Nrf2
Nrf2 è un fattore di trascrizione che regola l'espressione di proteine antiossidanti ed enzimi di detossificazione, svolgendo un ruolo fondamentale nella difesa cellulare contro lo stress ossidativo e l'infiammazione. L'attivazione della segnalazione Nrf2 fornisce protezione contro varie malattie, tra cui il cancro, la neurodegenerazione e i disturbi cardiovascolari. I modulatori di Nrf2 sono oggetto di studio per le loro potenziali applicazioni terapeutiche nella riduzione dei danni ossidativi e dell'infiammazione. Presso CymitQuimica, offriamo una gamma di modulatori della via Nrf2 di alta qualità per supportare la tua ricerca sullo stress ossidativo, l'infiammazione e la prevenzione delle malattie.
Trovati 80 prodotti per "Nrf2".
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NK-252
CAS:NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.Formula:C13H11N5O3Purezza:98.32%Colore e forma:SolidPeso molecolare:285.26(E/Z)-BCI
CAS:(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFormula:C22H23NOPurezza:99.94%Colore e forma:White SolidPeso molecolare:317.42Ref: TM-T11139
1mg56,00€5mg119,00€1mL*10mM (DMSO)129,00€10mg170,00€25mg290,00€50mg432,00€100mg620,00€BPK-29 hydrochloride
CAS:"BPK-29 hydrochloride targets NR0B1, altering C274 and hinders KEAP1-mutant cancer cell growth."Formula:C26H33Cl2N3O3Purezza:99.06%Colore e forma:SolidPeso molecolare:506.46Ref: TM-T13586L
5mg34,00€1mL*10mM (DMSO)37,00€10mg56,00€25mg102,00€50mg180,00€100mg260,00€200mg370,00€AA147
CAS:AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.Formula:C16H17NO2Purezza:99.24%Colore e forma:White SolidPeso molecolare:255.31Keap1-Nrf2-IN-9
CAS:Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.Formula:C31H30N2O11S2Colore e forma:SolidPeso molecolare:670.71Deacetylgedunin
CAS:Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.Formula:C26H32O6Colore e forma:SolidPeso molecolare:440.53Nrf2 activator-6
CAS:Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Formula:C31H37ClFN5O5Colore e forma:SolidPeso molecolare:614.11Keap1-IN-1
Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.Formula:C17H21Cl2N2O5PS3Colore e forma:SolidPeso molecolare:531.434Keap1/Nrf2/ARE activator 1
Keap1/Nrf2/ARE activator 1 (compound HT-3) functions as an activator of the Keap1/Nrf2/ARE pathway. This compound has antioxidant properties and offers neuroprotective effects.Formula:C19H20O6Colore e forma:SolidPeso molecolare:344.12599Anticonvulsant agent 10
Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.Colore e forma:Odour SolidAc-LDEETGEFL-NH2
CAS:Ac-LDEETGEFL-NH2 is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factorFormula:C48H72N10O19Colore e forma:SolidPeso molecolare:1093.14S217879
CAS:S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.Formula:C30H32N4O7SColore e forma:SolidPeso molecolare:592.67Keap1-Nrf2-IN-23
CAS:Keap1-Nrf2-IN-23 (compound 56) acts as an inhibitor of the Keap1–Nrf2 PPI (IC50=16.0 nM). It exhibits a Kd value of 3.07 nM when binding to Keap1 and demonstrates oral activity.Formula:C30H31ClN4O5Colore e forma:SolidPeso molecolare:563.04TPNA10168
CAS:TPNA10168 ,with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. TPNA10168 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C9H9ClO2S2Colore e forma:SolidPeso molecolare:248.75Nrf2/HO-1 activator 3
Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.Formula:C27H26N2O6Colore e forma:SolidPeso molecolare:474.51TAT 14
CAS:TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.Formula:C137H230N48O39Purezza:98%Colore e forma:SolidPeso molecolare:3173.59Butan-1-amine hydrochloride
CAS:1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).Formula:C4H12ClNColore e forma:SolidPeso molecolare:109.6Keap1-Nrf2-IN-6
Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nMFormula:C30H34N4O8SColore e forma:SolidPeso molecolare:610.6817-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.Formula:C22H30O3Colore e forma:SolidPeso molecolare:342.479Keap1-Nrf2-IN-27
Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.Colore e forma:Odour Solid
