CCR
I recettori delle chemochine C-C (CCR) sono un gruppo di GPCR che rispondono alle chemochine, molecole segnalatrici che guidano la migrazione delle cellule immunitarie verso i siti di infiammazione o infezione. I CCR svolgono ruoli cruciali nelle risposte immunitarie, nell'infiammazione e nello sviluppo di varie malattie, tra cui disturbi autoimmuni e cancro. La modulazione dell'attività dei CCR è esplorata come strategia terapeutica per condizioni come l'artrite reumatoide, la sclerosi multipla e l'infezione da HIV. Presso CymitQuimica, offriamo una gamma di modulatori CCR di alta qualità per supportare la tua ricerca in immunologia, infiammazione e sviluppo terapeutico.
Trovati 166 prodotti per "CCR".
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PNU-177864
CAS:PNU-177864 is a selective dopamine D3 receptor antagonist.Formula:C18H21F3N2O3SPurezza:99.92%Colore e forma:SolidPeso molecolare:402.431C-021 dihydrochloride
CAS:C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Formula:C27H43Cl2N5O2Purezza:98.67%Colore e forma:White SolidPeso molecolare:540.57HGS101
HGS101 is a fully humanized CCR5 monoclonal antibody that exhibits high affinity for CCR5. It binds to the second extracellular loop (ECL-2) and functions as a signaling antagonist. HGS101 restores the inhibitory effect of Maraviroc in Maraviroc-resistant HIV-1 infected PBMCs. In an uninfected simian immunodeficiency virus model of rhesus monkeys, HGS101 shows anti-HIV activity by inhibiting CCR5 signaling.Colore e forma:Odour LiquidAPC-3316 tosylate
CAS:APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.Formula:C39H46N4O7S2Colore e forma:SolidPeso molecolare:746.94CHS-114
CHS-114 (SRF-114) is a fully human IgG1 antibody targeting the (CCR8) receptor. It shows potential for research in head and neck squamous cell carcinoma (HNSCC). The isotype control for CHS-114 can be referred to as HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidTagmokitug
CAS:Tagmokitug is a humanized IgG1κ monoclonal antibody inhibitor targeting CCR8. It exhibits anti-tumor activity and is applicable in cancer immunotherapy research, including studies on breast cancer, colon cancer, and lung cancer.AF-399/42018025
CAS:AF-399/42018025 is a small-molecule CCR4 antagonist applied to investigate chemokine-mediated immune cell trafficking and inflammatory disease mechanisms.Formula:C26H16ClN3O4S3Purezza:99.96%Colore e forma:Yellow SolidPeso molecolare:566.07CCX354
CAS:CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Formula:C22H22ClN7O2Purezza:99.43% - 99.44%Colore e forma:SolidPeso molecolare:451.909GW 766994
CAS:GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.Formula:C21H24Cl2N4O3Purezza:98.77%Colore e forma:White SolidPeso molecolare:451.346CCR1 antagonist 9
CAS:CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. CCR1 inhibition in calcium flux assays.Formula:C20H16FN5O3SPurezza:99.13%Colore e forma:SolidPeso molecolare:425.436CCR4 antagonist 3-1
CAS:CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.Formula:C14H12N2SPurezza:99.87%Colore e forma:SolidPeso molecolare:240.32BI-6901
CAS:BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Formula:C23H27N5O3SPurezza:99.83% - 99.98%Colore e forma:White SolidPeso molecolare:453.557LM-108
LM-108 is a monoclonal antibody that targets CCR8. It selectively eliminates tumor-infiltrating regulatory T cells (Treg) and is applicable to gastric cancer research.AZ760
CAS:AZ760 is a CCR8 antagonist that demonstrates excellent potency, good lipophilicity, and a high free fraction in blood, but exhibits unacceptable hERG inhibition [1].Formula:C29H33N3O4Peso molecolare:487.59Ancriviroc
CAS:Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.Formula:C28H37BrN4O3Purezza:99.76% - 99.82%Colore e forma:SolidPeso molecolare:557.533GSK2239633A
CAS:GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Formula:C24H25ClN4O5S2Purezza:99.82%Colore e forma:White SolidPeso molecolare:549.062SB 328437
CAS:SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Formula:C21H18N2O5Purezza:99.54%Colore e forma:SolidPeso molecolare:378.38BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Formula:C28H34F3N5O4SPurezza:99.65%Colore e forma:SolidPeso molecolare:593.66CCR2 antagonist 5
CAS:JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Formula:C22H25F3N4O3SPurezza:99.98%Colore e forma:SolidPeso molecolare:482.519BMS-817399
CAS:BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.Formula:C23H36ClN3O4Purezza:99.7%Colore e forma:SolidPeso molecolare:454.003
