IκB/IKK

Il complesso IκB/IKK è un regolatore chiave della via di segnalazione NF-κB, che controlla l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione e nella sopravvivenza cellulare. Le proteine IκB inibiscono l'attività di NF-κB sequestrandolo nel citoplasma, mentre le IKK fosforilano IκB, portando alla sua degradazione e all'attivazione di NF-κB. La disregolazione della via IκB/IKK è legata a infiammazione cronica, cancro e malattie autoimmuni. Presso CymitQuimica, offriamo una selezione di modulatori IκB/IKK di alta qualità per supportare la tua ricerca in trasduzione del segnale, infiammazione e sviluppo terapeutico.

Trovati 59 prodotti di "IκB/IKK"

Purezza (%)

100

prodotti per pagina.

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Vinpocetine
CAS:
- 42971-09-5
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
Formula:C₂₂H₂₆N₂O₂
Purezza:99.85% - 99.98%
Colore e forma:White Crystalline Solid
Peso molecolare:350.45
Ref: TM-T0167
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Ac2-26 ammonium
Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.
Formula:C₁₄₁H₂₁₀N₃₂O₄₄S·xNH₃
Purezza:95.58%
Colore e forma:Solid
Peso molecolare:3089.43 (free base)
Ref: TM-T78371
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IMD-0560
CAS:
- 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
Formula:C₁₅H₈BrF₆NO₂
Purezza:99.51%
Colore e forma:Solid
Peso molecolare:428.12
Ref: TM-T15564
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BAY-985
CAS:
- 2409479-29-2
BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.
Formula:C₂₇H₃₀F₃N₉O
Purezza:99.62%
Colore e forma:Solid
Peso molecolare:553.58
Ref: TM-T10477
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TBK1/IKKε-IN-2
CAS:
- 1292310-49-6
TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.
Formula:C₂₆H₂₇N₅O₃
Purezza:98.89%
Colore e forma:Solid
Peso molecolare:457.52
Ref: TM-T15559
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IKK-IN-3
CAS:
- 615528-53-5
IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).
Formula:C₁₇H₁₇N₅S
Colore e forma:Solid
Peso molecolare:323.42
Ref: TM-T40700
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PS 1145 dihydrochloride
CAS:
- 1049743-58-9
IκB kinase (IKK) inhibitor
Formula:C₁₇H₁₃Cl₃N₄O
Purezza:98%
Colore e forma:Solid
Peso molecolare:395.67
Ref: TM-T23191
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HOIPIN-1
CAS:
- 2470242-33-0
HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-
Formula:C₁₇H₁₃NaO₄
Purezza:98.65%
Colore e forma:Soild
Peso molecolare:304.27
Ref: TM-T78557
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LY2409881
CAS:
- 946518-61-2
LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.
Formula:C₂₄H₂₉ClN₆OS
Colore e forma:Solid
Peso molecolare:485.05
Ref: TM-T41101
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MRT67307
CAS:
- 1190378-57-4
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.
Formula:C₂₆H₃₆N₆O₂
Purezza:99.25% - 99.84%
Colore e forma:Solid
Peso molecolare:464.6
Ref: TM-T0097
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SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.
Colore e forma:Odour Solid
Ref: TM-T200684
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PROTAC STING degrader-4
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).
Formula:C₃₉H₄₂Cl₂N₈O₉
Colore e forma:Solid
Peso molecolare:836.24518
Ref: TM-T207609
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Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.
Formula:C₂₀H₂₈O₆
Colore e forma:Solid
Peso molecolare:364.43
Ref: TM-T72578
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TBK1/IKKε-IN-6
CAS:
- 2306877-20-1
TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.
Formula:C₃₁H₃₆F₂N₈O₄
Colore e forma:Solid
Peso molecolare:622.678
Ref: TM-T39841
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Verproside
CAS:
- 50932-20-2
Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.
Formula:C₂₂H₂₆O₁₃
Colore e forma:Solid
Peso molecolare:498.437
Ref: TM-T124745
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IKK 16 hydrochloride
CAS:
- 1186195-62-9
IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.
Formula:C₂₈H₃₀ClN₅OS
Colore e forma:Solid
Peso molecolare:520.09
Ref: TM-T15557
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ML 120B dihydrochloride
CAS:
- 1782573-78-7
MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.
Formula:C₁₉H₁₇Cl₃N₄O₂
Colore e forma:Solid
Peso molecolare:439.72
Ref: TM-T39199
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2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:
- 4815-35-4
<p>2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.</p>
Formula:C₁₁H₁₀N₂OS
Purezza:99.48%
Colore e forma:Solid
Peso molecolare:218.27
Ref: TM-T8910
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AZD3264
CAS:
- 1609281-86-8
AZD3264 is a new type IKK2 inhibitor.
Formula:C₂₁H₂₃N₅O₄S
Purezza:98.98% - 99.17%
Colore e forma:Solid
Peso molecolare:441.5
Ref: TM-T6771
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MLN120B
CAS:
- 783348-36-7
<p>MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).</p>
Formula:C₁₉H₁₅ClN₄O₂
Purezza:98.92%
Colore e forma:Solid
Peso molecolare:366.8
Ref: TM-TQ0306

IκB/IKK

Trovati 59 prodotti di "IκB/IKK"

Vinpocetine

Ref: TM-T0167

Ac2-26 ammonium

Ref: TM-T78371

IMD-0560

Ref: TM-T15564

BAY-985

Ref: TM-T10477

TBK1/IKKε-IN-2

Ref: TM-T15559

IKK-IN-3

Ref: TM-T40700

PS 1145 dihydrochloride

Ref: TM-T23191

HOIPIN-1

Ref: TM-T78557

LY2409881

Ref: TM-T41101

MRT67307

Ref: TM-T0097

SU1261

Ref: TM-T200684

PROTAC STING degrader-4

Ref: TM-T207609

Siegesbeckialide I

Ref: TM-T72578

TBK1/IKKε-IN-6

Ref: TM-T39841

Verproside

Ref: TM-T124745

IKK 16 hydrochloride

Ref: TM-T15557

ML 120B dihydrochloride

Ref: TM-T39199

2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC

Ref: TM-T8910

AZD3264

Ref: TM-T6771

MLN120B

Ref: TM-TQ0306