Nrf2
Nrf2 è un fattore di trascrizione che regola l'espressione di proteine antiossidanti ed enzimi di detossificazione, svolgendo un ruolo fondamentale nella difesa cellulare contro lo stress ossidativo e l'infiammazione. L'attivazione della segnalazione Nrf2 fornisce protezione contro varie malattie, tra cui il cancro, la neurodegenerazione e i disturbi cardiovascolari. I modulatori di Nrf2 sono oggetto di studio per le loro potenziali applicazioni terapeutiche nella riduzione dei danni ossidativi e dell'infiammazione. Presso CymitQuimica, offriamo una gamma di modulatori della via Nrf2 di alta qualità per supportare la tua ricerca sullo stress ossidativo, l'infiammazione e la prevenzione delle malattie.
Trovati 80 prodotti per "Nrf2".
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BPK-29 hydrochloride
CAS:"BPK-29 hydrochloride targets NR0B1, altering C274 and hinders KEAP1-mutant cancer cell growth."Formula:C26H33Cl2N3O3Purezza:99.06%Colore e forma:SolidPeso molecolare:506.46Ref: TM-T13586L
5mg34,00€1mL*10mM (DMSO)37,00€10mg56,00€25mg102,00€50mg180,00€100mg260,00€200mg370,00€(E/Z)-BCI
CAS:(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFormula:C22H23NOPurezza:99.94%Colore e forma:White SolidPeso molecolare:317.42Ref: TM-T11139
1mg75,00€5mg146,00€1mL*10mM (DMSO)161,00€10mg268,00€25mg427,00€50mg605,00€100mg803,00€200mg1.063,00€NK-252
CAS:NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.Formula:C13H11N5O3Purezza:98.32%Colore e forma:SolidPeso molecolare:285.26AA147
CAS:AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.Formula:C16H17NO2Purezza:99.24%Colore e forma:White SolidPeso molecolare:255.31Keap1-IN-1
Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.Formula:C17H21Cl2N2O5PS3Colore e forma:SolidPeso molecolare:531.434Anticonvulsant agent 10
Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.Colore e forma:Odour SolidKeap1-Nrf2-IN-23
CAS:Keap1-Nrf2-IN-23 (compound 56) acts as an inhibitor of the Keap1–Nrf2 PPI (IC50=16.0 nM). It exhibits a Kd value of 3.07 nM when binding to Keap1 and demonstrates oral activity.Formula:C30H31ClN4O5Colore e forma:SolidPeso molecolare:563.04Eriodictyol-7-O-glucoside
CAS:Eriodictyol-7-O-glucoside, a flavonoid in pistachio skin, activates Nrf2 and protects against Cisplatin toxicity.Formula:C21H22O11Purezza:99.53% - 99.99%Colore e forma:Gray SolidPeso molecolare:450.39TBE-31
CAS:TBE-31 is a highly potent activator of Nrf2, a liver carcinogenesis blocker and a potent phase 2 cytoprotective pathway inducer.Formula:C21H18N2O2Colore e forma:SolidPeso molecolare:330.38Nrf2 degrader 30
CAS:Nrf2 degrader 30 PROTAC inhibits Nrf2 ubiquitination and proteasomal degradation, enhancing activity for antioxidant and protective mechanisms。Formula:C42H41FN8O7SPurezza:97.73% - 98.81%Colore e forma:SolidPeso molecolare:820.89His-Pro
CAS:His-Pro is a dipeptide consisting of histidyl and proline.Formula:C11H16N4O3Purezza:98%Colore e forma:SolidPeso molecolare:252.27Monascin
CAS:Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.Formula:C21H26O5Purezza:98%Colore e forma:SolidPeso molecolare:358.43Nrf2 activator 18
Nrf2 activator 18 (Compound 11a) is an orally active activator of the Keap1/Nrf2/HO-1 signaling pathway, promoting Nrf2 nuclear translocation and enhancing antioxidant effects. It inhibits IL-6 release with an IC50 of 4.816 μM. In a mouse model of PM2.5-induced lung injury, Nrf2 activator 18 demonstrates anti-inflammatory activity.Formula:C23H24FN3OColore e forma:SolidPeso molecolare:377.45Fraxinellone analog 1
Fraxinellone analog 1 (compound 2) is an effective and rapid activator of the Nrf2-mediated antioxidative defense system, providing protection against glutamate-mediated excitotoxicity. It induces the expression of antioxidative genes Gpx4, Sod1, and Nqo1. Additionally, Fraxinellone analog 1 exerts neuroprotective effects and modulates oxidative stress and inflammation, making it suitable for research on neurodegenerative diseases.Colore e forma:Odour SolidTPNA10168
CAS:TPNA10168 ,with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. TPNA10168 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C9H9ClO2S2Colore e forma:SolidPeso molecolare:248.75Keap1/Nrf2/ARE activator 1
Keap1/Nrf2/ARE activator 1 (compound HT-3) functions as an activator of the Keap1/Nrf2/ARE pathway. This compound has antioxidant properties and offers neuroprotective effects.Formula:C19H20O6Colore e forma:SolidPeso molecolare:344.12599Nrf2/HO-1 activator 3
Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.Formula:C27H26N2O6Colore e forma:SolidPeso molecolare:474.51Butan-1-amine hydrochloride
CAS:1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).Formula:C4H12ClNColore e forma:SolidPeso molecolare:109.6Nrf2 degrader 1
CAS:Nrf2 degrader 1 (compound 1), a PROTAC Nrf2 degrader, exhibits anticancer properties by inhibiting the growth of cancer cells. It demonstrates IC 50 values of 100 nM for A549 cells and 40 nM for LK-2 cells, indicating potent efficacy [1].Formula:C45H42N6O8SColore e forma:SolidPeso molecolare:826.92Nrf2 activator-8
Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory propertiesFormula:C13H11ClN2O3SColore e forma:SolidPeso molecolare:310.76Nrf2 activator-1
CAS:Nrf2 activator-1 activates Nrf2; used for COPD, asthma, ALI, ARDS, pulmonary fibrosis research.Formula:C30H34N4O6SPurezza:97.8%Colore e forma:SolidPeso molecolare:578.684-P-PDOT
CAS:4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.Formula:C19H21NOPurezza:99.91%Colore e forma:White SolidPeso molecolare:279.3817-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.Formula:C22H30O3Colore e forma:SolidPeso molecolare:342.479TAT 14
CAS:TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.Formula:C137H230N48O39Purezza:98%Colore e forma:SolidPeso molecolare:3173.59Ac-LDEETGEFL-NH2
CAS:Ac-LDEETGEFL-NH2 is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factorFormula:C48H72N10O19Colore e forma:SolidPeso molecolare:1093.14Keap1-Nrf2-IN-9
CAS:Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.Formula:C31H30N2O11S2Colore e forma:SolidPeso molecolare:670.71S217879
CAS:S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.Formula:C30H32N4O7SColore e forma:SolidPeso molecolare:592.67Keap1-Nrf2-IN-27
Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.Colore e forma:Odour SolidDeacetylgedunin
CAS:Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.Formula:C26H32O6Colore e forma:SolidPeso molecolare:440.53Keap1-Nrf2-IN-3
CAS:Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.Formula:C31H34N6O3Colore e forma:SolidPeso molecolare:538.652KI696 isomer
CAS:KI696 isomer is an isomer of KI696, a low affinity probe for the study of immune and metabolic diseases.Formula:C28H30N4O6SPurezza:99.8%Colore e forma:White SolidPeso molecolare:550.63Ref: TM-T11758
1mg87,00€5mg264,00€1mL*10mM (DMSO)289,00€10mg442,00€25mg892,00€50mg1.198,00€100mg1.575,00€I-152
CAS:Bepranemab (UCB 0107) is a humanized IgG monoclonal antibody against tau for the study of Alzheimer's disease (AD) and tau proteinopathies.Formula:C9H16N2O3S2Purezza:98.36%Colore e forma:SolidPeso molecolare:264.37Anti-NFE2L2 Antibody (9K94)
Anti-NFE2L2 Antibody (9K94) is a Mouse antibody targeting NFE2L2. Anti-NFE2L2 Antibody (9K94) can be used in ELISA, WB, IHC, IF, FCM.Purezza:>95%Colore e forma:Odour LiquidAnti-Phospho-NFE2L2 (Ser40) Antibody (6V851)
Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) is an antibody targeting Phospho-NFE2L2 (Ser40). Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) can be used in ELISA, WB, IHC, IF.Colore e forma:Odour LiquidAnti-NFE2L2 Antibody (6K859)
Anti-NFE2L2 Antibody (6K859) is an antibody targeting NFE2L2. Anti-NFE2L2 Antibody (6K859) can be used in ELISA, IF.Colore e forma:Odour LiquidDimethyl fumarate-D6
CAS:Dimethyl fumarate-D6 is a deuterium labeled Dimethyl fumarate (T0492). can induces upregulation of antioxidant gene expression.Formula:C6H8O4Purezza:98%Colore e forma:SolidPeso molecolare:150.16CBR-470-2
CAS:CBR-470-2 activates NRF2 signaling, aiding in glycolysis research.Formula:C12H13Cl2NO6S2Colore e forma:SolidPeso molecolare:402.26ML334
CAS:ML334 (LH601A) is an NRF2 activator that inhibits cardiac fibroblast activation and proliferation ameliorating myocardial infarction-induced cardiac fibrosis.Formula:C26H26N2O5Purezza:98.06% - 98.06%Colore e forma:SolidPeso molecolare:446.49ML162
CAS:ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity. Cost-effective and quality-assured.Formula:C23H22Cl2N2O3SPurezza:98.42% - 99.55%Colore e forma:SolidPeso molecolare:477.4Ref: TM-T8970
1mg43,00€5mg85,00€1mL*10mM (DMSO)92,00€10mg110,00€25mg215,00€50mg334,00€100mg467,00€200mg672,00€4-Octyl itaconate
CAS:4-Octyl Itaconate is a cell-permeable derivative of Itaconate, an anti-inflammatory metabolite.Formula:C13H22O4Purezza:99.3% - 99.94%Colore e forma:SolidPeso molecolare:242.31AT 14 acetate
TAT 14 acetate, a 14-mer peptide, activates Nrf2, has anti-inflammatory effects, and targets Keap1 without altering Nrf2 mRNA.Formula:C139H234N48O41Purezza:96.9%Colore e forma:SolidPeso molecolare:3233.64Kinsenoside
CAS:Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities.Formula:C10H16O8Purezza:99.2% - 99.92%Colore e forma:SolidPeso molecolare:264.23AEM1
CAS:AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.Formula:C20H14FN3O2SPurezza:98.37% - 99.88%Colore e forma:SolidPeso molecolare:379.41Artemisitene
CAS:Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.Formula:C15H20O5Purezza:99.58%Colore e forma:SolidPeso molecolare:280.32Ref: TM-T21065
1mg89,00€5mg177,00€1mL*10mM (DMSO)203,00€10mg313,00€25mg530,00€50mg757,00€100mg1.044,00€Brusatol
CAS:Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.Formula:C26H32O11Purezza:99.35% - 99.95%Colore e forma:SolidPeso molecolare:520.53Ref: TM-TQ0211
1mg37,00€5mg88,00€1mL*10mM (DMSO)102,00€10mg152,00€25mg295,00€50mg477,00€100mg677,00€200mg888,00€Trilobatin
CAS:Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentiallyFormula:C21H24O10Purezza:97.16%Colore e forma:SolidPeso molecolare:436.41Ref: TM-T2S0731
1mg50,00€5mg99,00€1mL*10mM (DMSO)109,00€10mg141,00€25mg260,00€50mg385,00€100mg557,00€200mg790,00€Diroximel fumarate
CAS:Diroximel fumarate (Diroximel Fumarete), a prodrug of monomethyl fumarate in a controlled-release formulation, rapidly and potently converts to MMF in the body.Formula:C11H13NO6Purezza:99.8% - 99.88%Colore e forma:SolidPeso molecolare:255.22Ref: TM-T4271
2mg35,00€5mg55,00€1mL*10mM (DMSO)55,00€10mg80,00€25mg126,00€50mg187,00€100mg301,00€200mg425,00€CBR-470-1
CAS:CBR-470-1 is a glycolytic phosphoglycerate kinase 1 inhibitor and Nrf2 activator that exhibits neuroprotective activity by activating the Keap1-Nrf2 cascade.Formula:C14H20ClNO4S2Purezza:98.87%Colore e forma:SolidPeso molecolare:365.9Nrf2-Activator-12G
CAS:Nrf2-Activator-12G is a potent Nrf-2 activator.Formula:C15H13ClO3SPurezza:99.92%Colore e forma:White SolidPeso molecolare:308.78AI-3
CAS:Nrf2/Keap1 and Keap1/Cul3 interaction inhibitorFormula:C11H13ClO3S2Purezza:98%Colore e forma:SolidPeso molecolare:292.8
