Pim
Le chinasi Pim sono una famiglia di chinasi serina/treonina che svolgono un ruolo chiave nella sopravvivenza cellulare, nella proliferazione e nell'apoptosi. Queste chinasi sono effettori a valle nella via di segnalazione JAK/STAT e sono coinvolte in vari processi fisiologici, comprese le risposte immunitarie e l'ematopoiesi. La sovraespressione delle chinasi Pim è stata associata allo sviluppo del cancro, rendendole importanti bersagli per l'intervento terapeutico. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori delle chinasi Pim di alta qualità per supportare la tua ricerca in oncologia, biologia cellulare e trasduzione del segnale.
Trovati 35 prodotti per "Pim".
Filtra per
Percentuale di purezza
0
100
|
0
|
50
|
90
|
95
|
100
- Prezzo più basso
- Prezzo più alto
- Purezza più bassa
- Purezza più alta
- Consegna più veloce
Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Formula:C14H17N3O3Purezza:99.92%Colore e forma:SolidPeso molecolare:275.3Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Formula:C26H29F3N5O7PPurezza:99.75% - 99.79%Colore e forma:SolidPeso molecolare:611.51Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Colore e forma:Odour SolidPim-1 kinase-IN-15
Pim-1 kinase-IN-15 (Compound 15) is a highly potent and selective inhibitor of Pim-1 kinase, with an IC50 value of 0.212 μM. This compound is capable of inducing apoptosis in tumor cells and inhibiting cell migration, making it a promising candidate for oncology research, including breast cancer studies.R8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Formula:C111H211N59O26SPurezza:98%Colore e forma:SolidPeso molecolare:2820.33PIM3-IN-1 hydrochloride
PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of PIM2/3 kinases, showing the strongest inhibition against PIM3 with an IC50 in the nanomolar range. PIM3-IN-1 hydrochloride is applicable in cancer research.Formula:C23H23Cl2N5Peso molecolare:439.13305Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formula:C11H9NO3SPurezza:99.78%Colore e forma:SolidPeso molecolare:235.2596-Methyl-1H-Indole-2-Carboxylic Acid
CAS:6-Methyl-1H-Indole-2-Carboxylic Acid is a PIM-1 inhibitor (IC₅₀ = 63.6 µM) and can be used in biochemical research.Formula:C10H9NO2Purezza:99.93%Peso molecolare:175.184TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Formula:C22H25F3N4OPurezza:99.8% - 99.95%Colore e forma:SolidPeso molecolare:418.4553Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Formula:C20H13N5OPurezza:97.03% - 98.69%Colore e forma:White SolidPeso molecolare:339.3501SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurezza:99.3% - >99.99%Colore e forma:SolidPeso molecolare:405.4168HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Formula:C14H11NO2Purezza:98.92%Colore e forma:SolidPeso molecolare:225.2426AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Formula:C21H21N3O2SPurezza:97.24% - 99.83%Colore e forma:Yellow SolidPeso molecolare:379.475(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Formula:C11H6F3NO2SPurezza:97.66% - 99.93%Colore e forma:White SolidPeso molecolare:273.231Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Formula:C15H10O8Purezza:99.65% - 99.91%Colore e forma:SolidPeso molecolare:318.2351TCS-PIM-1-4a
CAS:SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formula:C11H6F3NO2SPurezza:98.82% - 99.89%Colore e forma:White SolidPeso molecolare:273.231TCS PIM-1 1
CAS:TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Formula:C18H11BrN2O2Purezza:97% - 97.98%Colore e forma:SolidPeso molecolare:367.2Hispidulin
CAS:Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Formula:C16H12O6Purezza:98.53% - 99.87%Colore e forma:SolidPeso molecolare:300.26SMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formula:C13H13NO3SPurezza:99.99%Colore e forma:White SolidPeso molecolare:263.312CX-6258 hydrochloride
CAS:CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).Formula:C26H25Cl2N3O3Purezza:96.03% - 98.60%Colore e forma:SolidPeso molecolare:498.401
