NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 365 prodotti per "NF-κB".
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α-Lipoic Acid
CAS:α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.Formula:C8H14O2S2Purezza:98.39% - 99.92%Colore e forma:Yellow SolidPeso molecolare:206.326Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formula:C14H22N2OPurezza:99.88% - >99.99%Colore e forma:White SolidPeso molecolare:234.3373Sulindac
CAS:Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.Formula:C20H17FO3SPurezza:99.09% - 99.15%Colore e forma:White SolidPeso molecolare:356.41Theophylline monohydrate
CAS:Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFormula:C7H10N4O3Purezza:99.78%Colore e forma:SolidPeso molecolare:198.1793Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formula:C9H8O4Purezza:99.78% - 99.91%Colore e forma:SolidPeso molecolare:180.1574Dihydroartemisinin
CAS:Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!Formula:C15H24O5Purezza:98% - 99.41%Colore e forma:SolidPeso molecolare:284.35Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurezza:99.95%Colore e forma:SolidPeso molecolare:288.82NIK SMI1
CAS:NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).Formula:C20H19N3O4Purezza:99.04% - 99.99%Colore e forma:SolidPeso molecolare:365.3826Asatone
CAS:Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Formula:C24H32O8Purezza:99.84% - 99.92%Colore e forma:SolidPeso molecolare:448.5061Naringin dihydrochalcone
CAS:Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.Formula:C27H34O14Purezza:99.07% - 99.73%Colore e forma:White SolidPeso molecolare:582.55Sinomenine hydrochloride
CAS:Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Formula:C19H24ClNO4Purezza:99.43%Colore e forma:White SolidPeso molecolare:365.85TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formula:C26H27N5O3Purezza:98.89%Colore e forma:SolidPeso molecolare:457.5243Baicalin
CAS:Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFormula:C21H18O11Purezza:90.08% - 99.32%Colore e forma:SolidPeso molecolare:446.36DMAPT
CAS:DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Formula:C17H27NO3Purezza:99.91%Colore e forma:White SolidPeso molecolare:293.4012Sulfasalazine
CAS:Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.Formula:C18H14N4O5SPurezza:98.00% - 99.28%Colore e forma:Yellow SolidPeso molecolare:398.39Sodium salicylate
CAS:Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Formula:C7H5NaO3Purezza:99.36% - 99.95%Colore e forma:SolidPeso molecolare:160.1026Theophylline
CAS:Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and centralFormula:C7H8N4O2Purezza:99.74% - 99.98%Colore e forma:White SolidPeso molecolare:180.164R-HP210
R-HP210 is a SGRM that exerts anti-inflammatory activity by acting on the NF-κB-mediated inhibitory cross-talk (IC₅₀ = 3.80 μM).Formula:C22H19N3O2S2Purezza:99.35%Colore e forma:White SolidPeso molecolare:421.53SMU-R39
SMU-R39 is a TLR7 and TLR8 antagonist with IC50 values of 3.22 μM and 0.24 μM, respectively. It binds to recombinant mTLR7 protein (KD= 2.36 μM) and recombinant hTLR8 protein (KD= 105 nM). SMU-R39 inhibits downstream NF-κB and MAPK signaling pathways, reducing the secretion and transcription of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in PBMCs and THP-1 cells. In an Imiquimod (IMQ)-induced psoriasis mouse model, SMU-R39 exhibits anti-inflammatory activity and may be used for researching autoimmune diseases such as psoriasis.MJ210
MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.Colore e forma:Odour Solid
