CXCR
I CXCR sono una sottoclasse di GPCR che si legano alle chemochine, piccole proteine segnale che guidano il movimento delle cellule immunitarie verso i siti di infiammazione, infezione o lesione. I CXCR svolgono ruoli cruciali nelle risposte immunitarie, nella metastasi del cancro e nelle malattie infiammatorie. I modulatori dei CXCR sono studiati per il loro potenziale nel trattamento delle malattie autoimmuni, del cancro e delle condizioni infiammatorie croniche. Presso CymitQuimica, offriamo una gamma di modulatori di CXCR di alta qualità per supportare la tua ricerca in immunologia, oncologia e infiammazione.
Trovati 157 prodotti di "CXCR"
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Quetmolimab
CAS:<p>Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis.</p>Purezza:SDS-PAGE:95% SEC-HPLC:97.59%Colore e forma:LiquidPeso molecolare:150 kDaDelmetacin
CAS:<p>Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.</p>Formula:C18H15NO3Purezza:98.14%Colore e forma:SolidPeso molecolare:293.32VUF11207 fumarate
CAS:VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Formula:C31H39FN2O8Purezza:97.98%Colore e forma:SolidPeso molecolare:586.65Motixafortide TFA(664334-36-5,Free)
Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.Formula:C99H145F4N33O21S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:2273.54LY2510924 acetate(1088715-84-7 free base)
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.Formula:C64H91N13O13Purezza:97.32%Colore e forma:SolidPeso molecolare:1250.49AMG 487
CAS:AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Formula:C32H28F3N5O4Purezza:99.82% - 99.89%Colore e forma:SolidPeso molecolare:603.59Eldelumab
CAS:Eldelumab (BMS-936557) is an anti-IP-10 IgG 1 monoclonal antibody.Eldelumab has anti-inflammatory activity and is used to study rheumatoid arthritis.Purezza:95%Colore e forma:LiquidReparixin L-lysine salt
CAS:Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.Formula:C20H35N3O5SPurezza:99%Colore e forma:SolidPeso molecolare:429.57TC14012
CAS:CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).Formula:C90H140N34O19S2Purezza:98%Colore e forma:SolidPeso molecolare:2066.43ITIC-4F
CAS:ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.Formula:C94H78F4N4O2S4Purezza:98%Colore e forma:SolidPeso molecolare:1499.92ITIC
CAS:"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Formula:C94H82N4O2S4Purezza:98%Colore e forma:SolidPeso molecolare:1427.96CTCE-9908
CAS:CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.Formula:C86H147N27O23Purezza:98%Colore e forma:SolidPeso molecolare:1927.27PDE4D inhibitor 1
PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.Colore e forma:Odour SolidCXCR4 antagonist 2
CAS:CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.Formula:C25H36N6Colore e forma:SolidPeso molecolare:420.605PF-06835375
CAS:PF-06835375 is a humanized IgG1 antibody that selectively targets CXCR5 expressed on B cells, Tfh cells, and circulating Tfh-like cells (cTfh). It is applicable for research into systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).Colore e forma:LiquidCXCR7 modulator 1
CAS:CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.Formula:C48H57F2N7O7SPurezza:98%Colore e forma:SolidPeso molecolare:914.07VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Colore e forma:Odour SolidBam 12P
CAS:Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla.Formula:C62H97N21O16SPurezza:98%Colore e forma:SolidPeso molecolare:1424.64KRH-3955 hydrochloride
CAS:KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.Formula:C28H48Cl3N7Colore e forma:SolidPeso molecolare:589.09CXCR4 antagonist 1
CAS:CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.Formula:C27H43N7Colore e forma:SolidPeso molecolare:465.69Vimnerixin
CAS:Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.Formula:C19H25FN4O5S2Colore e forma:SolidPeso molecolare:472.55Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Formula:C90H141N33O18S2Colore e forma:SolidPeso molecolare:2037.42Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Formula:C39H59N13O8S2Colore e forma:SolidPeso molecolare:902.1ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Formula:C25H30N2OSColore e forma:SolidPeso molecolare:406.58CXCL-CXCR1/2-IN-1
CAS:<p>CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.</p>Formula:C14H8Cl2N4O3SPurezza:99.4%Colore e forma:SoildPeso molecolare:383.21CXCR2 Probe 1
CXCR2Probe 1 (Compound[18F]16b) is a selective ligand for CXCR2 and serves as a radioactive tracer for PET imaging of neutrophils in inflammatory diseases.Formula:C20H24FN3O4Peso molecolare:389.17508CCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Formula:C13H22N6OSPeso molecolare:310.15758CXCR4-IN-3
<p>CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).</p>CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Formula:C107H173N33O30Peso molecolare:2400.30261RCP168
<p>RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.</p>Formula:C365H585N105O95S5Peso molecolare:8119.27766BVT173187
CAS:BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.Formula:C14H10Cl3NO2Colore e forma:SolidPeso molecolare:330.59CX4338
CAS:CX4338 is a CXCL8-mediated chemotaxis inhibitor.Formula:C22H24N2OSColore e forma:SolidPeso molecolare:364.50NI-0801
<p>NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.</p>Purezza:97.9% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.4% (SEC-HPLC)Colore e forma:Odour LiquidCyclic MKEY
CAS:MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.Formula:C113H174N28O34S2Purezza:98%Colore e forma:SolidPeso molecolare:2532.89HuMax-IL8
HuMax-IL8 (MDX 018) is a humanized anti-IL-8 monoclonal antibody for the study of metastatic or unresectable solid tumors.Purezza:98.8% (SDS-PAGE); 97.4% (SEC-HPLC) - 98.8% (SDS-PAGE); 97.4% (SEC-HPLC)Colore e forma:Odour LiquidPeptide 78
CAS:Peptide 78 is identical to peptide 74 except that serine replaces cysteine. It does not inhibit 72-kDa type IV collagenase.Formula:C62H107N23O21SPurezza:98%Colore e forma:SolidPeso molecolare:1542.74ABX-IL8
ABX-IL8 is a humanized antibody targeting IL-8, capable of interfering with tube formation in human umbilical vein endothelial cells.Purezza:>95%Colore e forma:LiquidPeso molecolare:145.5 kDaPeptide R54
Peptide R54 (Pep R54; CXCR4 antagonist peptide 19) is an antagonistic polypeptide targeting CXCR4, known for its significant anticancer properties. It inhibits CXCR4-dependent cell migration, epithelial-mesenchymal transition, and the development of lung metastasis, offering better serum stability and higher CXCR4 affinity (IC50=20 nM) compared to the lead compound. Peptide R54 works synergistically with anti-PD-1 therapy to exhibit antitumor effects in vivo, enhancing granzyme activity and reducing Foxp3 cell infiltration. It is useful for research in colon cancer, ovarian cancer, and melanoma.Colore e forma:Odour SolidTC14012 TFA
TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .Formula:C92H141F3N34O21S2Purezza:96.31%Colore e forma:SolidPeso molecolare:2180.44Balixafortide TFA (1051366-32-5 free base)
Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.Formula:C82H113N22F3O23S2Purezza:98%Colore e forma:SolidPeso molecolare:1896.05vMIP-II (1-21) TFA
vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.Colore e forma:Odour SolidSDF-1α (human)
CAS:SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFormula:C356H578N106O93S4Purezza:98%Colore e forma:SolidPeso molecolare:7959.34E70K
E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuateFormula:C108H178N34O28Purezza:98%Colore e forma:SolidPeso molecolare:2400.784-Amino-D-phenylalanine
CAS:4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.Formula:C9H12N2O2Colore e forma:SolidPeso molecolare:180.2DOTA-CXCR4-L
<p>DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer</p>Formula:C58H78N16O14Purezza:98%Colore e forma:SolidPeso molecolare:1223.34Chemokine Inhibitor Library
<p>A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidVUF-11222
CAS:VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Formula:C25H31BrINPurezza:99.82%Colore e forma:SolidPeso molecolare:552.33LY2510924
CAS:LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).Formula:C62H88N14O10Colore e forma:SolidPeso molecolare:1189.45Peptide R TFA
<p>Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.</p>Formula:C39H57N13O8S2·xC2HF3O2Colore e forma:SolidPeso molecolare:900.08 (free base)PS372424 hydrochloride
CAS:PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.Formula:C33H45ClN6O4Purezza:95.03%Colore e forma:SolidPeso molecolare:625.2ACT-1004-1239
CAS:<p>ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.</p>Formula:C27H28F2N6O3Purezza:98.31%Colore e forma:SolidPeso molecolare:522.55Motixafortide
CAS:Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).Formula:C97H144FN33O19S2Purezza:98%Colore e forma:SolidPeso molecolare:2159.52CXCR2 antagonist 8
CAS:CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.Formula:C14H13N3O5Colore e forma:SolidPeso molecolare:303.27ATI-2341
CAS:ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.Formula:C104H178N26O25S2Colore e forma:SolidPeso molecolare:2256.82SRT3109
CAS:SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.Formula:C18H23F2N5O4S2Purezza:99.65% - 99.92%Colore e forma:SolidPeso molecolare:475.53WZ811
CAS:<p>WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).</p>Formula:C18H18N4Purezza:99.42% - ≥95%Colore e forma:SolidPeso molecolare:290.36UNBS5162
CAS:UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.Formula:C17H18N4O3Purezza:98.37% - 99.97%Colore e forma:SolidPeso molecolare:326.35AZD-5069
CAS:AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).Formula:C18H22F2N4O5S2Purezza:98.38% - 98.63%Colore e forma:SolidPeso molecolare:476.52ATI-2341 acetate(1337878-62-2 free base)
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13.Formula:C106H182N26O27S2Purezza:97.14%Colore e forma:SolidPeso molecolare:2316.87USL311
CAS:USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.Formula:C24H34N6OPurezza:98.46% - 99.56%Colore e forma:SolidPeso molecolare:422.57Baohuoside I
CAS:Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.Formula:C27H30O10Purezza:97.64% - 98.14%Colore e forma:SolidPeso molecolare:514.52SB225002
CAS:SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.Formula:C13H10BrN3O4Purezza:98.16% - 99.85%Colore e forma:SolidPeso molecolare:352.14Reparixin
CAS:Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.Formula:C14H21NO3SPurezza:98% - 99.89%Colore e forma:SolidPeso molecolare:283.39JMS-17-2 hydrochloride
CAS:JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.Formula:C25H27Cl2N3OColore e forma:SolidPeso molecolare:456.41MSX-130
CAS:MSX-130 is CXCR4 Antagonist.Formula:C36H26N4Purezza:99.19%Colore e forma:SolidPeso molecolare:514.62Mavorixafor trihydrochloride
CAS:Mavorixafor trihydrochloride blocks CXCR4 (IC50: 13 nM) and suppresses T-tropic HIV-1 replication (IC50: 1-9 nM). It's orally active.Formula:C21H30Cl3N5Purezza:98.00%Colore e forma:SolidPeso molecolare:458.86Elubrixin HCl
CAS:Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.Formula:C17H18Cl3FN4O4SColore e forma:SolidPeso molecolare:499.77NUCC-390 dihydrochloride
CAS:NUCC-390, a selective CXCR4 agonist, promotes nerve repair by inducing CXCR4 internalization, opposite to AMD3100.Formula:C23H35Cl2N5OColore e forma:SolidPeso molecolare:468.46Decursin
CAS:Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.Formula:C19H20O5Purezza:97.22% - 99.91%Colore e forma:SolidPeso molecolare:328.36Plerixafor
CAS:Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Formula:C28H54N8Purezza:99.17% - >99.99%Colore e forma:SolidPeso molecolare:502.78MSX-127
CAS:MSX-127 elicites positive response in peptide CXCR4.Formula:C16H24N2O4Purezza:98.43%Colore e forma:SolidPeso molecolare:308.37Navarixin
CAS:Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophilFormula:C21H23N3O5Purezza:98% - 99.51%Colore e forma:SolidPeso molecolare:397.42CTCE 9908 acetate
CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.Formula:C88H151N27O25Purezza:98.47%Colore e forma:SolidPeso molecolare:1987.31AMD-070 hydrochloride
CAS:AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.Formula:C21H28ClN5Purezza:98.38% - 98.57%Colore e forma:SolidPeso molecolare:385.93Alirocumab
CAS:Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.Purezza:95% - 97.1% (SDS-PAGE); 96.1% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:146.2 kDaJMS-17-2
CAS:JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).Formula:C25H26ClN3OPurezza:98.7% - 99.44%Colore e forma:SolidPeso molecolare:419.95FC131 TFA (606968-52-9 free base)
CAS:FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hivFormula:C38H48F3N11O8Purezza:99.39% - 99.67%Colore e forma:SolidPeso molecolare:843.85Danirixin
CAS:<p>Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).</p>Formula:C19H21ClFN3O4SPurezza:99.78% - >99.99%Colore e forma:SolidPeso molecolare:441.9Nicotinamide N-oxide
CAS:Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.Formula:C6H6N2O2Purezza:99.66% - 99.9%Colore e forma:SolidPeso molecolare:138.12Plerixafor octahydrochloride
CAS:Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.Formula:C28H62Cl8N8Purezza:98.01% - 99.79%Colore e forma:SolidPeso molecolare:794.46TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formula:C33H39ClN2O2Purezza:99.21%Colore e forma:SolidPeso molecolare:531.13AMD 3465 hexahydrobromide
CAS:AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.Formula:C24H44Br6N6Purezza:99.39%Colore e forma:SolidPeso molecolare:896.07MSX-122
CAS:MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Formula:C16H16N6Purezza:98.31% - 98.94%Colore e forma:SolidPeso molecolare:292.34SX-682
CAS:SX-682 is an orally available allosteric inhibitor of CXCR1 and CXCR2.Cost-effective and quality-assured.Formula:C19H14BF4N3O4SPurezza:98.19% - 99.61%Colore e forma:SolidPeso molecolare:467.2ML339
CAS:<p>ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.</p>Formula:C26H32ClN3O5Purezza:99.9%Colore e forma:SolidPeso molecolare:502SB-265610
CAS:<p>SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.</p>Formula:C14H9BrN6OPurezza:99.5%Colore e forma:SolidPeso molecolare:357.16ML 145
CAS:ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)Formula:C24H22N2O5S2Purezza:97.74%Colore e forma:SolidPeso molecolare:482.57ICT5040
CAS:ICT5040 is a CXCR4 antagonist.Formula:C10H8F3N3OSColore e forma:SolidPeso molecolare:275.25VUF10132
CAS:<p>VUF10132 is a full inverse CXCR3 N3.35A agonist.</p>Formula:C19H13BrCl4N2O2Purezza:98%Colore e forma:SolidPeso molecolare:523.03AMG 487 (S-enantiomer)
CAS:AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.Formula:C32H28F3N5O4Purezza:98%Colore e forma:SolidPeso molecolare:603.59HF50731
CAS:HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).Formula:C26H46N4Colore e forma:SolidPeso molecolare:414.67CXCR4 modulator-2
CAS:CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.Formula:C21H32N8O2Colore e forma:SolidPeso molecolare:428.53CXCR4 antagonist 9
CAS:CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.Formula:C21H27FN6Colore e forma:SolidPeso molecolare:382.48SB-332235
CAS:SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.Formula:C13H10Cl3N3O4SColore e forma:SolidPeso molecolare:410.66rac-NBI-74330
CAS:rac-NBI-74330 is an effective and selective CXCR3 antagonist.Formula:C32H27F4N5O3Purezza:99.6%Colore e forma:SolidPeso molecolare:605.58VUF11211
CAS:VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.Formula:C26H35Cl2N5OPurezza:98%Colore e forma:SolidPeso molecolare:504.49TN-14003
CAS:TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.Formula:C90H141N33O18S2Colore e forma:SolidPeso molecolare:2037.42CXCR4 antagonist 8
CAS:CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.Formula:C21H26N6Colore e forma:SolidPeso molecolare:362.47HF51116
CAS:HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.Formula:C29H46N8OColore e forma:SolidPeso molecolare:522.73SX-517
CAS:SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.Formula:C19H16BFN2O3SColore e forma:SolidPeso molecolare:382.22KRH-1636
CAS:KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.Formula:C32H37N7O2Colore e forma:SolidPeso molecolare:551.68IT1t
CAS:IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.Formula:C21H34N4S2Purezza:98%Colore e forma:SolidPeso molecolare:406.65SRT3190
CAS:SRT3190 is an antagonist of CXCR2.Formula:C18H23F2N5O4S2Purezza:98%Colore e forma:SolidPeso molecolare:475.53Burixafor hydrobromide
CAS:<p>Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.</p>Formula:C27H52BrN8O3PPurezza:98%Colore e forma:SolidPeso molecolare:647.644VUF5834
CAS:VUF5834 is a full inverse agonist of CXCR3 N3.35A.Formula:C31H41N5O2Purezza:98%Colore e forma:SolidPeso molecolare:515.69GSK812397
CAS:GSK812397 inhibits X4-tropic HIV-1 with high potency, targeting CXCR4 receptor noncompetitively and showing broad efficacy and good pharmacokinetics.Formula:C24H32N6OColore e forma:SolidPeso molecolare:420.55SCH 546738
CAS:SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.Formula:C23H31Cl2N7OPurezza:98.67%Colore e forma:SolidPeso molecolare:492.45PS372424
CAS:PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.Formula:C33H44N6O4Purezza:98%Colore e forma:SolidPeso molecolare:588.74AZ10397767
CAS:<p>AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.</p>Formula:C15H14ClFN4O2S2Colore e forma:SolidPeso molecolare:400.88AMD 3465
CAS:AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).Formula:C24H38N6Purezza:98%Colore e forma:SolidPeso molecolare:410.60GPR35 agonist 1
CAS:GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).Formula:C10H4BrN5O5Purezza:98%Colore e forma:SolidPeso molecolare:354.07SB02024
CAS:SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.Formula:C16H22F3N3O2Colore e forma:SolidPeso molecolare:345.36ACT-660602
CAS:ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.Formula:C20H20F6N8OSColore e forma:SolidPeso molecolare:534.48CXCR4 antagonist 5
CAS:CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.Formula:C21H30N6Colore e forma:SolidPeso molecolare:366.5CXCR3 Antagonist 6c
CAS:CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.Formula:C30H32Cl3N5O3Colore e forma:SolidPeso molecolare:616.97AZD8309
CAS:<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Formula:C15H14F2N4O2S2Purezza:98.35% - 99.67%Colore e forma:SolidPeso molecolare:384.42IT1t dihydrochloride
CAS:IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Formula:C21H36Cl2N4S2Purezza:99.91%Colore e forma:SolidPeso molecolare:479.57Elubrixin
CAS:<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Formula:C17H17Cl2FN4O4SPurezza:98.65% - 99.78%Colore e forma:SolidPeso molecolare:463.31Mavorixafor
CAS:<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Formula:C21H27N5Purezza:98.56%Colore e forma:SolidPeso molecolare:349.47AZD8797
CAS:AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.Formula:C19H25N5OS2Purezza:98.73% - 99.68%Colore e forma:SolidPeso molecolare:403.56NUCC-390
CAS:NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Formula:C23H33N5OPurezza:97.08%Colore e forma:SolidPeso molecolare:395.54Ladarixin Sodium
CAS:Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.Formula:C11H12F3NNaO6S2Colore e forma:SolidPeso molecolare:398.32AMD-3329 free base
CAS:AMD-3329 is a potent anti-HIV agent that blocks virus replication by targeting CXCR4, a key receptor for X4 viruses' entry.Formula:C34H50N8Colore e forma:SolidPeso molecolare:570.81Pentixafor
CAS:<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Formula:C60H80N14O14Purezza:98%Colore e forma:SolidPeso molecolare:1221.36CXCR2 antagonist 3
CAS:Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.Formula:C17H15FN2O4SColore e forma:SolidPeso molecolare:362.38AMD-3329 hydrobromide
CAS:AMD-3329 hydrobromide: strong, selective anti-HIV agent, blocks virus replication by targeting CXCR4 co-receptor.Formula:C34H58Br8N8Colore e forma:SolidPeso molecolare:1218.13CXCR2 antagonist 2
CAS:CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.Formula:C17H17FN2O4SColore e forma:SolidPeso molecolare:364.39(R,R)-CXCR2-IN-2
CAS:'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'Formula:C18H23ClN2O5SColore e forma:SolidPeso molecolare:414.9E6130
CAS:E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Formula:C28H37ClF3N3O3Colore e forma:SolidPeso molecolare:556.06CXCR4 antagonist 7
CAS:Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Formula:C15H17N5O3Colore e forma:SolidPeso molecolare:315.33(±)-AMG 487
AMG 487 is an effective and selective antagonist of chemokine receptor 3.Formula:C32H28F3N5O4Purezza:98%Colore e forma:SolidPeso molecolare:603.59AZD0233
CAS:AZD0233 is an orally-active CX3CR1 antagonist. AZD0233 can regulate the CX3CR1/CX3CL1 signaling axis, and has excellent physicochemical properties, metabolic stability, low toxicity and CYP inhibitory characteristics.Formula:C19H29FN6O4SPeso molecolare:456.54TIQ-15
CAS:TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.Formula:C23H32N4Purezza:98%Colore e forma:SolidPeso molecolare:364.53CXCR4 antagonist 6
CAS:CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.Formula:C21H30N6Colore e forma:SolidPeso molecolare:366.5CXCR2-IN-2
CAS:CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.Formula:C18H23ClN2O5SColore e forma:SolidPeso molecolare:414.9NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Formula:C23H35Cl2N5OPurezza:98%Colore e forma:SolidPeso molecolare:468.46CXCR2-IN-1
CAS:CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Formula:C19H20Cl2FN3O4SPurezza:99.89%Colore e forma:SolidPeso molecolare:476.35SCH 563705
CAS:SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formula:C23H27N3O5Purezza:98.03%Colore e forma:SolidPeso molecolare:425.48EMU-116
CAS:EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.Formula:C25H35N5Colore e forma:SolidPeso molecolare:405.58CXCR2 antagonist 7
CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.Formula:C14H14F2N6OSColore e forma:SolidPeso molecolare:352.36(R)-SCH 546738
CAS:(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formula:C23H31Cl2N7OColore e forma:SolidPeso molecolare:492.45ACT-672125
CAS:ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.Formula:C25H25F3N10O2SColore e forma:SolidPeso molecolare:586.59CXCR4 antagonist 10
CAS:CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Formula:C18H18N4O4Colore e forma:SolidPeso molecolare:354.36CXCR4 antagonist 3
CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.Formula:C22H31N5Colore e forma:SolidPeso molecolare:365.52CXCR4 modulator-1
CAS:CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Formula:C23H27N5O2Colore e forma:SolidPeso molecolare:405.49ACT-777991
CAS:ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Formula:C20H20F6N8O2SColore e forma:SolidPeso molecolare:550.48CXCR2 antagonist 6
CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).Formula:C17H16F2N4OSColore e forma:SolidPeso molecolare:362.4CXCR7 antagonist-1 hydrochloride
CAS:CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.Formula:C21H20ClFN6OColore e forma:SolidPeso molecolare:426.87Paeoniflorin-6′-O-benzene sulfonate
CAS:Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.Formula:C29H32O13SColore e forma:SolidPeso molecolare:620.622CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formula:C15H14F2N4O2SColore e forma:SolidPeso molecolare:352.36SLW131
CAS:SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formula:C21H27N5O5SColore e forma:SolidPeso molecolare:461.535CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Formula:C15H14F2N4OS2Colore e forma:SolidPeso molecolare:368.42CCX662
CAS:CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formula:C28H37N5O4SColore e forma:SolidPeso molecolare:539.69CXCR7 modulator 2
CAS:CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.Formula:C29H42N6O3Colore e forma:SolidPeso molecolare:522.68VUF11207 trifluoroacetate salt
CAS:VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.Formula:C29H36F4N2O6Colore e forma:SolidPeso molecolare:584.609CXCR4-IN-1
CAS:<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Formula:C23H32N6Purezza:98%Colore e forma:SolidPeso molecolare:392.54Ref: TM-T79059
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