NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 407 prodotti di "NF-κB"
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Asperbisabolane L
Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.Formula:C12H14O3Colore e forma:SolidPeso molecolare:206.24NF-κB/PON1-IN-1
CAS:NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.Formula:C20H16N6O4S2Colore e forma:SolidPeso molecolare:468.51Ro 106-9920
CAS:Inhibitor of NF-κB activationFormula:C10H7N5OSPurezza:98%Colore e forma:SolidPeso molecolare:245.26APC-0576
CAS:APC-0576, an (S,S)-isomer, blocks NF-kappaB gene activation and may reduce inflammation in human cells.Formula:C23H27N3O3Colore e forma:SolidPeso molecolare:393.48IT-901
CAS:IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.Formula:C17H14N2O4SPurezza:98.06%Colore e forma:SolidPeso molecolare:342.37NF-κB-IN-3
CAS:NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.Formula:C24H18ClF3N2O2Colore e forma:SolidPeso molecolare:458.86HE 3286
CAS:Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.Formula:C21H30O3Colore e forma:SolidPeso molecolare:330.46HSR1304
CAS:HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.Formula:C24H21ClN2O3Colore e forma:SolidPeso molecolare:420.89Anti-inflammatory agent 21
CAS:Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.Formula:C24H21FO6Colore e forma:SolidPeso molecolare:424.42TNF-α-IN-18
CAS:TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.Formula:C16H7ClF2O4Purezza:99.77%Colore e forma:SolidPeso molecolare:336.67DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Formula:C19H17FN8Colore e forma:SolidPeso molecolare:376.39IMD-ferulic
IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.Formula:C36H41N7O4Colore e forma:SolidPeso molecolare:635.76Avenanthramide-C methyl ester
CAS:Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).Formula:C17H15NO6Colore e forma:SolidPeso molecolare:329.31-Dehydro-[10]-gingerdione
CAS:1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.Formula:C21H30O4Colore e forma:SolidPeso molecolare:346.46ABD-350
CAS:ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation.Formula:C19H22F2O2Colore e forma:SolidPeso molecolare:320.37MHY884
CAS:MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.Formula:C15H14ClNO3SPurezza:98%Colore e forma:SolidPeso molecolare:323.79XT2
CAS:XT2 is a potent, oral NF-κB-inducing kinase (NIK) inhibitor with an IC50 of 9.1 nM, reduces ALT levels, and curbs immune cell liver infiltration.Formula:C19H14FN5OSColore e forma:SolidPeso molecolare:379.41Sul-121 HCl
CAS:Sul-121 HCl combats COPD by reducing inflammation and AHR via oxidative stress inhibition.Formula:C18H27ClN2O3Purezza:98%Colore e forma:SolidPeso molecolare:354.87HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formula:C19H16ClN3O3SPurezza:98.07% - 98.17%Colore e forma:SolidPeso molecolare:401.87Ref: TM-T11573
2mg137,00€5mg222,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.603,00€200mg2.187,00€1mL*10mM (DMSO)245,00€Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H25N3O4Purezza:98%Colore e forma:SolidPeso molecolare:395.45
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