TGF-beta/Smad
Gli inibitori del percorso TGF-beta/Smad sono composti che interferiscono con la via di segnalazione TGF-beta (Transforming Growth Factor-beta), mediata dalle proteine Smad. Questa via è coinvolta nella regolazione della crescita cellulare, della differenziazione, dell'apoptosi e della funzione delle cellule staminali. La disfunzione della segnalazione TGF-beta/Smad è associata al cancro, alla fibrosi e ad altre malattie. Gli inibitori di questa via sono strumenti importanti per studiare queste condizioni e sviluppare potenziali terapie. Presso CymitQuimica, forniamo inibitori di TGF-beta/Smad per supportare la tua ricerca nella segnalazione cellulare, in oncologia e nella riparazione dei tessuti.
Trovati 50 prodotti di "TGF-beta/Smad"
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Hydrochlorothiazide
CAS:Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。Formula:C7H8ClN3O4S2Purezza:99.43% - 99.50%Colore e forma:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Peso molecolare:297.74Ponsegromab
CAS:Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.Purezza:100% (SEC-HPLC) - > 95%Colore e forma:LiquidPeso molecolare:146.08 kDaIsoviolanthin
CAS:Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.Formula:C27H30O14Purezza:99.25% - 99.66%Colore e forma:SolidPeso molecolare:578.52Ref: TM-T13741
1mg87,00€5mg177,00€10mg334,00€25mg552,00€50mgPrezzo su richiesta1mL*10mM (DMSO)254,00€Oxymatrine
CAS:Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.Formula:C15H24N2O2Purezza:98.72% - 99.72%Colore e forma:SolidPeso molecolare:264.36Tubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Formula:C21H22N2O2Purezza:98.23%Colore e forma:SolidPeso molecolare:334.41TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Formula:C27H32N6O2Colore e forma:SolidPeso molecolare:472.582Fresolimumab
CAS:Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.Purezza:> 95% - > 95%Colore e forma:LiquidPeso molecolare:144.4 kDaDisitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Formula:C70H113N17O24S2Purezza:95.11%Colore e forma:SoildPeso molecolare:1640.88P17 Peptide
CAS:P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Formula:C95H139N27O21Colore e forma:SolidPeso molecolare:1995.29ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Formula:C20H23N7O2SColore e forma:SolidPeso molecolare:425.51SLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:SLLK is a control peptide for LSKL.
Formula:C21H41N5O6Purezza:98%Colore e forma:SolidPeso molecolare:459.58Prafnosbart
CAS:Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized inColore e forma:LiquidLSKL TFA
CAS:LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.Formula:C23H43F3N6O7Purezza:99.33%Colore e forma:SolidPeso molecolare:572.62Asiaticoside
CAS:Asiaticoside, in Centella asiatica, may treat wounds/burns.Formula:C48H78O19Purezza:98% - 99.96%Colore e forma:PowderPeso molecolare:959.12Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Formula:C22H19N5OPurezza:97.09% - 99.98%Colore e forma:SolidPeso molecolare:369.42Ref: TM-T2510
1g657,00€5mg46,00€10mg52,00€25mg84,00€50mg114,00€100mg178,00€200mg269,00€500mg442,00€1mL*10mM (DMSO)52,00€ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Formula:C27H29NO3Purezza:99.89% - >99.99%Colore e forma:SolidPeso molecolare:415.52Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Formula:C20H15NO3Purezza:96.25% - 97.79%Colore e forma:SolidPeso molecolare:317.34R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Formula:C20H18FN5OPurezza:99.61%Colore e forma:SolidPeso molecolare:363.39Ref: TM-T16708
1mg44,00€5mg93,00€10mg130,00€25mg250,00€50mg378,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)92,00€LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Formula:C25H44F6N6O9Purezza:99.75%Colore e forma:SolidPeso molecolare:686.64Ref: TM-T7676
2mg42,00€5mg54,00€10mg84,00€25mg138,00€50mg207,00€100mg316,00€200mg442,00€1mL*10mM (DMSO)93,00€BMP signaling agonist sb4
CAS:BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Formula:C14H10BrNOSPurezza:99.48% - 99.805%Colore e forma:SolidPeso molecolare:320.2Ref: TM-T7799
5mg44,00€10mg57,00€25mg94,00€50mg119,00€100mg177,00€200mg268,00€500mg465,00€1mL*10mM (DMSO)48,00€
