NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 443 prodotti di "NF-κB"
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N-Acetyldopamine dimer-2
CAS:<p>Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.</p>Formula:C20H20N2O6Colore e forma:SolidPeso molecolare:384.38Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Formula:C20H28O6Colore e forma:SolidPeso molecolare:364.43NF-κB-IN-9
<p>NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dual</p>Formula:C62H50N4O4SColore e forma:SolidPeso molecolare:947.15Salicortin
CAS:<p>Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.</p>Formula:C20H24O10Purezza:98%Colore e forma:SolidPeso molecolare:424.40Ginger extract
CAS:<p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>Colore e forma:Solid12-Oxo phytodienoic acid
CAS:<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Formula:C18H28O3Purezza:98%Colore e forma:SolidPeso molecolare:292.41Murrayafoline A
CAS:<p>Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.</p>Formula:C14H13NOColore e forma:SolidPeso molecolare:211.2643-(2-Hydroxyethyl) thio withaferin A
<p>3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.</p>Formula:C30H44O7SColore e forma:SolidPeso molecolare:548.73Gliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Formula:C13H14N2O4S2Purezza:98%Colore e forma:SolidPeso molecolare:326.39R-HP210
<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>Formula:C22H19N3O2S2Colore e forma:SolidPeso molecolare:421.5417-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Formula:C22H32O3Colore e forma:SolidPeso molecolare:344.495MJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Colore e forma:Odour SolidLemnalol
CAS:<p>Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.</p>Formula:C15H24OPurezza:98%Colore e forma:SolidPeso molecolare:220.35PROTAC STING degrader-3
<p>PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.</p>Colore e forma:Odour SolidHelenalin
CAS:<p>Helenalin: anti-inflammatory sesquiterpene, inhibits NF-κB by alkylating p65 cysteine groups, blocks DNA binding.</p>Formula:C15H18O4Purezza:98%Colore e forma:SolidPeso molecolare:262.3NF-κΒ activator 1
CAS:<p>NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.</p>Formula:C16H11FN2O2SPurezza:99.58%Colore e forma:SolidPeso molecolare:314.33R1-ICR-5
CAS:<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Formula:C54H70N8O7S2Colore e forma:SolidPeso molecolare:1007.31MRT67307
CAS:<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Formula:C26H36N6O2Purezza:99.25% - 99.84%Colore e forma:SolidPeso molecolare:464.6CAY10512
CAS:<p>CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.</p>Formula:C15H13FOColore e forma:SolidPeso molecolare:228.266CAY10657
CAS:<p>CAY10657 has a wide range of applications in life science related research.</p>Formula:C17H20N4O3SColore e forma:SolidPeso molecolare:360.43
