NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 445 prodotti di "NF-κB"
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GSK2982772
CAS:GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.Formula:C20H19N5O3Purezza:99.27% - 99.31%Colore e forma:SolidPeso molecolare:377.414-Deoxy-11,12-didehydroandrographolide
CAS:14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.Formula:C20H28O4Purezza:99.13% - 99.93%Colore e forma:SolidPeso molecolare:332.43Rucaparib Phosphate
CAS:<p>Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.</p>Formula:C19H18FN3O·H3PO4Purezza:99.37%Colore e forma:SolidPeso molecolare:421.36Damascenone
CAS:Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.Formula:C13H18OPurezza:99.81%Colore e forma:Colorless LiquidPeso molecolare:190.28IQ-1S free acid
CAS:<p>IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.</p>Formula:C15H9N3OPurezza:97.92% - 99.05%Colore e forma:SolidPeso molecolare:247.2520(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formula:C42H72O13Purezza:98.11% - 99.93%Colore e forma:SolidPeso molecolare:785.012,4-Diamino-6-hydroxypyrimidine
CAS:2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesisFormula:C4H6N4OPurezza:99.82%Colore e forma:White Solid CrystalsPeso molecolare:126.12Andrographolide
CAS:<p>Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential</p>Formula:C20H30O5Purezza:99.39% - 99.97%Colore e forma:PowderPeso molecolare:350.458-Deoxygartanin
CAS:8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it hasFormula:C23H24O5Purezza:99.04% - 99.88%Colore e forma:SolidPeso molecolare:380.43TAK-243
CAS:TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM).Formula:C19H20F3N5O5S2Purezza:98.09% - 98.93%Colore e forma:SolidPeso molecolare:519.52Caffeic Acid Phenethyl Ester
CAS:CAPE, in propolis, blocks NF-kappa B, suppresses p70S6K/Akt pathways, and inhibits PDGF, aiding in cancer protection and immune modulation.Formula:C17H16O4Purezza:99.18% - 99.35%Colore e forma:Less Transparent Liquid Colorless Transparent LiquidPeso molecolare:284.31Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formula:C30H48O3Purezza:98.22% - 99.7%Colore e forma:White Crystalline PowderPeso molecolare:456.70Indacaterol
CAS:<p>Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.</p>Formula:C24H28N2O3Purezza:99.96%Colore e forma:SolidPeso molecolare:392.49Rucaparib monocamsylate
CAS:<p>Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.</p>Formula:C29H34FN3O5SPurezza:99.82%Colore e forma:SolidPeso molecolare:555.66Tryptanthrin
CAS:Tryptanthrin is a natural DNA gyrase inhibitor.Formula:C15H8N2O2Purezza:99.64% - 99.94%Colore e forma:SolidPeso molecolare:248.24Sauchinone
CAS:Sauchinone: Treats infections, prevents liver fibrosis, reduces oxidative stress, and protects skin and vascular cells.Formula:C20H20O6Purezza:>99.99%Colore e forma:SolidPeso molecolare:356.37GSK547
CAS:GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.Formula:C20H18F2N6OPurezza:99.17%Colore e forma:SolidPeso molecolare:396.39Sanggenon C
CAS:<p>Sanggenon C inhibits NF-κB activity, the expression of inducible nitric oxide synthase, tumor necrosis factor-α-stimulated cell adhesion and the expression of vascular cell adhesion molecule-1 in RAW264.7 cells. Cost-effective and quality-assured.</p>Formula:C40H36O12Purezza:97.76% - 99.76%Colore e forma:SolidPeso molecolare:708.71HOMOPLANTAGININ
CAS:Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and showsFormula:C22H22O11Purezza:97.63% - 99.66%Colore e forma:SolidPeso molecolare:462.40SC75741
CAS:SC75741 is a potent P65 inhibitor with IC50 of 200 nMFormula:C29H23N7O2S2Purezza:99.44% - 99.54%Colore e forma:SolidPeso molecolare:565.67Sulforaphene
CAS:Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formula:C6H9NOS2Purezza:97.55% - 99.67%Colore e forma:Slightly Yellowish LiquidPeso molecolare:175.27Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Formula:C42H70O12Purezza:98% - 99.65%Colore e forma:SolidPeso molecolare:767.00WAY-169916
CAS:WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.Formula:C17H13F3N2O2Purezza:98.63% - 98.64%Colore e forma:SolidPeso molecolare:334.29Astilbin
CAS:Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.Formula:C21H22O11Purezza:97% - 99.86%Colore e forma:White PowderPeso molecolare:450.39Praeruptorin A
CAS:Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulinFormula:C21H22O7Purezza:99.63% - 99.65%Colore e forma:SolidPeso molecolare:386.4Tenuigenin
CAS:Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.Formula:C30H45ClO6Purezza:98.9% - 99.53%Colore e forma:SolidPeso molecolare:537.13Tectochrysin
CAS:<p>Tectochrysin: antioxidant, hinders ABCG2 transport, induces apoptosis in NSC-LC by blocking STAT3 and activating DR3/Fas.</p>Formula:C16H12O4Purezza:99.26%Colore e forma:SolidPeso molecolare:268.26INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formula:C15H16N2OPurezza:95.41%Colore e forma:SolidPeso molecolare:240.3Picroside II
CAS:Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides.Formula:C23H28O13Purezza:98% - 99.83%Colore e forma:SolidPeso molecolare:512.46Phorbol 12-myristate 13-acetate
CAS:<p>Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.</p>Formula:C36H56O8Purezza:98.55% - >99.99%Colore e forma:White To Off-White SolidPeso molecolare:616.83Handelin
CAS:<p>Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.</p>Formula:C32H40O8Purezza:99.02% - 99.345%Colore e forma:SolidPeso molecolare:552.66Sciadopitysin
CAS:Sciadopitysin may thwart diabetic bone disease, boost mitochondria, protect osteoblasts, and hinder Aβ aggregation/neurotoxicity.Formula:C33H24O10Purezza:98.67% - 99.17%Colore e forma:SolidPeso molecolare:580.54HS-1371
CAS:<p>HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.</p>Formula:C24H24N4OPurezza:98%Colore e forma:SolidPeso molecolare:384.47Okanin
CAS:<p>Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.</p>Formula:C15H12O6Purezza:95.19% - 99.4%Colore e forma:SolidPeso molecolare:288.25Schisantherin A
CAS:<p>Schisantherin A, a lignan from Schisandra fruit, is used as an antitussive, tonic, and sedative.</p>Formula:C30H32O9Purezza:98% - 99.989Colore e forma:SolidPeso molecolare:536.57Necrostatin 2 racemate
CAS:<p>Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.</p>Formula:C13H12ClN3O2Purezza:98% - 99.5%Colore e forma:SolidPeso molecolare:277.71Esculentoside H
CAS:Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Formula:C48H76O21Purezza:98.04% - 99.3%Colore e forma:SolidPeso molecolare:989.1Isoliquiritin apioside
CAS:Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Formula:C26H30O13Purezza:98.84% - 99.27%Colore e forma:SolidPeso molecolare:550.51Ginsenoside Re
CAS:Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Formula:C48H82O18Purezza:99.12% - >99.99%Colore e forma:White PowderPeso molecolare:947.15Suberosin
CAS:Suberosin: anti-inflammatory, anticoagulant, deters Aedes aegypti bites, potential mosquito larvicide.Formula:C15H16O3Purezza:97.08% - 99.26%Colore e forma:SolidPeso molecolare:244.29NDMC101
CAS:NDMC101 suppresses dipeptidyl peptidase-IV, NFATc1, and NF-κB in human T cells, modulating immunity.Formula:C13H9ClFNO2Purezza:99.89%Colore e forma:SolidPeso molecolare:265.67IRAK4-IN-1
CAS:IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.Formula:C19H23N5OPurezza:98.18% - 99.85%Colore e forma:SolidPeso molecolare:337.42BMS-345541 hydrochloride
CAS:<p>BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).</p>Formula:C14H18ClN5Purezza:99.13%Colore e forma:SolidPeso molecolare:291.78GSK2983559 active metabolite
CAS:GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.Formula:C21H22N4O4S2Purezza:97.07% - 99.57%Colore e forma:SolidPeso molecolare:458.55NF-κΒ activator 2
CAS:<p>NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM.</p>Formula:C16H11FN2O3Purezza:98.12%Colore e forma:SolidPeso molecolare:298.27Eurycomalactone
CAS:<p>Eurycomalactone, from Eurycoma longifolia, inhibits NF-κB (IC50 0.5 μM), stops protein synthesis and cyclin D1, spares IκBα and IKK.</p>Formula:C19H24O6Purezza:99.48% - 99.87%Colore e forma:SolidPeso molecolare:348.39JSH-23
CAS:<p>JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity without affecting IκB degradation. JSH-23 is an antioxidant. Cost effective and quality assured.</p>Formula:C16H20N2Purezza:98.03% - 99.67%Colore e forma:SolidPeso molecolare:240.34GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Formula:C28H19FN2O4Purezza:97.67%Colore e forma:SolidPeso molecolare:466.46Isodeoxyelephantopin
CAS:Isodeoxyelephantopin can inhibit the growth of various tumor cells.Formula:C19H20O6Purezza:99.88%Colore e forma:SolidPeso molecolare:344.36IKKγ NBD Inhibitory Peptide acetate
<p>IKKγ NBD Inhibitory Peptide acetate is a NEMO-binding domain peptide (NBD peptide) acetate corresponding to the NEMO amino-terminal alpha-helical region.</p>Purezza:99.15%Colore e forma:SolidPeso molecolare:N/A
