CCR
I recettori delle chemochine C-C (CCR) sono un gruppo di GPCR che rispondono alle chemochine, molecole segnalatrici che guidano la migrazione delle cellule immunitarie verso i siti di infiammazione o infezione. I CCR svolgono ruoli cruciali nelle risposte immunitarie, nell'infiammazione e nello sviluppo di varie malattie, tra cui disturbi autoimmuni e cancro. La modulazione dell'attività dei CCR è esplorata come strategia terapeutica per condizioni come l'artrite reumatoide, la sclerosi multipla e l'infezione da HIV. Presso CymitQuimica, offriamo una gamma di modulatori CCR di alta qualità per supportare la tua ricerca in immunologia, infiammazione e sviluppo terapeutico.
Trovati 140 prodotti di "CCR"
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2-Methoxyhydroquinone
CAS:2-Methoxyhydroquinone inhibits MAO-A and MAO-B and reduces TNF-α-induced CCL2 production, a precursor for synthesising the Hsp90 inhibitor Geldanamycin.Formula:C7H8O3Purezza:98.25%Colore e forma:SolidPeso molecolare:140.14Cafelkibart
Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidWAY-639418
CAS:WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.Formula:C17H16ClN5Purezza:99.89%Colore e forma:SolidPeso molecolare:325.8Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Colore e forma:Odour SolidHGS101
HGS101 is a fully humanized CCR5 monoclonal antibody that exhibits high affinity for CCR5. It binds to the second extracellular loop (ECL-2) and functions as a signaling antagonist. HGS101 restores the inhibitory effect of Maraviroc in Maraviroc-resistant HIV-1 infected PBMCs. In an uninfected simian immunodeficiency virus model of rhesus monkeys, HGS101 shows anti-HIV activity by inhibiting CCR5 signaling.Colore e forma:Odour LiquidCAP-100
CAP-100 is a monoclonal antibody targeting CCR7. It neutralizes the ligand binding site and signaling of CCR7. This compound effectively inhibits migration, extravasation, homing, and survival in chronic lymphocytic leukemia (CLL) samples induced by CCR7. CAP-100 can mediate potent tumor cell killing through host immune mechanisms and exhibits favorable toxicity profiles in related hematopoietic cell subsets. It is involved in research on antitumor activity and diseases like chronic lymphocytic leukemia (CLL).Colore e forma:Odour LiquidINCB 3284 dimesylate
CAS:INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.Formula:C28H39F3N4O10S2Purezza:98%Colore e forma:SolidPeso molecolare:712.76PF-232798
CAS:PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.Formula:C29H40FN5O2Colore e forma:SolidPeso molecolare:509.66CH-0076989
CAS:CH-0076989 is a chemokine receptor CCR3 agonist.Formula:C24H22Br2N2O2Colore e forma:SolidPeso molecolare:530.25Plozalizumab
CAS:Plozalizumab (MLN-1202) is a humanized selective and potent anti-CCR2 antibody.Plozalizumab has antitumor activity.Plozalizumab is used in the study of
Purezza:96.4%Colore e forma:LiquidPeso molecolare:146.02 kDaCCR4 antagonist 3
CAS:Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.Formula:C24H27Cl2N7OColore e forma:SolidPeso molecolare:500.43CKLF1-C27 TFA
CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.Formula:C153H244F3N39O39Colore e forma:SolidPeso molecolare:3310.8CMKLR1 antagonist 1
CMKLR1 antagonist 1 (compound S-26d) is a potent, orally active antagonist of the chemokine-like receptor 1 (CMKLR1), exhibiting a pIC50 of 7.44 in hCMKLR1-Colore e forma:Odour SolidMaceneolignan H
CAS:Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.Formula:C24H30O7Colore e forma:SolidPeso molecolare:430.49Chemokine Inhibitor Library
A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;
Colore e forma:Odour SolidSQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Formula:C22H26N4O5Colore e forma:SolidPeso molecolare:426.47CCR6 antagonist 1
CAS:CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.
Formula:C17H12F3NO2Purezza:99.83%Colore e forma:SoildPeso molecolare:319.28BMS-753426
CAS:BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .
Formula:C25H33F3N6O2Colore e forma:SolidPeso molecolare:506.574MLN-3897 TFA
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.Formula:C32H32ClF3N2O6Purezza:98.62%Colore e forma:SolidPeso molecolare:633.05Ref: TM-T28072L
1mg115,00€5mg245,00€10mg363,00€25mg562,00€50mg775,00€100mg1.035,00€200mg1.406,00€1mL*10mM (DMSO)Prezzo su richiestaNebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour Liquid
