gamma di modulatori del recettore degli androgeni di alta qualità per supportare la tua ricerca in endocrinologia, biologia del cancro e regolazione ormonale.
Trovati 226 prodotti di "Recettore degli androgeni"
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Zanoterone
CAS:<p>Zanoterone is an AR antagonist (androgen receptor).Zanoterone has antitumor activity for the treatment of genitourinary disorders and oncological disorders and</p>Formula:C23H32N2O3SPurezza:99.03% - 99.92%Colore e forma:SoildPeso molecolare:416.58Spironolactone
CAS:Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.Formula:C24H32O4SPurezza:99.87%Colore e forma:White PowderPeso molecolare:416.573,3'-Diindolylmethane
CAS:3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.Formula:C17H14N2Purezza:99.09%Colore e forma:SolidPeso molecolare:246.312,2,5,7,8-Pentamethyl-6-Chromanol
CAS:2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation andFormula:C14H20O2Purezza:98.72%Colore e forma:SolidPeso molecolare:220.31Cyproterone acetate
CAS:Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues andFormula:C24H29ClO4Purezza:98.43% - 99.83%Colore e forma:Crystals From Diisopropyl Ether OdourPeso molecolare:416.94BMS-986365
CAS:BMS-986365 (CC-94676) is an orally available, selective and highly potent AR degrader with potential anticancer activity that inhibits AR signaling and suppresses tumor growth for the study of prostate cancer.Formula:C41H45F3N8O5SPurezza:98.69% - 99.96%Colore e forma:SoildPeso molecolare:818.91Adrenocorticotropic hormone TFA
Adrenocorticotropic hormone TFA is an adrenocorticotropic hormone involved in neurohormonal regulation of the body.Purezza:99.71%Colore e forma:Odour SolidUT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFormula:C15H12F4N4O2Purezza:98.12%Colore e forma:SolidPeso molecolare:356.27Allylestrenol
CAS:Allylestrenol (Gestanin) is a synthetic steroid with progestational activity.Formula:C21H32OPurezza:>99.99%Colore e forma:White Crystalline PowderPeso molecolare:300.48BWA-6047
BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.Formula:C42H46ClN5O7Colore e forma:SolidPeso molecolare:767.30858Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidFaznolutamide
CAS:Faznolutamide is an antiandrogen agent [1] [2] .Formula:C19H17FN4O2SColore e forma:SolidPeso molecolare:384.43Dipropyl phthalate
CAS:Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.Formula:C14H18O4Purezza:98.62%Colore e forma:SolidPeso molecolare:250.29ARD-2585
CAS:ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.Formula:C41H43ClN8O5Colore e forma:SolidPeso molecolare:763.2811-Ketodihydrotestosterone
CAS:<p>11-Ketodihydrotestosterone is a metabolite of 11β-Hydroxyandrostenedione. It is an active androgen and is also a potent androgen receptor (AR) agonist (Ki: 20.4 nM, EC50: 1.35 nM for human AR).</p>Formula:C19H28O3Colore e forma:SolidPeso molecolare:304.42Inocoterone acetate
CAS:Inocoterone acetate is a nonsteroidal antiandrogen that binds to the androgen receptor and possesses antiandrogenic activity in animal models.Formula:C18H26O3Colore e forma:SolidPeso molecolare:290.40PROTAC AR Degrader-8
CAS:PROTAC AR Degrader-8 (Compound NP18) functions as a PROTAC degrader targeting the androgen receptor (AR) and effectively degrades AR-FL in both 22Rv1 and LNCaP cells with DC50 values of 0.018 μM and 0.14 μM, respectively. It also degrades AR-V7 in 22Rv1 cells with a DC50 of 0.026 μM. Additionally, PROTAC AR Degrader-8 inhibits the proliferation of 22Rv1 and LNCaP cancer cells, exhibiting IC50 values of 0.038 μM and 1.11 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in 22Rv1 cells (apoptosis). Demonstrating anticancer efficacy, PROTAC AR Degrader-8 shows activity in both mouse and zebrafish models. [Pink: ligand for target protein AR ligand-33; Black: linker; Blue: ligand for E3 ligase Cereblon]Formula:C40H41N5O7Colore e forma:SolidPeso molecolare:703.783ODM-204
CAS:ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme(IC50s of 80 nM and 22 nM, respectively).Formula:C20H21F3N4Purezza:98%Colore e forma:SolidPeso molecolare:374.402-sec-Butylphenol
CAS:2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.Formula:C10H14OColore e forma:SolidPeso molecolare:150.22MTX-23
CAS:MTX-23, an AR-targeted Proteolysis Targeting Chimera (PROTAC), effectively degrades both AR-V7 and AR-FL, inhibiting the proliferation of CaP cells and inducingFormula:C43H53F2N7O7S2Colore e forma:SolidPeso molecolare:882.05
