CAS 1092939-17-7

Jakafi

Descrizione:

Jakafi, conosciuto genericamente come ruxolitinib, è un inibitore selettivo delle chinasi Janus (JAK1 e JAK2) ed è utilizzato principalmente nel trattamento di alcune neoplasie mieloproliferative, come la policitemia vera e la mielofibrosi. Funziona modulando la risposta immunitaria e riducendo l'infiammazione inibendo le vie di segnalazione di varie citochine. Il ruxolitinib viene somministrato per via orale ed è caratterizzato dalla sua capacità di migliorare i sintomi correlati a queste condizioni, come la splenomegalia e i sintomi costituzionali. La sostanza ha una formula molecolare che riflette la sua struttura complessa, che include un nucleo di pirrolo[2,3-d]pirimidina. La sua farmacocinetica indica una biodisponibilità moderata, con il metabolismo che avviene principalmente nel fegato tramite le enzimi del citocromo P450. Gli effetti collaterali comuni possono includere anemia, trombocitopenia e un aumento del rischio di infezioni a causa delle sue proprietà immunosoppressive. In generale, Jakafi rappresenta un significativo progresso nelle terapie mirate per i disturbi ematologici.

Formula: C₁₇H₁₈N₆·H₃PO₄

InChI: InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1

InChI key: InChIKey=JFMWPOCYMYGEDM-XFULWGLBSA-N

SMILES: [C@H](CC#N)(N1C=C(C2=C3C(=NC=N2)NC=C3)C=N1)C4CCCC4.P(=O)(O)(O)O

Sinonimi:

• (Betar)-Beta-Cyclopentyl-4-(7H-Pyrrolo(2,3-D)Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile
• 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, phosphate (1:1)
• INC 424 phosphate
• INCB 018424 phosphate
• Incb-018424
• Jakafi
• Jakavi
• R-Incb018424
• R-Ruxolitinib
• Ruxolitinib (INCB 018424)
• Ruxolitinib phosphate
• Ruxolitinib phosphate salt
• INC424
• INCB018424;INCB-018424;INCB 018424
• (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate
• Ruxolitinib phosphate(INCB018424)
• Beta-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(Betar)-1H-pyrazole-1-propanenitrile, phosphate
• (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
• INCB018424 PHOSPHATE;INCB 018424 PHOSPHATE;INCB-018424 PHOSPHATE;RUXOLITINIB
• phosphenoperoxoic acid compound with (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile and dihydrogen (1:1:1)
• (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosph
• Ruxolitinib (INCB-18424) phosphate
• Ruxolitinib Phosphate (INC-424, INCB-18424, INCB-018424, Jakafi and Jakavi)
• (R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate
• INCB018424 (phosphate)
• Ruxolitinib phosphate ISO 9001：2015 REACH
• (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate
• Jakafi (ruxolitinib)
• INCB 018424(Ruxolitinib Phosphate)
• RUXOLITINIB(INCB018424) PHOSPHATE
• Ruxotinib phosphate
• 10-dimethoxyptercarpan
• (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphoric acid
• Ruxolitinib phosphate, >=98%
• (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazole-1-propanenitrile Phosphate

(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

CAS: 1092939-17-7

(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

Formula: C₁₇H₁₈N₆·H₃PO₄

Purezza: 98%

Peso molecolare: 404.3602

Ref: 54-OR302722

Ruxolitinib Phosphate Salt

CAS: 1092939-17-7

Ruxolitinib Phosphate Salt

Formula: C₁₇H₁₈N₆·H₃PO₄

Purezza: >99%

Colore e forma: White Solid

Peso molecolare: 404.3602

Ref: 54-BIFK0028

Ruxolitinib Phosphate

CAS: 1092939-17-7

Formula: C₁₇H₁₈N₆·H₃O₄P

Colore e forma: White To Off-White Solid

Peso molecolare: 306.37 97.99

Ref: 4Z-R-093001

Ruxolitinib phosphate

CAS: 1092939-17-7

Ruxolitinib phosphate

Formula: C₁₇H₂₁N₆O₄P

Purezza: ≥98%

Colore e forma: Solid

Peso molecolare: 404.36

Ref: 54-BUP17785

Ruxolitinib . phosphate salt

CAS: 1092939-17-7

Ref: 7W-GW4048

Ruxolitinib phosphate

CAS: 1092939-17-7

Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.

Formula: C₁₇H₂₁N₆O₄P

Purezza: 98% - >99.99%

Colore e forma: White Solid

Peso molecolare: 404.36

Ref: TM-T3043

Ruxolitinib Phosphate

CAS: 1092939-17-7

Formula: C₁₇H₁₈N₆H₃O₄P

Peso molecolare: 306.37 : 97.99

Ref: ST-EA-CP-R53020

Ruxolitinib Phosphate

Prodotto controllato

CAS: 1092939-17-7

Applications The phosphate salt of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.
References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);

Formula: C₁₇H₁₈N₆·H₃O₄P

Colore e forma: Neat

Peso molecolare: 404.36

Ref: TR-R702005

Ruxolitinib phosphate

CAS: 1092939-17-7

(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

Formula: C₁₇H₂₁N₆O₄P

Purezza: 98%

Peso molecolare: 404.36

Ref: IN-DG243856

Ruxolitinib phosphate

CAS: 1092939-17-7

Purezza: 99%

Peso molecolare: 404.367

Ref: 10-F979379

Ruxolitinib phosphate

Prodotto controllato

CAS: 1092939-17-7

Ruxolitinib is a janus tyrosine kinase inhibitor active specifically on sub-types JAK1 and JAK2 with IC50 values in the nanomolar range. JAK1 and JAK2 are kinases involved in the regulation of hematopoiesis. Clinically applied to the treatment of intermediate and high-risk myelofibrosis, ruxolitinib is usually well tolerated by patients.

Formula: C₁₇H₁₈N₆•H₃O₄P

Purezza: Min. 95%

Peso molecolare: 404.36 g/mol

Ref: 3D-FR167906