STAT
Le proteine STAT sono componenti critici della via di segnalazione JAK/STAT, che trasmette segnali extracellulari da citochine e fattori di crescita al nucleo cellulare, influenzando l'espressione genica. Le proteine STAT sono coinvolte nella regolazione delle risposte immunitarie, della crescita cellulare, della differenziazione e della sopravvivenza. La disregolazione della segnalazione STAT è implicata in varie malattie, tra cui cancro, disturbi autoimmuni e infiammazione cronica. Presso CymitQuimica, offriamo una gamma completa di modulatori della via STAT per supportare la tua ricerca sulla trasduzione del segnale, immunologia e sviluppo terapeutico.
Trovati 98 prodotti di "STAT"
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STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Formula:C22H30F3NO7Colore e forma:SolidPeso molecolare:477.471STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Formula:C19H16N2O4SColore e forma:SolidPeso molecolare:368.41STX-0119
CAS:<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Formula:C22H14N4O3Purezza:99.61%Colore e forma:SolidPeso molecolare:382.37Neocucurbitacin A
CAS:<p>Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].</p>Formula:C31H42O8Purezza:98%Colore e forma:SolidPeso molecolare:542.66STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Formula:C25H27N5OColore e forma:SolidPeso molecolare:413.51MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formula:C15H12N2O2Purezza:99.74%Colore e forma:SolidPeso molecolare:252.27Balsalazide
CAS:Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Formula:C17H15N3O6Purezza:99.31%Colore e forma:Yellow To Orange Crystalline PowderPeso molecolare:357.32Stafib-1
CAS:Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Formula:C26H24N2O11P2Purezza:97.18%Colore e forma:SolidPeso molecolare:602.42C188-9
CAS:C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.Formula:C27H21NO5SPurezza:98.07% - >99.99%Colore e forma:SolidPeso molecolare:471.52AS1517499
CAS:AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!Formula:C20H20ClN5O2Purezza:98.27% - 99.3%Colore e forma:SolidPeso molecolare:397.86Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Formula:C15H12O5Purezza:99.42% - 99.82%Colore e forma:SolidPeso molecolare:272.25Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formula:C15H18O2Purezza:97.55% - 99.92%Colore e forma:SolidPeso molecolare:230.3Picroside I
CAS:Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.Formula:C24H28O11Purezza:99.70%Colore e forma:SolidPeso molecolare:492.47RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formula:C14H5F6N5OPurezza:98% - 98.85%Colore e forma:SolidPeso molecolare:373.211-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
CAS:<p>SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.</p>Formula:C21H13ClF3N3O2Purezza:99.41%Colore e forma:SolidPeso molecolare:431.8Saikosaponin D
CAS:Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.Formula:C42H68O13Purezza:98.34% - 99.73%Colore e forma:White PowderPeso molecolare:780.98HJC0152 hydrochloride
CAS:HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.Formula:C15H14Cl3N3O4Purezza:99.01% - 99.06%Colore e forma:SolidPeso molecolare:406.64AS1810722
CAS:AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.Formula:C25H25F2N7OPurezza:99.13%Colore e forma:SolidPeso molecolare:477.51TPCA-1
CAS:<p>TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases</p>Formula:C12H10FN3O2SPurezza:95.03% - 97.86%Colore e forma:SolidPeso molecolare:279.29ML116
CAS:ML116 is a potent and selective STAT3 inhibitor.Formula:C18H19N3SPurezza:99.49%Colore e forma:SolidPeso molecolare:309.43
