MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 893 prodotti di "MAPK"
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Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Formula:C24H24F3N5O5S3Purezza:99.45% - 99.82%Colore e forma:SolidPeso molecolare:615.67APS-2-79 hydrochloride
CAS:APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.Formula:C23H21N3O3·HClPurezza:98.64% - 99.55%Colore e forma:SolidPeso molecolare:423.89ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Formula:C19H19N9O2Purezza:99.92%Colore e forma:SolidPeso molecolare:405.41PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Formula:C17H14ClF2N3O3SPurezza:97.78% - 99.83%Colore e forma:SolidPeso molecolare:413.83Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Formula:C22H27ClFN7O4SPurezza:99.51% - 99.83%Colore e forma:SolidPeso molecolare:540.01(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Formula:C30H30F2N6O3Purezza:99.05% - 99.76%Colore e forma:SolidPeso molecolare:560.594Necrosulfonamide
CAS:<p>Necrosulfonamide ((E)-Necrosulfonamide) is a necroptosis inhibitor that targets MLKL and is selective. High-Quality, Low-Cost!</p>Formula:C18H15N5O6S2Purezza:98.85% - 99.49%Colore e forma:SolidPeso molecolare:461.47SLV-2436
CAS:SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).Formula:C19H15ClN4OPurezza:98.56%Colore e forma:SolidPeso molecolare:350.8NG25
CAS:NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.Formula:C29H30F3N5O2Purezza:98.32% - ≥95%Colore e forma:SolidPeso molecolare:537.58ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Formula:C40H48F3N7O4Purezza:99.71%Colore e forma:SolidPeso molecolare:747.85Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purezza:99.42% - 99.65%Colore e forma:SolidPeso molecolare:801.01ERK5-IN-2
CAS:<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Formula:C17H11BrFN3O2Purezza:99.01%Colore e forma:SolidPeso molecolare:388.19Skepinone-L
CAS:<p>Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.</p>Formula:C24H21F2NO4Purezza:99.56% - >99.99%Colore e forma:SolidPeso molecolare:425.42BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Formula:C28H33F2N7O2SPurezza:97.33% - 99.07%Colore e forma:SolidPeso molecolare:569.67UM-164
CAS:<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Formula:C30H31F3N8O3SPurezza:98.72% - 99.52%Colore e forma:SolidPeso molecolare:640.68ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Formula:C21H31N5O2Purezza:99.56%Colore e forma:SolidPeso molecolare:385.5BI-D1870
CAS:BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.Cost-effective and quality-assured.Formula:C19H23F2N5O2Purezza:98.51% - 99.43%Colore e forma:SolidPeso molecolare:391.42SGX-523
CAS:<p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>Formula:C18H13N7SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:359.41Pimasertib
CAS:<p>Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Formula:C15H15FIN3O3Purezza:98.25% - 99.57%Colore e forma:SolidPeso molecolare:431.2PF-4708671
CAS:<p>PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 is potent for S6K1(Ki50=20 nM, IC50=160 nM).</p>Formula:C19H21F3N6Purezza:99.48% - 99.67%Colore e forma:SolidPeso molecolare:390.41GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Formula:C23H21ClN2O3Purezza:99.73%Colore e forma:SolidPeso molecolare:408.87APS6-45
CAS:<p>APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.</p>Formula:C23H16F8N4O3Purezza:99.39%Colore e forma:SolidPeso molecolare:548.39Cerdulatinib hydrochloride
CAS:<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Formula:C20H28ClN7O3SPurezza:99.85%Colore e forma:SolidPeso molecolare:482Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formula:C26H19ClN8Purezza:99.91%Colore e forma:SolidPeso molecolare:478.94GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Formula:C23H20N2O3Purezza:99.75%Colore e forma:SolidPeso molecolare:372.42ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Formula:C14H17ClN2O3SPurezza:98.92% - 99.84%Colore e forma:SolidPeso molecolare:328.814Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFormula:C21H23Cl3N4O2Purezza:99.85%Colore e forma:SolidPeso molecolare:469.79TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formula:C27H23F2N7O3Purezza:99.58%Colore e forma:SolidPeso molecolare:531.51NCB-0846
CAS:NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Formula:C21H21N5O2Purezza:97.04% - 99.89%Colore e forma:SolidPeso molecolare:375.42VX-702
CAS:<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Formula:C19H12F4N4O2Purezza:99% - >99.99%Colore e forma:SolidPeso molecolare:404.32AZD0022
CAS:AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.Formula:C34H30F4N6OPurezza:98.73%Colore e forma:SoildPeso molecolare:614.64Trametiglue
CAS:Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.Formula:C25H24FIN6O5SColore e forma:SolidPeso molecolare:666.46AMG410
CAS:AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,Formula:C31H32ClF2N7O5Purezza:98.01% - 99.84%Colore e forma:SoildPeso molecolare:656.08ASK1-IN-6
CAS:ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp,uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.Formula:C17H14F4N6O2Peso molecolare:410.33FMK
CAS:<p>FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。</p>Formula:C18H19FN4O2Purezza:99.71%Colore e forma:SolidPeso molecolare:342.37ETC-168
CAS:ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].Formula:C24H19N5O2Colore e forma:SolidPeso molecolare:409.44Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Formula:C40H37N5OPurezza:99.4%Colore e forma:SolidPeso molecolare:603.756H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Formula:C20H30ClN3O2S3Purezza:98%Colore e forma:SolidPeso molecolare:476.12SC-68376
CAS:SC-68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase.Formula:C15H12N2OPurezza:98%Colore e forma:SolidPeso molecolare:236.27Cephradine monohydrate
CAS:<p>Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.</p>Formula:C16H21N3O5SPurezza:99.91%Colore e forma:SolidPeso molecolare:367.42PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Formula:C24H22F2N6O3SPurezza:99.51% - 99.66%Colore e forma:SolidPeso molecolare:512.53Cot inhibitor-2
CAS:Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.Formula:C26H25Cl2FN8Purezza:99.85%Colore e forma:SolidPeso molecolare:539.43Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Formula:C20H17FO2SPurezza:99.35%Colore e forma:SolidPeso molecolare:340.41(R)-PD 0325901CL
CAS:<p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>Formula:C16H14ClF2IN2O4Colore e forma:SolidPeso molecolare:498.65BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Formula:C22H18F2N4O3SPurezza:98.2% - 98.41%Colore e forma:SolidPeso molecolare:456.47ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Formula:C29H32ClN5O4Purezza:98.81%Colore e forma:SolidPeso molecolare:550.05PF-05381941
CAS:PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.Formula:C27H26N6O2Purezza:98.04%Colore e forma:SolidPeso molecolare:466.53MEK-IN-1
CAS:MEK-IN-1 is a MEK inhibitor.Formula:C24H20N4O4Purezza:98%Colore e forma:SolidPeso molecolare:428.44PAF (C16)
CAS:<p>PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.</p>Formula:C26H54NO7PPurezza:98%Colore e forma:SolidPeso molecolare:523.68B-Raf IN 13
CAS:<p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>Formula:C19H19ClFN3O4SPurezza:99.41% - >99.99%Colore e forma:SoildPeso molecolare:439.89KRAS G12D inhibitor 10
CAS:KRAS G12D inhibitor 10 targets KRAS G12D in cancer research (WO2021108683A1, compound 34).Formula:C33H41ClN8O2Colore e forma:SolidPeso molecolare:617.18GGTI-286
CAS:GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.Formula:C23H31N3O3SColore e forma:SolidPeso molecolare:429.58MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Formula:C33H36N2O3Purezza:97.23%Colore e forma:OilPeso molecolare:508.65KYA1797
CAS:KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.Formula:C17H12N2O6S2Purezza:98%Colore e forma:SolidPeso molecolare:404.42RSK2-IN-2
CAS:<p>RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].</p>Formula:C16H11N5OColore e forma:SolidPeso molecolare:289.29GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFormula:C18H24O4Purezza:98%Colore e forma:SolidPeso molecolare:304.38B-Raf IN 8
CAS:<p>B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast & prostate cancer with IC50s from 9.78 to 29.85 μM.</p>Formula:C18H17N3O2Colore e forma:SolidPeso molecolare:307.35HPK1-IN-24
CAS:<p>HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].</p>Formula:C19H14FN5Colore e forma:SolidPeso molecolare:331.35UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Formula:C25H22ClNO2Colore e forma:SolidPeso molecolare:403.9JNK3 inhibitor-2
CAS:<p>JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.</p>Formula:C20H14N2O2Colore e forma:SolidPeso molecolare:314.34Tpl2 Kinase Inhibitor 1
CAS:Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.Formula:C21H14ClFN6Purezza:98%Colore e forma:SolidPeso molecolare:404.83SX 011
CAS:SX 011 is a p38α inhibitor.Formula:C26H27ClFN3O3Purezza:98%Colore e forma:SolidPeso molecolare:483.96KRAS inhibitor-7
CAS:<p>KRAS inhibitor-7 is a potent KRAS G12C inhibitor.</p>Formula:C26H27ClF2N6O2Purezza:98%Colore e forma:SolidPeso molecolare:528.98HPK1-IN-25
CAS:HPK1-IN-25, an HPK1 inhibitor, IC50 129 nM, may aid cancer research.Formula:C23H25N5OColore e forma:SolidPeso molecolare:387.48KRAS G12C inhibitor 43
CAS:<p>KRAS G12C inhibitor 43 strongly blocks KRAS G12C, H358 cell growth (IC50: 0.001-1μM), less effective on A549, HCC cells (IC50>1μM).</p>Formula:C33H35N7O3Colore e forma:SolidPeso molecolare:577.68GGTI-286 hydrochloride
CAS:GGTI-286 HCl strongly inhibits GGTase I (IC50: 2 μM) and K-Ras4B farnesylation (IC50: 1 μM).Formula:C23H32ClN3O3SColore e forma:SolidPeso molecolare:466.04SMAP-2
CAS:SMAP-2: oral PP2A activator, targets Aα subunit, halts KRAS-mutant lung cancer growth.Formula:C27H27F3N2O4SPurezza:98%Colore e forma:SolidPeso molecolare:532.57HPK1-IN-26
CAS:HPK1-IN-26, from WO2021254118A1, is a potent dual HPK1/GLK inhibitor for studying animal infections.Formula:C19H21N5OSColore e forma:SolidPeso molecolare:367.47ZINC09659342
CAS:<p>ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).</p>Formula:C23H15F3N2O4Colore e forma:SolidPeso molecolare:440.37NSC-658497
CAS:NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.Formula:C20H10N2O6S2Purezza:98%Colore e forma:SolidPeso molecolare:438.43SR 3576
CAS:JNK3 inhibitor, potent and selectiveFormula:C27H27N5O5Purezza:98%Colore e forma:SolidPeso molecolare:501.53CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Formula:C22H17Cl2FN4O2Colore e forma:SolidPeso molecolare:459.3KRAS G12C inhibitor 22
CAS:KRAS G12C inhibitor 22 is a KRAS G12C inhibitor.Formula:C32H41N7O2Colore e forma:SolidPeso molecolare:555.71Quazinone
CAS:Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.Formula:C11H10ClN3OColore e forma:SolidPeso molecolare:235.67SB-747651A
CAS:SB-747651A: ATP-competitive MSK1 inhibitor (IC50=11nM), affects N-terminal domain, also hinders MSK2, PKA, PKB, RSK, p70S6K.Formula:C16H22N8OPurezza:98%Colore e forma:SolidPeso molecolare:342.4EO 1428
CAS:p38α and p38β2 inhibitorFormula:C20H16BrClN2OPurezza:98%Colore e forma:SolidPeso molecolare:415.71PD 334581
CAS:MEK1 inhibitorFormula:C20H19F3IN5O2Purezza:98%Colore e forma:SolidPeso molecolare:545.3p38α inhibitor 2
CAS:P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.Formula:C27H33N5O3Colore e forma:SolidPeso molecolare:475.58pan-KRAS-IN-16
CAS:3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.Formula:C24H26N2O3Purezza:98%Colore e forma:SolidPeso molecolare:390.47B-Raf IN 6
CAS:B-Raf IN 6: potent B-Raf kinase inhibitor, IC50 of 1.7 nM, doesn't target PXR, metabolically stable, potential in cancer research.Formula:C24H21F3N6O2S2Colore e forma:SolidPeso molecolare:546.59(R)-CE3F4
CAS:(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),Formula:C11H10Br2FNOColore e forma:SolidPeso molecolare:351.01SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Formula:C29H25FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:512.53TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFormula:C17H15F3N2O4Colore e forma:SolidPeso molecolare:368.31B-Raf IN 7
CAS:"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."Formula:C15H16N6O3Colore e forma:SolidPeso molecolare:328.33KB-5246
CAS:KB-5246, displays antibacterial activities.is a tetracyclic quinolone.Formula:C18H17ClFN3O4SPurezza:98%Colore e forma:SolidPeso molecolare:425.86KRas G12C inhibitor 4
CAS:KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Formula:C33H38ClN7O2Purezza:98%Colore e forma:SolidPeso molecolare:600.15Avutometinib potassium
CAS:Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.Formula:C21H17FKN5O5SColore e forma:SolidPeso molecolare:509.553,4-Dephostatin
CAS:3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.Formula:C7H8N2O3Colore e forma:SolidPeso molecolare:168.15ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Formula:C24H23Cl2FN4O2Colore e forma:SolidPeso molecolare:489.37Ras modulator-1
CAS:Ras modulator-1 is a modulator of Ras.Formula:C29H21N5O4SColore e forma:SolidPeso molecolare:535.57KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Formula:C32H36ClN7O2Purezza:98%Colore e forma:SolidPeso molecolare:586.13MW108
CAS:MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.Formula:C21H19ClN4Colore e forma:SolidPeso molecolare:362.86(S)-CCG-1423
(S)-CCG-1423, a stereoisomer, inhibits Rho to block myocardin-related transcription factor A & serum response signaling.Formula:C18H13ClF6N2O3Purezza:98%Colore e forma:SolidPeso molecolare:454.8K-Ras G12C-IN-3
CAS:K-Ras G12C-IN-3: novel, irreversible inhibitor of K-Ras G12C mutant protein for cancer treatment.Formula:C21H19Cl3N2O3Colore e forma:SolidPeso molecolare:453.75ML 3403
CAS:p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β & TNF-α release in PBMC assay; IC50: 0.039μM & 0.16μM.Formula:C23H21FN4SColore e forma:SolidPeso molecolare:404.5CCG-232601
CAS:CCG-232601 is a inhibitor of the Rho/MRTF/SRF transcriptional pathway.Formula:C24H20ClF2N3O2Purezza:98%Colore e forma:SolidPeso molecolare:455.88Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Formula:C19H19ClF2N4O3SColore e forma:SolidPeso molecolare:456.89PHT-7.3
CAS:PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitorFormula:C24H23N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:433.52BRAF V600E/CRAF-IN-1
CAS:BRAF V600E/CRAF-IN-1: potent BRAF/CRAF inhibitor, induces cell cycle arrest and apoptosis in HCT-116 cells, promising for cancer research.Formula:C25H17F6N3O2Colore e forma:SolidPeso molecolare:505.41KRAS inhibitor-6
CAS:KRAS inhibitor-6 is a potent KRAS G12C inhibitor.Formula:C27H30ClF2N5O3Purezza:98%Colore e forma:SolidPeso molecolare:546.01(R)-STU104
CAS:(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.Formula:C18H18O4Purezza:98.91% - 99.42%Colore e forma:SolidPeso molecolare:298.33REDX05358
CAS:REDX05358: Selective pan RAF inhibitor for BRAF/RAS mutant tumors with high affinity, safety, and low paradoxical activation.Formula:C26H21ClN4O3Colore e forma:SolidPeso molecolare:472.92KRAS inhibitor-3
CAS:KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.Formula:C25H27N5OColore e forma:SolidPeso molecolare:413.51Spiclomazine HCl
CAS:Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.Formula:C22H25Cl2N3OS2Colore e forma:SolidPeso molecolare:482.49PF-04880594
CAS:PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].Formula:C19H16F2N8Colore e forma:SolidPeso molecolare:394.38KRAS G12C inhibitor 48
KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.Formula:C36H39ClN8O2Colore e forma:SolidPeso molecolare:651.2KRAS G12C inhibitor 31
CAS:KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.Formula:C25H22ClFN6O3Colore e forma:SolidPeso molecolare:508.93L-167307
CAS:L-167307 is a p38 kinase inhibitor.Formula:C22H17FN2OSPurezza:98%Colore e forma:SolidPeso molecolare:376.45KRAS4b-IN-D14
CAS:KRAS4b-IN-D14 inhibits oncogenic KRAS4b, shrinks tumors, and induces cancer cell apoptosis.Formula:C24H24ClN5O4Colore e forma:SolidPeso molecolare:481.93HPK1-IN-15
CAS:HPK1-IN-15 selectively inhibits HPK1, a MAP4K family kinase, potentially aiding in cancer treatment.Formula:C24H21ClF3N5Colore e forma:SolidPeso molecolare:471.91KRAS G12D inhibitor 13
CAS:KRAS G12D inhibitor 13 targets KRAS G12D-mediated cancers with potency (WO2021108683A1, cmpd 142).Formula:C31H33F2N7O3Colore e forma:SolidPeso molecolare:589.64KRAS G12C inhibitor 42
CAS:KRAS G12C inhibitor 42 targets KRAS G12C for potential cancer therapy. (Patent WO2020146613A1, compound 10)Formula:C33H34FN7O2Colore e forma:SolidPeso molecolare:579.67p38-α MAPK-IN-4
CAS:p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM.Formula:C17H13BrN2OColore e forma:SolidPeso molecolare:341.2LCRF-0004
CAS:LCRF-0004 inhibits RON kinase, key in KRAS-driven pancreatic cancer, reducing cell migration and enhancing chemo sensitivity.Formula:C28H18F4N6O2SColore e forma:SolidPeso molecolare:578.54KRAS G12C inhibitor 39
CAS:KRAS G12C inhibitor 39 effectively targets KRAS G12C, a key protein in cancer research.Formula:C37H43N9O2Colore e forma:SolidPeso molecolare:645.8CBS-3595
CAS:CBS-3595: potent p38α MAPK/PDE-4 dual inhibitor, strong anti-inflammatory, low toxicity.Formula:C18H17FN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:372.42GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Formula:C26H21F3N4OColore e forma:SolidPeso molecolare:462.47JNK-1-IN-1
CAS:JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Formula:C24H22N6SColore e forma:SolidPeso molecolare:426.54ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Formula:C22H18Cl2N4O2S2Colore e forma:SolidPeso molecolare:505.44JX 401
CAS:JX 401 is a p38α inhibitor.Formula:C21H25NO2SPurezza:98%Colore e forma:SolidPeso molecolare:355.49SB 204900
CAS:SB 204900 inhibit the release of histamine and TNF-α from RBL-2H3 cells.Formula:C18H17NO2Colore e forma:SolidPeso molecolare:279.33HPK1-IN-29
CAS:"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."Formula:C26H18F3N5O2Colore e forma:SolidPeso molecolare:489.45DDO3711
CAS:"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."Formula:C42H41N9O6Colore e forma:SolidPeso molecolare:767.83KRAS G12C inhibitor 29
CAS:KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.Formula:C23H21ClFN5O2Colore e forma:SolidPeso molecolare:453.98-CPT-2Me-cAMP, sodium salt
CAS:8-CPT-2Me-cAMP sodium activates Epac GEFS, targets Rap1/2, has 2.2 μM EC50 for Epac1, doesn't activate PKA, and prompts Ca2+ release in β-cells.Formula:C17H16ClN5NaO6PSColore e forma:SolidPeso molecolare:507.82SCH-53870
CAS:SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.Formula:C18H18N2O4SColore e forma:SolidPeso molecolare:358.41KRAS inhibitor-16
CAS:KRAS inhibitor-16 blocks KRAS G12C and p-ERK in cancer cells; potential for pancreatic, colorectal, lung cancer treatment. IC50: 0.457 μM.Formula:C20H16Cl2FN3O2SColore e forma:SolidPeso molecolare:452.33SOS1-IN-12
CAS:SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).Formula:C23H26F3N5Colore e forma:SolidPeso molecolare:429.48MTBT
CAS:MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.Formula:C14H11NO2S2Colore e forma:SolidPeso molecolare:289.37ARS-2102
CAS:ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .Formula:C28H31ClF2N6O2Colore e forma:SolidPeso molecolare:557.03ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Formula:C16H11Cl2FN4O2Colore e forma:SolidPeso molecolare:381.19KRAS inhibitor-15
CAS:KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).Formula:C20H17Cl2FN4OSColore e forma:SolidPeso molecolare:451.34(S)-p38 MAPK Inhibitor III
CAS:(S)-p38 MAPK inhibitor III: a cell-permeable, methylsulfanylimidazole; IC50s: 0.90 µM for p38 MAPK, 0.37 µM TNF-α, 0.044 µM IL-1β.Formula:C23H21FN4SColore e forma:SolidPeso molecolare:404.5RAS inhibitor Abd-7
CAS:Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.Formula:C23H25N3O3Colore e forma:SolidPeso molecolare:391.46RAF-IN-1
CAS:RAF-IN-1: strong b/cRAF inhibitor; cRAF IC50=3.8 nM; bRAFwt IC50=36 nM; bRAFV600E IC50=29.4 nM; A375/H358 bRAFV600E GI50=3.4/2.9 nM.Formula:C26H22F3N3O4Colore e forma:SolidPeso molecolare:497.47KRAS inhibitor-4
CAS:KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.Formula:C30H39ClN8OPurezza:98%Colore e forma:SolidPeso molecolare:563.14Anti-inflammatory agent 33
CAS:Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.Formula:C22H15N3O5SColore e forma:SolidPeso molecolare:433.44RSK2-IN-3
CAS:<p>RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.</p>Formula:C24H26N4O5Colore e forma:SolidPeso molecolare:450.49MLKL-IN-5
CAS:MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .Formula:C18H20N6O4SColore e forma:SolidPeso molecolare:416.45HPK1-IN-28
CAS:HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.Formula:C25H22F3N5O4Colore e forma:SolidPeso molecolare:513.47JTP-70902
CAS:<p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>Formula:C24H21BrFN5O5SColore e forma:SolidPeso molecolare:590.42Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Formula:C26H28BrF3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:565.43p38 MAP Kinase Inhibitor IV
CAS:p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.Formula:C12H4Cl6O4SColore e forma:SolidPeso molecolare:456.94KRAS inhibitor-10
CAS:KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.Formula:C30H37N3O5Colore e forma:SolidPeso molecolare:519.63KRAS G12C inhibitor 45
CAS:KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .Formula:C32H33F2N5O5SColore e forma:SolidPeso molecolare:637.7JNK3 inhibitor-4
CAS:<p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>Formula:C28H27N7OColore e forma:SolidPeso molecolare:477.56HPK1-IN-17
CAS:HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.Formula:C26H28N6OColore e forma:SolidPeso molecolare:440.54KRAS inhibitor-17
CAS:KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.Formula:C21H18Cl2FN3O2SColore e forma:SolidPeso molecolare:466.36BRAF V600E/CRAF-IN-2
CAS:Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.Formula:C30H30F3N5O2Colore e forma:SolidPeso molecolare:549.59KRAS4b-PDEδ stabilizer C19
CAS:KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis viaFormula:C18H20Cl2N2O3Colore e forma:SolidPeso molecolare:383.27SCH 51344
CAS:SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].Formula:C16H20N4O3Colore e forma:SolidPeso molecolare:316.36LX-3
CAS:LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.Formula:C20H13BrN4OSColore e forma:SolidPeso molecolare:437.31KRAS G12C inhibitor 47
CAS:KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.Formula:C30H28ClFN4O3Colore e forma:SolidPeso molecolare:547.02SOS1-IN-3
CAS:<p>SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.</p>Formula:C21H21F3N4OColore e forma:SolidPeso molecolare:402.41SOS1 activator 1
CAS:<p>SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).</p>Formula:C26H32ClFN6Colore e forma:SolidPeso molecolare:483.026-T-GDP
CAS:<p>6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.</p>Formula:C10H15N5O10P2SColore e forma:SolidPeso molecolare:459.27GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Formula:C19H18N4O2Purezza:99.62%Colore e forma:SolidPeso molecolare:334.37Tpl2-IN-I
CAS:Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.Formula:C21H14ClFN6Purezza:98%Colore e forma:SolidPeso molecolare:404.83NSC1011
CAS:NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).Formula:C23H18N2O3Purezza:98%Colore e forma:SolidPeso molecolare:370.4AZD6703 free base
CAS:AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).Formula:C24H27N5O2Colore e forma:SolidPeso molecolare:417.5Kobe2601
CAS:Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.Formula:C13H10FN5O4SPurezza:98%Colore e forma:SolidPeso molecolare:351.31GSK329
CAS:GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.Formula:C19H14Cl2F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:472.25HCI-2184
CAS:HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.Formula:C23H28ClN7O2SPurezza:98%Colore e forma:SolidPeso molecolare:502.03GSK649A
CAS:GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Formula:C15H12ClFN6OSPurezza:98%Colore e forma:SolidPeso molecolare:378.81CP-281384
CAS:CP-281384 is a potent, p38alpha-selective inhibitor.Formula:C18H14F2N4OPurezza:98%Colore e forma:SolidPeso molecolare:340.33RBC6
CAS:RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.Formula:C16H14Cl2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:365.21CP-944629
CAS:CP-944629 is a novel, potent, and selective inhibitor of p38alpha.Formula:C19H15F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:372.34BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Formula:C16H14N2O3Purezza:98%Colore e forma:SolidPeso molecolare:282.29(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Formula:C18H16N6S2Colore e forma:SolidPeso molecolare:380.49Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formula:C25H26N8OPurezza:98.31%Colore e forma:SolidPeso molecolare:454.53PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Formula:C14H22BO4PColore e forma:SolidPeso molecolare:296.11D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Formula:C17H15N5OSColore e forma:SolidPeso molecolare:337.4SW-034538
CAS:SW-034538 is a TAO2 inhibitor (IC 50= 300 nM).Formula:C18H20N4O3S2Colore e forma:SolidPeso molecolare:404.51BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formula:C15H12ClN5OPurezza:98.09%Colore e forma:SolidPeso molecolare:313.74Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Formula:C13H10BrNOColore e forma:SolidPeso molecolare:276.13CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Formula:C17H12FN3O2Purezza:99.31%Colore e forma:SolidPeso molecolare:309.29BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Formula:C19H13F4IN4O4SColore e forma:SolidPeso molecolare:596.29SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formula:C28H26N8OPurezza:99.38% - 99.71%Colore e forma:SolidPeso molecolare:490.56GNE-1858
CAS:GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).Formula:C21H26F2N8Purezza:99.36%Colore e forma:SolidPeso molecolare:428.48Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Formula:C18H18N2O4Colore e forma:SolidPeso molecolare:326.35J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formula:C17H9ClFN3O2SPurezza:99.90%Colore e forma:SolidPeso molecolare:373.79TAK1/MAP4K2 inhibitor 1
CAS:TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.Formula:C29H31F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:552.59RMM-46
CAS:<p>RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.</p>Formula:C24H26N4O5Purezza:98.89%Colore e forma:SolidPeso molecolare:450.49LY-2584702 hydrochloride
CAS:<p>Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.</p>Formula:C21H20ClF4N7Purezza:98%Colore e forma:SolidPeso molecolare:481.88MEK inhibitor
CAS:MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.Formula:C26H26N4O2Purezza:97.48%Colore e forma:SolidPeso molecolare:426.51NSC-70220
CAS:SOS1-IN-1 is an inhibitor of SOS1.Formula:C22H15NO2Purezza:98%Colore e forma:SolidPeso molecolare:325.36MNK1/2-IN-5
CAS:MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.Formula:C17H16N4O2Purezza:98.04%Colore e forma:SolidPeso molecolare:308.33MEK-IN-4
CAS:<p>MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.</p>Formula:C21H18N4OSPurezza:98.35% - 99.16%Colore e forma:SolidPeso molecolare:374.46Nek2-IN-5
CAS:Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).Formula:C15H12N6OPurezza:98.11%Colore e forma:SolidPeso molecolare:292.3mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Formula:C93H150N20O25Purezza:99.26%Colore e forma:SolidPeso molecolare:1948.31BI-2852
CAS:BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.Formula:C31H28N6O2Purezza:98.98%Colore e forma:SolidPeso molecolare:516.59RMC-0331
CAS:RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.Formula:C22H25ClF3N5O3Purezza:97.84%Colore e forma:SolidPeso molecolare:499.91ZINC12409120
CAS:ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23Formula:C20H16N4O2Purezza:99.71% - 99.95%Colore e forma:SolidPeso molecolare:344.37JNK-IN-11
CAS:JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Formula:C12H11NO3S2Purezza:98.82%Colore e forma:SolidPeso molecolare:281.35MKK7-COV-9
CAS:MKK7-COV-9 is an MKK7 inhibitor that inhibits MKK7-induced protein-protein interactions and interrupts the activation of primary B cells in response to LPS.Formula:C18H16N4O2Purezza:99.73% - 99.83%Colore e forma:SolidPeso molecolare:320.35UR13870
CAS:<p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>Formula:C24H16F2N4Purezza:99.18% - >99.99%Colore e forma:SolidPeso molecolare:398.41DS12881479
CAS:DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].Formula:C16H19N3OSPurezza:99.85%Colore e forma:SolidPeso molecolare:301.41GSK2008607
CAS:<p>GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.</p>Formula:C31H28F3N7O3S2Purezza:99.36%Colore e forma:SolidPeso molecolare:667.72(E)-GABAB receptor antagonist 1
CAS:(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.Formula:C18H24O4Purezza:98.09%Colore e forma:SolidPeso molecolare:304.38
