TLR
I recettori Toll-like (TLR) sono una classe di proteine che svolgono un ruolo fondamentale nel sistema immunitario innato riconoscendo i pattern molecolari associati ai patogeni (PAMP) e iniziando risposte immunitarie. I TLR sono coinvolti nel rilevamento di un'ampia gamma di patogeni, tra cui batteri, virus e funghi, e sono essenziali per l'attivazione delle vie di segnalazione infiammatorie. La disregolazione della segnalazione dei TLR è associata a malattie infiammatorie croniche, disturbi autoimmuni e cancro. Presso CymitQuimica, offriamo una varietà di modulatori TLR di alta qualità per supportare la tua ricerca sull'immunità innata, l'infiammazione e le malattie infettive.
Trovati 76 prodotti di "TLR"
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IAXO-102
CAS:<p>IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.</p>Formula:C35H71NO5Purezza:98.17%Colore e forma:SolidPeso molecolare:585.94CU-CPT17e
CAS:CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Formula:C27H24N2O8Purezza:98.49%Colore e forma:SolidPeso molecolare:504.49TLR7/8 agonist 3
CAS:<p>TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.</p>Formula:C17H23N5OPurezza:99.84%Colore e forma:SolidPeso molecolare:313.4BMS-905
CAS:BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Formula:C23H29N3Purezza:99.94%Colore e forma:SoildPeso molecolare:347.5CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formula:C17H13F3N4O2Purezza:99.84%Colore e forma:SolidPeso molecolare:362.31CU-CPT22
CAS:CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Formula:C19H22O7Purezza:98.66% - 99.80%Colore e forma:SolidPeso molecolare:362.37ODN 4084-F
CAS:ODN 4084-F, a class B ('broadly-active') inhibitory ODN, is a potent inhibitor of TLR9-induced B cells and macrophages.Colore e forma:SolidL07-2
CAS:L07-2 (Compound 6) is an active scaffold that includes a TLR7/8 agonist. It is suitable for the synthesis of immune-stimulating antibody conjugates (ISACs) used in cancer research.Formula:C56H83N15O14Colore e forma:SolidPeso molecolare:1190.35Tilsotolimod sodium
CAS:Tilsotolimod sodium, a synthetic Toll-like receptor 9 (TLR9) agonist, has shown antitumor activity in preclinical models.Formula:C223H262N74Na22O115P22S22Colore e forma:SolidPeso molecolare:7711.51PVP-037.2
CAS:PVP-037.2 is a TLR7/8 agonist that acts as an adjuvant to enhance vaccine-induced TH1 immune responses and boost the production of antigen-specific antibodies IgG1 and IgG2c.Formula:C23H20F3N5OColore e forma:SoildPeso molecolare:439.43Ezeprogind
CAS:<p>Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can Trust</p>Formula:C25H44N6Purezza:99.28%Colore e forma:SolidPeso molecolare:428.66TLR7 agonist 17
CAS:TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Formula:C25H37N7O3Colore e forma:SolidPeso molecolare:483.61Pam3CSK4-Biotin
CAS:Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Formula:C103H192N14O17S2Purezza:98%Colore e forma:SolidPeso molecolare:1962.85Pam2CSK4
CAS:<p>TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.</p>Formula:C65H126N10O12SPurezza:98%Colore e forma:SolidPeso molecolare:1271.83MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA
MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA is the trifluoroacetate form of MC-Val-Cit-PAB-Amide-TLR7 agonist 4,a HER2-TLR7 and HER2- TLR8 immune agonist complexes.Formula:C54H73F3N12O13Purezza:99.67%Colore e forma:SolidPeso molecolare:1155.22RKH acetate
RKH acetate offers protective effects against mortality and organ damage caused by sepsis. It can directly bind to Toll-like receptor 4 (TLR4) and inhibit TLR4 signaling in immune cells.Formula:C18H33N9O4·xC2H4O2CRX 527
CAS:CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.Formula:C81H151N2O19PColore e forma:SolidPeso molecolare:1488.04MTvkPABC-P5 TFA
<p>MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).</p>Colore e forma:Odour SolidTLR7/8 agonist 12
<p>TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.</p>Formula:C29H38N6O3Colore e forma:SolidPeso molecolare:518.65TLR7 agonist 24
TLR7 agonist24 (Compound 21) is an agonist of TLR7 with an EC50 of 3.72 μM. When combined with Aluminum Hydroxide, it can be employed as a vaccine adjuvant to enhance the immune response to antigens from SARS-CoV-2 and hepatitis B.Colore e forma:Odour SolidRKH
PKH is a TLR4 antagonist, and it is a new tripeptide derived from Akkermansia muciniphila. PKH reduces inflammation-related cell activation and the overproduction of pro-inflammatory factors induced by sepsis.Formula:C18H33N9O4Peso molecolare:439.26555IPH33
IPH33 is a human monoclonal antibody (mAb) targeting TLR3/CD283. It is useful for research in cancer and inflammation.Colore e forma:Odour LiquidTomaralimab
CAS:<p>Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).</p>Purezza:100% (SEC-HPLC) - > 95%Colore e forma:LiquidPeso molecolare:145.32 kDaCU-115
CAS:<p>CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.</p>Formula:C21H11F7INO2Purezza:99.96%Colore e forma:SolidPeso molecolare:569.21TLR8 agonist 8
CAS:<p>TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.</p>Formula:C53H63N11O10Colore e forma:SolidPeso molecolare:1014.14TLR8 agonist 7
CAS:<p>TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.</p>Formula:C54H63N9O16Colore e forma:SolidPeso molecolare:1094.13(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 serves as the E3 ubiquitin ligase ligand and linker for PROTAC(R)-NX-2127, utilized in cancer research.Formula:C29H33N5O4Colore e forma:SolidPeso molecolare:515.6Toll-like receptor modulator
CAS:Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.Formula:C15H13F5N2O2Purezza:98%Colore e forma:SolidPeso molecolare:348.27TLR7 agonist 3
CAS:<p>TLR7 agonist 3 is a Toll-like receptor 7 (TLR7) agonist that has anticancer activity and is used in the study of diseases of the immune system.</p>Formula:C18H24N4OPurezza:99.27%Colore e forma:SolidPeso molecolare:312.41Neoseptin-3
CAS:Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.Formula:C29H34N2O4Purezza:98%Colore e forma:SolidPeso molecolare:474.59Desethyl chloroquine diphosphate
CAS:Desethyl chloroquine diphosphate is the active metabolite of Desethylchloroquine, an inhibitor of TLRs with antiplasmodial activity and inhibition of autophagy.Formula:C16H28ClN3O8P2Purezza:99.72%Colore e forma:SolidPeso molecolare:487.81Pam3CSK4
CAS:Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.Formula:C81H156N10O13SPurezza:98%Colore e forma:SolidPeso molecolare:1510.23Pam3CSK4 TFA (112208-00-1 free base)
CAS:<p>Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.Cost-effective and quality-assured.</p>Formula:C87H159F9N10O19SPurezza:96.4% - 99.01%Colore e forma:SolidPeso molecolare:1852.33TLR7 agonist 2
CAS:<p>TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).</p>Formula:C17H16N6O2Purezza:99.33%Colore e forma:SolidPeso molecolare:336.35TLR7/8 agonist 1
CAS:<p>TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.</p>Formula:C22H25N5Purezza:99.4%Colore e forma:SolidPeso molecolare:359.47Telratolimod
CAS:<p>Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.</p>Formula:C36H59N5O2Purezza:98.61%Colore e forma:SolidPeso molecolare:593.89Enpatoran
CAS:<p>Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).</p>Formula:C16H15F3N4Purezza:97.08% - 99.38%Colore e forma:SolidPeso molecolare:320.31Gardiquimod
CAS:<p>Gardiquimod, an imidazoquinoline TLR7 agonist, inhibits HIV-1 in macrophages and PBMCs under 10μM.</p>Formula:C17H23N5OPurezza:98.02% - 99.68%Colore e forma:SolidPeso molecolare:313.4CU-CPT-8m
CAS:CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)Formula:C14H12N4OPurezza:99.00%Colore e forma:SolidPeso molecolare:252.27SM-324405
CAS:SM-324405 is an agonist of TLR7.Formula:C19H23N5O4Purezza:97.83%Colore e forma:SolidPeso molecolare:385.42CU-CPT9b
CAS:<p>CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).</p>Formula:C16H13NO2Purezza:98.1%Colore e forma:SolidPeso molecolare:251.28MD2-IN-1
CAS:MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).Formula:C20H22O6Purezza:99.87%Colore e forma:SolidPeso molecolare:358.39C29
CAS:C29 inhibits TLR2/1 and TLR2/6 in human cells, but only TLR2/1 in mouse macrophages.Formula:C16H15NO4Purezza:96.34% - 97.37%Colore e forma:SolidPeso molecolare:285.29TLR3-IN-1
CAS:<p>TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the TNF-α and IL-1β.</p>Formula:C18H13ClFNO3SPurezza:98.56%Colore e forma:SolidPeso molecolare:377.82CU-CPT-9a
CAS:<p>CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-</p>Formula:C17H15NO2Purezza:99.01%Colore e forma:SolidPeso molecolare:265.31TLR7/8/9-IN-1
CAS:TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.Formula:C27H37N3O2Purezza:99.56%Colore e forma:SolidPeso molecolare:435.6TLR4-IN-C34
CAS:<p>TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis</p>Formula:C17H27NO9Purezza:99.69%Colore e forma:SolidPeso molecolare:389.4Bropirimine
CAS:Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.Formula:C10H8BrN3OPurezza:99.01%Colore e forma:SolidPeso molecolare:266.091V209
CAS:<p>1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.</p>Formula:C16H17N5O5Purezza:99.61%Colore e forma:SolidPeso molecolare:359.34TH1020
CAS:TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.Formula:C23H15N7S2Purezza:99.23%Colore e forma:SolidPeso molecolare:453.54
