Immunologia e infiammazione
Gli inibitori dell'immunologia e dell'infiammazione sono composti che modulano la risposta immunitaria e i processi infiammatori. Questi inibitori sono fondamentali per studiare i meccanismi della regolazione immunitaria, dell'autoimmunità e dell'infiammazione cronica, nonché per sviluppare trattamenti per malattie infiammatorie, allergie e disturbi correlati al sistema immunitario. Mirando a percorsi chiave nel sistema immunitario, questi inibitori possono aiutare a ridurre risposte immunitarie eccessive o inappropriate. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità per supportare le tue ricerche in immunologia, infiammazione e sviluppo terapeutico.
Sottocategorie di "Immunologia e infiammazione"
- CCR(140 prodotti)
- CXCR(159 prodotti)
- Parete cellulare(5 prodotti)
- Ricettore IL(110 prodotti)
- IκB/IKK(58 prodotti)
- LTR(3 prodotti)
- MALT(25 prodotti)
- MRP(6 prodotti)
- NADPH-ossidasi(1 prodotti)
- NF-κB(415 prodotti)
- NOD(23 prodotti)
- NOS(61 prodotti)
- Nrf2(82 prodotti)
- Sintasi PGE(31 prodotti)
- ROS(70 prodotti)
- TGF-beta/Smad(63 prodotti)
- TLR(73 prodotti)
- Tioredossina(12 prodotti)
- gp120/CD4(4 prodotti)
Mostrare 11 più sottocategorie
Trovati 3385 prodotti di "Immunologia e infiammazione"
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hDDAH-1-IN-2 sulfate
hDDAH-1-IN-2: selective oral hDDAH-1 inhibitor with low cell toxicity.Formula:C8H24N4O10S2Colore e forma:SolidPeso molecolare:400.43STING agonist-43
CAS:STINGagonist-43 (Compound 67) is a selective STING agonist with an EC50 of 20.53 μM. It selectively enhances the cGAMP-dependent STING pathway activation by modulating STING oligomerization. STINGagonist-43 demonstrates antitumor activity in a B16.F10 mouse melanoma model and can be utilized in cancer immunotherapy research.Formula:C21H23NO4Colore e forma:SolidPeso molecolare:353.41CYP1B1-IN-10
CAS:CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.Formula:C23H18N2Colore e forma:SolidPeso molecolare:322.40Antifungal agent 134
CAS:Antifungalagent 134 (Compound B13) is an antifungal agent effective against Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata with EC50 values of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL, respectively. It disrupts the fungal cell membranes and mitochondria, leading to substantial accumulation of reactive oxygen species (ROS). Additionally, Antifungalagent 134 exhibits significant herbicidal activity on field weeds such as Amaranthus retroflexus L and Abutilon theophrasti Medicus, and is applicable in crop disease and field weed research.Formula:C18H12F4N2O4Colore e forma:SolidPeso molecolare:396.29COX-2/15-LOX-IN-5
CAS:COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.Formula:C25H21N3O3SColore e forma:SolidPeso molecolare:443.52TrxR-IN-5
TrxR-IN-5 (compound 4f) is an effective inhibitor of thioredoxin reductase (TrxR) with an IC₅₀ of 0.16 μM. anti-proliferative and anti-metastatic.Formula:C26H22O3Colore e forma:SolidPeso molecolare:382.46IL-6-IN-2
CAS:IL-6-IN-2 (Compound 15) is an inhibitor of the interaction between IL-6 and IL-6R proteins. The compound's binding free energy (∆G) is −36.50 kcal/mol. In its binding with IL-6, the contributions from Lys66, Phe74, Gln175, Ser176, and Arg179 are -1.10, -8.68, -6.91, -3.69, and -1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption rates.Formula:C26H24N4O3Colore e forma:SolidPeso molecolare:440.49Factor B-IN-4
CAS:Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.Formula:C27H32N2O4Colore e forma:SolidPeso molecolare:448.55Cyazofamid
CAS:Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.Formula:C13H13ClN4O2SColore e forma:SolidPeso molecolare:324.79Z-Val-Val-Nle-diazomethylketone
CAS:Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.Formula:C25H37N5O5Colore e forma:SolidPeso molecolare:487.59AS2690168 hydrochloride
CAS:AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formula:C17H15Cl2F3N4OColore e forma:SolidPeso molecolare:419.228NOTA-FAPI
CAS:NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.Formula:C36H47F2N9O8Purezza:99.748%Colore e forma:SolidPeso molecolare:771.81ABZI
CAS:(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.Formula:C23H24N6O3Colore e forma:SolidPeso molecolare:432.48AMC-04
CAS:AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].Formula:C26H28N2O3Colore e forma:SolidPeso molecolare:416.51a15:0-i15:0 PE
CAS:a15:0-i15:0 PE is a dia-cyl phosphatidylethanolamine with two branched chains. It functions as an atypical TLR2-TLR1 heterodimer agonist and is immunogenic. This compound activates T cell and dendritic cell (DC) signaling, exhibiting anti-inflammatory properties. Additionally, a15:0-i15:0 PE induces the production of TNFα and IL-6. It is a major component of the A. muciniphila lipid membrane, constituting approximately 50%.Formula:C35H70NO8PColore e forma:SolidPeso molecolare:663.91MIF2-IN-1
MIF2-IN-1, potent inhibitor of MIF2 (IC50: 1μM), halts non-small cell lung cancer growth via MAPK pathway.Formula:C26H19F3N2O2SColore e forma:SolidPeso molecolare:480.5IRAK1/4/pan-FLT3 Kinase-IN-2
CAS:IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.Formula:C20H22F3N5OColore e forma:SolidPeso molecolare:405.42COX-2/PI3K-IN-2
COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).Formula:C16H17N5O2Colore e forma:SolidPeso molecolare:311.34IRAK4-IN-31
CAS:IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).Formula:C27H33N5O5Colore e forma:SolidPeso molecolare:507.58DEG-35
CAS:DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).Formula:C25H21N3O5Colore e forma:SolidPeso molecolare:443.45
