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TGF-beta/Smad

TGF-beta/Smad

Gli inibitori del percorso TGF-beta/Smad sono composti che interferiscono con la via di segnalazione TGF-beta (Transforming Growth Factor-beta), mediata dalle proteine Smad. Questa via è coinvolta nella regolazione della crescita cellulare, della differenziazione, dell'apoptosi e della funzione delle cellule staminali. La disfunzione della segnalazione TGF-beta/Smad è associata al cancro, alla fibrosi e ad altre malattie. Gli inibitori di questa via sono strumenti importanti per studiare queste condizioni e sviluppare potenziali terapie. Presso CymitQuimica, forniamo inibitori di TGF-beta/Smad per supportare la tua ricerca nella segnalazione cellulare, in oncologia e nella riparazione dei tessuti.

Trovati 60 prodotti di "TGF-beta/Smad"

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  • Asiaticoside
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    Asiaticoside

    CAS:
    Asiaticoside, in Centella asiatica, may treat wounds/burns.
    Formula:C48H78O19
    Purezza:98% - 99.96%
    Colore e forma:Powder
    Peso molecolare:959.12

    Ref: TM-T3025

  • Chebulinic acid
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    Chebulinic acid

    CAS:
    Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
    Formula:C41H32O27
    Purezza:98.91% - 99.71%
    Colore e forma:Solid
    Peso molecolare:956.68

    Ref: TM-TQ0184

  • (E)-SIS3
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    (E)-SIS3

    CAS:
    (E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!
    Formula:C28H27N3O3·HCl
    Purezza:95.64% - 98%
    Colore e forma:Solid
    Peso molecolare:489.99

    Ref: TM-T3636

  • R-268712
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    R-268712

    CAS:
    R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.
    Formula:C20H18FN5O
    Purezza:99.61%
    Colore e forma:Solid
    Peso molecolare:363.39

    Ref: TM-T16708

  • SJ000291942
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    SJ000291942

    CAS:
    SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
    Formula:C16H15FN2O4
    Purezza:99.66%
    Colore e forma:Solid
    Peso molecolare:318.3

    Ref: TM-T4662

  • LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
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    LSKL, Inhibitor of Thrombospondin TSP-1 2TFA

    LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .
    Formula:C25H44F6N6O9
    Purezza:99.75%
    Colore e forma:Solid
    Peso molecolare:686.64

    Ref: TM-T7676

  • Kartogenin
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    Kartogenin

    CAS:
    Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
    Formula:C20H15NO3
    Purezza:96.25% - 97.79%
    Colore e forma:Solid
    Peso molecolare:317.34

    Ref: TM-T1748

  • ITD-1
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    ITD-1

    CAS:
    ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
    Formula:C27H29NO3
    Purezza:99.89% - >99.99%
    Colore e forma:Solid
    Peso molecolare:415.52

    Ref: TM-T2273

  • Galunisertib
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    Galunisertib

    CAS:
    Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.
    Formula:C22H19N5O
    Purezza:97.09% - 99.98%
    Colore e forma:Solid
    Peso molecolare:369.42

    Ref: TM-T2510

  • Alantolactone
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    Alantolactone

    CAS:
    Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.
    Formula:C15H20O2
    Purezza:99.02% - 99.66%
    Colore e forma:Crystalline Powder
    Peso molecolare:232.32

    Ref: TM-T2896

  • BMP signaling agonist sb4
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    BMP signaling agonist sb4

    CAS:
    BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)
    Formula:C14H10BrNOS
    Purezza:99.48% - 99.805%
    Colore e forma:Solid
    Peso molecolare:320.2

    Ref: TM-T7799

  • BMS986260
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    BMS986260

    CAS:
    BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
    Formula:C18H12ClFN6O
    Purezza:97.67%
    Colore e forma:Solid
    Peso molecolare:382.78

    Ref: TM-T8730

  • BIO-013077-01
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    BIO-013077-01

    CAS:
    BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.
    Formula:C17H13N5
    Purezza:99.87%
    Colore e forma:Solid
    Peso molecolare:287.32

    Ref: TM-T8330

  • Trimethylamine N-oxide dihydrate
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    Trimethylamine N-oxide dihydrate

    CAS:
    TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.
    Formula:C3H13NO3
    Purezza:98.75%
    Colore e forma:White Crystal
    Peso molecolare:111.14

    Ref: TM-T5247

  • LY3200882
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    LY3200882

    CAS:
    LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
    Formula:C24H29N5O3
    Purezza:99.46% - 99.63%
    Colore e forma:Solid
    Peso molecolare:435.52

    Ref: TM-T5125

  • SRI-011381
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    SRI-011381

    CAS:
    SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
    Formula:C20H31N3O
    Purezza:98.64%
    Colore e forma:Solid
    Peso molecolare:329.48

    Ref: TM-T4283

  • Logo CymitQuimica
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    Trevogrumab

    CAS:
    Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).
    Purezza:95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)
    Colore e forma:Liquid

    Ref: TM-T80951

  • Logo CymitQuimica
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    Ginisortamab

    CAS:
    Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, IC50=8.2 nM and 9 nM against human and mouse Gremlin-1, respectively.
    Purezza:95% - 96.0% (SDS-PAGE); 97.0% (SEC-HPLC)
    Colore e forma:Liquid

    Ref: TM-T78320

  • Logo CymitQuimica
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    Nisevokitug

    CAS:
    Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.
    Purezza:95%
    Colore e forma:Liquid

    Ref: TM-T80562

  • Logo CymitQuimica
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    Metelimumab

    CAS:
    Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).
    Purezza:95%
    Colore e forma:Liquid

    Ref: TM-T76819