TGF-beta/Smad
Gli inibitori del percorso TGF-beta/Smad sono composti che interferiscono con la via di segnalazione TGF-beta (Transforming Growth Factor-beta), mediata dalle proteine Smad. Questa via è coinvolta nella regolazione della crescita cellulare, della differenziazione, dell'apoptosi e della funzione delle cellule staminali. La disfunzione della segnalazione TGF-beta/Smad è associata al cancro, alla fibrosi e ad altre malattie. Gli inibitori di questa via sono strumenti importanti per studiare queste condizioni e sviluppare potenziali terapie. Presso CymitQuimica, forniamo inibitori di TGF-beta/Smad per supportare la tua ricerca nella segnalazione cellulare, in oncologia e nella riparazione dei tessuti.
Trovati 60 prodotti di "TGF-beta/Smad"
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Oxymatrine
CAS:Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.Formula:C15H24N2O2Purezza:98.72% - 99.72%Colore e forma:SolidPeso molecolare:264.36Garetosmab
CAS:Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.Purezza:> 95% - > 95%Colore e forma:LiquidPeso molecolare:145.52 kDaIsoviolanthin
CAS:Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.Formula:C27H30O14Purezza:99.25% - 99.66%Colore e forma:SolidPeso molecolare:578.52Ref: TM-T13741
1mg92,00€5mg187,00€10mg354,00€25mg582,00€50mgPrezzo su richiesta1mL*10mM (DMSO)268,00€Ponsegromab
CAS:Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.Purezza:100% (SEC-HPLC) - > 95%Colore e forma:LiquidPeso molecolare:146.08 kDaHydrochlorothiazide
CAS:Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。Formula:C7H8ClN3O4S2Purezza:99.43% - 99.50%Colore e forma:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Peso molecolare:297.74Rilogrotug
CAS:Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Formula:C20H23N7O2SColore e forma:SolidPeso molecolare:425.51Prafnosbart
CAS:Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized inColore e forma:LiquidCirevetmab
CAS:Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.Colore e forma:LiquidFresolimumab
CAS:Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.Purezza:> 95% - > 95%Colore e forma:LiquidPeso molecolare:144.4 kDaLerdelimumab
CAS:Lerdelimumab (CAT-152) is an IgG4 monoclonal antibody targeting TGF-β2, used in glaucoma scarring research.Colore e forma:LiquidTubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Formula:C21H22N2O2Purezza:98.23%Colore e forma:SolidPeso molecolare:334.41Sotatercept
CAS:Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.Purezza:97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Colore e forma:LiquidEmugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidSLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:<p>SLLK is a control peptide for LSKL.</p>Formula:C21H41N5O6Purezza:98%Colore e forma:SolidPeso molecolare:459.58Linavonkibart
CAS:Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.Purezza:97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Colore e forma:LiquidTGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Formula:C27H32N6O2Colore e forma:SolidPeso molecolare:472.582Bintrafusp alfa
CAS:Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.Purezza:96.1% (SDS-PAGE); 99.2% (SEC-HPLC) - 96.1% (SDS-PAGE); 99.2% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:177.25 kDaGalunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Formula:C22H19N5OPurezza:97.09% - 99.98%Colore e forma:SolidPeso molecolare:369.42Ref: TM-T2510
1g692,00€5mg48,00€10mg55,00€25mg88,00€50mg120,00€100mg188,00€200mg284,00€500mg467,00€1mL*10mM (DMSO)50,00€ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Formula:C27H29NO3Purezza:99.89% - >99.99%Colore e forma:SolidPeso molecolare:415.52
