JAK
Gli inibitori della Janus chinasi (JAK) sono composti che prendono di mira la via di segnalazione JAK-STAT, coinvolta nella crescita cellulare, nella risposta immunitaria e nell'angiogenesi. Inibendo JAK, questi composti possono ridurre la segnalazione che porta alla formazione di nuovi vasi sanguigni nei tumori, inibendo così la crescita tumorale. Gli inibitori di JAK sono importanti nel trattamento del cancro e delle malattie infiammatorie. Presso CymitQuimica, offriamo una vasta gamma di inibitori di JAK di alta qualità per supportare la tua ricerca in oncologia, immunologia e angiogenesi.
Trovati 246 prodotti di "JAK"
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Ruxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formula:C17H18N6Purezza:99.37% - 99.79%Colore e forma:SolidPeso molecolare:306.36G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purezza:97.3%Colore e forma:SolidPeso molecolare:383.39WP1066
CAS:<p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>Formula:C17H14BrN3OPurezza:98.92% - 99.73%Colore e forma:SolidPeso molecolare:356.22Ruxolitinib phosphate
CAS:<p>Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.</p>Formula:C17H21N6O4PPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:404.36Oclacitinib maleate
CAS:Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.Formula:C15H23N5O2S·C4H4O4Purezza:99.17% - 99.92%Colore e forma:SolidPeso molecolare:453.51Gandotinib
CAS:LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formula:C23H25ClFN7OPurezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:469.94Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formula:C27H36N6O3SPurezza:97.31% - 99.96%Colore e forma:SolidPeso molecolare:524.68Deucravacitinib
CAS:Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formula:C20H19D3N8O3Purezza:98.52% - >99.99%Colore e forma:SolidPeso molecolare:425.46TG101209
CAS:<p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>Formula:C26H35N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:509.67Pacritinib hydrochloride
CAS:Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.Formula:C28H32N4O3·xClHColore e forma:SolidXL019
CAS:XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.Formula:C25H28N6O2Purezza:99.19%Colore e forma:SolidPeso molecolare:444.53BD750
CAS:BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormula:C14H13N3OSPurezza:99.02%Colore e forma:SolidPeso molecolare:271.34Baricitinib phosphate
CAS:Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Formula:C16H20N7O6PSPurezza:99.4% - 99.91%Colore e forma:SolidPeso molecolare:469.41FM-381
CAS:FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Formula:C24H24N6O2Purezza:98.44%Colore e forma:SolidPeso molecolare:428.49Cucurbitacin I
CAS:<p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>Formula:C30H42O7Purezza:96.69% - 99.8%Colore e forma:SolidPeso molecolare:514.65Gusacitinib HCl
CAS:<p>Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.</p>Formula:C24H29ClN8O2Colore e forma:SolidPeso molecolare:497BMS-911543
CAS:BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.Formula:C23H28N8OPurezza:97.69% - 99.98%Colore e forma:SolidPeso molecolare:432.52GDC-0214
CAS:GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Formula:C28H28ClF2N9O3Purezza:99.75%Colore e forma:SolidPeso molecolare:612.03Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formula:C15H18O2Purezza:97.55% - 99.92%Colore e forma:SolidPeso molecolare:230.3SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formula:C15H8Cl2FN3OPurezza:99.56%Colore e forma:SolidPeso molecolare:336.15
