NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 361 prodotti per "NF-κB".
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Anti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.Formula:C18H19F3N2O2SeColore e forma:SolidPeso molecolare:432.05638NF-κB Signaling Compound Library
A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;Colore e forma:Odour SolidRef: TM-L3800
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaHalleridone
CAS:Halleridone, a natural product, is identified in Teuanchum decipiens and Abeliophyllum distichum.Formula:C8H10O3Colore e forma:SolidPeso molecolare:154.165Gliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Formula:C13H14N2O4S2Purezza:98%Colore e forma:SolidPeso molecolare:326.39SN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Formula:C129H230N36O29S·XCF3COOHColore e forma:SolidPeso molecolare:2781.5 (free base)Apo A-I mimetic 5A peptide
Apo A-I mimetic 5A peptide is a synthetic peptide molecule designed based on the structure and function of naturally occurring apolipoprotein A-I (Apo A-I). It facilitates the efflux of cholesterol from inside cells, helping to reduce intracellular cholesterol accumulation. Additionally, Apo A-I mimetic 5A peptide exhibits anti-inflammatory properties, lowering inflammatory markers in blood and tissues. This peptide is used in cardiovascular disease research.Formula:C197H295N47O56Colore e forma:SolidPeso molecolare:4215.16808Mesalamine impurity P
CAS:Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.Formula:C13H11NO6SColore e forma:SolidPeso molecolare:309.307-O-Methylaloeasinol
CAS:7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.Formula:C20H26O9Colore e forma:SolidPeso molecolare:410.419NF-κB-IN-9
NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dualFormula:C62H50N4O4SColore e forma:SolidPeso molecolare:947.15Anti-inflammatory agent 7
Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.Formula:C36H40N4O9Colore e forma:SolidPeso molecolare:672.72TBK1/IKKε-IN-6
CAS:TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Formula:C31H36F2N8O4Colore e forma:SolidPeso molecolare:622.678Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Formula:C20H28O6Colore e forma:SolidPeso molecolare:364.43MJ210
MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.Colore e forma:Odour SolidIKKγ NBD Inhibitory Peptide
CAS:A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNFFormula:C170H259N49O42S1Purezza:98%Colore e forma:SolidPeso molecolare:3693.3R-HP210
R-HP210 is a SGRM that exerts anti-inflammatory activity by acting on the NF-κB-mediated inhibitory cross-talk (IC₅₀ = 3.80 μM).Formula:C22H19N3O2S2Purezza:99.35%Colore e forma:White SolidPeso molecolare:421.53CAY10512
CAS:CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.Formula:C15H13FOColore e forma:SolidPeso molecolare:228.266Lemnalol
CAS:Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.Formula:C15H24OPurezza:98%Colore e forma:SolidPeso molecolare:220.3517-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).Formula:C22H32O3Colore e forma:SolidPeso molecolare:344.495CAY10657
CAS:CAY10657 has a wide range of applications in life science related research.Formula:C17H20N4O3SColore e forma:SolidPeso molecolare:360.43PROTAC STING degrader-3
PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.Colore e forma:Odour Solid
